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Tirosina quinasa / adaptadores

Tirosina quinasa / adaptadores

Los inhibidores de tirosina quinasa y adaptadores son compuestos que se dirigen a las tirosina quinasas y sus proteínas adaptadoras asociadas, las cuales desempeñan roles cruciales en la señalización celular, el crecimiento y la diferenciación. Estos inhibidores son herramientas esenciales en la investigación del cáncer, ya que muchas tirosina quinasas están involucradas en las vías de señalización que impulsan el crecimiento tumoral y la metástasis. Al inhibir las tirosina quinasas, estos compuestos pueden bloquear cascadas de señalización críticas, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades que implican una señalización celular anormal. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa y adaptadores de alta calidad para apoyar su investigación en oncología, biología molecular y desarrollo de terapias dirigidas.

Subcategorías de "Tirosina quinasa / adaptadores"

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Se han encontrado 1342 productos de "Tirosina quinasa / adaptadores"

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  • UniPR505
    Targetmol
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    UniPR505

    CAS:
    <p>UniPR505 is a potent EphA2 antagonist (IC50: 0.95 µM), a novel 3α-carbamoyloxy derivative with antiangiogenic properties.</p>
    Fórmula:C39H57N3O5
    Pureza:98.23%
    Forma y color:Solid
    Peso molecular:647.89

    Ref: TM-T73368

  • AXL-IN-15
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    AXL-IN-15

    CAS:
    <p>AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1</p>
    Fórmula:C26H32F3N9O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:575.59

    Ref: TM-T79045

  • UniPR1447
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    UniPR1447

    CAS:
    <p>UniPR1447 is a dual antagonist for both EphA2 and EphB2 receptors, exhibiting an IC50 value of 6.6 μM against EphA2-ephrin-A1 binding [1].</p>
    Fórmula:C36H50N2O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:574.79

    Ref: TM-T80897

  • EGFR-IN-33
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    EGFR-IN-33

    CAS:
    <p>EGFR-IN-33, a low-toxicity acrylamide, inhibits EGFR, aiding against cancer, especially NSCLC (from WO2021185348A1, comp. 13).</p>
    Fórmula:C26H25ClN6O2
    Forma y color:Solid
    Peso molecular:488.97

    Ref: TM-T63264

  • (Z)-RG-13022
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    (Z)-RG-13022

    CAS:
    <p>(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 μM for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E)-RG-13022 (IC50 = 38 μM). This compound is applied in breast cancer cell research [1] [2].</p>
    Fórmula:C16H14N2O2
    Forma y color:Solid
    Peso molecular:266.29

    Ref: TM-T84525

  • BEBT-109
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    BEBT-109

    CAS:
    <p>BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.</p>
    Fórmula:C27H32N8O3
    Pureza:97.26%
    Forma y color:Solid
    Peso molecular:516.6

    Ref: TM-T80643

  • BPIQ-I
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    BPIQ-I

    CAS:
    <p>BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.</p>
    Fórmula:C16H12BrN5
    Forma y color:Solid
    Peso molecular:354.2

    Ref: TM-T70227

  • FGFR4-IN-16
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    FGFR4-IN-16

    CAS:
    <p>FGFR4-IN-16 (CY-15-2) is a covalent inhibitor targeting FGFR-4, utilized in cancer research [1].</p>
    Fórmula:C35H30Cl2N6O5
    Pureza:98%
    Forma y color:Solid
    Peso molecular:685.56

    Ref: TM-T79880

  • KB SRC 4
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    KB SRC 4

    CAS:
    KB SRC 4 is a selective and potent c-Src inhibitor with antitumour activity that inhibits the growth of cancer cells.CAS 번호13460-73-83-4
    Fórmula:C32H23ClN8
    Pureza:98.83% - 99.34%
    Forma y color:Solid
    Peso molecular:555.03

    Ref: TM-T11745

  • TRK-IN-24
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    TRK-IN-24

    CAS:
    <p>TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L,</p>
    Fórmula:C39H45N7O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:659.82

    Ref: TM-T79706

  • TG 100572 Hydrochloride
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    TG 100572 Hydrochloride

    CAS:
    <p>TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.</p>
    Fórmula:C26H27Cl2N5O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:512.43

    Ref: TM-T13156L

  • JGK-068S
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    JGK-068S

    CAS:
    <p>Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].</p>
    Fórmula:C22H23BrFN5O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:488.35

    Ref: TM-T79124

  • FGFR4-IN-8
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    FGFR4-IN-8

    CAS:
    <p>FGFR4-IN-8 is a selective, ATP-competitive FGFR4 inhibitor with IC50s as low as 0.25 nM, halting growth of Hep3B cells at 29 nM and showing in vivo efficacy.</p>
    Fórmula:C32H34Cl2FN7O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:654.56

    Ref: TM-T73121

  • EGFR-IN-61
    Targetmol
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    EGFR-IN-61

    CAS:
    <p>EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 &amp; H1975 cell growth (IC50: 2.14 &amp; 1.82 μM).</p>
    Fórmula:C33H37ClN8O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:629.15

    Ref: TM-T73128

  • EGFR-IN-85
    Targetmol
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    EGFR-IN-85

    CAS:
    <p>EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFR</p>
    Fórmula:C26H30N8O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:486.57

    Ref: TM-T78574

  • Logo de CymitQuimica
    Targetmol
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    Type II TRK inhibitor 1

    CAS:
    <p>Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type.</p>
    Fórmula:C35H33F3N8O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:670.68

    Ref: TM-T72289

  • FGFR-IN-11
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    FGFR-IN-11

    CAS:
    <p>FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (</p>
    Fórmula:C28H29ClN4O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:521.01

    Ref: TM-T79257

  • ENT-C225
    Targetmol
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    ENT-C225

    CAS:
    <p>ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.</p>
    Fórmula:C26H40N4O5
    Pureza:99.36% - 99.36%
    Forma y color:Solid
    Peso molecular:488.62

    Ref: TM-T73397

  • Logo de CymitQuimica
    Targetmol
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    EGFR/CSC-IN-1

    CAS:
    <p>EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential</p>
    Fórmula:C54H54Cl2FN7O7S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:1067.08

    Ref: TM-T73995

  • EGFR-IN-87
    Targetmol
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    EGFR-IN-87

    CAS:
    EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750,
    Fórmula:C28H33N7O2
    Pureza:98.64%
    Forma y color:Solid
    Peso molecular:499.61

    Ref: TM-T79888