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Metabolismo

Metabolismo

Los inhibidores del metabolismo son compuestos que interfieren con las vías metabólicas, alterando la producción y utilización de energía dentro de las células. Estos inhibidores se utilizan para estudiar la regulación del metabolismo, el papel de las vías metabólicas en enfermedades como el cáncer y la diabetes, y para desarrollar nuevas estrategias terapéuticas. Los inhibidores del metabolismo pueden dirigirse a diversas enzimas y procesos involucrados en la glucólisis, la oxidación de ácidos grasos y otras funciones metabólicas. En CymitQuimica, ofrecemos una amplia gama de inhibidores del metabolismo de alta calidad para apoyar su investigación en bioquímica, trastornos metabólicos y desarrollo de fármacos.

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  • CTL26


    <p>CTL26 is an effective, orally active α-glucosidase inhibitor, with an IC50 value of 2.81 µM, demonstrating antidiabetic properties.</p>
    Fórmula:C25H18N6O3S
    Peso molecular:482.11611
  • MPO-IN-6


    <p>MPO-IN-6 (compound ADC) is an electrophilic agent with excellent antioxidant and anti-inflammatory properties. It acts as an inhibitor of myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD), with IC50 values of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 may serve as a potential cardiovascular protective agent.</p>
    Fórmula:C16H12N2O6
    Peso molecular:328.06954
  • GPX4-IN-16


    <p>GPX4-IN-16 ((R)-9i) is a potent inhibitor of GPX4 with a KD value of 20.4 nM, exhibiting cytotoxic properties and anticancer activity.</p>
    Fórmula:C29H24N4O3S2
    Forma y color:Solid
    Peso molecular:540.656
  • 20,26-Dihydroxyecdysone

    CAS:
    <p>20,26-Dihydroxyecdysone is a predominant ecdysteroid metabolite [1] .</p>
    Fórmula:C27H44O8
    Forma y color:Solid
    Peso molecular:496.63
  • Thalifendine chloride

    CAS:
    <p>Thalifendine chloride is a metabolite of berberine,the methoxy group at the C-10 position undergoes demethylation by CYP51. cytotoxicity against P-388 cells.</p>
    Fórmula:C19H16ClNO4
    Forma y color:Solid
    Peso molecular:357.79
  • α-Amylase/α-Glucosidase-IN-18


    <p>α-Amylase/α-Glucosidase-IN-18 (Compound 9g) is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 49.17 nM and 10.71 nM, respectively. It is suitable for research related to type 2 diabetes.</p>
    Fórmula:C29H26N6O2S
    Forma y color:Solid
    Peso molecular:522.62
  • Creatine-d3

    CAS:
    <p>Creatine-d3 is an isotopically labeled version of creatine. Creatine is an endogenous amino acid metabolite that plays a crucial role in cellular energy, particularly within muscles and the brain.</p>
    Fórmula:C4H9N3O2
    Forma y color:Solid
    Peso molecular:134.15
  • DG013A formate


    <p>DG013A (formate) is a tripeptide-mimicking inhibitor of hypophosphorous acid. It exhibits IC50 values of 33 nM for ERAP1 and 11 nM for ERAP2. This compound can be utilized in research related to autoimmune diseases and cancer.</p>
    Fórmula:C27H37N4O4PCH2O2
    Forma y color:Solid
    Peso molecular:530.99
  • CK1δ/CK1ε liagnd-1


    <p>CK1δ/CK1ε ligand-1 is a ligand of CK1δ/CK1ε and can serve as a target protein ligand for the synthesis of the CK1 PROTAC degrader AH078.</p>
    Fórmula:C21H20F2N6
    Forma y color:Solid
    Peso molecular:394.42
  • α-Amylase/α-Glucosidase-IN-17


    <p>α-Amylase/α-Glucosidase-IN-17 (Compound 3) is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 14.61 μM and 25.38 μM, respectively. It exhibits some inhibitory activity against A549 cancer cells and possesses both antitumor and antidiabetic properties.</p>
    Fórmula:C19H18FNO
    Forma y color:Solid
    Peso molecular:295.35
  • Corynecin IV

    CAS:
    <p>Corynecin IV is a metabolite similar to chloramphenicol, originally isolated from corynebacteria.</p>
    Fórmula:C13H16N2O6
    Forma y color:Solid
    Peso molecular:296.276
  • iso-C15:0 3-OH

    CAS:
    <p>Iso-C15:0 3-OH is a fatty acid that can be isolated from the PLRT strain. PLRT is a rod-shaped, Gram-negative, chemolithoheterotrophic, obligately aerobic bacterium, obtained from the feces of the mollusk Aplysia punctata.</p>
    Fórmula:C15H30O3
    Forma y color:Solid
    Peso molecular:258.397
  • Pegevongitide

    CAS:
    <p>Pegevongitide acts as an agonist of the angiopoietin-1 receptor.</p>
    Forma y color:Solid
    Peso molecular:14600 (Approximately)
  • Anticancer agent 232


    Anticanceragent 232 (compound 12f) is a sugar hybrid designed from 1-azide glycosides derived from d-glucose, d-galactose, and d-mannose. The IC50 values for this compound are 1.05 μM against MCF-7 cells and 18.03 μM for MDA-MB231 cells.
    Fórmula:C32H31BrN4O11
    Peso molecular:726.11727
  • 3α,7α-Dihydroxycoprostanic acid

    CAS:
    3α,7α-Dihydroxycoprostanic acid, an endogenous metabolite and bile acid, serves as the precursor to chenodeoxycholic acid [1].
    Fórmula:C27H46O4
    Peso molecular:434.65
  • (±)-Δ7-Mesembrenone

    CAS:
    (±) - Δ 7-Mesembrenone is an alkaloid found in S.tortuosum.
    Fórmula:C17H21NO3
    Peso molecular:287.35
  • Carboxypeptidase Y, Baker's yeast (S. cerevisiae)


    CarboxypeptidaseY, Baker's yeast (S. cerevisiae) serves as a biocatalyst and is a crucial enzyme in advanced biocatalyst technology. Enzyme engineering focuses on improving the kinetics of enzyme reactions, substrate selectivity, and performance under challenging conditions, such as low or high pH. Introducing stimulus-responsive modifications to these enzymes also enables dynamic control of their activity.
  • L 645164

    CAS:
    <p>L 645164 is an inhibitor of hydroxymethylglutaryl-CoA reductase.</p>
    Fórmula:C22H23FO3
    Forma y color:Solid
    Peso molecular:354.41
  • Arginase

    CAS:
    <p>Arginase (L-Arginine amidinase) is a key hydrolytic enzyme in the urea cycle, which hydrolyzes L-arginine into urea and L-ornithine.</p>
    Forma y color:Solid
  • Benzoyl coenzyme A sodium


    Benzoyl coenzyme A (sodium) is the sodium salt form of Benzoyl coenzyme A. It is a derivative of coenzyme A (CoA), where the thiol group of CoA is linked to a benzoyl group. This compound serves as a substrate in acyl transfer reactions, playing a role in catalysis. Benzoyl coenzyme A (sodium) is a versatile metabolic intermediate used in studies exploring enzyme substrate specificity, metabolic regulation, and drug metabolism.
    Fórmula:C28H39N7NaO17P3S
    Peso molecular:893.12337