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Tirosina quinasa / adaptadores

Tirosina quinasa / adaptadores

Los inhibidores de tirosina quinasa y adaptadores son compuestos que se dirigen a las tirosina quinasas y sus proteínas adaptadoras asociadas, las cuales desempeñan roles cruciales en la señalización celular, el crecimiento y la diferenciación. Estos inhibidores son herramientas esenciales en la investigación del cáncer, ya que muchas tirosina quinasas están involucradas en las vías de señalización que impulsan el crecimiento tumoral y la metástasis. Al inhibir las tirosina quinasas, estos compuestos pueden bloquear cascadas de señalización críticas, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades que implican una señalización celular anormal. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa y adaptadores de alta calidad para apoyar su investigación en oncología, biología molecular y desarrollo de terapias dirigidas.

Subcategorías de "Tirosina quinasa / adaptadores"

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Se han encontrado 1370 productos de "Tirosina quinasa / adaptadores"

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  • NS-062
    Targetmol
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    NS-062

    CAS:
    <p>NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.</p>
    Fórmula:C28H30Cl2F2N6O4
    Forma y color:Solid
    Peso molecular:623.48

    Ref: TM-T201773

  • Enrupatinib
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    Enrupatinib

    CAS:
    <p>Enrupatinib is an inhibitor of the colony stimulating factor 1 receptor (CSF1R), exhibiting antitumor activity.</p>
    Fórmula:C27H26N6O3
    Forma y color:Solid
    Peso molecular:482.53

    Ref: TM-T201165

  • EGFR-IN-149
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    EGFR-IN-149

    CAS:
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Fórmula:C16H15N3OS
    Forma y color:Solid
    Peso molecular:297.375

    Ref: TM-T205658

  • EGFR-IN-130
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    EGFR-IN-130

    <p>EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.</p>
    Fórmula:C27H25N3O6S
    Forma y color:Solid
    Peso molecular:519.57

    Ref: TM-T201686

  • c-Met-IN-26
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    c-Met-IN-26

    CAS:
    c-Met-IN-26 (compound 1-170) is an effective inhibitor of c-Met, exhibiting an IC50 of 1.6 nM.
    Fórmula:C24H19F2N9
    Forma y color:Solid
    Peso molecular:471.46

    Ref: TM-T201085

  • Fanregratinib
    Targetmol
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    Fanregratinib

    CAS:
    Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.
    Fórmula:C27H33ClN6O2
    Forma y color:Solid
    Peso molecular:509.04

    Ref: TM-T201139

  • Logo de CymitQuimica
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    HER2-IN-9

    <p>HER2-IN-9, an oral HER2 inhibitor (IC50: 0.03 μM), hinders growth and spread of HER2+ breast cancer.</p>
    Fórmula:C19H14BrF3N2O
    Forma y color:Solid
    Peso molecular:423.23

    Ref: TM-T62271

  • FGFR-IN-16
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    FGFR-IN-16

    CAS:
    <p>FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, exhibiting IC50 values of 8 nM, 4 nM, and 3.8 nM respectively. It plays a crucial role in cancer research.</p>
    Fórmula:C30H27Cl2N7O4
    Forma y color:Solid
    Peso molecular:620.49

    Ref: TM-T201714

  • WS-11
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    WS-11

    CAS:
    <p>WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust π-π interactions with PHE540, and p-π interactions with LYS430 within the active pocket.</p>
    Fórmula:C26H22FN9O2
    Forma y color:Solid
    Peso molecular:511.51

    Ref: TM-T201126

  • BML-265
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    BML-265

    CAS:
    <p>BML-265 is a potent inhibitor of EGFR tyrosine kinase (EGFR tyrosine kinase). It disrupts Golgi apparatus integrity in human cells and hinders the transport of secretory proteins across various substances. In contrast, BML-265 does not affect the integrity and transport of the Golgi apparatus in rodent cells.</p>
    Fórmula:C18H15N3O2
    Forma y color:Solid
    Peso molecular:305.331

    Ref: TM-T204769

  • FGFR-IN-15
    Targetmol
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    FGFR-IN-15

    <p>FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.</p>
    Fórmula:C22H23N5O5S
    Forma y color:Solid
    Peso molecular:469.51

    Ref: TM-T201821

  • c-Met-IN-2
    Targetmol
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    c-Met-IN-2

    CAS:
    <p>c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.</p>
    Fórmula:C24H21FN10O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:484.49

    Ref: TM-T10654

  • MerTK-IN-1
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    MerTK-IN-1

    CAS:
    <p>MerTK-IN-1 (compound 31) serves as an inhibitor of MerTK, with the capability to bind to the target in vivo.</p>
    Fórmula:C23H26N8O4
    Forma y color:Solid
    Peso molecular:478.50

    Ref: TM-T200963

  • Dyrk1A-IN-11
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    Dyrk1A-IN-11

    CAS:
    <p>Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.</p>
    Fórmula:C23H23F5N8O
    Forma y color:Solid
    Peso molecular:522.47

    Ref: TM-T201128

  • Tesevatinib tosylate
    Targetmol
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    Tesevatinib tosylate

    CAS:
    <p>Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.</p>
    Fórmula:C31H33Cl2FN4O5S
    Forma y color:Solid
    Peso molecular:663.59

    Ref: TM-T201865

  • Logo de CymitQuimica
    Targetmol
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    EGFR/BRAF-IN-1

    <p>EGFR/BRAF-IN-1 inhibits EGFR/BRAF (BRAFV600E IC50: 45 nM, GI50: 35 nM) and has antioxidant properties.</p>
    Fórmula:C26H28ClN3O4
    Forma y color:Solid
    Peso molecular:481.97

    Ref: TM-T63189

  • EGFR-IN-125
    Targetmol
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    EGFR-IN-125

    CAS:
    <p>EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of &lt;0.3 nM for EGFR(d746-750/T790M/C797S), 0.52 nM for EGFR(L858R/T790M/C797S), 0.5 nM for EGFR(d746-750/C797S), 0.69 nM for EGFR(L858R/C797S), and 0.92 nM for EGFR (wild type).</p>
    Fórmula:C30H26N8O
    Forma y color:Solid
    Peso molecular:514.58

    Ref: TM-T204450

  • Logo de CymitQuimica
    Targetmol
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    EGFR-IN-58

    <p>EGFR-IN-58 is a potent, selective, ATP-competitive inhibitor of EGFR. EGFR-IN-58 exhibits significant cytotoxicity against melanoma, colon and blood cancers.</p>
    Fórmula:C31H30FN7O
    Forma y color:Solid
    Peso molecular:535.61

    Ref: TM-T63774

  • HER2-IN-7
    Targetmol
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    HER2-IN-7

    CAS:
    <p>HER2-IN-7 is a potent HER2 inhibitor with potential for researching ErbB-related diseases, especially cancer.</p>
    Fórmula:C28H26F3N7O3
    Forma y color:Solid
    Peso molecular:565.55

    Ref: TM-T64003

  • EG31
    Targetmol
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    EG31

    CAS:
    <p>EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.</p>
    Fórmula:C30H13Br2N3O6
    Forma y color:Solid
    Peso molecular:671.25

    Ref: TM-T207269