Metabolismo
Los inhibidores del metabolismo son compuestos que interfieren con las vías metabólicas, alterando la producción y utilización de energía dentro de las células. Estos inhibidores se utilizan para estudiar la regulación del metabolismo, el papel de las vías metabólicas en enfermedades como el cáncer y la diabetes, y para desarrollar nuevas estrategias terapéuticas. Los inhibidores del metabolismo pueden dirigirse a diversas enzimas y procesos involucrados en la glucólisis, la oxidación de ácidos grasos y otras funciones metabólicas. En CymitQuimica, ofrecemos una amplia gama de inhibidores del metabolismo de alta calidad para apoyar su investigación en bioquímica, trastornos metabólicos y desarrollo de fármacos.
Subcategorías de "Metabolismo"
- AhR(41 productos)
- Aminopeptidasa(67 productos)
- CETP(18 productos)
- Anhídrido carbónico(178 productos)
- Caseína quinasa(130 productos)
- DHFR(33 productos)
- Descarboxilasa(4 productos)
- Deshidrogenasa(269 productos)
- FAAH(64 productos)
- FXR(58 productos)
- Factor Xa(80 productos)
- Ácido graso sintasa(32 productos)
- Ferroptosis(215 productos)
- GR(3 productos)
- GSNOR(3 productos)
- Glucoquinasa(54 productos)
- HIF / HIF Prolilhidroxilasa(142 productos)
- HMG-CoA reductasa(33 productos)
- Hidroxilasa(30 productos)
- IDO(82 productos)
- LDL(8 productos)
- Lipasa(97 productos)
- Lípido(59 productos)
- Lipoxigenasa(124 productos)
- MAO(87 productos)
- MPO(2 productos)
- NAMPT(36 productos)
- P450(6 productos)
- PAI-1(25 productos)
- PDE(166 productos)
- PED(1 productos)
- PKM(15 productos)
- PPAR(164 productos)
- Fosfolipasa(82 productos)
- ROR(42 productos)
- Receptor de retinoides(29 productos)
- SGK(11 productos)
- Tiorredoxina(12 productos)
- Transferasa(30 productos)
- Transportador(42 productos)
- UGT(4 productos)
- Inhibidores de la xantina oxidasa (XO)(9 productos)
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Se han encontrado 8626 productos de "Metabolismo"
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CYP2C1/CYP2C19-IN-2
<p>CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.</p>Fórmula:C27H28N2O6SForma y color:SolidPeso molecular:508.59PDE4-IN-12
<p>PDE4-IN-12 is a potent and safe PDE4 ubiquitous inhibitor that acts on PDE4 (IC50: 3.5 nM, SI: 2.71) and PDE7 (IC50: 15 nM, SI: 4.27).</p>Fórmula:C34H35NO6Forma y color:SolidPeso molecular:553.64HIF-2α-IN-5
CAS:<p>HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].</p>Fórmula:C15H12F4O3S2Forma y color:SolidPeso molecular:380.38RORγt inverse agonist 29
<p>RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM.</p>Fórmula:C25H24N2O5SForma y color:SolidPeso molecular:464.53Etoricoxib N1'-oxide
CAS:<p>EtoricoxibN1'-oxide is a metabolite of Etoricoxib. It does not inhibit COX-1 and does not significantly inhibit COX-2.</p>Fórmula:C18H15ClN2O3SForma y color:SolidPeso molecular:374.841Carbonic anhydrase inhibitor 9
<p>Carbonic anhydrase inhibitor 9 targets hCA II and IX with Ki of 56.4 and 56.9 nM respectively; shows antiproliferative activity.</p>Fórmula:C22H20BrN5O4SForma y color:SolidPeso molecular:530.39PPI-2458
CAS:<p>PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.</p>Fórmula:C22H36N2O6Forma y color:SolidPeso molecular:424.53α-Glucosidase-IN-12
<p>α-Glucosidase-IN-12 is a potent inhibitor of α-glucosidase (IC50: 10.20 μM).</p>Fórmula:C25H30N4O4S2Forma y color:SolidPeso molecular:514.66BMS-185354
CAS:<p>BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM, offering potential for cancer research.</p>Fórmula:C26H27NO3Forma y color:SolidPeso molecular:401.497LDHA-IN-5
CAS:<p>LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primary</p>Fórmula:C27H22FN7O6S3Forma y color:SolidPeso molecular:655.7Rostratin B
CAS:<p>Rostratin B, a cytotoxic disulfide, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an IC50 value of 1.9 μg/mL.</p>Fórmula:C18H20N2O6S2Forma y color:SolidPeso molecular:424.49Casein kinase 1δ-IN-30
CAS:<p>Casein kinase1δ-IN-30 (Compound 581) is an inhibitor of casein kinase 1δ (CK1δ). It can be utilized in research related to neurodegenerative diseases.</p>Fórmula:C18H15BrN6O2SForma y color:SolidPeso molecular:459.32ALOX15-IN-1
<p>ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.</p>Fórmula:C24H31N3O5SForma y color:SolidPeso molecular:473.59Keto lovastatin
CAS:<p>Keto lovastatin is an impurity of lovastatin with antibacterial properties. Lovastatin is a cell-permeable HMG-CoA reductase (HMG-CoA reductase) inhibitor used to reduce cholesterol levels.</p>Fórmula:C24H34O6Forma y color:SolidPeso molecular:418.523(2S,4S)-Sacubitril
CAS:<p>(2S,4S)-Sacubitril (Sacubitril Impurity C) is a stereoisomer derived from Sacubitril which is a potent NEP inhibitor.</p>Fórmula:C24H29NO5Pureza:98%Forma y color:SolidPeso molecular:411.49PDHK-IN-3
<p>PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].</p>Fórmula:C17H16N2O2Forma y color:SolidPeso molecular:280.32Carbonic anhydrase inhibitor 10
<p>CA inhibitor 10 targets MCF-7 cells, IC50: 11.9 μM; potent h CA IX inhibitor, Ki: 6.2 nM. Anti-cancer research.</p>Fórmula:C14H17N5O3SForma y color:SolidPeso molecular:335.38ATX inhibitor 22
<p>ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1.</p>Fórmula:C19H17Cl3F2N2O4SForma y color:SolidPeso molecular:513.77LEQ803
CAS:<p>LEQ803 (N-DesmethylRibociclib) is a metabolite of the CDK4/6 inhibitor Ribociclib, produced through metabolism by CYP3A4. This compound holds potential applications in the field of oncology.</p>Fórmula:C22H28N8OForma y color:SolidPeso molecular:420.511JTT-553
CAS:<p>JTT-553 is a DGAT1 inhibitor with an IC50 of 2.38 nM. It effectively reduces plasma levels of glucose, insulin, non-esterified fatty acids (NEFA), total cholesterol (TC), and liver triglycerides (TG). JTT-553 enhances insulin-dependent glucose absorption and glucose intolerance in the adipose tissue of diet-induced obese (DIO) mice. In KK-Ay mice, it lowers TNF-α mRNA levels and elevates GLUT4 mRNA levels in adipose tissue. By contributing to weight loss, JTT-553 improves insulin resistance in adipose tissue and overall glucose metabolism. This compound is useful for research on obesity and type 2 diabetes mellitus (T2DM).</p>Fórmula:C25H27F3N4O3Forma y color:SolidPeso molecular:488.50AZ513
CAS:<p>AZ513 is a reversible FAAH inhibitor, exhibiting an IC50 of 551 nM for human FAAH and 27 nM for rat FAAH. It inhibits the hydrolysis of arachidonoyl ethanolamide in HEK293 cells transfected with human FAAH, with an IC50 of 360 nM.</p>Fórmula:C14H9Cl2N3OForma y color:SolidPeso molecular:306.147PTP1B-IN-18
<p>PTP1B-IN-18 is an orally active, fully mixed protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 35.2 μM).PTP1B-IN-18 can be used to study type 2 diabetes.</p>Fórmula:C26H19N3O4SForma y color:SolidPeso molecular:469.51Vimirogant hydrochloride
<p>Vimirogant (VTP-43742) HCl: Oral, selective RORγt inhibitor (IC50: 17 nM, Ki: 3.5 nM), >1000x selectivity over RORα/β, targets Th17, not Th1/2/Treg.</p>Fórmula:C27H36ClF3N4O3SForma y color:SolidPeso molecular:588.21487FXIa-IN-6
CAS:<p>FXIa-IN-6: Potent, selective FXIa inhibitor (Ki=0.3 nM); strong PK with high oral bioavailability, low clearance preclinically.</p>Fórmula:C31H29ClF2N4O4Forma y color:SolidPeso molecular:595.04Buspirone N-oxide
CAS:<p>Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone. Buspirone is an orally active 5-HT1A receptor agonist and a dopamine D2 (dopamine D2) autoreceptor antagonist. It is an anxiolytic agent used for research in generalized anxiety disorder.</p>Fórmula:C21H31N5O3Forma y color:SolidPeso molecular:401.5035-Carboxy-2′-deoxycytidine
CAS:<p>5-Carboxy-2′-deoxycytidine is a metabolite of Trifluridine.</p>Fórmula:C10H13N3O6Forma y color:SolidPeso molecular:271.227NR1H4 activator 1
CAS:<p>NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR).</p>Fórmula:C34H53NO7SPureza:98%Forma y color:SolidPeso molecular:619.85L 691816
CAS:<p>L 691816 is an effective inhibitor of the 5-LO reaction.</p>Fórmula:C36H35ClN6OSPureza:98%Forma y color:SolidPeso molecular:635.22FAAH/MAGL-IN-1
<p>FAAH/MAGL-IN-1 (SIH 3) inhibits FAAH & MAGL with IC50 of 31 & 29 nM, useful in neuropathic pain research.</p>Fórmula:C15H9Cl2N3O3Forma y color:SolidPeso molecular:350.16PLAP-IN-1
CAS:<p>PLAP-IN-1: Potent, selective inhibitor of PLAP, IC50 of 32 nM; doesn't notably inhibit TNAP.</p>Fórmula:C25H21Cl2N3O5Forma y color:SoildPeso molecular:514.36Lp-PLA2-IN-5
CAS:<p>Lp-PLA2-IN-5 inhibits Lp-PLA2 and PAF-AH, potentially useful in Alzheimer's and atherosclerosis studies.</p>Fórmula:C23H18F5N3O4Forma y color:SolidPeso molecular:495.4Hcyb1
<p>Hcyb1 specifically inhibits PDE2A with 0.57 μM IC50, over 250x selective, and has neuroprotective and antidepressant effects.</p>Fórmula:C24H20N4OForma y color:SolidPeso molecular:380.44hDHODH-IN-10
<p>hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.</p>Fórmula:C21H15ClF4N2O4Forma y color:SolidPeso molecular:470.8hMAO-B/MB-COMT-IN-1
<p>Dual hMAO-B/MB-COMT inhibitor, IC50: 2.5 μΜ (hMAO-B), 3.84 μΜ (MB-COMT); potential in Parkinson's research.</p>Fórmula:C16H19NO3Forma y color:SolidPeso molecular:273.33Homodestcardin
CAS:<p>Homodestcardin: cyclic depsipeptide from T. roseum with immunosuppressant properties; inhibits mouse T cell proliferation.</p>Fórmula:C32H55N5O7Forma y color:SolidPeso molecular:621.81Lapaquistat
CAS:<p>Lapaquistat: active TAK-475 metabolite; reduces cholesterol synthesis and statin myotoxicity.</p>Fórmula:C31H39ClN2O8Pureza:98%Forma y color:SolidPeso molecular:603.1A-800141
CAS:<p>A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.</p>Fórmula:C24H30N2O4SForma y color:SolidPeso molecular:442.571Casein kinase 1δ-IN-23
CAS:<p>Casein kinase1δ-IN-23 (compound 423) is an effective inhibitor of casein kinase1δ. It is applicable in research related to neurodegenerative diseases such as Alzheimer's disease.</p>Fórmula:C19H15N3O3SForma y color:SolidPeso molecular:365.406Danifexor
CAS:<p>Danifexor is an agonist of the farnesoid X receptor (Farnesoid X receptor).</p>Fórmula:C29H20Cl2N2O5Forma y color:SolidPeso molecular:547.386T-3764518
CAS:<p>T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).</p>Fórmula:C20H17F6N5O2Pureza:98%Forma y color:SolidPeso molecular:473.37α-Glucosidase-IN-15
<p>α-Glucosidase-IN-15 (Compound 14B) exhibits potent inhibitory activity against α-glucosidase, with an IC50 value of 3.34 μM.</p>Fórmula:C24H24N2SForma y color:SolidPeso molecular:372.53Lunacalcipol
CAS:<p>Lunacalcipol is used for the treatment of Secondary Hyperparathyroidism.</p>Fórmula:C28H42O4SForma y color:SolidPeso molecular:474.7Desmonomethylpromazine
CAS:<p>Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.</p>Fórmula:C16H18N2SForma y color:SolidPeso molecular:270.39AChE/PDE4-IN-1
<p>AChE/PDE4-IN-1, compound 12c, dual inhibitor; IC50: 0.28μM for AChE, 1.88μM for PDE4D, may reduce Alzheimer's neuroinflammation.</p>Fórmula:C23H28N2O3Forma y color:SolidPeso molecular:380.48RXR antagonist 1
<p>RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes.</p>Fórmula:C28H33F3N2O3Forma y color:SolidPeso molecular:502.57CK1δ-IN-5
CAS:<p>CK1δ-IN-5 (Compound 24) is an inhibitor of casein kinase 1δ (CK1δ) and can be used in the study of neurodegenerative diseases.</p>Fórmula:C22H21N5Forma y color:SolidPeso molecular:355.436hCAVII/IX-IN-1
CAS:<p>hCAVII/IX-IN-1 (compound 4) functions as an inhibitor of hCAVII/IX, exhibiting Ki values of 56.5 nM and 38.2 nM, respectively. It is applicable in the field of cancer research.</p>Fórmula:C7H7N3O2S2Forma y color:SolidPeso molecular:229.279CK1δ-IN-6
CAS:<p>CK1δ-IN-6 (Compound 303) is an inhibitor of Casein kinase 1δ, with potential applications in Alzheimer's disease research.</p>Fórmula:C23H17N3O4Forma y color:SolidPeso molecular:399.399L 731735
CAS:<p>L 731735 is a farnesyltransferase inhibitor.</p>Fórmula:C19H40N4O4SPureza:98%Forma y color:SolidPeso molecular:420.61CA IX-IN-3
CAS:<p>CAIX-IN-3 (Compound 27) is a selective and potent inhibitor of carbonic anhydrase IX (CAIX), with an IC50 of 0.48 nM.</p>Fórmula:C21H19N5O4S2Forma y color:SolidPeso molecular:469.537
