Metabolismo
Los inhibidores del metabolismo son compuestos que interfieren con las vías metabólicas, alterando la producción y utilización de energía dentro de las células. Estos inhibidores se utilizan para estudiar la regulación del metabolismo, el papel de las vías metabólicas en enfermedades como el cáncer y la diabetes, y para desarrollar nuevas estrategias terapéuticas. Los inhibidores del metabolismo pueden dirigirse a diversas enzimas y procesos involucrados en la glucólisis, la oxidación de ácidos grasos y otras funciones metabólicas. En CymitQuimica, ofrecemos una amplia gama de inhibidores del metabolismo de alta calidad para apoyar su investigación en bioquímica, trastornos metabólicos y desarrollo de fármacos.
Subcategorías de "Metabolismo"
- AhR(41 productos)
- Aminopeptidasa(67 productos)
- CETP(18 productos)
- Anhídrido carbónico(177 productos)
- Caseína quinasa(130 productos)
- DHFR(32 productos)
- Descarboxilasa(4 productos)
- Deshidrogenasa(267 productos)
- FAAH(63 productos)
- FXR(58 productos)
- Factor Xa(80 productos)
- Ácido graso sintasa(32 productos)
- Ferroptosis(215 productos)
- GR(3 productos)
- GSNOR(3 productos)
- Glucoquinasa(53 productos)
- HIF / HIF Prolilhidroxilasa(142 productos)
- HMG-CoA reductasa(32 productos)
- Hidroxilasa(30 productos)
- IDO(82 productos)
- LDL(8 productos)
- Lipasa(96 productos)
- Lípido(59 productos)
- Lipoxigenasa(124 productos)
- MAO(87 productos)
- MPO(2 productos)
- NAMPT(36 productos)
- P450(6 productos)
- PAI-1(25 productos)
- PDE(166 productos)
- PED(1 productos)
- PKM(15 productos)
- PPAR(164 productos)
- Fosfolipasa(82 productos)
- ROR(42 productos)
- Receptor de retinoides(29 productos)
- SGK(11 productos)
- Tiorredoxina(12 productos)
- Transferasa(30 productos)
- Transportador(42 productos)
- UGT(4 productos)
- Inhibidores de la xantina oxidasa (XO)(9 productos)
Mostrar 34 subcategorías más
Se han encontrado 8595 productos de "Metabolismo"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
ICMT-IN-18
CAS:<p>ICMT-IN-18 (compound 35) serves as an ICMT inhibitor with an IC50 value of 0.066 μM [1].</p>Fórmula:C22H26N2OForma y color:SolidPeso molecular:334.45D-threo-PDMP
CAS:<p>D-threo-PDMP inhibits glucoceramide synthase, cutting cell surface glycosphingolipids and hindering neurite growth.</p>Fórmula:C23H38N2O3Forma y color:SolidPeso molecular:390.56Arbaprostil
CAS:<p>Arbaprostil, a synthetic PGE analog, guards stomach lining, aids ulcer healing, and blocks pancreatic function and tumor growth.</p>Fórmula:C21H34O5Forma y color:SolidPeso molecular:366.49Gisadenafil
CAS:<p>Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.</p>Fórmula:C23H33N7O5SPureza:98.82% - 99.50%Forma y color:SolidPeso molecular:519.62NEP-IN-1
CAS:<p>NEP-IN-1 is an inhibitor of neutral endopeptidase (NEP, IC50 = 2 nM) and can be used in studies about female sexual arousal disorders.</p>Fórmula:C21H30ClNO4Pureza:99.69%Forma y color:SolidPeso molecular:395.92CCT365623
CAS:<p>CCT365623: oral Lysyl Oxidase inhibitor, potent, selective, good pharmacokinetics, anti-metastatic.</p>Fórmula:C18H17NO4S3Pureza:97.299% - 99.49%Forma y color:SolidPeso molecular:407.53PA452
CAS:<p>PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.</p>Fórmula:C26H37N3O3Pureza:97.14%Forma y color:SolidPeso molecular:439.59OGT 2115
CAS:<p>OGT 2115 blocks heparanase (IC50=0.4µM), cleaving heparan sulfate; antiangiogenic (IC50=1µM).</p>Fórmula:C24H16BrFN2O4Pureza:97.17%Forma y color:SolidPeso molecular:495.3Ranirestat
CAS:<p>Ranirestat (AS-3201) is an AR inhibitor with neuroprotective properties that improves peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy</p>Fórmula:C17H11BrFN3O4Pureza:98.83% - 99.44%Forma y color:SolidPeso molecular:420.19DGAT-1 inhibitor 2
CAS:<p>DGAT-1 inhibitor 2: effective against obesity, targets enzyme in triglyceride synthesis for diabetes treatment.</p>Fórmula:C24H28N4O3Pureza:98.36%Forma y color:SolidPeso molecular:420.5TPN171
CAS:<p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>Fórmula:C24H35N5O3Pureza:>99.99%Forma y color:SolidPeso molecular:441.57KB-74935
CAS:<p>KB-74935: enzyme inhibitor, mineralocorticoid blocker, treats cholesterol, hypolipidemia, neurological issues, Alzheimer's.</p>Fórmula:C19H18ClF4N3O3SPureza:99.4%Forma y color:SolidPeso molecular:479.88Calcium channel-modulator-1
CAS:<p>Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction.</p>Fórmula:C26H24Cl2N2O7SPureza:99.95%Forma y color:SolidPeso molecular:579.45Rilapladib
CAS:<p>Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2(Lp-PLA2, IC50 = 230 pM) and an antagonist of the platelet activating</p>Fórmula:C40H38F5N3O3SPureza:99.92%Forma y color:SolidPeso molecular:735.8Cudetaxestat
CAS:<p>Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.</p>Fórmula:C21H15Cl2F2N3O2SPureza:99.9%Forma y color:SolidPeso molecular:482.33p-Ethynylphenylalanine
CAS:<p>p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a tryptophan hydroxylase (TPH) inhibitor, is competitive, effective, selective, and reversible, with a Ki of</p>Fórmula:C11H11NO2Pureza:97.57%Forma y color:SolidPeso molecular:189.21Inolitazone
CAS:<p>Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.</p>Fórmula:C27H26N4O4SPureza:99.41% - 99.53%Forma y color:SolidPeso molecular:502.58WAY-620147
CAS:<p>WAY-620147 inhibits Monoamine Oxidase and can be used for the study of neurological disorders.</p>Fórmula:C12H16BrN3O2Pureza:99.55%Forma y color:SolidPeso molecular:314.18Cis-22a
CAS:<p>Cis-22a: selective TRPV6 inhibitor (IC50=0.32μM), halts T47D breast cancer cell growth.</p>Fórmula:C24H30F3N3O2Pureza:99.07%Forma y color:SolidPeso molecular:449.51Setileuton
CAS:<p>Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.</p>Fórmula:C22H17F4N3O4Pureza:98.85% - 99.35%Forma y color:SolidPeso molecular:463.38AMG 579
CAS:<p>AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).</p>Fórmula:C25H23N5O3Pureza:99.87%Forma y color:SolidPeso molecular:441.48Xanthine oxidase-IN-1
CAS:<p>Xanthine oxidase-IN-1 is an effective inhibitor of xanthine oxidase with an IC50 value of 6.5 nM.</p>Fórmula:C16H8F2N2O3Pureza:97.36% - 99.22%Forma y color:SolidPeso molecular:314.24HIF-2α agonist 2
CAS:HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.Fórmula:C13H8Br2N2O2SPureza:98.87%Forma y color:SoildPeso molecular:416.09RS 8359
CAS:<p>RS 8359 is a selective MAO-A reversible inhibitor with a 2200:1 A:B ratio, exhibiting antidepressant effects.</p>Fórmula:C14H12N4OPureza:99.3%Forma y color:SolidPeso molecular:252.27Ecopladib
CAS:<p>Ecopladib inhibits cPLA2α with IC50 of 0.15 μM (micelles) & 0.11 μM (rat blood).</p>Fórmula:C39H33Cl3N2O5SPureza:95.15%Forma y color:SolidPeso molecular:748.11Varespladib methyl
CAS:<p>Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.</p>Fórmula:C22H22N2O5Pureza:99.42% - 99.97%Forma y color:SolidPeso molecular:394.42Fluspirilene
CAS:<p>Fluspirilene is a long-acting antipsychotic for schizophrenia, inhibiting L-type calcium channels (IC50: 0.03 μM).</p>Fórmula:C29H31F2N3OPureza:99.59%Forma y color:SolidPeso molecular:475.57Enpp-1-IN-16
CAS:<p>Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.</p>Fórmula:C23H32N4O4Pureza:99.87%Forma y color:SolidPeso molecular:428.52ER 50891
CAS:<p>ER-50891 is a potent RARα antagonist, countering retinoic acid inhibition and aiding BMP2-induced osteoblast differentiation.</p>Fórmula:C29H24N2O2Pureza:>99.99%Forma y color:SolidPeso molecular:432.51ALDH2 modulator 1
CAS:<p>ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.</p>Fórmula:C18H18ClFN2O3Pureza:99.68%Forma y color:SoildPeso molecular:364.8PXS-6302 hydrochloride
CAS:<p>PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3</p>Fórmula:C10H11ClF3NO2SPureza:99.89%Forma y color:SoildPeso molecular:301.71CB29
CAS:<p>CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).</p>Fórmula:C15H15N3O5SPureza:99.36%Forma y color:SolidPeso molecular:349.36WAY-297848
CAS:<p>WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.</p>Fórmula:C13H13ClN2O2SPureza:98.19%Forma y color:SolidPeso molecular:296.77Mitiperstat
CAS:<p>Mitiperstat, a strong MPO inhibitor, helps prevent heart failure and coronary artery disease.</p>Fórmula:C15H15ClN4OSPureza:98.36%Forma y color:SolidPeso molecular:334.827-BIA
CAS:<p>7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with anti-addictive properties and can be used in the study of neuropathic pain.</p>Fórmula:C15H18O6Pureza:≥98% - ≥98%Forma y color:SolidPeso molecular:294.3NPAS3-IN-1
CAS:<p>NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.</p>Fórmula:C10H5N3O2S3Pureza:99.56%Forma y color:SolidPeso molecular:295.36PDE9-IN-(S)-C33
CAS:<p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>Fórmula:C18H20ClN5OPureza:98.75%Forma y color:SolidPeso molecular:357.84h-NTPDase-IN-2
CAS:<p>h-NTPDase-IN-2 is a broad-spectrum NTPDase inhibitor that inhibits multiple h-NTPDas isoforms.</p>Fórmula:C19H16N4SPureza:99.58%Forma y color:SolidPeso molecular:332.42BI-3231
CAS:<p>BI-3231 is a hydroxysteroid 17ß-dehydrogenase 13 HSD17B13 inhibitor that inhibits hHSD17B13 .BI-3231 can be used to study cirrhosis.</p>Fórmula:C16H14F2N4O3SPureza:98.2%Forma y color:SolidPeso molecular:380.37Dechloro Rivaroxaban
CAS:<p>Dechloro Rivaroxaban is a Factor Xa inhibitor that inhibits free FXa and plasminogen and fibrin-associated FXa activity in humans.</p>Fórmula:C19H19N3O5SPureza:98.63%Forma y color:SolidPeso molecular:401.444A3-SC8
CAS:<p>4A3-SC8 is a modular, degradable dendrimer facilitating the extension of survival in aggressive liver cancer models through the delivery of small RNAs [1].</p>Fórmula:C75H139N3O16S4Pureza:99.87%Forma y color:SolidPeso molecular:1467.18TP-10
CAS:<p>TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.</p>Fórmula:C26H19F3N4OPureza:99.21%Forma y color:SolidPeso molecular:460.45ML400
CAS:<p>ML400 (CID73050863) is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.</p>Fórmula:C24H29N3OPureza:99.95%Forma y color:SolidPeso molecular:375.51Mutant IDH1-IN-2
CAS:<p>Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of 16.6 nM in Fluorescence biochemical assay, IC50 of ＜22 nM in LS-</p>Fórmula:C24H31F2N5O2Pureza:99.88%Forma y color:SolidPeso molecular:459.53Monoamine Oxidase B inhibitor 6
CAS:<p>Monoamine OxidaseB inhibitor 6 (Compound BT5) is a highly selective, reversible, and competitive MAO-B inhibitor capable of crossing the blood-brain barrier, with an IC50 of 0.11 μM. It exhibits antioxidant and neuroprotective properties, making it suitable for research into neurodegenerative diseases.</p>Fórmula:C15H15N3OSForma y color:SolidPeso molecular:285.364PDHK-IN-3
<p>PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].</p>Fórmula:C17H16N2O2Forma y color:SolidPeso molecular:280.32CIT-ALD
CAS:<p>CIT-ALD is an aldehyde intermediate formed during the metabolism of Citalopram. It has potential applications in the research of neurological disorders.</p>Fórmula:C18H14FNO2Peso molecular:295.31Tabimorelin hemifumarate
CAS:<p>orally active ghrelin receptor (GHS-R1a) agonist</p>Fórmula:C32H40N403C4H404Pureza:98%Forma y color:SolidPeso molecular:586.7213(R)-HODE
CAS:<p>13(R)-HODE, produced from linoleic acid, inhibits platelet aggregation (IC50=2.7μM) and is found in bovine endothelial cells.</p>Fórmula:C18H32O3Forma y color:SolidPeso molecular:296.44LASSBio-1632
<p>LASSBio-1632: Novel anti-asthmatic, blocks PDE4A/D, reduces AHR & lung TNF-α, crosses BBB.</p>Fórmula:C18H20N2O6SForma y color:SolidPeso molecular:392.43Z21090
CAS:<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Fórmula:C12H14ClN3O3Forma y color:SolidPeso molecular:283.71Asimicin
CAS:<p>Asimicin is a effective complex I inhibitor.</p>Fórmula:C37H66O7Pureza:98%Forma y color:SolidPeso molecular:622.92Keto lovastatin
CAS:<p>Keto lovastatin is an impurity of lovastatin with antibacterial properties. Lovastatin is a cell-permeable HMG-CoA reductase (HMG-CoA reductase) inhibitor used to reduce cholesterol levels.</p>Fórmula:C24H34O6Forma y color:SolidPeso molecular:418.523NAMPT activator-6
CAS:<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Fórmula:C17H21N5O3SForma y color:SolidPeso molecular:375.45ALOX15-IN-1
<p>ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.</p>Fórmula:C24H31N3O5SForma y color:SolidPeso molecular:473.59Antidiabetic agent 5
CAS:<p>Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].</p>Fórmula:C17H15N3O4SForma y color:SolidPeso molecular:357.38RORγt/DHODH-IN-1
CAS:<p>RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant</p>Fórmula:C24H26ClF6N3O3SForma y color:SolidPeso molecular:585.99Rostratin B
CAS:<p>Rostratin B, a cytotoxic disulfide, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an IC50 value of 1.9 μg/mL.</p>Fórmula:C18H20N2O6S2Forma y color:SolidPeso molecular:424.49Carbonic anhydrase inhibitor 2
CAS:<p>Compound 7c inhibits carbonic anhydrase II, lowering intraocular pressure in glaucomatous rabbits.</p>Fórmula:C12H16N4O6SForma y color:SolidPeso molecular:344.34hCAII-IN-5
CAS:<p>hCAII-IN-5 (compound 12h) is a potent, selective inhibitor of human carbonic anhydrase II (hCA II) with an inhibition constant (IC50) of 4.55 µM [1].</p>Fórmula:C29H18N2O7Forma y color:SolidPeso molecular:506.46CYP121A1-IN-1
<p>CYP121A1-IN-1: Strong inhibitor for CYP121A1, hinders Mycobacterium tuberculosis growth (MIC 90 ~6.25 μM), reduces mycocyclosin synthesis.</p>Fórmula:C22H20N4OForma y color:SolidPeso molecular:356.42α-Glucosidase-IN-12
<p>α-Glucosidase-IN-12 is a potent inhibitor of α-glucosidase (IC50: 10.20 μM).</p>Fórmula:C25H30N4O4S2Forma y color:SolidPeso molecular:514.66ACLY-IN-1
CAS:<p>ACLY-IN-1 (compound 55) is a potent ACLY inhibitor with an IC50 of 8.3 nM, and it can be utilized in hyperlipidemia research.</p>Fórmula:C20H12BrClF2N2O4SForma y color:SolidPeso molecular:529.74PPI-2458
CAS:<p>PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.</p>Fórmula:C22H36N2O6Forma y color:SolidPeso molecular:424.53Carbonic anhydrase inhibitor 9
<p>Carbonic anhydrase inhibitor 9 targets hCA II and IX with Ki of 56.4 and 56.9 nM respectively; shows antiproliferative activity.</p>Fórmula:C22H20BrN5O4SForma y color:SolidPeso molecular:530.39PDE5-IN-8
CAS:<p>PDE5-IN-8 (compound 2) is an inhibitor of PDEs.</p>Fórmula:C22H20ClN3O2Forma y color:SolidPeso molecular:393.87RORγt inverse agonist 29
<p>RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM.</p>Fórmula:C25H24N2O5SForma y color:SolidPeso molecular:464.53PNPLA3 modifier 1
CAS:<p>PNPLA3 Modifier 1 (Compound 10), a modifier of patatin-like phospholipase domain-containing protein 3 (pnpla3), exhibits a geometric mean EC50 of 4.9 nM.</p>Fórmula:C16H19ClF2N2O4SForma y color:SolidPeso molecular:408.85PDE4-IN-12
<p>PDE4-IN-12 is a potent and safe PDE4 ubiquitous inhibitor that acts on PDE4 (IC50: 3.5 nM, SI: 2.71) and PDE7 (IC50: 15 nM, SI: 4.27).</p>Fórmula:C34H35NO6Forma y color:SolidPeso molecular:553.64Deamino-NAD sodium
CAS:<p>Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.</p>Fórmula:C21H25N6NaO15P2Forma y color:SolidPeso molecular:686.39Enpp-1-IN-11
<p>Enpp-1-IN-11 inhibits ENPP1 with a 45 nM Ki, is plasma stable, and has low clearance in human/mouse livers, potentially aiding cancer research.</p>Fórmula:C15H15N5O3SForma y color:SolidPeso molecular:345.38TMX-4116
CAS:<p>TMX-4116 is a CK1α degrader targeting multiple cell lines with DC50s below 200 nM, used in multiple myeloma research and protein degradation strategy studies.</p>Fórmula:C17H19N5O4SForma y color:SolidPeso molecular:389.434-Acetylphenylboronic acid
CAS:<p>4-Acetylphenylboronic acid acts as an effective inhibitor targeting carbonic anhydrase II (CAII), displaying inhibitory concentrations (IC50) of 246 μM for bovine CAII (bCA II) and 281.40 μM for human CAII (hCA II).</p>Fórmula:C8H9BO3Forma y color:SolidPeso molecular:163.97NAZ2329
CAS:<p>NAZ2329: Cell-permeable, targets R5 RPTPs, inhibits hPTPRZ1 (IC50=7.5 μM) & hPTPRG (IC50=4.8 μM), hampers glioblastoma growth, affects stem cell traits.</p>Fórmula:C21H18F3NO4S3Forma y color:SoildPeso molecular:501.56Homomoschatoline
CAS:<p>Homomoschatoline is an antibacterial isolated from Artabotrys crassifolius.</p>Fórmula:C19H15NO4Pureza:98%Forma y color:SolidPeso molecular:321.33ABD957
CAS:<p>ABD957: covalent ABHD17 depalmitoylases inhibitor, IC50 0.21µM for ABHD17B, blocks N-Ras, halts NRAS-mutant AML cell growth.</p>Fórmula:C27H36F3N7O5SForma y color:SolidPeso molecular:627.68AubipyOMe
CAS:<p>AubipyOMe serves as an effective inhibitor of Tartrate-resistant Acid Phosphatase (TRAP/ACP5), a metalloenzyme identified in activated osteoclasts and macrophages. It exhibits inhibitory IC50 values of 1.3 μM against TRAP5a and 1.8 μM against TRAP5b. Additionally, it effectively suppresses TRAP activity in extracts from mouse macrophages and human lung tissues.</p>Fórmula:C12H12AuCl2F6N2O2PForma y color:SolidPeso molecular:629.07hMAO-B/MB-COMT-IN-2
<p>Dual inhibitor hMAO-B/MB-COMT-IN-2 targets hMAO-B (IC50: 4.27μM) & MB-COMT (IC50: 2.69μM), aids in neurodegenerative research.</p>Fórmula:C17H18N2O3Forma y color:SolidPeso molecular:298.34EC33
CAS:<p>EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].</p>Fórmula:C4H11NO3S2Forma y color:SolidPeso molecular:185.27BMS-214662 mesylate
CAS:<p>BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research.</p>Fórmula:C26H27N5O5S3Forma y color:SolidPeso molecular:585.718MAGL-IN-15
CAS:<p>MAGL-IN-15 (Compound 6), a MAGL inhibitor, holds potential for research into diseases and disorders associated with the regulation of endocannabinoid system signaling activities [1].</p>Fórmula:C16H16F6N4O3Forma y color:SolidPeso molecular:426.31Lp-PLA2-IN-10
<p>Lp-PLA2-IN-10, a potent Lp-PLA2 inhibitor, may research neurodegenerative and cardiovascular diseases.</p>Fórmula:C21H15F5N4O4Forma y color:SolidPeso molecular:482.36CYP1B1-IN-2
<p>CYP1B1-IN-2 (compound 9j) is a highly potent and selective inhibitor of CYP1B1, a cytochrome P450 enzyme. It exhibits an IC50 value of 0.52 nM [1].</p>Fórmula:C20H11F3O2Forma y color:SolidPeso molecular:340.3Glucosylceramide synthase-IN-4
CAS:<p>Glucosylceramide Synthase-IN-4 (compound 12) serves as a potent inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 of 6.8 nM. It demonstrates superior pharmacokinetic properties and robust stability in human hepatocytes. Additionally, this compound is noted for its effective CNS penetration and acceptable PXR selectivity [1].</p>Fórmula:C22H18F5N3O3Forma y color:SolidPeso molecular:467.39Nampt activator-4
CAS:<p>Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].</p>Fórmula:C26H22F3N7OSForma y color:SolidPeso molecular:537.56O-Desmethyl Brinzolamide hydrochloride
CAS:<p>O-Desmethyl Brinzolamide hydrochloride (compound 6a), a potent metabolite derived from Brinzolamide, serves as a carbonic anhydrase (CA) inhibitor. It exhibits a dissociation constant (Kd) of 0.136 nM for CA II and an inhibitory concentration (IC50) of 165 nM for CA IV [1].</p>Fórmula:C11H20ClN3O5S3Forma y color:SolidPeso molecular:405.94Fmoc-NH-PEG6-alcohol
CAS:<p>Fmoc-NH-PEG6-alcohol, a cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs) [1].</p>Fórmula:C27H37NO8Forma y color:SolidPeso molecular:503.58DOCP
CAS:<p>DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate) is a lipid characterized by an opposite charge orientation compared to traditional phosphatidylcholine (PC) lipids, featuring quaternary ammonium near the bilayer interface and phosphate groups projecting into the aqueous environment. This unique structure of iPC lipids presents an excellent opportunity to investigate the biophysical characteristics and biological activities influenced by the reversal of surface charges on bilayers.</p>Fórmula:C43H82NO8PForma y color:SolidPeso molecular:772.09α-Glucosidase-IN-63
CAS:<p>α-Glucosidase-IN-63 (Compound 4d) serves as an α-Glucosidase inhibitor with an IC 50 value of 0.44 μM. Additionally, it exhibits inhibitory activity against hCA II, demonstrating a K i of 7.0 nM. The compound is also effective when administered orally. [1]</p>Fórmula:C16H12FN3O3S2Forma y color:SolidPeso molecular:377.41ABCB1-IN-4
CAS:<p>ABCB1-IN-4 (Compound C6z) is an orally active inhibitor of α-amylase and α-glucosidase, with IC50 values of 1.63 μM and 0.14 μM, respectively. It holds potential for diabetes research.</p>Fórmula:C16H14N4SForma y color:SolidPeso molecular:294.374PTP1B-IN-21
<p>PTP1B-IN-21 inhibits PTP1B (IC50=1.56μM) selectively over TCPTP, a type 2 diabetes target.</p>Fórmula:C22H22O11Forma y color:SolidPeso molecular:462.4E234G HYPE-IN-1
CAS:<p>Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].</p>Fórmula:C14H9N5O2Forma y color:SolidPeso molecular:279.25APOL1-IN-3
CAS:<p>APOL1-IN-3 is an APOL1 inhibitor used for kidney disease research.</p>Fórmula:C16H19F3N4O2SForma y color:SolidPeso molecular:388.41GKA50 quarterhydrate
<p>GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.</p>Fórmula:C26H30N2O7Forma y color:SolidPeso molecular:469.01MAGL-IN-19
CAS:<p>MAGL-IN-19 (compound 7o) is a highly effective and selective inhibitor of MAGL.</p>Fórmula:C21H26F3N3O3Forma y color:SolidPeso molecular:425.45HIF-1α-IN-4
<p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>Fórmula:C16H12N2O3Forma y color:SolidPeso molecular:280.28α-Glucosidase-IN-13
<p>α-Glucosidase-IN-13 is an inhibitor of α-glucosidase (IC50: 5.69 μM).</p>Fórmula:C25H28N4O3S2Forma y color:SolidPeso molecular:496.64Mitochondrial-IN-1
CAS:<p>Mitochondrial-IN (C458) is a potent inhibitor of mitochondrial complex I. It offers significant protection against Aβ toxicity, exhibits favorable pharmacokinetic properties, and has minimal off-target effects.</p>Fórmula:C22H30N2OForma y color:SolidPeso molecular:338.49NTPDase-IN-3
CAS:<p>NTPDase-IN-3 inhibits NTPDase1/2/3/8 (IC50: 0.21/1.07/0.38/0.05 μM), useful for cancer and thrombosis research.</p>Fórmula:C22H24ClN3OS2Forma y color:SolidPeso molecular:446.03ZK824859 hydrochloride
<p>ZK824859 hydrochloride: oral uPA inhibitor with IC50 of 79 nM (uPA), 1580 nM (tPA), 1330 nM (fibrin).</p>Fórmula:C23H23ClF2N2O4Forma y color:SolidPeso molecular:464.89
