Neurociencia

<p>(S)-4CPG ((S)-4-Carboxyphenylglycine) is a competitive mGlu1 receptor antagonist that attenuates nociceptive hypersensitivity and nociceptive abnormalities associated with sciatic nerve constriction injuries in rats, and may be used in the study of neurological disorders.</p>

ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human EFNA1, and the Human EFNA1 standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human EFNA1. After TMB substrate solution is added, only those wells that contain Human EFNA1 and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human EFNA1 in the samples is then determined by comparing the OD of the samples to the standard curve.

(S)-Mirtazapine ((S)-Org3770) is a 5-HT2 receptor antagonist with pro-nociceptive effects that can be used to study depression.

<p>Monepantel (AAD1566) is an organic anthelmintic and an antagonist of nAChRs from roundworms and esophageostomy.</p>

<p>Darigabat (PF-06372865) is a GABAA receptor modulator with anxiolytic activity that inhibits α2, α1 PAM, and α2 PAM.</p>

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PSA, and the Human PSA standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human PSA. After TMB substrate solution is added, only those wells that contain Human PSA and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PSA in the samples is then determined by comparing the OD of the samples to the standard curve.

<p>Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.</p>

Pipecuronium bromide (RGH-1106) is an nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker that causes muscle relaxation.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GH, and the Human GH standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human GH. After TMB substrate solution is added, only those wells that contain Human GH and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human GH in the samples is then determined by comparing the OD of the samples to the standard curve.

<p>Stability Very Hygroscopic<br>Applications RTI-55 is a semi-synthetic alkaloid that is a cocaine analogue belonging to the phenyltropane group. RTI-55 acts as a dopamine reuptake inhibitor (DRI) with siginificant abuse potential. RTI-55 is used to assess the rate of dopamine neuron degradation in the brains of patients with Parkinson’s disease.<br>References Fujita, M. et al.: J. Chem. Neuroanat., 7, 13 (1994); Elmer, G.I. et al.: Pharmacol. Biochem. Behav., 53, 911 (1996); Coulter, C.L. et al.: Brain Res., 690, 217 (1995);<br></p>

Setiptiline (Org-8282) is a norepinephrine reuptake inhibitor, 2-adrenergic receptor antagonist, H1 receptor inverse agonist with antidepressant activity.

RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.

Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets.

Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist used in the study of irritable bowel syndrome.

<p>GSK-1034702 is an M1 mAChR agonist that improves cognitive deficits and may be useful in the study of neurologic disorders.</p>

<p>S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2</p>

UCM 608 (2-Phenylmelatonin) is an antagonist of melatonin-induced contractile responses at low concentrations and induces an increase in GDP-GTP exchange.

Rotigotine (1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-) is an antiparkinson agent and dopamine receptor agonist.

<p>Applications A psychotropic agent with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a precursor to the active substance Desmethyldiazepam (D291595).<br>References Ochs, H.R. et al.: J. Clin. Pharmacol., 24, 446 (1984); Takagi, H. et al.: Nip. Yakur. Zas., 66, 134 (1970);<br></p>

Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.

<p>Tandospirone (SM-3997) is a 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity used in the study of central nervous system disorders.</p>

<p>Stability Store Tightly Sealed at RT<br>Applications A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively.<br>References Honore, et al. Science, 241, 701 (1988),Haas, H.S., et al.: Int. J. Oncol., 27, 867 (2005), Kobayashi, K., et al.: J. Pharmacol. Sci., 108, 517 (2008), Shabat-Simon, M., et al.: J. Neurosci., 28, 8406 (2008), Cruz, L.A., et al.: J. Med. Chem., 51, 5856 (2008),<br></p>

Ketanserin tartrate (KJK-945 tartrate) is a 5-HT2A receptor and α1-adrenergic receptor antagonist for the study of systemic sclerosis.

<p>L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.</p>

<p>γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.</p>

Velufenacin is an antagonist of muscarinic receptor[1].

<p>HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.</p>

LP-533401 hydrochloride is a peripheral Tph inhibitor that does not cross the BBB and can be used to study periodontal disease and hepatic steatosis.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human BNP, and the Human BNP standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human BNP. After TMB substrate solution is added, only those wells that contain Human BNP and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human BNP in the samples is then determined by comparing the OD of the samples to the standard curve.

WAY-100635 Maleate is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).

Rizatriptan (Risatriptan) is a selective 5-hydroxytryptamine 1B/1D receptor agonist used in the study of migraine.

<p>(R)-Mirtazapine ((R)-Org3770) is a 5-HT3 receptor antagonist, a potential analgesic with anti-injury perception properties.</p>

4-Hydroxyindole: aromatic, antioxidant, used in cancer treatment and preventing neurodegenerative diseases.

<p>Oxyphenbutazone: Non-selective COX inhibitor, anti-inflammatory, kills dormant Mycobacterium tuberculosis.</p>

<p>Xanomeline tartrate (LY 246708 tartrate) 是 M1和 M4 mAChR 激动剂，具有抗精神病样活性，可改善认知，可用于研究精神分裂症和阿尔茨海默病。</p>

Jatrorrhizine chloride (Neprotine chloride) is an alkaloid isolated from Rhizoma coptidis with neuroprotective, antimicrobial, and antiplasmodial activities.

<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>

<p>SB 243213 is a 5-HT2C receptor antagonist with anxiolytic and antidepressant activity used in schizophrenia and movement disorders.</p>

<p>Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).</p>

Pyridostigmine D6 bromide is the deuterium labeled Pyridostigmine, which is a parasympathomimetic and a reversible inhibitor of cholinesterase.

<p>Acephate-d3 (acetyl-d3) is a deuterated compound of Acephate. Acephate has a CAS number of 30560-19-1. Acephate is an anticholinesterase insecticide with a weak inhibitory effect on AChE in rats, but it can effectively inhibit AChE in cockroaches.</p>

<p>Fenitrothion-d6 (O,O-dimethyl-d6) is a deuterated compound of Fenitrothion. Fenitrothion has a CAS number of 122-14-5. Fenitrothion is an organothiophosphate cholinesterase inhibitor. Fenitrothion is used as an insecticide.</p>

Donepezil-d5 is a deuterated compound of Donepezil. Donepezil has a CAS number of 120014-06-4. Donepezil is a piperidine-based, potent, specific, and reversible inhibitor of acetylcholinesterase (AChE). It can be used for the treatment of mild to moderate dementia of the Alzheimer's type.

<p>Chlorpyrifos (diethyl-d10) is a deuterated compound of Chlorpyrifos. Chlorpyrifos has a CAS number of 2921-88-2. Chlorpyrifos is an organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.</p>

Sulindac EP Impurity C-d3 is a deuterated compound of Sulindac EP Impurity C. Sulindac EP Impurity C has a CAS number of 32004-67-4. (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease [1].

Varenicline (CP 526555) is a selective partial agonist of the α4β2 nAChR and a full agonist of the α3β4 nAChR and α7 nAChR.

<p>R 59-022 (DKGI-I) is a DGK inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells.</p>

<p>Gefapixant citrate is an orally active P2X3R blocker used for chronic cough and knee osteoarthritis. IC50: ~30 nM (hP2X3), 100-200 nM (hP2X2/3).</p>

<p>Cyproheptadine hydrochloride (Periactin hydrochloride) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.</p>