Neurociencia
Los inhibidores en neurociencia son compuestos diseñados para modular la actividad de proteínas, enzimas o receptores específicos dentro del sistema nervioso. Estos inhibidores son cruciales para estudiar los mecanismos moleculares subyacentes a la función neuronal, la transmisión sináptica y las enfermedades neurodegenerativas. Al dirigirse a los receptores de neurotransmisores, canales iónicos y vías de señalización, los inhibidores en neurociencia ayudan en la exploración de la función cerebral y en el desarrollo de estrategias terapéuticas para trastornos neurológicos como el Alzheimer, Parkinson y la epilepsia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de neurociencia de alta calidad para apoyar su investigación en neurobiología, neurofarmacología y ciencias cognitivas.
Subcategorías de "Neurociencia"
- Receptor 5-HT(1.025 productos)
- ACK(1 productos)
- AChR(645 productos)
- ATP Citrato Liasa(17 productos)
- Receptor adrenérgico(3.018 productos)
- BACE(37 productos)
- Beta amiloide(228 productos)
- CAMK(73 productos)
- Inhibidores de ciclooxigenasa (COX)(600 productos)
- Receptor de dopamina(445 productos)
- Receptor GABA(372 productos)
- Gamma-secretasa(61 productos)
- GluR(265 productos)
- GlyT(26 productos)
- Receptor de histamina(385 productos)
- LRRK2(43 productos)
- Receptor de melatonina(26 productos)
- NMDAR(10 productos)
- Receptor de OX(41 productos)
- Receptor de opioides(327 productos)
Mostrar 12 subcategorías más
Se han encontrado 5530 productos de "Neurociencia"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
K1833
K1833 is an inhibitor and reactivator of human acetylcholinesterase (hrAChE), exhibiting an inhibition concentration (IC50) of 58$.Forma y color:Odour SolidLY86057
CAS:LY86057 is a bioactive chemical.Fórmula:C20H26N2O3Forma y color:SolidPeso molecular:342.439Trivalent GalNAc-DBCO
CAS:Trivalent GalNAc-DBCO is a synthetic ligand composed of three GalNAc units linked to DBCO. Trivalent GalNAc-DBCO undergoes strain-promoted alkyne–azide cycloaddition (SPAAC) reactions with azide-containing molecules without the need for copper catalysis. Trivalent GalNAc-DBCO binds specifically to the asialoglycoprotein receptor (ASGPR), thereby directing conjugated molecules into hepatocytes for lysosomal degradation through receptor-mediated endocytosis. Trivalent GalNAc-DBCO is extensively applied in studies of liver-targeted drug delivery, targeted degradation strategies, and hepatocyte-specific molecular engineering.Fórmula:C91H144N12O34Pureza:96.33%Peso molecular:1950.18PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Fórmula:C20H19ClF3NO3SForma y color:SolidPeso molecular:445.88C2-8
CAS:C2-8 inhibits polyQ aggregation, IC50=25 μM (HDQ51), 0.05 μM (PC12 cells), reduces neurodegeneration in Huntington's models.Fórmula:C19H14Br2N2O3SForma y color:SolidPeso molecular:510.2SCH-900229
CAS:SCH-900229, a potent presenilin 1 selective γ-secretase inhibitor, used to treat Alzheimer’s Disease.Fórmula:C21H21ClF2O6S2Forma y color:SolidPeso molecular:506.97mHTT-IN-1
CAS:mHTT-IN-1 is a potent inhibitor of toxic mHTT, linked to Huntington's disease, with an EC50 of 46 nM.Fórmula:C18H19N7OSForma y color:SolidPeso molecular:381.45N-desmethyl Zolmitriptan
CAS:DZT, an active metabolite of zolmitriptan, agonizes 5-HT1B/D receptors; contracts human cerebral arteries (EC50=100nM).Fórmula:C15H19N3O2Forma y color:SolidPeso molecular:273.33Imidafenacin Metabolite M4
CAS:Imidafenacin M4 is a CYP3A4-formed metabolite of the muscarinic antagonist imidafenacin.Fórmula:C18H19N3O3Forma y color:SolidPeso molecular:325.368SB236057
CAS:SB236057: potent selective inverse agonist at 5-HT autoreceptors; increases brain 5-HT; teratogen causing musculoskeletal defects in rodents.Fórmula:C33H34N4O3Pureza:98%Forma y color:SolidPeso molecular:534.655-HT1AR/5-HT6R ligand-1
5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.Fórmula:C25H29ClN4O2SForma y color:SolidPeso molecular:485.04CUR-IPA
CUR-IPA is a cholinesterase inhibitor with IC50 values of 5.99 μM for eAChE (electric eel), 59.30 μM for hAChE (human), and 60.66 μM for hBChE (human). It has free radical scavenging and antioxidant activity and is useful for researching cognitive dysfunction.Fórmula:C43H38N2O8Forma y color:SolidPeso molecular:710.77AChE/MAO-B-IN-7
AChE/MAO-B-IN-7 (VAV-8) is a compound that acts as a dual inhibitor of acetylcholinesterase (AChE) and MAO-B, with the ability to cross the blood-brain barrier. It also inhibits the aggregation of Aβ42, making it a valuable compound for Alzheimer's disease (AD) research.
Fórmula:C22H21N3O3Forma y color:SolidPeso molecular:375.42Anticonvulsant agent 9
Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.Fórmula:C22H24N4O2Forma y color:SolidPeso molecular:376.45AC 253
CAS:Amylin (AMY3) receptor antagonist; blocks cAMP, Ca2+, PKA, MAPK, Akt, and cFOS activity; prevents Aβ-induced neuronal death. Cyclic AC 253 variant exists.Fórmula:C122H196N40O39Pureza:98%Forma y color:SolidPeso molecular:2847.11β-Amyloid (25-35) acetate
β-Amyloid (25-35) acetate is the Aβ(25-35) fragment of amyloid beta peptide, neurotoxicity, construct Alzheimer's disease cell and animal models.Pureza:98.26%GABAA receptor modulator-3
GABAA receptor modulator-3 (compound 3b) is a positive allosteric modulator (PAM). It inhibits the peak current and steady-state current of α1β3γ2 GABAAR with IC50 values of 671 μM and 64 μM, respectively.Fórmula:C18H22O2Forma y color:SolidPeso molecular:270.375-HT6 inverse agonist 1
CAS:5-HT6 inverse agonist 1 (Compound 33) is an antagonist of the 5-HT6 receptor with a Ki of 23 nM and a Kb of 6.62 nM. This compound can inhibit 5-HT6R-mediated Cdk5 and mTOR signaling pathways and reduce tactile allodynia induced by spinal nerve ligation (SNL) in rat models.Fórmula:C22H22Cl2FN3O3SForma y color:SolidPeso molecular:498.4Notch 1
CAS:Notch1 (Notchhomolog 1, translocation-associated) encodes a protein that is a member of the NOTCH family. This type I transmembrane protein family is characterized by common structural features, including an extracellular domain made up of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of various types of domains.Fórmula:C62H97N15O22S3Forma y color:SolidPeso molecular:1500.72PSEM 308 hydrochloride
PSAM agonist targeting PSAML141F-GlyR and related ion channels in mice; ideal concentration ≤5 mg/kg; plasmids at Addgene.Forma y color:Solid
