Metabolismo
Los inhibidores del metabolismo son compuestos que interfieren con las vías metabólicas, alterando la producción y utilización de energía dentro de las células. Estos inhibidores se utilizan para estudiar la regulación del metabolismo, el papel de las vías metabólicas en enfermedades como el cáncer y la diabetes, y para desarrollar nuevas estrategias terapéuticas. Los inhibidores del metabolismo pueden dirigirse a diversas enzimas y procesos involucrados en la glucólisis, la oxidación de ácidos grasos y otras funciones metabólicas. En CymitQuimica, ofrecemos una amplia gama de inhibidores del metabolismo de alta calidad para apoyar su investigación en bioquímica, trastornos metabólicos y desarrollo de fármacos.
Subcategorías de "Metabolismo"
- AhR(41 productos)
- Aminopeptidasa(67 productos)
- CETP(18 productos)
- Anhídrido carbónico(177 productos)
- Caseína quinasa(130 productos)
- DHFR(32 productos)
- Descarboxilasa(4 productos)
- Deshidrogenasa(267 productos)
- FAAH(63 productos)
- FXR(58 productos)
- Factor Xa(80 productos)
- Ácido graso sintasa(32 productos)
- Ferroptosis(215 productos)
- GR(3 productos)
- GSNOR(3 productos)
- Glucoquinasa(53 productos)
- HIF / HIF Prolilhidroxilasa(142 productos)
- HMG-CoA reductasa(32 productos)
- Hidroxilasa(30 productos)
- IDO(82 productos)
- LDL(8 productos)
- Lipasa(96 productos)
- Lípido(59 productos)
- Lipoxigenasa(124 productos)
- MAO(87 productos)
- MPO(2 productos)
- NAMPT(36 productos)
- P450(6 productos)
- PAI-1(25 productos)
- PDE(166 productos)
- PED(1 productos)
- PKM(15 productos)
- PPAR(164 productos)
- Fosfolipasa(82 productos)
- ROR(42 productos)
- Receptor de retinoides(29 productos)
- SGK(11 productos)
- Tiorredoxina(12 productos)
- Transferasa(30 productos)
- Transportador(42 productos)
- UGT(4 productos)
- Inhibidores de la xantina oxidasa (XO)(9 productos)
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Se han encontrado 8595 productos de "Metabolismo"
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ZK159222
CAS:<p>ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.</p>Fórmula:C32H48O5Pureza:98%Forma y color:SolidPeso molecular:512.72Dioctanoylphosphatidic acid sodium
CAS:<p>Dioctanoylphosphatidic acid sodium serves as a modulator of phagocyte respiratory bursts, a precursor to diacylglycerol and lyso-phosphatidic acid, and influences the phosphorylation of the mammalian target of rapamycin (mTOR). Additionally, it enhances the viability of gallbladder cancer cells inhibited by histone deacetylase inhibitors (HDACI). This compound is derived from glycerophospholipids through the action of phospholipase D.</p>Fórmula:C19H36NaO8PForma y color:SolidPeso molecular:446.457α,24(S)-Dihydroxycholesterol
CAS:<p>7α,24(S)-Dihydroxycholesterol ((3β,7α,24S)-Cholest-5-ene-3,7,24-triol) acts as a ligand for liver X receptors (LXR), specifically binding to the ligand-binding domains of LXRα and LXRβ. This compound is synthesized through the E-α,β-unsaturated ketone process, starting with arsindole and J-secondary-butyl dimethylsiloxy-bis-positive-5-cholestenal as the initial materials. It undergoes a series of transformations to produce 7α,24(S)-dihydroxycholesterol.</p>Fórmula:C27H46O3Forma y color:SolidPeso molecular:418.65Aripiprazole N,N-Dioxide
CAS:<p>AripiprazoleN,N-Dioxide is a metabolite of the atypical antipsychotic drug aripiprazole, formed through its oxidation.</p>Fórmula:C23H27Cl2N3O4Peso molecular:480.38α-Amylase-IN-7
CAS:<p>α-Amylase-IN-7 (Compound 6e) is an inhibitor of α-Amylase, with an IC50 of 40 μM, indicating its potency. This compound shows potential as an anti-diabetic medication.</p>Fórmula:C18H15ClN6O2SPeso molecular:414.87Lp-PLA2-IN-6
CAS:<p>Lp-PLA2-IN-6: Potent tetracyclic inhibitor of rhLp-PLA2, with pIC50 of 10.0, and potential in neurodegenerative research.</p>Fórmula:C25H21F5N4O3Forma y color:SolidPeso molecular:520.45NSC 828467
<p>NSC 828467 is one of the top five CA-IX inhibitors with significant in vitro anticancer activity (IC50: 27.2 nM).</p>Fórmula:C21H19N9O2SForma y color:SolidPeso molecular:461.5Complex III-IN-2
<p>Complex III-IN-2 inhibits complex III, with antifungal EC50: 29.31 mg/L vs R. solani, 29.98 mg/L vs S. sclerotiorum.</p>Fórmula:C15H21ClN2O2SForma y color:SolidPeso molecular:328.86PF-07202954
CAS:<p>PF-07202954, a weakly basic diacylglycerol O-acyltransferase 2 (DGAT2) inhibitor, exhibits an inhibition concentration half-maximum (IC50) of 10 nM against</p>Fórmula:C22H23FN6O3Pureza:98%Forma y color:SolidPeso molecular:438.452-Amino-5-methyl-5-hexenoic acid
CAS:<p>2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) acts as a methionine analog, competing with methionine and thereby hindering cell growth. This compound inhibits protein synthesis in Salmonella typhimurium TA1535 and Escherichia coli K-12 without affecting the synthesis of DNA or RNA.</p>Fórmula:C7H13NO2Forma y color:SolidPeso molecular:143.184PTP1B-IN-19
<p>PTP1B-IN-19, a benzimidazole, selectively inhibits protein tyrosine phosphatase 1B with a Ki of 23.3 μM, potential for type 2 diabetes research.</p>Fórmula:C26H19N3O4SForma y color:SolidPeso molecular:469.51RORγt Inverse agonist 2
CAS:<p>RORγt Inverse agonist 2 is a selective, orally active inverse agonist of RORγt(EC50 of 119 nM).</p>Fórmula:C27H25F8NO5SPureza:98%Forma y color:SolidPeso molecular:627.54Sekikaic Acid
CAS:<p>Sekikaic acid, a phenolic lichen metabolite in H. obscurata, has antioxidant and antiviral properties, inhibiting MLL1-CBP.</p>Fórmula:C22H26O8Forma y color:SolidPeso molecular:418.449(S)-HETE
CAS:<p>9(S)-HETE is an enantiomer of (±)9-HETE, not an enzymatic product, and doesn't promote cell adhesion like 12(S)-HETE. Identified by chiral HPLC.</p>Fórmula:C20H32O3Forma y color:SolidPeso molecular:320.47Casein Kinase II Inhibitor IV Hydrochloride
CAS:<p>Casein Kinase II Inhibitor IV HCl promotes keratinocyte differentiation, potential for skin disorder therapy.</p>Fórmula:C24H24ClN5O3Pureza:98%Forma y color:SolidPeso molecular:465.933-Ferrocenylpropionic anhydride
CAS:<p>3-Ferrocenylpropionic anhydride is extensively used in compound synthesis, serving as an intermediary for producing various bioactive compounds. Additionally, by modulating specific enzyme activities, 3-Ferrocenylpropionic anhydride has demonstrated potential anti-tumor properties.</p>Fórmula:C26H26Fe2O3Forma y color:SolidPeso molecular:498.17RBM14C12
CAS:<p>RBM14C12 is a compound known for its cell signaling activity. It plays a crucial role in researching lipid metabolism and cell membrane structure. Additionally, RBM14C12 can be utilized in the development of novel compounds aimed at modulating the biological mechanisms associated with lipid-related diseases.</p>Fórmula:C26H39NO6Forma y color:SolidPeso molecular:461.59(S)-CPP sodium
CAS:<p>(S)-CPP sodium serves as an inhibitor of the branched-chain α-keto acid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, (S)-CPP (IC50 of 6.3 μM) inhibits BDK, which activates the complex, leading to a significant reduction in the levels of leucine/isoleucine and valine in the plasma of wild-type mice.</p>Fórmula:C9H8ClNaO2Forma y color:SolidPeso molecular:206.60OMDM169
CAS:<p>OMDM169: potent/selective MAGL inhibitor, raises 2-AG, analgesic via cannabinoid receptors, IC50: 0.13-0.41μM in rat/COS-7, inactive at CB1/CB2.</p>Fórmula:C25H45NO5Pureza:98%Forma y color:SolidPeso molecular:439.636-trans-12-epi-Leukotriene B4
CAS:<p>6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, serves as a potent anti-inflammatory agent.</p>Fórmula:C20H32O4Forma y color:SolidPeso molecular:336.47Rosiptor acetate
CAS:<p>Rosiptor (AQX-1125) activates SHIP1, inhibits Akt, and reduces inflammation and allergy in rodents.</p>Fórmula:C22H39NO4Pureza:98%Forma y color:Solid PowderPeso molecular:381.55BLT-4
CAS:<p>BLT-4 is a specific and reversible inhibitor of scavenger receptor class B type I (SR-BI). It effectively blocks the SR-BI-mediated transfer of lipids between high-density lipoprotein (HDL) and cells.</p>Fórmula:C18H16N2O2Forma y color:SolidPeso molecular:292.332JTZ-951 HCl
CAS:<p>JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).</p>Fórmula:C17H17ClN4O4Pureza:98%Forma y color:SolidPeso molecular:376.79PDE4B/7A-IN-2
CAS:<p>5-HT1A/5-HT7 antagonist; 5-HT1A Ki=8 nM, 5-HT7 Ki=451 nM; PDE4B IC50=80.4 μM, PDE7A IC50=151.3 μM; stronger than escitalopram.</p>Fórmula:C25H35N3O2Forma y color:SolidPeso molecular:409.56Turoctocog alfa
CAS:<p>Turoctocog alfa: recombinant FVIII from CHO cells for hemophilia A study.</p>Forma y color:SolidMRS4458
CAS:<p>MRS4458 is an effective inhibitor of the P2Y14 Receptor.</p>Fórmula:C24H20F3N5O3SPureza:98%Forma y color:SolidPeso molecular:515.51Tovinontrine
CAS:<p>Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.</p>Fórmula:C21H26N6O2Pureza:98.14%Forma y color:SolidPeso molecular:394.47DH376
CAS:<p>DH376 inhibits DAGLα in a time and dose dependent manner in mouse brain. DH376 shows picomolar activity.</p>Fórmula:C31H28F2N4O3Forma y color:SolidPeso molecular:542.58Calcipotriol Impurity C
CAS:<p>Calcipotriol Impurity C is the impurity of Calcipotriol. Calcipotriol is a VDR-like receptors ligand.</p>Fórmula:C27H40O3Pureza:98%Forma y color:SolidPeso molecular:412.614LXRβ agonist-3
CAS:<p>LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM).</p>Fórmula:C30H33N3O6SForma y color:SolidPeso molecular:563.66EB-0156
<p>EB-0156: potent ER α-glucosidase inhibitor, IC50 of 0.0479/ <0.001 μM, N-substituted valerian, broad-spectrum antiviral potential.</p>Fórmula:C21H32N6O7Forma y color:SolidPeso molecular:480.51HIF-2α-IN-5
CAS:<p>HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].</p>Fórmula:C15H12F4O3S2Forma y color:SolidPeso molecular:380.38Retezorogant
CAS:<p>Retezorogant is a retinoic acid receptor-related orphan receptor gamma (RORγ) antagonist.</p>Fórmula:C23H33ClN2O3Forma y color:SolidPeso molecular:420.97SAL-0010042
CAS:<p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>Fórmula:C15H15FN4OForma y color:SolidPeso molecular:286.304PTP1B-IN-21
<p>PTP1B-IN-21 inhibits PTP1B (IC50=1.56μM) selectively over TCPTP, a type 2 diabetes target.</p>Fórmula:C22H22O11Forma y color:SolidPeso molecular:462.4ent-8-iso-15(S)-Prostaglandin F2α
CAS:<p>Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid.</p>Fórmula:C20H34O5Forma y color:SolidPeso molecular:354.48Enpp-1-IN-7
<p>Enpp-1-IN-7: potent enpp-1 inhibitor, broad specificity, potential in cancer/infectious disease research. (WO2021203772A1)</p>Fórmula:C18H19N7O4SForma y color:SolidPeso molecular:429.45SAR114137
CAS:<p>SAR114137 is a highly effective pharmaceutical compound characterized by potent bioactivity. It exhibits variations in its amorphous content during the physical processing of crystalline active pharmaceutical ingredients (APIs). The amorphous API content of SAR114137 significantly decreases when subjected to various jet milling techniques. Additionally, SAR114137 demonstrates good chemical stability in drug formulations.</p>Fórmula:C17H24F2N4O2Forma y color:SolidPeso molecular:354.39Pyrocatechol sulfate
CAS:<p>Pyrocatechol sulfate, a phenolic metabolite found in human plasma, is associated with the intake of specific foods such as berries and the state of the gut microbiome. It serves as a potential urinary biomarker for kidney function, dialysis clearance rates, whole grain consumption, and regular coffee intake. Additionally, in conjunction with other phenolic sulfates, pyrocatechol sulfate plays a role in regulating various biological functions, including those related to brain health and the rhythmic beating of cardiac cells.</p>Fórmula:C6H6O5SForma y color:SolidPeso molecular:190.17GSK 366
CAS:<p>GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).</p>Fórmula:C17H16ClN3O4Pureza:98%Forma y color:SolidPeso molecular:361.78CAII-IN-3
<p>CAII-IN-3, a thiosemicarbazone, potently inhibits CA-II with an IC50 of 13.4 μM.</p>Fórmula:C18H18F2N4SForma y color:SolidPeso molecular:360.42FTI-2153 TFA
<p>FTI-2153 TFA inhibits farnesyltransferase with high selectivity (IC50: 1.4 nM), over 3000x more than Rap1A processing.</p>Fórmula:C27H31F3N4O5SForma y color:SolidPeso molecular:580.62Arphamenine A
CAS:<p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>Fórmula:C16H24N4O3Forma y color:SolidPeso molecular:320.387CP 524515
CAS:<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Fórmula:C27H27F9N2O4Forma y color:SolidPeso molecular:614.5Benfooxythiamine
CAS:<p>Benfooxythiamine is a transketolase (TKT) inhibitor that suppresses SARS-CoV-2 replication and enhances the activity of the glycolysis inhibitor 2DG. It exhibits antiviral properties.</p>Fórmula:C19H22N3O7PSForma y color:SolidPeso molecular:467.433Mutant IDH1-IN-3
CAS:<p>Mutant IDH1-IN-3 (Compound 1) is a selective allosteric inhibitor targeting the mutant isocitrate dehydrogenase 1 (IDH1), with an IC50 of 13 nM for R132HIDH1. It effectively suppresses the production of D-2-hydroxyglutarate (2HG) in cells and is applicable for research in oncology.</p>Fórmula:C22H30N4OForma y color:SolidPeso molecular:366.5RMGPa-IN-1
CAS:<p>RMGPa-IN-1 (Compound 10C) is an inhibitor of rabbit muscle glycogen phosphorylase a (RMGPa), exhibiting an IC50 value of 82.5 μM. This compound holds potential for research in diabetes.</p>Fórmula:C33H54O4Forma y color:SolidPeso molecular:514.779NADH-IN-2
CAS:<p>NADH-IN-2 (compound 8) is a Type II NADH dehydrogenase inhibitor.</p>Fórmula:C16H16N2Forma y color:SolidPeso molecular:236.31β-Glucuronidase/hCAII-IN-2
<p>β-Glucuronidase/hCAII-IN-2 is a potent inhibitor of β-glucuronidase and hCA II, and their IC50 values were 670.7 μM and 21.77 μM, respectively.</p>Fórmula:C31H23NO8Forma y color:SolidPeso molecular:537.52Sitamaquine hydrochloride
CAS:<p>Sitamaquine hydrochloride (WR 6026) is an orally active 8-aminoquinoline analog with antileishmanial activity. This compound inhibits mitochondrial complex II (succinate dehydrogenase) and is characterized by its lipophilic weak base properties. It rapidly accumulates in the acidic compartments of Leishmania parasites, predominantly localizing within the acidocalcisomes.</p>Fórmula:C21H35Cl2N3OForma y color:SolidPeso molecular:416.43
