Metabolismo
Los inhibidores del metabolismo son compuestos que interfieren con las vías metabólicas, alterando la producción y utilización de energía dentro de las células. Estos inhibidores se utilizan para estudiar la regulación del metabolismo, el papel de las vías metabólicas en enfermedades como el cáncer y la diabetes, y para desarrollar nuevas estrategias terapéuticas. Los inhibidores del metabolismo pueden dirigirse a diversas enzimas y procesos involucrados en la glucólisis, la oxidación de ácidos grasos y otras funciones metabólicas. En CymitQuimica, ofrecemos una amplia gama de inhibidores del metabolismo de alta calidad para apoyar su investigación en bioquímica, trastornos metabólicos y desarrollo de fármacos.
Subcategorías de "Metabolismo"
- AhR(41 productos)
- Aminopeptidasa(67 productos)
- CETP(18 productos)
- Anhídrido carbónico(177 productos)
- Caseína quinasa(130 productos)
- DHFR(32 productos)
- Descarboxilasa(4 productos)
- Deshidrogenasa(267 productos)
- FAAH(63 productos)
- FXR(58 productos)
- Factor Xa(80 productos)
- Ácido graso sintasa(32 productos)
- Ferroptosis(215 productos)
- GR(3 productos)
- GSNOR(3 productos)
- Glucoquinasa(53 productos)
- HIF / HIF Prolilhidroxilasa(142 productos)
- HMG-CoA reductasa(32 productos)
- Hidroxilasa(30 productos)
- IDO(82 productos)
- LDL(8 productos)
- Lipasa(96 productos)
- Lípido(59 productos)
- Lipoxigenasa(124 productos)
- MAO(87 productos)
- MPO(2 productos)
- NAMPT(36 productos)
- P450(6 productos)
- PAI-1(25 productos)
- PDE(166 productos)
- PED(1 productos)
- PKM(15 productos)
- PPAR(164 productos)
- Fosfolipasa(82 productos)
- ROR(42 productos)
- Receptor de retinoides(29 productos)
- SGK(11 productos)
- Tiorredoxina(12 productos)
- Transferasa(30 productos)
- Transportador(42 productos)
- UGT(4 productos)
- Inhibidores de la xantina oxidasa (XO)(9 productos)
Mostrar 34 subcategorías más
Se han encontrado 8595 productos de "Metabolismo"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
JPHM-2-167
CAS:<p>PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.</p>Fórmula:C30H28N6O2Forma y color:SolidPeso molecular:504.58211-trans Leukotriene E4
CAS:<p>Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.</p>Fórmula:C23H37NO5SForma y color:SolidPeso molecular:439.61ZK159222
CAS:<p>ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.</p>Fórmula:C32H48O5Pureza:98%Forma y color:SolidPeso molecular:512.72GlcCer (d18:1/18:0)
CAS:<p>GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a sphingolipid with potential applications in research on Parkinson's disease and Lewy body dementia.</p>Fórmula:C42H81NO8Forma y color:SolidPeso molecular:728.094JTZ-951 HCl
CAS:<p>JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).</p>Fórmula:C17H17ClN4O4Pureza:98%Forma y color:SolidPeso molecular:376.79ZK824859 hydrochloride
<p>ZK824859 hydrochloride: oral uPA inhibitor with IC50 of 79 nM (uPA), 1580 nM (tPA), 1330 nM (fibrin).</p>Fórmula:C23H23ClF2N2O4Forma y color:SolidPeso molecular:464.89RWJ-445167
CAS:<p>RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.</p>Fórmula:C18H24N6O5SPureza:98%Forma y color:SolidPeso molecular:436.49hCAII-IN-3
<p>hCAII-IN-3 inhibits key hCA isoforms with Ki: hCA I (403.8 nM), hCA II (5.1 nM), hCA IX (10.2 nM), hCA XII (5.2 nM); shows anticancer potential.</p>Fórmula:C17H21N3O3SForma y color:SolidPeso molecular:347.43ZK168281
CAS:<p>ZK168281 is a 1α,25(OH)2D3 analog, VDR antagonist with 0.1 nM Kd, and blocks receptor CoA interaction.</p>Fórmula:C32H46O5Pureza:98%Forma y color:SolidPeso molecular:510.704-(4-Bromophenyl)-4-hydroxypiperidine
CAS:<p>4-(4-Bromophenyl)-4-hydroxypiperidine (BPHP) is a metabolite of Bromperidol (BRO), produced through the N-dealkylation of BRO.</p>Fórmula:C11H14BrNOForma y color:SolidPeso molecular:256.139NTPDase-IN-2
CAS:<p>NTPDase-IN-2 inhibits h-NTPDase-2/-8 (IC50: 0.04, 2.27 µM), non-competitive for h-NTPDase-1/-2 (Km: 74 µM); useful in cancer, immune, bacterial research.</p>Fórmula:C24H20FN3OS2Forma y color:SolidPeso molecular:449.56ABHD antagonist 1
CAS:<p>ABHD antagonist 1 is an inhibitor of ABHD6 (α/β-Hydrolase domain containing 6), involved in modulating biochemical pathways affected by ABHD6, thereby influencing cell function and inflammatory responses. This compound is applicable for research in fields such as pain, neurological disorders, inflammatory diseases, autoimmune diseases, metabolic disorders, and cancer.</p>Fórmula:C19H20BrN3O3SForma y color:SolidPeso molecular:450.35Lecufexor
CAS:<p>Lecufexor is an agonist of the farnesoid X receptor (FXR).</p>Fórmula:C32H21Cl3N2O5Forma y color:SolidPeso molecular:619.88Fonadelpar
CAS:<p>Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.</p>Fórmula:C25H23F3N2O4SPureza:98%Forma y color:SolidPeso molecular:504.52β-Glucuronidase/hCAII-IN-2
<p>β-Glucuronidase/hCAII-IN-2 is a potent inhibitor of β-glucuronidase and hCA II, and their IC50 values were 670.7 μM and 21.77 μM, respectively.</p>Fórmula:C31H23NO8Forma y color:SolidPeso molecular:537.52Ketomethylenebestatin
CAS:<p>Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.</p>Fórmula:C17H25NO4Pureza:98%Forma y color:SolidPeso molecular:307.387-Hydroxyrisperidone
CAS:<p>7-Hydroxyrisperidone (7-RispOH) is a metabolite of Risperidone. Risperidone acts as a 5-HT2 receptor blocker, an inhibitor of P-glycoprotein (P-Glycoprotein), and an antagonist of the dopamine D2 receptor.</p>Fórmula:C23H27FN4O3Forma y color:SolidPeso molecular:426.484DX-9065A HCl hydrate
CAS:<p>DX-9065a: Competitive fXa/prothrombinase inhibitor; blocks proinflammatory events; Ki ~10-20 nM.</p>Fórmula:C26H39ClN4O8Pureza:98%Forma y color:SolidPeso molecular:571.06PD-224378
CAS:<p>PD-224378 is the lactam form of glycamine (β-isomer), produced through a Maillard reaction between pregabalin and lactose.</p>Fórmula:C20H35NO11Forma y color:SolidPeso molecular:465.492Casein kinase 1δ-IN-16
CAS:<p>Casein kinase1δ-IN-16 (compound 506) is an inhibitor of casein kinase 1δ (CK1δ). This compound is applicable in research related to neurodegenerative diseases.</p>Fórmula:C17H12N4S2Forma y color:SolidPeso molecular:336.434Porphobilinogen
CAS:<p>Porphobilinogen act as a phytotoxin, a metabotoxin, and a neurotoxin.</p>Fórmula:C10H14N2O4Pureza:98%Forma y color:SolidPeso molecular:226.23Ro 23-9358
CAS:<p>Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.</p>Fórmula:C30H51NO6Forma y color:SolidPeso molecular:521.7297-APB hydrochloride
CAS:<p>7-APB hydrochloride is a benzofuran compound and serves as a metabolite of 7-MAPB.</p>Fórmula:C11H14ClNOForma y color:SolidPeso molecular:211.688Arphamenine A
CAS:<p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>Fórmula:C16H24N4O3Forma y color:SolidPeso molecular:320.387PTP1B-IN-16
<p>PTP1B-IN-16: selective benzimidazole inhibitor of PTP1B, Ki: 12.6 μM, potential for type 2 diabetes research.</p>Fórmula:C26H18ClN3O4SForma y color:SolidPeso molecular:503.96Casein kinase 1δ-IN-25
CAS:<p>Casein kinase1δ-IN-25 (compound 487) is a potent inhibitor of casein kinase1δ. It is applicable in research on neurodegenerative diseases such as Alzheimer's disease.</p>Fórmula:C20H14FN3O4S2Forma y color:SolidPeso molecular:443.471β-Glucuronidase/hCAII-IN-1
CAS:<p>β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a compound that effectively inhibits both β-glucuronidase and human Carbonic Anhydrase II (hCA II), exhibiting IC50</p>Fórmula:C30H21NO9Forma y color:SolidPeso molecular:539.49MAGL-IN-15
CAS:<p>MAGL-IN-15 (Compound 6), a MAGL inhibitor, holds potential for research into diseases and disorders associated with the regulation of endocannabinoid system signaling activities [1].</p>Fórmula:C16H16F6N4O3Forma y color:SolidPeso molecular:426.31CP 524515
CAS:<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Fórmula:C27H27F9N2O4Forma y color:SolidPeso molecular:614.54-MDM
CAS:<p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>Fórmula:C14H14OForma y color:SolidPeso molecular:198.26RORγt/DHODH-IN-3
<p>RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 has</p>Fórmula:C24H26ClF6N3O3SForma y color:SolidPeso molecular:585.99Dopaminechrome
CAS:<p>Dopaminechrome (DACHR) is an oxidation product of dopamine that promotes the generation of H2O2 at mitochondrial complex I in the brain in a concentration- and respiration-dependent manner. It possesses neurotoxic properties and can be utilized in Parkinson's disease research.</p>Fórmula:C8H7NO2Forma y color:SolidPeso molecular:149.147ERAP1 modulator-2
CAS:<p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>Fórmula:C22H25F3N2O4SForma y color:SolidPeso molecular:470.505A-800141
CAS:<p>A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.</p>Fórmula:C24H30N2O4SForma y color:SolidPeso molecular:442.571GSK2945 hydrochloride
<p>GSK2945 HCl is a specific Rev-erbα antagonist, EC50: 21.5 μM (mouse), 20.8 μM (human), increases cholesterol 7α-hydroxylase.</p>Fórmula:C20H19Cl3N2O2SForma y color:SolidPeso molecular:457.8LU 2443
CAS:<p>LU 2443 is an orally active antiepileptic agent that is extensively absorbed, with up to 18% remaining unabsorbed in rats. The active half-life in plasma is 13.17 hours.</p>Fórmula:C9H8N2S2Forma y color:SolidPeso molecular:208.3CAII-IN-2
<p>CAII-IN-2 (3g): potent, selective CA-II inhibitor; IC50-12.1 μM for bovine CA-II; valuable in CA-related disorder research.</p>Fórmula:C18H19BrN4SForma y color:SolidPeso molecular:403.34Imipramine Blue chloride
<p>Imipramine Blue chloride is an effective anti-invasive agent capable of inhibiting glioma invasion. It suppresses the production of reactive oxygen species (reactive oxygen species) mediated by NADPH oxidase.</p>Fórmula:C40H51ClN4Forma y color:SolidPeso molecular:623.31Morocromen
CAS:<p>Morocromen is a 2-benzamidobenzoic acid derivative characterized by its ability to enhance coronary activity.</p>Fórmula:C21H27N3O5Forma y color:SolidPeso molecular:401.464-Hexen-3-one
CAS:<p>4-Hexen-3-one inhibits the growth of H. pylori in the ATCC 43526 strain and TDR strain. Additionally, this compound suppresses urease activity.</p>Fórmula:C6H10OForma y color:SolidPeso molecular:98.14PDE4-IN-5
<p>PDE4-IN-5: potent PDE4 inhibitor, IC50 = 3.1 nM, superb skin penetration, anti-psoriasis effect.</p>Fórmula:C21H28N2O3Forma y color:SolidPeso molecular:356.46PKR-IN-1
CAS:<p>PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor with antifungal properties, exhibiting an EC50 of 0.21 μg/mL against Rhizoctonia solani (R. solani).</p>Fórmula:C9HCl5N4OS2Forma y color:SolidPeso molecular:422.525ATX inhibitor 12
<p>Oral ATX inhibitor 12 (IC50: 1.72 nM) at 60 mg/kg prevents lung damage in C57Bl/6J mice.</p>Fórmula:C30H34FN5O2Forma y color:SolidPeso molecular:515.621-Phenylethanamine
CAS:<p>1-Phenylethanamine, a potential central nervous system stimulant related to β-phenylethylamine (β-phenylethylamine), exhibits diminished glycogenolysis activity in the brain due to its benzene ring being replaced by an indole group. This reduction in activity makes it useful for investigating how the chemical structure of phenylethylamine derivatives influences their effects on the central nervous system. Additionally, 1-Phenylethanamine is also utilized in the synthesis of the tyrosine kinase (tyrosine kinase) inhibitor CLM3.</p>Fórmula:C8H11NForma y color:SolidPeso molecular:121.18AChE/CA I-IN-1
<p>AChE/CA I-IN-1 (Compound 2g) acts as an inhibitor for both AChE and hCA I, with Ki values of 1.85 µM and 0.53 µM, respectively. It has shown potential applications in the research of Alzheimer's disease, glaucoma, and epilepsy.</p>Fórmula:C14H19NO6SForma y color:SolidPeso molecular:329.37ZMC3
CAS:<p>ZMC3 (NSC328784), a zinc chelator, exhibits properties as a zinc metallochaperone. It shows enhanced sensitivity in cells with the p53-R175H mutation and increases the cellular levels of ROS (reactive oxygen species).</p>Fórmula:C17H20N6SeForma y color:SolidPeso molecular:387.34RORγt inhibitor 2
CAS:<p>RORγt Inhibitor 2, a potent inhibitor of RORγt, exhibits an IC50 of 9.2 nM and is utilized in the study of cancer, inflammation, or autoimmune diseases that are</p>Fórmula:C31H33F5N2O7SForma y color:SolidPeso molecular:672.66PDHK-IN-4
<p>PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.</p>Fórmula:C24H25N5O3Forma y color:SolidPeso molecular:431.49Clopidogrel-β-D-glucuronide
CAS:<p>Clopidogrel-β-D-glucuronide is a metabolite of Clopidogrel. It directly interacts with the CYP2C8 enzyme and strongly inhibits the hepatic enzyme CYP2C8.</p>Fórmula:C21H22ClNO8SForma y color:SolidPeso molecular:483.919Asimicin
CAS:<p>Asimicin is a effective complex I inhibitor.</p>Fórmula:C37H66O7Pureza:98%Forma y color:SolidPeso molecular:622.92Keto lovastatin
CAS:<p>Keto lovastatin is an impurity of lovastatin with antibacterial properties. Lovastatin is a cell-permeable HMG-CoA reductase (HMG-CoA reductase) inhibitor used to reduce cholesterol levels.</p>Fórmula:C24H34O6Forma y color:SolidPeso molecular:418.523Pyripyropene A
CAS:<p>Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 μM).</p>Fórmula:C31H37NO10Pureza:98%Forma y color:SolidPeso molecular:583.63ALOX15-IN-1
<p>ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.</p>Fórmula:C24H31N3O5SForma y color:SolidPeso molecular:473.59P053
CAS:<p>P053: potent, selective CerS1 inhibitor, IC50 = 0.5µM, curbs muscle fat oxidation, affects body fat.</p>Fórmula:C18H21Cl2NO2Pureza:98%Forma y color:SolidPeso molecular:354.27Myxothiazol
CAS:<p>Myxothiazol blocks mitochondrial complex III and triggers SESN2, a gene important for stress response.</p>Fórmula:C25H33N3O3S2Forma y color:SolidPeso molecular:487.68RO5101576
CAS:<p>RO5101576 is a potent antagonist of LTB4 receptor.</p>Fórmula:C36H38O8SPureza:98%Forma y color:SolidPeso molecular:630.75RORγt/DHODH-IN-1
CAS:<p>RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant</p>Fórmula:C24H26ClF6N3O3SForma y color:SolidPeso molecular:585.99hCAII-IN-5
CAS:<p>hCAII-IN-5 (compound 12h) is a potent, selective inhibitor of human carbonic anhydrase II (hCA II) with an inhibition constant (IC50) of 4.55 µM [1].</p>Fórmula:C29H18N2O7Forma y color:SolidPeso molecular:506.46(±)-HIP-B
CAS:<p>(±)-HIP-B is an excitatory amino acid transporter blocker.</p>Fórmula:C6H8N2O4Pureza:98%Forma y color:SolidPeso molecular:172.14BMS-986339
CAS:<p>BMS-986339: oral, potent FXR agonist; binds to His298/ASN287; for PBC, PSC, NASH, anti-fibrosis research.</p>Fórmula:C35H41F4N3O4Forma y color:SolidPeso molecular:643.71FXIa-IN-9
CAS:<p>FXIa-IN-9, a potent FXIa inhibitor (K i : human 0.17 nM, rabbit 0.5 nM), forms hydrogen bonds and has anticoagulant properties.</p>Fórmula:C23H18Cl2F3N9O2Forma y color:SolidPeso molecular:580.35L-Sepiapterin
CAS:<p>L-Sepiapterin aids in making BH4, a coenzyme essential for eNOS, enhancing artery function and angiogenesis, while suppressing ovarian cancer cell growth.</p>Fórmula:C9H11N5O3Forma y color:SolidPeso molecular:237.22FAAH/MAGL-IN-2
CAS:<p>FAAH/MAGL-IN-2: potent, reversible, oral FAAH & MAGL inhibitor, IC50: 11/36 nM, may research neuropathic pain, no locomotion issue.</p>Fórmula:C15H13Cl2N3O3SForma y color:SolidPeso molecular:386.251,2-Dipentadecanoyl-rac-glycerol
CAS:<p>1,2-Dipentadecanoyl-rac-glycerol (DG(15:0/15:0/0:0)) is a compound referenced in studies examining the effect of insulin on the content of 1,2-diacylglycerol in rat hearts. Insulin is observed to increase the amount of 1,2-diacylglycerol containing specific fatty acid compositions in the heart, which may be linked to cardiac contractility.</p>Fórmula:C33H64O5Forma y color:SolidPeso molecular:540.863β,7β-Dihydroxy-5-cholestenoic acid
CAS:<p>3β,7β-Dihydroxy-5-cholestenoic acid is a C27 acid whose levels are elevated in Niemann-Pick Type C and B diseases, leading to toxicity in ocular motor neurons. It is synthesized by the enzymatic action of hydroxysteroid 11-β dehydrogenase 1 from 3β-hydroxy-7-oxocholest-5-en-(25R)26-enoic acid (3βH,7O-CA).</p>Fórmula:C27H44O4Forma y color:SolidPeso molecular:432.64PKM2-IN-9
CAS:<p>PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.</p>Fórmula:C24H22N4O2Forma y color:SolidPeso molecular:398.457Enpp-1-IN-11
<p>Enpp-1-IN-11 inhibits ENPP1 with a 45 nM Ki, is plasma stable, and has low clearance in human/mouse livers, potentially aiding cancer research.</p>Fórmula:C15H15N5O3SForma y color:SolidPeso molecular:345.38TMX-4116
CAS:<p>TMX-4116 is a CK1α degrader targeting multiple cell lines with DC50s below 200 nM, used in multiple myeloma research and protein degradation strategy studies.</p>Fórmula:C17H19N5O4SForma y color:SolidPeso molecular:389.43Carbonic anhydrase inhibitor 5
<p>Potent hCA inhibitor: targets hCA II, IX & XII with IC50s of 42.9, 47.6, & 6.7 nM respectively.</p>Fórmula:C24H20ClN3O3SForma y color:SolidPeso molecular:465.95BMS-214662 mesylate
CAS:<p>BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research.</p>Fórmula:C26H27N5O5S3Forma y color:SolidPeso molecular:585.7189-cis-β-Carotene
CAS:<p>9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal.</p>Fórmula:C40H56Pureza:98%Forma y color:SolidPeso molecular:536.87UGT1A1-IN-1
CAS:<p>UGT1A1-IN-1 (compound 2) acts as a non-competitive inhibitor of UGT1A1, effectively inhibiting the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. This compound binds to the same ligand-binding site on UGT1A1 as bilirubin and additionally functions as a 'turn-on' fluorescent probe substrate for UGT1A1 [1].</p>Fórmula:C22H19NO3Forma y color:SolidPeso molecular:345.392,4-Dihydroxybutanoic acid
CAS:<p>2,4-Dihydroxybutanoic acid is typically not found in extracts of normal human urine and is present only in trace amounts in newborns, while cases of succinic semialdehyde dehydrogenase deficiency consistently exhibit elevated levels of this metabolite.</p>Fórmula:C4H8O4Forma y color:SolidPeso molecular:120.107-Hydroxy-4-phenylcoumarin
CAS:<p>7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.</p>Fórmula:C15H10O3Forma y color:SolidPeso molecular:238.238Mucidin
CAS:<p>Mucidin is an antifungal antibiotic that inhibits electron transfer reactions within the mitochondrial respiratory chain's cytochrome bc1 complex.</p>Fórmula:C16H18O3Peso molecular:258.31S-15176
CAS:<p>S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). It effectively suppresses mitochondrial swelling induced by tert-butyl hydroperoxide, with an IC50 value of 45.7 μM. S-15176 prevents the opening of PTP, thus averting the dissipation of mitochondrial membrane potential and the oxidation of NAD(P)H, while enhancing mitochondrial calcium loading capacity. It holds potential for research into ischemia-reperfusion injury.</p>Fórmula:C31H48N2O4SForma y color:SolidPeso molecular:544.79NAMPT activator-6
CAS:<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Fórmula:C17H21N5O3SForma y color:SolidPeso molecular:375.45Etoricoxib N1'-oxide
CAS:<p>EtoricoxibN1'-oxide is a metabolite of Etoricoxib. It does not inhibit COX-1 and does not significantly inhibit COX-2.</p>Fórmula:C18H15ClN2O3SForma y color:SolidPeso molecular:374.841α-Glucosidase-IN-13
<p>α-Glucosidase-IN-13 is an inhibitor of α-glucosidase (IC50: 5.69 μM).</p>Fórmula:C25H28N4O3S2Forma y color:SolidPeso molecular:496.64CK1δ-IN-7
CAS:<p>CK1δ-IN-7 (Compound 488) is an inhibitor of casein kinase 1δ (CK1δ).</p>Fórmula:C23H23N5OForma y color:SolidPeso molecular:385.462E234G HYPE-IN-1
CAS:<p>Compound I2.10 (E234G HYPE-IN-1) functions as an AMPylase inhibitor and exhibits low cytotoxicity toward human cell lines [1].</p>Fórmula:C14H9N5O2Forma y color:SolidPeso molecular:279.25Zaragozic acid C
CAS:<p>Zaragozic acid C is an effective inhibitor of squalene synthase.</p>Fórmula:C40H50O14Pureza:98%Forma y color:SolidPeso molecular:754.82HIF-1α-IN-4
<p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>Fórmula:C16H12N2O3Forma y color:SolidPeso molecular:280.28SelB-1
CAS:<p>SelB-1 acts as a dual inhibitor of Topoisomerase I/II (TopoisomeraseI/II), exhibiting anticancer activity suitable for research on prostate and colon cancers. Additionally, SelB-1 can induce the expression of autophagy (autophagy) genes and lipid peroxidation while reducing GSH levels.</p>Fórmula:C32H24O5Forma y color:SolidPeso molecular:488.53ABCB1-IN-4
CAS:<p>ABCB1-IN-4 (Compound C6z) is an orally active inhibitor of α-amylase and α-glucosidase, with IC50 values of 1.63 μM and 0.14 μM, respectively. It holds potential for diabetes research.</p>Fórmula:C16H14N4SForma y color:SolidPeso molecular:294.374CB30865
CAS:<p>CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.</p>Fórmula:C26H22BrN5O2Pureza:99.04%Forma y color:SolidPeso molecular:516.39FXR agonist 12
CAS:<p>FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.</p>Fórmula:C26H44O3Forma y color:SolidPeso molecular:404.626Etamicastat
CAS:<p>Etamicastat can be used in the research of cardiovascular diseases.</p>Fórmula:C14H15F2N3OSPureza:98%Forma y color:SolidPeso molecular:311.35α-Glucosidase-IN-15
<p>α-Glucosidase-IN-15 (Compound 14B) exhibits potent inhibitory activity against α-glucosidase, with an IC50 value of 3.34 μM.</p>Fórmula:C24H24N2SForma y color:SolidPeso molecular:372.53α-Glucosidase-IN-63
CAS:<p>α-Glucosidase-IN-63 (Compound 4d) serves as an α-Glucosidase inhibitor with an IC 50 value of 0.44 μM. Additionally, it exhibits inhibitory activity against hCA II, demonstrating a K i of 7.0 nM. The compound is also effective when administered orally. [1]</p>Fórmula:C16H12FN3O3S2Forma y color:SolidPeso molecular:377.41Fmoc-NH-PEG6-alcohol
CAS:<p>Fmoc-NH-PEG6-alcohol, a cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs) [1].</p>Fórmula:C27H37NO8Forma y color:SolidPeso molecular:503.58APOL1-IN-3
CAS:<p>APOL1-IN-3 is an APOL1 inhibitor used for kidney disease research.</p>Fórmula:C16H19F3N4O2SForma y color:SolidPeso molecular:388.41MGAT2-IN-1
CAS:<p>MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).</p>Fórmula:C27H21ClF5N7O3SForma y color:SolidPeso molecular:654.01Lp(a)-IN-7
CAS:<p>Lp(a)-IN-7 (example 1) is an inhibitor of lipoprotein (a) [Lp(a)] formation, exhibiting an IC50 of 2.51 nM in media containing apolipoprotein B (apoB) and apolipoprotein (a). This compound is applicable in cardiovascular disease research.</p>Fórmula:C20H30Cl2N2O4Forma y color:SolidPeso molecular:433.369O-Desmethyl Brinzolamide hydrochloride
CAS:<p>O-Desmethyl Brinzolamide hydrochloride (compound 6a), a potent metabolite derived from Brinzolamide, serves as a carbonic anhydrase (CA) inhibitor. It exhibits a dissociation constant (Kd) of 0.136 nM for CA II and an inhibitory concentration (IC50) of 165 nM for CA IV [1].</p>Fórmula:C11H20ClN3O5S3Forma y color:SolidPeso molecular:405.94PTP1B-IN-21
<p>PTP1B-IN-21 inhibits PTP1B (IC50=1.56μM) selectively over TCPTP, a type 2 diabetes target.</p>Fórmula:C22H22O11Forma y color:SolidPeso molecular:462.4SAL-0010042
CAS:<p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>Fórmula:C15H15FN4OForma y color:SolidPeso molecular:286.304CK1δ-IN-5
CAS:<p>CK1δ-IN-5 (Compound 24) is an inhibitor of casein kinase 1δ (CK1δ) and can be used in the study of neurodegenerative diseases.</p>Fórmula:C22H21N5Forma y color:SolidPeso molecular:355.436Lunacalcipol
CAS:<p>Lunacalcipol is used for the treatment of Secondary Hyperparathyroidism.</p>Fórmula:C28H42O4SForma y color:SolidPeso molecular:474.7HIF-2α-IN-7
CAS:<p>HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.</p>Fórmula:C18H9F6NO2Forma y color:SolidPeso molecular:385.26
