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Tirosina quinasa / adaptadores

Tirosina quinasa / adaptadores

Los inhibidores de tirosina quinasa y adaptadores son compuestos que se dirigen a las tirosina quinasas y sus proteínas adaptadoras asociadas, las cuales desempeñan roles cruciales en la señalización celular, el crecimiento y la diferenciación. Estos inhibidores son herramientas esenciales en la investigación del cáncer, ya que muchas tirosina quinasas están involucradas en las vías de señalización que impulsan el crecimiento tumoral y la metástasis. Al inhibir las tirosina quinasas, estos compuestos pueden bloquear cascadas de señalización críticas, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades que implican una señalización celular anormal. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa y adaptadores de alta calidad para apoyar su investigación en oncología, biología molecular y desarrollo de terapias dirigidas.

Subcategorías de "Tirosina quinasa / adaptadores"

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Se han encontrado 1357 productos de "Tirosina quinasa / adaptadores"

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  • IGF-1R inhibitor-4
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    IGF-1R inhibitor-4

    CAS:
    <p>IGF-1Rinhibitor-4 (compound 22) is a potent inhibitor of IGF-1R, demonstrating an inhibition rate of 63% at a concentration of 10 μM. This compound plays a significant role in cancer research.</p>
    Fórmula:C13H15ClN4O
    Forma y color:Solid
    Peso molecular:278.737

    Ref: TM-T204141

  • Andamertinib
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    Andamertinib

    CAS:
    <p>Andamertinib is an EGFR inhibitor with antitumor activity.</p>
    Fórmula:C31H36N8O3
    Forma y color:Solid
    Peso molecular:568.669

    Ref: TM-T206579

  • Logo de CymitQuimica
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    EGFR/BRAF-IN-1

    <p>EGFR/BRAF-IN-1 inhibits EGFR/BRAF (BRAFV600E IC50: 45 nM, GI50: 35 nM) and has antioxidant properties.</p>
    Fórmula:C26H28ClN3O4
    Forma y color:Solid
    Peso molecular:481.97

    Ref: TM-T63189

  • EGFR-IN-139
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    EGFR-IN-139

    CAS:
    <p>EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S). It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC).</p>
    Fórmula:C27H25ClN2O4
    Forma y color:Solid
    Peso molecular:476.951

    Ref: TM-T204772

  • Pimicotinib hydrochloride
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    Pimicotinib hydrochloride

    CAS:
    <p>Pimicotinib hydrochloride is an inhibitor of CSF1R, displaying antitumor activity.</p>
    Fórmula:C22H25ClN6O3
    Forma y color:Solid
    Peso molecular:456.925

    Ref: TM-T204920

  • ITK inhibitor 2
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    ITK inhibitor 2

    CAS:
    <p>ITK inhibitor 2 (compound 4) is a potent and selective ITK inhibitor with an IC50= 2 nM.</p>
    Fórmula:C25H33N5O2
    Pureza:99.67%
    Forma y color:Solid
    Peso molecular:435.56

    Ref: TM-T11690

  • DYR530
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    DYR530

    CAS:
    DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.
    Fórmula:C23H24FN7
    Forma y color:Solid
    Peso molecular:417.48

    Ref: TM-T201243

  • PF-06273340
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    PF-06273340

    CAS:
    <p>PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。</p>
    Fórmula:C23H22ClN7O3
    Pureza:98% - 98.00%
    Forma y color:Solid
    Peso molecular:479.92

    Ref: TM-T19649

  • c-Met-IN-2
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    c-Met-IN-2

    CAS:
    <p>c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.</p>
    Fórmula:C24H21FN10O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:484.49

    Ref: TM-T10654

  • CGP062464
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    CGP062464

    CAS:
    <p>CGP062464 is an inhibitor of the tyrosine kinase c-Src, with an IC50 of less than 50 nM. It is utilized in research related to osteoporosis and tumor-induced hypercalcemia.</p>
    Fórmula:C18H14N4
    Forma y color:Solid
    Peso molecular:286.331

    Ref: TM-T205732

  • EGFR-IN-149
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    EGFR-IN-149

    CAS:
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Fórmula:C16H15N3OS
    Forma y color:Solid
    Peso molecular:297.375

    Ref: TM-T205658

  • 2-Methyl-3-phenylquinoxaline
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    2-Methyl-3-phenylquinoxaline

    CAS:
    <p>2-Methyl-3-phenylquinoxaline (compound 38) serves as an effective inhibitor of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase (PDGF-RTK), exhibiting significant inhibitory activity against the full-length PDGFR kinase in intact cells (IC50 greater than 100 μM).</p>
    Fórmula:C15H12N2
    Forma y color:Solid
    Peso molecular:220.27

    Ref: TM-T201514

  • EGFR-IN-130
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    EGFR-IN-130

    <p>EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.</p>
    Fórmula:C27H25N3O6S
    Forma y color:Solid
    Peso molecular:519.57

    Ref: TM-T201686

  • Enrupatinib
    Targetmol
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    Enrupatinib

    CAS:
    <p>Enrupatinib is an inhibitor of the colony stimulating factor 1 receptor (CSF1R), exhibiting antitumor activity.</p>
    Fórmula:C27H26N6O3
    Forma y color:Solid
    Peso molecular:482.53

    Ref: TM-T201165

  • c-Met-IN-26
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    c-Met-IN-26

    CAS:
    c-Met-IN-26 (compound 1-170) is an effective inhibitor of c-Met, exhibiting an IC50 of 1.6 nM.
    Fórmula:C24H19F2N9
    Forma y color:Solid
    Peso molecular:471.46

    Ref: TM-T201085

  • BNN-20
    Targetmol
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    BNN-20

    CAS:
    <p>BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.</p>
    Fórmula:C20H30O2
    Forma y color:Solid
    Peso molecular:302.45

    Ref: TM-T201864

  • Fanregratinib
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    Fanregratinib

    CAS:
    Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.
    Fórmula:C27H33ClN6O2
    Forma y color:Solid
    Peso molecular:509.04

    Ref: TM-T201139

  • Logo de CymitQuimica
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    HER2-IN-9

    <p>HER2-IN-9, an oral HER2 inhibitor (IC50: 0.03 μM), hinders growth and spread of HER2+ breast cancer.</p>
    Fórmula:C19H14BrF3N2O
    Forma y color:Solid
    Peso molecular:423.23

    Ref: TM-T62271

  • FGFR-IN-16
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    FGFR-IN-16

    CAS:
    <p>FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, exhibiting IC50 values of 8 nM, 4 nM, and 3.8 nM respectively. It plays a crucial role in cancer research.</p>
    Fórmula:C30H27Cl2N7O4
    Forma y color:Solid
    Peso molecular:620.49

    Ref: TM-T201714

  • WS-11
    Targetmol
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    WS-11

    CAS:
    <p>WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust π-π interactions with PHE540, and p-π interactions with LYS430 within the active pocket.</p>
    Fórmula:C26H22FN9O2
    Forma y color:Solid
    Peso molecular:511.51

    Ref: TM-T201126