Proteasas / Proteasoma
Los inhibidores de proteasas y proteasomas son compuestos que bloquean la actividad de las proteasas y del proteasoma, que están involucrados en la degradación y renovación de proteínas. Estos inhibidores son vitales para estudiar la regulación de la homeostasis proteica, el control del ciclo celular y la apoptosis. Los inhibidores de proteasas y proteasomas también se utilizan en el tratamiento de enfermedades como el cáncer, donde la degradación anormal de proteínas desempeña un papel en la progresión de la enfermedad. Al inhibir las proteasas o el proteasoma, estos compuestos pueden inducir la muerte celular en células cancerosas y son herramientas esenciales tanto en la investigación básica como en el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteasas y proteasomas de alta calidad para apoyar su investigación en bioquímica, biología celular y desarrollo de fármacos.
Subcategorías de "Proteasas / Proteasoma"
- Acetil-CoA Carboxilasa(36 productos)
- Cisteína proteasa(110 productos)
- DPP-4(24 productos)
- Glutaminasa(44 productos)
- Proteasa del VIH(496 productos)
- PAI-1(26 productos)
- Inhibidores de la proteasa(50 productos)
- Receptor activado por proteasa(54 productos)
- Proteasoma(87 productos)
- Serina proteasa(51 productos)
- p97(15 productos)
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Se han encontrado 992 productos de "Proteasas / Proteasoma"
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Neurodegenerative Disorder-Targeting Compound 1
CAS:Neurodegenerative Disorder-Targeting Compound 1 is an inhibitor of calpain [1].Fórmula:C28H28N4O4Pureza:98%Forma y color:SolidPeso molecular:484.55LU-002i
CAS:LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].Fórmula:C35H52N4O7Pureza:98%Forma y color:SolidPeso molecular:640.81MMP-145
CAS:MMP-145 is used as a protease inhibitor.Fórmula:C20H20N2O7SPureza:98%Forma y color:SolidPeso molecular:432.45BMS-189664
CAS:BMS-189664 is an inhibitor of thrombin.Fórmula:C22H34N6O4SPureza:98%Forma y color:SolidPeso molecular:478.61MMP-3 Inhibitor VIII
CAS:Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, is a critical enzyme involved in tissue remodeling and repair through its role in degrading extracellular matrix proteins, facilitating cell migration. This enzyme has been implicated in various physiological processes including vascular remodeling associated with aneurysm formation, wound healing, the progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII, a cell-permeable sulfonamide-based hydroxamic acid, effectively inhibits MMP-3 by binding to its active site (Ki = 23 nM), thus blocking its enzymatic activity. Additionally, this inhibitor has been demonstrated to suppress the activity of mouse macrophage metalloelastase MME/MMP-12, with an IC50 value of 13 nM, highlighting its potential utility in research on tissue remodeling and disease processes involving MMPs.Fórmula:C20H26N2O5SForma y color:SolidPeso molecular:406.5GSK-625433
CAS:GSK-625433: Homochiral inhibitor blocks HCV genotypes 1a/1b polymerase.Fórmula:C26H32N4O5SForma y color:SolidPeso molecular:512.62AA74-1
CAS:AA74-1 is a potent, selective APEH inhibitor that significantly enhances T-cell proliferation by inhibiting APEH activity [1].Fórmula:C16H28N4O2Pureza:98%Forma y color:SolidPeso molecular:308.42Z-LVG
CAS:Z-LVG, an irreversible cysteine protease inhibitor and a tripeptide derivative of cystatin C, serves as an inhibitor of viral replication and is utilized inFórmula:C21H31N3O6Forma y color:SolidPeso molecular:421.49Berotralstat HCl
CAS:Berotralstat HCl is a selective plasma kallikrein inhibitor, reducing pain and swelling in HAE by blocking bradykinin release.Fórmula:C30H28Cl2F4N6OForma y color:SolidPeso molecular:635.4886Proteasome-IN-5
CAS:Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].Fórmula:C20H30BN5O7Pureza:98%Forma y color:SolidPeso molecular:463.29SQ 32056
CAS:SQ 32056 is a cathepsin E inhibitor.Fórmula:C37H56N4O5Pureza:98%Forma y color:SolidPeso molecular:636.86Dim16
CAS:Dim16, a dual inhibitor of PCSK9/HMG-CoAR, demonstrates potent activity with an IC50 of 19 nM against PCSK9 and significantly impedes PCSK9-LDLR interactionFórmula:C29H38IN5Forma y color:SolidPeso molecular:583.55M867
CAS:M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].Fórmula:C27H43N7O6Pureza:98%Forma y color:SolidPeso molecular:561.67HCV-IN-43
CAS:HCV-IN-43 (compound 2), an HCV NS5B protein inhibitor, efficiently inhibits HCV virus replication and is utilized in the study of HCV infection [1].Fórmula:C26H26FN3O5SForma y color:SolidPeso molecular:511.57Proteasome β2c/i-IN-1
CAS:Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].Fórmula:C32H48N4O7Pureza:98%Forma y color:SolidPeso molecular:600.75Kallikrein-IN-2
CAS:Kallikrein-IN-2 (compound 1) is an inhibitor of the kinin-releasing enzyme Kallikrein.Fórmula:C28H25F3N4O4Forma y color:SolidPeso molecular:538.52Proteasome-IN-4
Proteasome-IN-4, a potent non-covalent inhibitor (IC50=8.39nM), halts cancer cell growth, useful for oncology studies.Fórmula:C44H58N6O5Forma y color:SolidPeso molecular:750.97HCV-IN-44
CAS:HCV-IN-44 (compound 28) is an inhibitor of the HCV NS5B protein, efficacious in suppressing HCV virus replication and useful for researching HCV infection [1].Fórmula:C24H26FN3O5SForma y color:SolidPeso molecular:487.54MMP13-IN-3
CAS:MMP13-IN-3 is an oral, selective MMP-13 inhibitor with IC50 of 1 nM, >1000x selective, for osteoarthritis treatment.Fórmula:C24H22N4O5Pureza:99.76%Forma y color:SolidPeso molecular:446.46Ref: TM-T16124
1mg93,00€5mg205,00€10mg334,00€25mg587,00€50mg802,00€100mg1.108,00€1mL*10mM (DMSO)227,00€MMP-7-IN-2
CAS:MMP-7-IN-2 acts as a selective and potent MMP7 inhibitor and can be used to study inflammatory responses and vascular-related diseases.Fórmula:C28H40ClF3N6O9SPureza:97.82%Forma y color:SolidPeso molecular:729.17
