Metabolismo
Los inhibidores del metabolismo son compuestos que interfieren con las vías metabólicas, alterando la producción y utilización de energía dentro de las células. Estos inhibidores se utilizan para estudiar la regulación del metabolismo, el papel de las vías metabólicas en enfermedades como el cáncer y la diabetes, y para desarrollar nuevas estrategias terapéuticas. Los inhibidores del metabolismo pueden dirigirse a diversas enzimas y procesos involucrados en la glucólisis, la oxidación de ácidos grasos y otras funciones metabólicas. En CymitQuimica, ofrecemos una amplia gama de inhibidores del metabolismo de alta calidad para apoyar su investigación en bioquímica, trastornos metabólicos y desarrollo de fármacos.
Subcategorías de "Metabolismo"
- AhR(41 productos)
- Aminopeptidasa(67 productos)
- CETP(18 productos)
- Anhídrido carbónico(177 productos)
- Caseína quinasa(130 productos)
- DHFR(32 productos)
- Descarboxilasa(4 productos)
- Deshidrogenasa(267 productos)
- FAAH(63 productos)
- FXR(58 productos)
- Factor Xa(80 productos)
- Ácido graso sintasa(32 productos)
- Ferroptosis(215 productos)
- GR(3 productos)
- GSNOR(3 productos)
- Glucoquinasa(53 productos)
- HIF / HIF Prolilhidroxilasa(142 productos)
- HMG-CoA reductasa(32 productos)
- Hidroxilasa(30 productos)
- IDO(82 productos)
- LDL(8 productos)
- Lipasa(96 productos)
- Lípido(59 productos)
- Lipoxigenasa(124 productos)
- MAO(87 productos)
- MPO(2 productos)
- NAMPT(36 productos)
- P450(6 productos)
- PAI-1(25 productos)
- PDE(166 productos)
- PED(1 productos)
- PKM(15 productos)
- PPAR(164 productos)
- Fosfolipasa(82 productos)
- ROR(42 productos)
- Receptor de retinoides(29 productos)
- SGK(11 productos)
- Tiorredoxina(12 productos)
- Transferasa(30 productos)
- Transportador(42 productos)
- UGT(4 productos)
- Inhibidores de la xantina oxidasa (XO)(9 productos)
Mostrar 34 subcategorías más
Se han encontrado 8595 productos de "Metabolismo"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
α-Glucosidase-IN-87
<p>α-Glucosidase-IN-87 (Compound 11c) is an orally active inhibitor of α-glucosidase with an IC50 of 119.7 μM. It exhibits hypoglycemic properties and is applicable in research on metabolic diseases such as diabetes.</p>Forma y color:Odour SolidLOC1886
CAS:<p>LOC1886 is a covalent inhibitor of GPX4, with slightly lower potency compared to RSL3 and ML162.</p>Fórmula:C13H11N3O2Forma y color:SolidPeso molecular:241.25DSM705
CAS:<p>DSM705: Pyrrole-based, potent nanomolar Plasmodium DHODH inhibitor with strong antimalarial efficacy; spares mammalian DHODH.</p>Fórmula:C19H19F3N6OForma y color:SolidPeso molecular:404.397ASM-IN-3
CAS:<p>ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 μM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.</p>Fórmula:C17H13ClN2O4Forma y color:SolidPeso molecular:344.75H-Pro-Phe-OH
CAS:<p>H-Pro-Phe-OH is a dipeptide formed from proline and phenylalanine, serving as a substrate for prolylase and in peptide synthesis.</p>Fórmula:C14H18N2O3Forma y color:SolidPeso molecular:262.30DSPE-PEG2000-VIP
<p>DSPE-PEG2000-VIP is a PEG-based compound composed of DSPE and the vasoactive intestinal peptide (VIP). This compound is useful for drug delivery applications.</p>Forma y color:Odour Solidα-Amylase/α-Glucosidase-IN-6
<p>α-Amylase/α-Glucosidase-IN-6 (compound 5j) serves as a potent dual inhibitor of both α-amylase and α-glucosidase, exhibiting IC50 values of 17.0 µM and 40.1 µM</p>Forma y color:Odour SolidMortatarin F
<p>Mortatarin F (Compound 1), a renyleted flavonoid derived from mulberry leaves, functions as an α-glucosidase inhibitor with an IC50 value of 8.7 μM, making it</p>Fórmula:C25H30O7Pureza:98%Forma y color:SolidPeso molecular:442.5Oxodipine
CAS:<p>Oxodipine blocks rabbit aortic contraction and weakens rat cardiac force; reduces Ca currents in myocytes; side effects: mouse constipation, dog gum swelling.</p>Fórmula:C19H21NO6Pureza:99.24%Forma y color:SolidPeso molecular:359.372-Aminoflubendazole
CAS:<p>2-Aminoflubendazole, a metabolite of benzimidazoles (BZ), belongs to a class of drugs effective against fungi, protozoa, and helminths.</p>Fórmula:C14H10FN3OForma y color:SolidPeso molecular:255.25CCR1/5/8 activator 1
CAS:<p>CCR1/5/8 activator 1 is a cytoplasmic phospholipase A inhibitor with antifungal activity.</p>Fórmula:C10H9NOPureza:>99.99%Forma y color:SolidPeso molecular:159.18PROTAC CYP1B1 degrader-2
CAS:<p>PROTAC CYP1B1 degrader-2 (compound PV2), a VHL (von Hippel - Landau) E3 ligase-based degrader of CYP1B1, exhibits a DC50 of 1.0 nM after 24 hours in A549/Taxol cells. Furthermore, it effectively inhibits the growth, migration, and invasion of A549/Taxol cells.</p>Fórmula:C49H56ClN7O5S3Forma y color:SolidPeso molecular:954.66IETP2
CAS:<p>IETP2 targets low-density lipoprotein receptor-related protein 1 (LRP1) with a KD of 738 nM, making it useful for delivering drugs and imaging agents across the blood-labyrinth barrier (BLB).</p>Fórmula:C107H171N39O29Forma y color:SolidPeso molecular:2467.75AK-4
<p>AK-4 is an antidiabetic agent that functions as a mitochondrial uncoupler.</p>Fórmula:C21H14Cl2N2O4SForma y color:SolidPeso molecular:461.32Secaubryenol
CAS:<p>Secaubryenol is a 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla.</p>Fórmula:C30H48O3Pureza:98%Forma y color:SolidPeso molecular:456.713-cis Acitretin D3
CAS:<p>13-cis Acitretin D3, a deuterium-labeled metabolite of Acitretin, is a second-gen systemic retinoid.</p>Fórmula:C21H26O3Pureza:98%Forma y color:SolidPeso molecular:329.454Sp-cAMPS triethylamine
CAS:<p>Sp-cAMPS triethylamine activates PKA I/II and inhibits PDE3A (Ki 47.6µM), binds PDE10 GAF (EC50 40µM).</p>Fórmula:C16H27N6O5PSForma y color:SolidPeso molecular:446.46ZG-2033
CAS:<p>ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.</p>Fórmula:C15H14N2O2SForma y color:SolidPeso molecular:286.35DSPE-PEG2000-pPB
<p>DSPE-PEG2000-pPB is a PEG compound comprised of DSPE and the cyclic oligopeptide (pPB). The pPB component exhibits a high binding affinity for PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG2000-pPB is utilizable for drug delivery applications.</p>Forma y color:Odour SolidDSPE-PEG2000-ESBP
<p>DSPE-PEG2000-ESBP is a PEGylated compound composed of DSPE and E-selectin binding peptide (ESBP). As a tumor-targeting peptide, ESBP can specifically recognize and bind to receptors or markers on the surface of tumor cells.</p>Forma y color:Odour Solid(±)14-HDHA
CAS:<p>(±)14-HDHA is an oxidized metabolite of DHA and can be further oxidized to the 14-oxoDHA, 14-HDoHE inhibits LPS-induced IL-6 mRNA expression.</p>Fórmula:C22H32O3Forma y color:SolidPeso molecular:344.49(±)7(8)-EpDPA
CAS:<p>Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina.</p>Fórmula:C22H32O3Forma y color:SolidPeso molecular:344.495Endocrocin
CAS:<p>Endocrocin is a useful organic compound for research related to life sciences. The catalog number is T124800 and the CAS number is 481-70-9.</p>Fórmula:C16H10O7Forma y color:SolidPeso molecular:314.249FXR agonist 11
CAS:<p>FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.</p>Fórmula:C18H16N2O5Forma y color:SolidPeso molecular:340.33sEH inhibitor-20
<p>sEH inhibitor-20 is a metabolically stable, orally active sEH inhibitor with an IC50 of 0.2 nM. It exhibits significant analgesic and anti-inflammatory properties, making it a promising candidate for researching neuropathic pain.</p>Forma y color:Odour SolidCyano-myracrylamide
CAS:<p>Cyano-myracrylamide is an inhibitor of zinc finger DHHC domain-containing palmitoyltransferase 20 (zDHHC20) with an IC50 value of 1.35 µM. It also inhibits the S-palmitoylation of EGFR and CD36. In HEK293T cells expressing recombinant E. coli GobX, recombinant human MyD88, or endogenous Ras, Cyano-myracrylamide inhibits the S-palmitoylation of E. coli E3 ligase GobX, MyD88, and Ras, which are substrates of zDHHC20, zDHHC9, and zDHHC6.</p>Fórmula:C19H34N2OForma y color:SolidPeso molecular:306.49DSPE-PEG5000-MPG
<p>DSPE-PEG5000-MPG is a PEG compound composed of DSPE and a peptide carrier (MPG). MPG is derived from the nuclear localization sequence (NLS) of the SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. This compound effectively delivers short oligonucleotides into cells independently of the endosomal pathway.</p>Forma y color:Odour SolidH-Gly-Pro-Gly-NH2
CAS:<p>H-Gly-Pro-Gly-NH2, a tripeptide, inhibits HIV-1 and HIV-2 replication (EC50: 35µM, 30µM) by blocking capsid formation.</p>Fórmula:C9H16N4O3Forma y color:SolidPeso molecular:228.25DPP-4-IN-11
<p>DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC50=2.75 μM) with anti-type 2 diabetes activity. This compound exerts its hypoglycemic effects by inhibiting the activity of α-glucosidase (IC50=3.02 μM) and α-amylase (IC50=3.3 μM).</p>Forma y color:Odour SolidLH1513
<p>LH1513 is a dioxalate salt derivative of l-lysine that inhibits CaOx crystallization more effectively than citrate and pyruvate. It shows potential preventive activity in hyperoxaluria models and effectively prevents urinary CaOx crystal formation in Agxt knockout mice. AGXT-1 is a mitochondrial protein involved in metabolic processes.</p>Fórmula:C10H11N2Na3O8Forma y color:SolidPeso molecular:356.17DSPE-PEG5000-F3
<p>DSPE-PEG5000-F3 consists of DSPE and the nucleolin-targeting peptide (F3) and is a PEGylated compound. The F3 peptide specifically binds to nucleolin on the cell surface, facilitating efficient transport from the cell surface to the nucleus. DSPE-PEG5000-F3 is applicable for drug delivery.</p>Forma y color:Odour SolidFXR agonist 10
<p>FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.</p>Fórmula:C15H22O4Forma y color:SolidPeso molecular:266.33PPARγ agonist 15
<p>PPARγ agonist15 (Compound 7c) functions as an agonist of PPARγ, inhibiting the expression of α-amylase (HPA) and α-glucosidase (HLAG) with IC50 values of 28.35 µM and 26.21 µM, respectively. It enhances glucose uptake in L6 myotubes and improves glucose homeostasis, insulin sensitivity, and lipid metabolism in a rat model of Streptozotocin-induced diabetes.</p>Fórmula:C21H16N4O3S2Forma y color:SolidPeso molecular:436.512-Amino-5-bromo-2’-chlorobenzophenone
CAS:<p>2-Amino-5-bromo-2’-chlorobenzophenone is an active metabolite of Phenazepam.</p>Fórmula:C13H9BrClNOForma y color:SolidPeso molecular:310.57Anticancer agent 260
CAS:<p>Anticanceragent 260 (Compound 3g/4d) is an orally effective anticancer agent that inhibits the proliferation of cancer cells HCT-116, MIA-PaCa2, and MDA-MB231, with IC50 values of 98.7, 81.0, and 77.2 µg/mL, respectively. It also promotes ulcer formation and lipid peroxidation, and exhibits anti-inflammatory and analgesic activities.</p>Fórmula:C14H11N3OForma y color:SolidPeso molecular:237.26(3R,5R)-Octahydrocurcumin
CAS:<p>(3R,5R)-Octahydrocurcumin (Compound 7) is a metabolite of Curcumin produced by gut microbiota. It exhibits neuroprotective effects against Aβ25-35-induced cell damage in SH-SY5Y cells and possesses anti-inflammatory properties in LPS-stimulated BV-2 mouse microglia.</p>Fórmula:C21H28O6Forma y color:SolidPeso molecular:376.443,4-Dihydroxyamphetamine hydrochloride
CAS:<p>3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a minor metabolite of 3,4-Methylenedioxymethamphetamine (MDMA) and exhibits cytotoxicity in rat hepatocytes. Additionally, 3,4-Dihydroxyamphetamine (hydrochloride) is applicable in hypertension research.</p>Fórmula:C9H14ClNO2Forma y color:SolidPeso molecular:203.67Ovalbumin (154-159)
CAS:<p>Ovalbumin (154-159), a peptide fragment derived from ovalbumin, acts as a potent inhibitor of the angiotensin-converting enzyme (ACE) and is utilized in</p>Fórmula:C28H52N10O9Pureza:98%Forma y color:SolidPeso molecular:672.77Ellagic acid 4-O-β-D-xylopyranoside
CAS:<p>Ellagic acid 4-O-β-D-xylopyranoside, an ellagitannin found naturally, exhibits antimicrobial properties and acts as an inhibitor of xanthine oxidase, displaying</p>Fórmula:C19H14O12Forma y color:SolidPeso molecular:434.31Defensin HNP-2 human
CAS:<p>Defensin HNP-2 is a naturally occurring antibiotic and monocyte chemotactic peptide synthesized by human neutrophils.</p>Fórmula:C147H223N43O37S6Forma y color:SolidPeso molecular:3377.03N,S-Bis-Fmoc-Glutathione
CAS:<p>N,S-Bis-Fmoc-Glutathione is a potent inhibitor of glyoxalase II, exhibiting a K i of 0.32 mM [1].</p>Fórmula:C40H37N3O10SForma y color:SolidPeso molecular:751.8Febuxostat impurity 8
CAS:<p>Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] .</p>Fórmula:C16H17NO4SForma y color:SolidPeso molecular:319.38Carbolactone
CAS:<p>Carbolactone is a biologically active metabolite from fungi [1] .</p>Fórmula:C24H36O3Forma y color:SolidPeso molecular:372.54LYS006 hydrochloride
CAS:<p>LYS006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) with an IC50 value of 2 nM. It is applicable in the study of inflammatory and autoimmune diseases. For further details, please refer to compound 29 in patent document WO2015092740A1.</p>Fórmula:C16H15Cl2FN6O3Forma y color:SolidPeso molecular:429.23LH10
<p>LH10 is an FXR agonist based on fexaramine, with an EC50 of 0.14 μM. It offers hepatoprotective effects, mitigating conditions such as cholestasis induced by alpha naphthylisothiocyanate (ANIT), acute liver injury caused by APAP, and non-alcoholic steatohepatitis (NASH).</p>Fórmula:C34H33N3O2Forma y color:SolidPeso molecular:515.64DSPE-PEG5000-T7
<p>DSPE-PEG5000-T7 is a PEG-based compound composed of DSPE and transferrin receptor peptide (T7). T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG5000-T7 is applicable in drug delivery.</p>Forma y color:Odour Solid5,6-Dihydroabiraterone
CAS:<p>5,6-Dihydroabiraterone, a metabolite of Abiraterone, is a strong, irreversible CYP17A1 inhibitor, effective in CRPC.</p>Fórmula:C24H33NOForma y color:SolidPeso molecular:351.52MTHFD2-IN-4 sodium
<p>MTHFD2-IN-4 sodium, a potent inhibitor of MTHFD2 and a tricyclic coumarin derivative, is applicable in cancer research [1].</p>Fórmula:C26H21F6N2NaO5Forma y color:SolidPeso molecular:578.44Febuxostat n-butyl isomer
CAS:<p>Febuxostat n-butyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] .</p>Fórmula:C16H16N2O3SForma y color:SolidPeso molecular:316.38MJ33-OH lithium
CAS:<p>MJ33-OH lithium is a metabolite of MJ33.</p>Fórmula:C22H43F3LiO7PPureza:98%Forma y color:SolidPeso molecular:514.48
