Neurociencia

Renzapride is a 5-HT3 antagonist and 5-HT4 agonist. Renzapride also functions as a 5-HT2B antagonist and has some affinity for the 5-HT2A and 5-HT2C receptors.

<p>PHCCC is a Group I mGluR antagonist and enhances mGluR4 function; also blocks mGluR2/8.</p>

<p>W-84 dibromide (HDMPPA) is a M2-receptor selective modulator.</p>

GSK2578215A is a potent and selective LRRK2 kinase inhibitor.

ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5.

Hemicholinium 3 is a potent and selective choline uptake blocker.

<p>Autocamtide 2 TFA, selective CaMKII peptide substrate, used in its activity assay.</p>

Ansofaxine hydrochloride (LY03005) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively).

Nelotanserin (APD125): strong 5-HT2A inverse agonist (IC50: 1.7 nM), moderate 5-HT2C (79 nM), weak 5-HT2B (791 nM).

AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.

Tebanicline hydrochloride (Ebanicline hydrochloride) , is an effective synthetic nicotinic (non-opioid) analgesic drug.

VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.

Glypromate acetate is a neuroprotective agent, is a weak NMDA receptor agonist.

<p>Cholesterol myristate, a natural steroid in Chinese medicine, affects GABAA, nicotinic receptors, and potassium channels.</p>

Setiptiline (Org-8282) is a norepinephrine reuptake inhibitor, 2-adrenergic receptor antagonist, H1 receptor inverse agonist with antidepressant activity.

RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.

<p>HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.</p>

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human BNP, and the Human BNP standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human BNP. After TMB substrate solution is added, only those wells that contain Human BNP and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human BNP in the samples is then determined by comparing the OD of the samples to the standard curve.

γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.

<p>Applications A psychotropic agent with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a precursor to the active substance Desmethyldiazepam (D291595).<br>References Ochs, H.R. et al.: J. Clin. Pharmacol., 24, 446 (1984); Takagi, H. et al.: Nip. Yakur. Zas., 66, 134 (1970);<br></p>