Tirosina quinasa / adaptadores
Los inhibidores de tirosina quinasa y adaptadores son compuestos que se dirigen a las tirosina quinasas y sus proteínas adaptadoras asociadas, las cuales desempeñan roles cruciales en la señalización celular, el crecimiento y la diferenciación. Estos inhibidores son herramientas esenciales en la investigación del cáncer, ya que muchas tirosina quinasas están involucradas en las vías de señalización que impulsan el crecimiento tumoral y la metástasis. Al inhibir las tirosina quinasas, estos compuestos pueden bloquear cascadas de señalización críticas, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades que implican una señalización celular anormal. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa y adaptadores de alta calidad para apoyar su investigación en oncología, biología molecular y desarrollo de terapias dirigidas.
Subcategorías de "Tirosina quinasa / adaptadores"
- ALK(116 productos)
- CSF-1R(42 productos)
- EGFR(572 productos)
- Receptor de efrina(23 productos)
- FLT(91 productos)
- Receptor del factor de crecimiento de fibroblastos (FGFR)(169 productos)
- HER(5 productos)
- Hck(3 productos)
- IGF-1R(92 productos)
- PDGFR(126 productos)
- PYK2(7 productos)
- Src(80 productos)
- Receptor TAM(32 productos)
- Tie-2(21 productos)
- Receptor de Trk(59 productos)
- Tirosina quinasas(26 productos)
- VEGFR(262 productos)
- c-Fms(108 productos)
- c-Kit(102 productos)
- c-Met / HGFR(129 productos)
- c-RET(51 productos)
Mostrar 13 subcategorías más
Se han encontrado 1342 productos de "Tirosina quinasa / adaptadores"
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Imgatuzumab
CAS:<p>Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.</p>Forma y color:LiquidPeso molecular:145.0 (kDa)Barzolvolimab
CAS:<p>Barzolvolimab (CDX 0159), a humanized IgG1 monoclonal antibody, blocks KIT activation and treats chronic urticaria.</p>Forma y color:LiquidDusigitumab
CAS:<p>Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.</p>Pureza:95% - 95%Forma y color:LiquidZanidatamab
CAS:<p>Zanidatamab (ZW25) is a bispecific, humanized monoclonal antibody that targets two distinct epitopes (ECD2 and ECD4) of the HER2 receptor, exhibiting anti-tumor</p>Forma y color:LiquidFutuximab
CAS:<p>Futuximab, a chimeric monoclonal antibody, targets distinct epitopes on the epidermal growth factor receptor (EGFR), exhibiting antineoplastic activity [1].</p>Pureza:95% - 95%Forma y color:LiquidAnbenitamab
CAS:<p>Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.</p>Forma y color:LiquidAnti-Mouse CD117 Antibody
<p>Anti-Mouse CD117 Antibody, a rat-derived IgG2b isotype, acts as an inhibitor specific to the mouse CD117 antigen.</p>Pureza:98%Forma y color:Odour SolidIcotinib
CAS:<p>Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.</p>Fórmula:C22H21N3O4Pureza:99.76% - 99.94%Forma y color:SolidPeso molecular:391.42CSF1R-IN-19
CAS:<p>CSF1R-IN-19 is a robust inhibitor of CSF1R that influences the exchange of inflammatory factors between TAMs and glioma cells. It holds potential for cancer research [1].</p>Fórmula:C20H27N7OForma y color:SolidPeso molecular:381.478-Chloro-cAMP sodium
CAS:<p>8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.</p>Fórmula:C10H10ClN5NaO6PForma y color:SolidPeso molecular:385.63S961
CAS:S961: High-affinity IR antagonist; IC50: HIR-A 0.048 nM, HIR-B 0.027 nM, HIGF-IR 630 nM.Fórmula:C211H297N55O71S2Pureza:98%Forma y color:SolidPeso molecular:4804.13IGF-1R modulator 1
CAS:<p>IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.</p>Fórmula:C22H17N3O4Forma y color:SolidPeso molecular:387.39lavendustin A
CAS:<p>lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.</p>Fórmula:C21H19NO6Pureza:98%Forma y color:Off-White SolidPeso molecular:381.38Dovitinib Dilactic Acid
CAS:<p>Dovitinib dilactic acid: multitarget RTK inhibitor for FLT3/c-Kit (IC50=1-2 nM), FGFR1/3, VEGFR1-4 (IC50=8-13 nM), less effective on InsR, EGFR. Phase 4.</p>Fórmula:C21H21FN6O·2C3H6O3Pureza:98%Forma y color:SolidPeso molecular:572.598-MA-cAMP
CAS:<p>8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.</p>Fórmula:C11H15N6O6PForma y color:SolidPeso molecular:358.25ZM323881 hydrochloride
CAS:ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.Fórmula:C22H19ClFN3O2Pureza:99.43%Forma y color:SolidPeso molecular:411.86Icotinib Hydrochloride
CAS:<p>Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.</p>Fórmula:C22H22ClN3O4Pureza:99.89%Forma y color:SolidPeso molecular:427.88BMS-754807
CAS:<p>BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.</p>Fórmula:C23H24FN9OPureza:99.69% - 99.94%Forma y color:SolidPeso molecular:461.49TAK-285
CAS:<p>TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.</p>Fórmula:C26H25ClF3N5O3Pureza:99.73%Forma y color:SolidPeso molecular:547.96AMG-458
CAS:<p>AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.</p>Fórmula:C30H29N5O5Pureza:99.91% - 99.98%Forma y color:SolidPeso molecular:539.58GW843682X
CAS:<p>GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).</p>Fórmula:C22H18F3N3O4SPureza:99.92%Forma y color:SolidPeso molecular:477.46CP-547632
CAS:<p>CP-547632 is an oral ATP-competitive inhibitor of VEGFR-2/FGF kinase with IC50s of 11/9 nM, highly selective, has antitumor activity.</p>Fórmula:C20H24BrF2N5O3SPureza:99.39%Forma y color:SolidPeso molecular:532.4Infigratinib phosphate
CAS:<p>Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and</p>Fórmula:C26H34Cl2N7O7PPureza:99.24% - 99.6%Forma y color:SolidPeso molecular:658.47EGFR mutant-IN-2
CAS:<p>EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].</p>Fórmula:C27H27F3N6O2SForma y color:SolidPeso molecular:556.6Glesatinib hydrochloride
CAS:<p>Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO.</p>Fórmula:C31H28ClF2N5O3S2Pureza:98%Forma y color:SolidPeso molecular:656.16Antiproliferative agent-34
CAS:<p>Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.</p>Fórmula:C27H27N7O5Pureza:98%Forma y color:SolidPeso molecular:529.55Spebrutinib besylate
CAS:<p>Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).</p>Fórmula:C28H28FN5O6SPureza:98%Forma y color:SolidPeso molecular:581.62JNJ-64264681
CAS:<p>JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).</p>Fórmula:C27H30N6O3SPureza:98%Forma y color:SolidPeso molecular:518.63MS 154N
CAS:<p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>Fórmula:C47H56ClFN8O8Forma y color:SolidPeso molecular:915.45c-Fms-IN-8
CAS:c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.Fórmula:C27H30N2O5Pureza:98%Forma y color:SolidPeso molecular:462.54EGFR-IN-31
CAS:<p>EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)</p>Fórmula:C32H36FN7O2Forma y color:SolidPeso molecular:569.67RTC-5
CAS:<p>RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.</p>Fórmula:C24H22ClF3N2O3SPureza:98.14%Forma y color:SolidPeso molecular:510.96EAI001
CAS:<p>EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.</p>Fórmula:C19H15N3O2SPureza:>99.99%Forma y color:SolidPeso molecular:349.41Mutated EGFR-IN-2
CAS:Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Fórmula:C29H35FN8O3Pureza:98%Forma y color:SolidPeso molecular:562.64EGFR-IN-69
CAS:<p>EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.</p>Fórmula:C31H37Cl2N7O3SForma y color:SolidPeso molecular:658.64EGFR-IN-67
CAS:<p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>Fórmula:C18H17N3SForma y color:SolidPeso molecular:307.41NSC114126
CAS:<p>NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>Fórmula:C22H20O4Forma y color:SolidPeso molecular:348.39EML4-ALK kinase inhibitor 1
CAS:<p>Potent oral EML4-ALK inhibitor with a 1 nM IC50.</p>Fórmula:C31H48N8O3Pureza:99.62%Forma y color:SolidPeso molecular:580.76AXL-IN-13
CAS:<p>AXL-IN-13: potent, oral AXL inhibitor, IC50=1.6nM, Kd=0.26nM, anti-cancer, inhibits EMT, cell migration & invasion.</p>Fórmula:C34H41FN6O5Pureza:99.20%Forma y color:SolidPeso molecular:632.72EGFR/HER2-IN-3
CAS:<p>EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.</p>Fórmula:C26H23N5O3Forma y color:SolidPeso molecular:453.49SDZ281-977
CAS:<p>SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.</p>Fórmula:C18H20O5Pureza:99.64%Forma y color:SolidPeso molecular:316.35CE-245677 mesylate
CAS:<p>CE-245677 mesylate is a selective Tie2 kinase inhibitor with oral activity and potential anti-tumor effects, useful in pain research.</p>Fórmula:C25H26Cl2N6O6SPureza:99.42%Forma y color:SolidPeso molecular:609.48GW 583340 dihydrochloride
CAS:<p>GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.</p>Fórmula:C28H27Cl3FN5O3S2Pureza:98.80%Forma y color:SolidPeso molecular:671.03AMG-Tie2-1
CAS:<p>AMG-Tie2-1 is a Tie2 and VEGFR2 inhibitor with anticancer and antitumor activity for the study of cardiovascular disease and cancer.</p>Fórmula:C25H20F3N5O2Pureza:98.9%Forma y color:SolidPeso molecular:479.45EGFR-IN-2
CAS:<p>EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.</p>Fórmula:C26H33N9O3SPureza:98.52% - 99.79%Forma y color:SolidPeso molecular:551.66EGFR-IN-54
CAS:<p>EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.</p>Fórmula:C17H14N4O4S3Forma y color:SolidPeso molecular:434.51EGFR-IN-50
CAS:<p>EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.</p>Fórmula:C24H26BrN3O4S2Forma y color:SolidPeso molecular:564.51OXSI-2
CAS:<p>OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM.</p>Fórmula:C18H15N3O3SPureza:98%Forma y color:Dark Orange SolidPeso molecular:353.39RO9021
CAS:<p>RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).</p>Fórmula:C18H25N7OPureza:97.19%Forma y color:SolidPeso molecular:355.44FLT3-IN-4
CAS:<p>FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous</p>Fórmula:C23H25N7O2Pureza:99.9%Forma y color:SolidPeso molecular:431.49
