Metabolismo

<p>Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1</p>

<p>VER-246608 inhibits PDK (IC50: 35-91 nM), boosts PDC, reduces glycolysis, causes cancer cell cytostasis, and enhances doxorubicin effects.</p>

<p>PF-9601N: potent, selective MAO-BI with neuroprotection in PD models.</p>

<p>Milacemide is a glycine prodrug and MAO-B inhibitor.</p>

<p>ABX-1431 (Elcubragistat) is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).</p>

<p>PCC0208009 (IDO-IN-2) is an IDO inhibitor.</p>

<p>Tofisopam (Grandaxin) is a 2,3-benzodiazepine compound with anxiolytic activity that can be taken orally.</p>

<p>Novel 2,6-naphthyridine inhibits PKC/PKD, identified by HTS.</p>

<p>S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.</p>

<p>2,3-dihydroxy-3-methylbutanoic acid, a leucine metabolite, boosts muscle growth by activating mTOR.</p>

<p>U-73343 is an inactive analog of U-73122 and can be used as a negative control. U-73122 dose-dependently inhibits acid secretion irrespective of the stimulant.</p>

<p>AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for</p>

<p>PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).</p>

<p>Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6.</p>

<p>PHPS1 sodium inhibits Shp2; Kis: Shp2 (0.73μM), Shp2-R362K (5.8μM), Shp1 (10.7μM), PTP1B (5.8μM), PTP1B-Q (0.47μM).</p>

<p>Tarenflurbil, the R-enantiomer of flurbiprofen, lacks COX inhibition and was tested for Alzheimer's treatment.</p>

<p>β-Aminopropionitrile hydrochloride is a selective, oral, irreversible inhibitor of lysyl oxidase (LOX) that reduces metastatic seeding potential.</p>

<p>Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.</p>

Inosine (NSC-20262), an endogenous purine nucleoside produced by the catabolism of adenosine, is an agonist of adenosine receptors A1R and A2AR. Low-Cost!

<p>N-Biotinyl-6-aminohexanoic acid (N-(+)-Biotinyl-6-aminohexanoic acid) can be used to perform N-terminal biotinylation.</p>

<p>GFT505 (Elafibranor) (Elafibranor) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.</p>

<p>CDD3506 (1-TRITYL-1H-IMIDAZOL-4-AMINE) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.</p>

<p>Cyclo(his-pro) is a cyclic dipeptide that shields against oxidative damage by activating Nrf2.</p>

<p>Sun(4H-Furo[3,2-b]pyrrole-5-carboxylic acid) is an orally active and potent inhibitor of DAAO (DAO)</p>

<p>Tuftsin 3TFA is a tetrapeptide. It is a macrophage/microglial activator.</p>

<p>WWL229 selectively inhibits Ces3 without affecting Ces1f, ABHD6, or other serine hydrolases, mimicking WWL113 in adipocytes.</p>

<p>StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor.</p>

<p>Tazarotenic acid (AGN-190299) is a retinoid prodrug which is converted to its active form</p>

<p>Nifurtimox (BAY-A-2502) is an antiprotozoal agent (IC50s = 9.91, 12.28, and 10.44 μM against Taluahuén, LQ, and Brener strains of T.</p>

<p>Aldicarb sulfone is a cholinesterase inhibitor .</p>

<p>4-Nonylphenylboronic acid is a inhibitor of FAAH.</p>

<p>Clinofibrate lowers lipids, blocks HMGCR (IC50: 0.47 mM), and controls cholesterol/triacylglycerides.</p>

<p>Maltoheptaose is an activator of phosphorylase B for the preparation of heptulose-2-phosphate.</p>

<p>Carbutamide is a sulfonylurea antidiabetic agent with hypoglycemic activity.</p>

1-phenyl-3,4-dihydroisochinoline: dopamine analog, interacts with CNS receptors, studied for Parkinson's, Alzheimer's, and Huntington's.

<p>Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696.</p>

<p>Alfacalcidol (Etalpha) (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.</p>

<p>L-Cysteinesulfinic acid monohydrate activates rat mGluR1/2/4/5/6/8 with pEC50s of 3.92, 3.9, 2.7, 4.6, 4.0, 3.94 respectively.</p>

<p>Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate</p>

<p>CD00509 is a tyrosyl-DNA phosphodiesterase inhibitor.</p>

<p>Ethyl potassium malonate, a competitive inhibitor of the enzyme succinate dehydrogenase, acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is</p>

<p>Indoximod (NLG-8189) is a methylated tryptophan that inhibits IDO to boost T cell function by preventing tryptophan depletion.</p>

<p>Tebufenpyrad (Comanche) (mitochondrial complex-1 inhibitors) is an agro-chemically important acaricide that functions like the known mitochondrial toxicant</p>

<p>N-Benzyllinoleamide ((9Z,12Z)-N-Benzyloctadeca-9,12-dienamide) is a natural product isolated from Lepidium meyenii Walp, has pharmaceutical property against</p>

XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.

<p>Sephin1 (IFB-088) is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that</p>

<p>Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human STH. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human STH. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human STH, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human STH in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat HK2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat HK2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat HK2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat HK2 in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Leucic acid (α-Hydroxyisocaproic acid) is an amino acid widely found in plants and animals that prevents muscle loss and is broken down into glucose.</p>