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Tirosina quinasa / adaptadores

Tirosina quinasa / adaptadores

Los inhibidores de tirosina quinasa y adaptadores son compuestos que se dirigen a las tirosina quinasas y sus proteínas adaptadoras asociadas, las cuales desempeñan roles cruciales en la señalización celular, el crecimiento y la diferenciación. Estos inhibidores son herramientas esenciales en la investigación del cáncer, ya que muchas tirosina quinasas están involucradas en las vías de señalización que impulsan el crecimiento tumoral y la metástasis. Al inhibir las tirosina quinasas, estos compuestos pueden bloquear cascadas de señalización críticas, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades que implican una señalización celular anormal. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa y adaptadores de alta calidad para apoyar su investigación en oncología, biología molecular y desarrollo de terapias dirigidas.

Subcategorías de "Tirosina quinasa / adaptadores"

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Se han encontrado 1357 productos de "Tirosina quinasa / adaptadores"

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  • Zidesamtinib
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    Zidesamtinib

    CAS:
    <p>Zidesamtinib (NVL-520) is a ROS1 fusion and resistance mutation inhibitor that inhibits ROS1 and can be used to study non-small cell lung cancer.</p>
    Fórmula:C22H22FN7O
    Pureza:99.74%
    Forma y color:Solid
    Peso molecular:419.455

    Ref: TM-T72953

  • EGFR-IN-1 hydrochloride
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    EGFR-IN-1 hydrochloride

    CAS:
    <p>EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.</p>
    Fórmula:C28H31ClN6O4
    Pureza:99.16%
    Forma y color:Solid
    Peso molecular:551.04

    Ref: TM-T11157L

  • EGFR/ErbB-2 inhibitor-1
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    EGFR/ErbB-2 inhibitor-1

    CAS:
    <p>EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.</p>
    Fórmula:C23H15ClFN3OS2
    Pureza:98.93%
    Forma y color:Solid
    Peso molecular:467.97

    Ref: TM-T79861

  • EGFR-IN-87
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    EGFR-IN-87

    CAS:
    EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750,
    Fórmula:C28H33N7O2
    Pureza:98.64%
    Forma y color:Solid
    Peso molecular:499.61

    Ref: TM-T79888

  • FIIN-1
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    FIIN-1

    CAS:
    <p>FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3,</p>
    Fórmula:C32H39Cl2N7O4
    Pureza:98.75%
    Forma y color:Solid
    Peso molecular:656.6

    Ref: TM-T37426

  • BGB-8035
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    BGB-8035

    CAS:
    <p>BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.</p>
    Fórmula:C24H31N5O4
    Pureza:96.74%
    Forma y color:Solid
    Peso molecular:453.53

    Ref: TM-T73381

  • TAK-020
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    TAK-020

    CAS:
    <p>TAK-020 is a potent covalent inhibitor of Btk with potential antitumor activity for the study of rheumatoid arthritis and immune-related diseases.</p>
    Fórmula:C18H17N5O3
    Pureza:98.79%
    Forma y color:Solid
    Peso molecular:351.36

    Ref: TM-T9529

  • EGFR-IN-8
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    EGFR-IN-8

    CAS:
    <p>EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC</p>
    Fórmula:C32H23ClF3N7O4
    Pureza:99.51%
    Forma y color:Solid
    Peso molecular:662.02

    Ref: TM-T11162

  • AZ-23
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    AZ-23

    CAS:
    <p>AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C.</p>
    Fórmula:C17H19ClFN7O
    Pureza:99.4%
    Forma y color:Solid
    Peso molecular:391.83

    Ref: TM-T14363

  • Src Inhibitor 3
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    Src Inhibitor 3

    CAS:
    Src Inhibitor 3 blocks c-Src kinase (IC50 <3 nM CSK HTRF, <4 nM Caliper), boosting T cell growth from receptor signals.
    Fórmula:C34H32ClFN8O4
    Pureza:98.35%
    Forma y color:Solid
    Peso molecular:671.12

    Ref: TM-T13000

  • FGFR-IN-15
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    FGFR-IN-15

    <p>FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.</p>
    Fórmula:C22H23N5O5S
    Forma y color:Solid
    Peso molecular:469.51

    Ref: TM-T201821

  • GENZ-882706
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    GENZ-882706

    CAS:
    <p>GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.</p>
    Fórmula:C26H25N5O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:455.51

    Ref: TM-T11390

  • Tyrphostin 63
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    Tyrphostin 63

    CAS:
    <p>Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor, with an IC50 of 375 μM and a Ki of 123 μM.</p>
    Fórmula:C10H8N2O
    Forma y color:Solid
    Peso molecular:172.183

    Ref: TM-T204167

  • TrkA-IN-9
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    TrkA-IN-9

    CAS:
    <p>TrkA-IN-9 (VMD-928) is an orally active and selective inhibitor of tropomyosin receptor kinase A (TrkA). It disrupts downstream signaling pathways activated by nerve growth factor (NGF) binding to TrkA, thereby inhibiting cell proliferation and invasion, and promoting cancer cell death. TrkA-IN-9 shows potential for research in various cancers, including prostate cancer, thymic carcinoma, mesothelioma, head and neck squamous cell carcinoma, lung cancer, ovarian cancer, and hepatocellular carcinoma.</p>
    Fórmula:C31H32N4O4
    Forma y color:Solid
    Peso molecular:524.61

    Ref: TM-T206381

  • FMP-API-1
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    FMP-API-1

    CAS:
    <p>FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).</p>
    Fórmula:C13H14N2O2
    Forma y color:Solid
    Peso molecular:230.262

    Ref: TM-T204439

  • Logo de CymitQuimica
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    c-Fms-IN-15

    CAS:
    <p>c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with an IC50 of 563 nM.</p>
    Fórmula:C29H28F3N7O2
    Peso molecular:563.57

    Ref: TM-T210059

  • TrkC-IN-1
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    TrkC-IN-1

    CAS:
    <p>TrkC-IN-1 (Compound 6c) is an inhibitor of TrkC, with IC50 values of 3.3-7.1 and 7.3-10.2 μΜ for EBC-1 and HT-29 cells, respectively. This compound shows potential for research in the field of cancer therapeutics.</p>
    Fórmula:C28H20BrN5O2
    Forma y color:Solid
    Peso molecular:538.395

    Ref: TM-T206472

  • Logo de CymitQuimica
    Targetmol
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    DDR1-IN-8

    CAS:
    <p>DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, exhibiting IC50 values of 0.045 μM and 0.126 μM, respectively, and possesses antitumor activity.</p>
    Fórmula:C23H24F3N5O2
    Peso molecular:459.46

    Ref: TM-T209082

  • TrkA-IN-8
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    TrkA-IN-8

    CAS:
    <p>TrkA-IN-8 (Compound 2) is a TrkA inhibitor with a Kd value of 3.3 µM. RTKs-IN-1 demonstrates a concentration-dependent inhibitory effect on the proliferation of lung cancer cell lines and holds potential for research in non-small cell lung cancer.</p>
    Fórmula:C20H16N4
    Forma y color:Solid
    Peso molecular:312.368

    Ref: TM-T205511

  • Tesevatinib tosylate
    Targetmol
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    Tesevatinib tosylate

    CAS:
    <p>Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.</p>
    Fórmula:C31H33Cl2FN4O5S
    Forma y color:Solid
    Peso molecular:663.59

    Ref: TM-T201865