Metabolismo
Los inhibidores del metabolismo son compuestos que interfieren con las vías metabólicas, alterando la producción y utilización de energía dentro de las células. Estos inhibidores se utilizan para estudiar la regulación del metabolismo, el papel de las vías metabólicas en enfermedades como el cáncer y la diabetes, y para desarrollar nuevas estrategias terapéuticas. Los inhibidores del metabolismo pueden dirigirse a diversas enzimas y procesos involucrados en la glucólisis, la oxidación de ácidos grasos y otras funciones metabólicas. En CymitQuimica, ofrecemos una amplia gama de inhibidores del metabolismo de alta calidad para apoyar su investigación en bioquímica, trastornos metabólicos y desarrollo de fármacos.
Subcategorías de "Metabolismo"
- AhR(41 productos)
- Aminopeptidasa(67 productos)
- CETP(18 productos)
- Anhídrido carbónico(178 productos)
- Caseína quinasa(130 productos)
- DHFR(33 productos)
- Descarboxilasa(4 productos)
- Deshidrogenasa(270 productos)
- FAAH(64 productos)
- FXR(58 productos)
- Factor Xa(80 productos)
- Ácido graso sintasa(33 productos)
- Ferroptosis(215 productos)
- GR(3 productos)
- GSNOR(3 productos)
- Glucoquinasa(54 productos)
- HIF / HIF Prolilhidroxilasa(142 productos)
- HMG-CoA reductasa(33 productos)
- Hidroxilasa(30 productos)
- IDO(82 productos)
- LDL(8 productos)
- Lipasa(97 productos)
- Lípido(59 productos)
- Lipoxigenasa(125 productos)
- MAO(87 productos)
- MPO(2 productos)
- NAMPT(36 productos)
- P450(6 productos)
- PAI-1(25 productos)
- PDE(166 productos)
- PED(1 productos)
- PKM(15 productos)
- PPAR(164 productos)
- Fosfolipasa(82 productos)
- ROR(42 productos)
- Receptor de retinoides(29 productos)
- SGK(11 productos)
- Tiorredoxina(12 productos)
- Transferasa(30 productos)
- Transportador(42 productos)
- UGT(4 productos)
- Inhibidores de la xantina oxidasa (XO)(9 productos)
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Se han encontrado 8625 productos de "Metabolismo"
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BI-3231
CAS:<p>BI-3231 is a hydroxysteroid 17ß-dehydrogenase 13 HSD17B13 inhibitor that inhibits hHSD17B13 .BI-3231 can be used to study cirrhosis.</p>Fórmula:C16H14F2N4O3SPureza:98.2%Forma y color:SolidPeso molecular:380.37AMG 579
CAS:<p>AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).</p>Fórmula:C25H23N5O3Pureza:99.87%Forma y color:SolidPeso molecular:441.48h-NTPDase-IN-2
CAS:<p>h-NTPDase-IN-2 is a broad-spectrum NTPDase inhibitor that inhibits multiple h-NTPDas isoforms.</p>Fórmula:C19H16N4SPureza:99.58%Forma y color:SolidPeso molecular:332.42ER 50891
CAS:<p>ER-50891 is a potent RARα antagonist, countering retinoic acid inhibition and aiding BMP2-induced osteoblast differentiation.</p>Fórmula:C29H24N2O2Pureza:>99.99%Forma y color:SolidPeso molecular:432.51PXS-6302 hydrochloride
CAS:<p>PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3</p>Fórmula:C10H11ClF3NO2SPureza:99.89%Forma y color:SoildPeso molecular:301.71NPAS3-IN-1
CAS:<p>NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.</p>Fórmula:C10H5N3O2S3Pureza:99.56%Forma y color:SolidPeso molecular:295.36Varespladib methyl
CAS:<p>Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.</p>Fórmula:C22H22N2O5Pureza:99.42% - 99.97%Forma y color:SolidPeso molecular:394.42KB-74935
CAS:<p>KB-74935: enzyme inhibitor, mineralocorticoid blocker, treats cholesterol, hypolipidemia, neurological issues, Alzheimer's.</p>Fórmula:C19H18ClF4N3O3SPureza:99.4%Forma y color:SolidPeso molecular:479.88Ecopladib
CAS:<p>Ecopladib inhibits cPLA2α with IC50 of 0.15 μM (micelles) & 0.11 μM (rat blood).</p>Fórmula:C39H33Cl3N2O5SPureza:95.15%Forma y color:SolidPeso molecular:748.11Fluspirilene
CAS:<p>Fluspirilene is a long-acting antipsychotic for schizophrenia, inhibiting L-type calcium channels (IC50: 0.03 μM).</p>Fórmula:C29H31F2N3OPureza:99.59%Forma y color:SolidPeso molecular:475.57DGAT-1 inhibitor 2
CAS:<p>DGAT-1 inhibitor 2: effective against obesity, targets enzyme in triglyceride synthesis for diabetes treatment.</p>Fórmula:C24H28N4O3Pureza:98.36%Forma y color:SolidPeso molecular:420.5Calcium channel-modulator-1
CAS:<p>Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction.</p>Fórmula:C26H24Cl2N2O7SPureza:99.95%Forma y color:SolidPeso molecular:579.45Dechloro Rivaroxaban
CAS:<p>Dechloro Rivaroxaban is a Factor Xa inhibitor that inhibits free FXa and plasminogen and fibrin-associated FXa activity in humans.</p>Fórmula:C19H19N3O5SPureza:98.63%Forma y color:SolidPeso molecular:401.44ALDH2 modulator 1
CAS:<p>ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.</p>Fórmula:C18H18ClFN2O3Pureza:99.68%Forma y color:SoildPeso molecular:364.8Cis-22a
CAS:<p>Cis-22a: selective TRPV6 inhibitor (IC50=0.32μM), halts T47D breast cancer cell growth.</p>Fórmula:C24H30F3N3O2Pureza:99.07%Forma y color:SolidPeso molecular:449.51p-Ethynylphenylalanine
CAS:<p>p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a tryptophan hydroxylase (TPH) inhibitor, is competitive, effective, selective, and reversible, with a Ki of</p>Fórmula:C11H11NO2Pureza:97.57%Forma y color:SolidPeso molecular:189.21WAY-297848
CAS:<p>WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.</p>Fórmula:C13H13ClN2O2SPureza:98.19%Forma y color:SolidPeso molecular:296.77Mutant IDH1-IN-2
CAS:<p>Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of 16.6 nM in Fluorescence biochemical assay, IC50 of ＜22 nM in LS-</p>Fórmula:C24H31F2N5O2Pureza:99.88%Forma y color:SolidPeso molecular:459.53ABD957
CAS:<p>ABD957: covalent ABHD17 depalmitoylases inhibitor, IC50 0.21µM for ABHD17B, blocks N-Ras, halts NRAS-mutant AML cell growth.</p>Fórmula:C27H36F3N7O5SForma y color:SolidPeso molecular:627.68trans-Doxercalciferol
CAS:<p>trans-Doxercalciferol is an isomer of Doxercalciferol. Doxercalciferol is an activator of the Vitamin D receptor and prevents renal disease.</p>Fórmula:C28H44O2Pureza:98%Forma y color:SolidPeso molecular:412.65PDE4B/7A-IN-2
CAS:<p>5-HT1A/5-HT7 antagonist; 5-HT1A Ki=8 nM, 5-HT7 Ki=451 nM; PDE4B IC50=80.4 μM, PDE7A IC50=151.3 μM; stronger than escitalopram.</p>Fórmula:C25H35N3O2Forma y color:SolidPeso molecular:409.56Deltasonamide 2 hydrochloride
<p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>Fórmula:C30H40Cl2N6O4S2Pureza:98%Forma y color:SolidPeso molecular:683.71RWJ-445167
CAS:<p>RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.</p>Fórmula:C18H24N6O5SPureza:98%Forma y color:SolidPeso molecular:436.49Glucosylceramide synthase-IN-3
<p>Glucosylceramide synthase-IN-3 (BZ1) is a potent, brain-accessible, oral GCS inhibitor with a 16 nM IC50, relevant for Gaucher's disease study.</p>Fórmula:C21H20FN3O3Forma y color:SolidPeso molecular:381.4Omesdafexor
CAS:<p>Omesdafexor is an FXR agonist that can be used to study diseases caused by liver disease or metabolic inflammation.</p>Fórmula:C34H43N3O3Forma y color:SolidPeso molecular:541.72CK1δ-IN-3
CAS:<p>CK1δ-IN-3 (compound 376) is a CK1δ (casein kinase 1δ) inhibitor that can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>Fórmula:C24H19N3O2SPureza:99.27%Forma y color:SolidPeso molecular:413.49SGK1-IN-3
<p>SGK1-IN-3: Potent oral inhibitor of SGK1, may target osteoarthritis.</p>Fórmula:C23H20Cl2N6O3SForma y color:SolidPeso molecular:531.41Sulclamide
CAS:<p>Sulclamide, a sulfamoylbenzoic acid derivative, exhibits diuretic activity and functions as an inhibitor of carbonic anhydrase [1].</p>Fórmula:C7H7ClN2O3SForma y color:SolidPeso molecular:234.664-MDM
CAS:<p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>Fórmula:C14H14OForma y color:SolidPeso molecular:198.26Nampt activator-4
CAS:<p>Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].</p>Fórmula:C26H22F3N7OSForma y color:SolidPeso molecular:537.56PF-07202954
CAS:<p>PF-07202954, a weakly basic diacylglycerol O-acyltransferase 2 (DGAT2) inhibitor, exhibits an inhibition concentration half-maximum (IC50) of 10 nM against</p>Fórmula:C22H23FN6O3Pureza:98%Forma y color:SolidPeso molecular:438.45Glucosylceramide synthase-IN-4
CAS:<p>Glucosylceramide Synthase-IN-4 (compound 12) serves as a potent inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 of 6.8 nM. It demonstrates superior pharmacokinetic properties and robust stability in human hepatocytes. Additionally, this compound is noted for its effective CNS penetration and acceptable PXR selectivity [1].</p>Fórmula:C22H18F5N3O3Forma y color:SolidPeso molecular:467.394-Acetylphenylboronic acid
CAS:4-Acetylphenylboronic acid acts as an effective inhibitor targeting carbonic anhydrase II (CAII), displaying inhibitory concentrations (IC50) of 246 μM for bovine CAII (bCA II) and 281.40 μM for human CAII (hCA II).Fórmula:C8H9BO3Forma y color:SolidPeso molecular:163.97SAL-0010042
CAS:<p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>Fórmula:C15H15FN4OForma y color:SolidPeso molecular:286.304DEL-I25
CAS:<p>DEL-I25 is an effective activator of GPX4 that protects cells from ferroptosis (iron-dependent cell death).</p>Fórmula:C21H23N5O3Forma y color:SolidPeso molecular:393.44RORγt/DHODH-IN-1
CAS:<p>RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant</p>Fórmula:C24H26ClF6N3O3SForma y color:SolidPeso molecular:585.99LXRα agonist 1
CAS:<p>LXRα agonist 1 (Compound 40) is a selective activator of LXRα, with an EC50 of 42 nM, and also demonstrates some activation effects on LXRβ, with an EC50 of 266 nM. It promotes target gene transcription by stabilizing the ligand-binding domain (LBD) of LXRα. When combined with the Raf inhibitor Sorafenib, LXRα agonist 1 shows significant antitumor activity in liver cancer cells. This compound is applicable in research focused on lipotoxicity-related cancers.</p>Fórmula:C28H27N3O2Forma y color:SolidPeso molecular:437.533α-Amylase/α-Glucosidase-IN-7
CAS:<p>α-Amylase/α-Glucosidase-IN-7 (Compound 3f) serves as a competitive inhibitor for the enzymes α-glucosidase and α-amylase, exhibiting IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, it effectively inhibits AChE and BChE, with IC50 values of 9.25 µM and 10.06 µM, respectively. This compound is useful in research related to diabetes and Alzheimer's [1].</p>Fórmula:C15H9Cl2FN2OSForma y color:SolidPeso molecular:355.21Indoluidin E
<p>Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.</p>Fórmula:C28H30N4O2Forma y color:SolidPeso molecular:454.56ICMT-IN-55
CAS:<p>ICMT-IN-55 (compound 31) acts as an ICMT inhibitor, exhibiting an IC50 value of 90 nM [1].</p>Fórmula:C22H26F3NO2Forma y color:SolidPeso molecular:393.44Antidiabetic agent 5
CAS:<p>Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].</p>Fórmula:C17H15N3O4SForma y color:SolidPeso molecular:357.38sEH inhibitor-2
<p>SEH inhibitor-2 is an orally active sEH blocker (IC50=0.9 nM) with predicted 71.2-88.4% absorption, potentially aiding cardiovascular health.</p>Fórmula:C23H18N4O3Forma y color:SolidPeso molecular:398.41Gcase activator 2
CAS:<p>Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.</p>Fórmula:C21H24N4O2Pureza:99.51% - 99.76%Forma y color:SolidPeso molecular:364.44(+)-Potassium Ds-threo-isocitrate monobasic
CAS:<p>(+)-Potassium Ds-threo-isocitrate monobasic is a bioactive compound known for its role in enhancing cellular metabolism and regulating energy production. This substance is also utilized in researching metabolic pathways and the regulation of enzyme activities. Widely applied in biochemical research, (+)-Potassium Ds-threo-isocitrate monobasic is studied for its potential functions in cellular processes and disease mechanisms.</p>Fórmula:C6H7KO7Forma y color:SolidPeso molecular:230.21NAMPT activator-6
CAS:<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Fórmula:C17H21N5O3SForma y color:SolidPeso molecular:375.45OH-α-PVP TFA
CAS:OH-α-PVP (OH-α-Pyrrolidinovalerophenone) TFA is a metabolite of α-pyrrolidinovalerophenone, which is a synthetic cathinone stimulant.Fórmula:C17H24F3NO3Peso molecular:347.37HSD17B13-IN-40
CAS:HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Fórmula:C23H14Cl2F3N3O3Peso molecular:508.28HSD17B13-IN-32
CAS:HSD17B13-IN-32 (Compound 67) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤0.1 μM for estradiol. It can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].Fórmula:C23H15Cl2N5O3Peso molecular:480.3Z21090
CAS:<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Fórmula:C12H14ClN3O3Forma y color:SolidPeso molecular:283.71DS44470011
CAS:<p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>Fórmula:C21H19N3O4Forma y color:SolidPeso molecular:377.39
