Tirosina quinasa / adaptadores
Los inhibidores de tirosina quinasa y adaptadores son compuestos que se dirigen a las tirosina quinasas y sus proteínas adaptadoras asociadas, las cuales desempeñan roles cruciales en la señalización celular, el crecimiento y la diferenciación. Estos inhibidores son herramientas esenciales en la investigación del cáncer, ya que muchas tirosina quinasas están involucradas en las vías de señalización que impulsan el crecimiento tumoral y la metástasis. Al inhibir las tirosina quinasas, estos compuestos pueden bloquear cascadas de señalización críticas, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades que implican una señalización celular anormal. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa y adaptadores de alta calidad para apoyar su investigación en oncología, biología molecular y desarrollo de terapias dirigidas.
Subcategorías de "Tirosina quinasa / adaptadores"
- ALK(116 productos)
- CSF-1R(42 productos)
- EGFR(572 productos)
- Receptor de efrina(23 productos)
- FLT(91 productos)
- Receptor del factor de crecimiento de fibroblastos (FGFR)(169 productos)
- HER(5 productos)
- Hck(3 productos)
- IGF-1R(92 productos)
- PDGFR(126 productos)
- PYK2(7 productos)
- Src(80 productos)
- Receptor TAM(32 productos)
- Tie-2(21 productos)
- Receptor de Trk(59 productos)
- Tirosina quinasas(26 productos)
- VEGFR(262 productos)
- c-Fms(108 productos)
- c-Kit(102 productos)
- c-Met / HGFR(129 productos)
- c-RET(51 productos)
Mostrar 13 subcategorías más
Se han encontrado 1342 productos de "Tirosina quinasa / adaptadores"
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XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Fórmula:C22H31N9OPureza:99.07%Forma y color:SolidPeso molecular:437.54Tetramethylcurcumin
CAS:<p>Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also</p>Fórmula:C25H28O6Pureza:97.69% - 99.94%Forma y color:SolidPeso molecular:424.49AG 555
CAS:<p>AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.</p>Fórmula:C19H18N2O3Pureza:98.02% - 99.94%Forma y color:SolidPeso molecular:322.36PKA inhibitor fragment (6-22) amide Acetate
PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM).Fórmula:C82H134N28O26Pureza:99.30%Forma y color:SolidPeso molecular:1928.11123C4
CAS:<p>123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4 (Ki=0.65 μM)[1].</p>Fórmula:C43H47ClN8O6Pureza:98.94%Forma y color:SolidPeso molecular:807.34AMG 925
CAS:<p>AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.</p>Fórmula:C26H29N7O2Pureza:99.75%Forma y color:SolidPeso molecular:471.55ID-8
CAS:<p>ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.</p>Fórmula:C16H14N2O4Pureza:99.32%Forma y color:SolidPeso molecular:298.29UNC2025
CAS:<p>UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor.</p>Fórmula:C28H40N6OPureza:99.53% - 99.74%Forma y color:SolidPeso molecular:476.66AG-1478
CAS:<p>AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.</p>Fórmula:C16H14ClN3O2Pureza:99.03% - 99.71%Forma y color:SolidPeso molecular:315.75AG 1406
CAS:<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Fórmula:C16H18N2OPureza:98.12%Forma y color:SolidPeso molecular:254.33BFH772
CAS:<p>BFH772, a BAW2881 analogue, selectively inhibits VEGFR2 (IC50: 3 nM) and blocks RET, PDGFR, KIT phosphorylation (IC50: 30-160 nM).</p>Fórmula:C23H16F3N3O3Pureza:97.71% - 99.36%Forma y color:SolidPeso molecular:439.39Ceritinib dihydrochloride
CAS:<p>Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.</p>Fórmula:C28H38Cl3N5O3SPureza:99.85% - 99.99%Forma y color:SolidPeso molecular:631.06ZAP-180013
CAS:<p>ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM).</p>Fórmula:C19H17Cl2N3O4SPureza:98.89%Forma y color:SolidPeso molecular:454.33Su1498
CAS:<p>Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the VEGF receptor 2, having negligible activity at several other serine/threonine and tyrosine kinases.</p>Fórmula:C25H30N2O2Pureza:99.54%Forma y color:SolidPeso molecular:390.52PD-166866
CAS:<p>PD-166866 is a selective FGFR tyrosine kinase inhibitor.</p>Fórmula:C20H24N6O3Pureza:98.29%Forma y color:SolidPeso molecular:396.44BIIB068
CAS:<p>BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.</p>Fórmula:C23H29N7O2Pureza:97.98%Forma y color:SolidPeso molecular:435.52Desmethyl Erlotinib
CAS:<p>Desmethyl Erlotinib (CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).</p>Fórmula:C21H21N3O4Pureza:97.92% - 98.62%Forma y color:SolidPeso molecular:379.417-Hydroxy-4H-chromen-4-one
CAS:<p>7-Hydroxy-4H-chromen-4-one (7-hydroxy-4-benzopyrone) is a Src kinase inhibitor (IC50 of <300 μM).</p>Fórmula:C9H6O3Pureza:97.65%Forma y color:SolidPeso molecular:162.14WHI-P258
CAS:<p>WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.</p>Fórmula:C16H15N3O2Pureza:99.66% - 99.92%Forma y color:SolidPeso molecular:281.31CHMFL-BMX-078
CAS:<p>CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.</p>Fórmula:C33H35N7O6Pureza:>99.99%Forma y color:SolidPeso molecular:625.67UNC2250
CAS:<p>UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).</p>Fórmula:C24H36N6O2Pureza:98.57% - 99.87%Forma y color:SolidPeso molecular:440.58BTK IN-1
CAS:<p>BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).</p>Fórmula:C19H21ClN6OPureza:97.38%Forma y color:SolidPeso molecular:384.86Tolebrutinib
CAS:<p>Tolebrutinib is an oral, selective BTK inhibitor, effective for MS research, with brain penetration and IC50s of 0.4/0.7 nM in cells.</p>Fórmula:C26H25N5O3Pureza:98.4% - 98.82%Forma y color:SolidPeso molecular:455.51Tesevatinib
CAS:<p>Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Fórmula:C24H25Cl2FN4O2Pureza:97.89% - 98.66%Forma y color:SolidPeso molecular:491.39PHA-680632
CAS:<p>PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.</p>Fórmula:C28H35N7O2Pureza:98.2%Forma y color:SolidPeso molecular:501.62EBE-A22
CAS:<p>EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.</p>Fórmula:C17H16BrN3O2Pureza:99.087% - 99.88%Forma y color:SolidPeso molecular:374.23CNX-2006
CAS:<p>CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.</p>Fórmula:C26H27F4N7O2Pureza:98.85% - 99.16%Forma y color:SolidPeso molecular:545.53Sapitinib
CAS:<p>Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or</p>Fórmula:C23H25ClFN5O3Pureza:98.89% - 99.83%Forma y color:SolidPeso molecular:473.93WZ-3146
CAS:<p>WZ3146: EGFR(L858R/E746_A750) inhibitor, IC50=2 nM, selective, doesn't block ERBB2(T798I).</p>Fórmula:C24H25ClN6O2Pureza:97.15%Forma y color:SolidPeso molecular:464.95CZC-8004
CAS:<p>CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.</p>Fórmula:C17H16FN5Pureza:99.29%Forma y color:SolidPeso molecular:309.34TPX-0046
CAS:<p>TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.</p>Fórmula:C21H21FN6O3Pureza:99.95%Forma y color:SolidPeso molecular:424.43BAY-474
CAS:<p>BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probe</p>Fórmula:C17H15N5Pureza:98.98%Forma y color:SolidPeso molecular:289.33Pelitinib
CAS:<p>Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).</p>Fórmula:C24H23ClFN5O2Pureza:98.37% - 99.84%Forma y color:Off-White SolidPeso molecular:467.92Selpercatinib
CAS:<p>"Selpercatinib (LOXO-292) is a RET tyrosine kinase inhibitor with IC50s of 14.0, 24.1, 530.7 nM for different RET mutations."</p>Fórmula:C29H31N7O3Pureza:99.89% - >99.99%Forma y color:SolidPeso molecular:525.6GW2580
CAS:<p>GW2580 (SC-203877) is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.</p>Fórmula:C20H22N4O3Pureza:99.48% - >99.99%Forma y color:SolidPeso molecular:366.41NVP-ACC789
CAS:<p>ACC-789 (NVP-ACC789 (ZK202650); ZK-202650) is an effective, specific and orally active inhibitor of the VEGF receptor tyrosine kinases.</p>Fórmula:C21H17BrN4Pureza:99.44% - 99.63%Forma y color:SolidPeso molecular:405.29Olmutinib
CAS:<p>Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.</p>Fórmula:C26H26N6O2SPureza:99.63%Forma y color:SolidPeso molecular:486.59Almonertinib mesylate
CAS:Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.Fórmula:C31H39N7O5SPureza:99.92%Forma y color:SolidPeso molecular:621.75LDN-193189 HCl
CAS:LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.Fórmula:C25H22N6·HClPureza:99.49% - 99.53%Forma y color:SolidPeso molecular:442.94BMS-2
CAS:<p>BMS-2 is a Met/Flt-3/VEGFR2 tyrosine kinase inhibitor.</p>Fórmula:C25H16F2N4O3Pureza:98.33%Forma y color:SolidPeso molecular:458.42(Rac)-JBJ-04-125-02
CAS:<p>(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.</p>Fórmula:C29H26FN5O3SPureza:97.57%Forma y color:SolidPeso molecular:543.61Nintedanib
CAS:<p>Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/</p>Fórmula:C31H33N5O4Pureza:98% - 99.92%Forma y color:SolidPeso molecular:539.62Cyasterone
CAS:<p>Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising</p>Fórmula:C29H44O8Pureza:99.32% - 99.70%Forma y color:SolidPeso molecular:520.65Leptomycin B
CAS:<p>Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.</p>Fórmula:C33H48O6Pureza:97.10% - 99.04%Forma y color:White Crystalline SolidPeso molecular:540.73Genistein
CAS:<p>Genistein (NPI 031L) is a natural soy isoflavone, a multi-targeted tyrosine kinase inhibitor. Genistein has antitumor effects. Cost effective and quality assured.</p>Fórmula:C15H10O5Pureza:98.22% - 99.64%Forma y color:Rectangular Or Six-Sided Rods From 60% Alcohol Dendritic Needles From Ether SolidPeso molecular:270.24Rostafuroxin
CAS:<p>Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.</p>Fórmula:C23H34O4Pureza:99.08% - >99.99%Forma y color:SolidPeso molecular:374.51Fenebrutinib
CAS:<p>Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).</p>Fórmula:C37H44N8O4Pureza:98.26% - 98.94%Forma y color:SolidPeso molecular:664.8RET V804M-IN-1
CAS:<p>RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).</p>Fórmula:C19H16N6OPureza:97.94% - 99.62%Forma y color:SolidPeso molecular:344.37Mobocertinib
CAS:<p>Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent</p>Fórmula:C32H39N7O4Pureza:99.47% - 99.97%Forma y color:SolidPeso molecular:585.7Oclacitinib maleate
CAS:<p>Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with no effect on 38 non-JAK kinases.</p>Fórmula:C15H23N5O2S·C4H4O4Pureza:99.17%Forma y color:SolidPeso molecular:453.51
