APIs para investigación e impurezas

<p>2,3-Dichlorobenzoic acid is an organic compound that belongs to the class of carboxylates. It is used as a drug substance in the treatment of mycobacterial infections. 2,3-Dichlorobenzoic acid has been shown to have antimicrobial activity against Mycobacterium tuberculosis and other mycobacteria. The sensitivity index for this compound was determined using a chromatographic method with human erythrocytes as the test organism. 2,3-Dichlorobenzoic acid displays its antibacterial activity by inhibiting protein synthesis and cell division. This drug also forms crystalline solids that are soluble in organic solvents such as chloroform or benzene.</p>

<p>11-(1-Piperazinyl)dibenzo[b,f][1,4]thiazepine hydrochloride is a drug product that is used as an impurity standard in the manufacture of 11-aminoundecanoic acid. It is also used to study the metabolism of this compound. This drug product is not intended for use in humans or animals.</p>

<p>4-[2-(Tetrazol-5-yl)phenyl] phenyl]methyl is a metabolite of the drug product 4-(1-Hydroxy-1-methylethyl)-2-propyl-1[4-[2-(tetrazol-5-yl)phenyl]phenyl]methyl imidazole-5-carboxylate. 4-[2-(Tetrazol-5-yl)phenyl] phenyl]methyl is a yellowish solid with a melting point of 128°C and a molecular weight of 246.8 g/mol. The impurity standard for 4-[2-(Tetrazol-5-yl)phenyl] phenyl]methyl is available in the form of an analytical grade, HPLC standard, or pharmacopoeia grade.</p>

<p>Doxorubicin is an organic compound that belongs to the class of polycyclic aromatic hydrocarbons. It is used as a cancer therapy, primarily in the treatment of breast cancer. The chemical sensing of impurities in doxorubicin can be done using phase transfer methods. The quantification of these impurities can be done using high-performance liquid chromatography (HPLC) or gas chromatography (GC).</p>

<p>Biotin impurity C is a metabolite that is found in drugs that contain biotin. It is an impurity standard for HPLC analysis, which can be used to identify and quantify the amount of biotin in a drug product. Biotin impurity C is also used as an analytical standard. This compound has been shown to have pharmacological properties, such as anti-inflammatory effects and immunomodulatory effects.</p>

<p>Ritonavir is a protease inhibitor that prevents HIV from replicating. It binds to the active site of the protease enzyme and inhibits its activity, which prevents the conversion of viral proteins into their respective functional forms. Ritonavir impurity G is a metabolite that is not present in the final drug product. This impurity standard has been characterized by HPLC and NMR spectroscopy.</p>

<p>Di-isopropyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate is a metabolite of gatifloxacin. It is a natural product and its CAS number is 21881-78-7. Diisopropyl 1,4-dihydro 2,6-dimethyl 4-(3 nitrophenyl) pyridine 3,5 di carboxylate is an impurity standard for gatifloxacin. It has been synthesized and can be custom made to meet the pharmacopeia or API impurity requirements for drug development. The purity of this compound ranges from 98% to 100%. This compound is used in HPLC standards for research and development purposes such as metabolism studies.</p>

<p>2-Ethoxy-4-[2-oxo-2-[[2-phenyl-1-[2-(1-piperidinyl)phenyl]ethyl]amino]ethyl]benzoic acid is a drug product that has not yet been approved for use in humans. It is currently undergoing research and development to determine its safety, efficacy, and optimal dosage range. 2EtOBA has shown pharmacological activity in animal models of inflammation and pain. 2EtOBA is metabolized by esterases, glutathione reductase, cytochrome P450 enzymes, reduction by glutathione reductase or conjugation with glucuronic acid. The metabolite of 2EtOBA is the parent compound with a different side chain. This impurity standard can be used in HPLC methods to measure the concentration of this metabolite.</p>

<p>3'-N,N-Didesmethyl-N-(methoxycarbonyl) azithromycin is a research and development impurity standard. It is synthesized by reacting 3-desacetylazithromycin with methoxycarbonyl chloride in the presence of triethylamine. This product has been tested for purity by HPLC. CAS No. 16892-65-2</p>

<p>Dihydroergotamine mesylate impurity C is an analytical standard used for the determination of purity in Dihydroergotamine Mesylate drug products. The impurity is a metabolite that has been shown to be pharmacologically active and thus should not exceed the limit of detection.</p>

<p>3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one is an antibacterial agent that inhibits bacterial growth by binding to the 50S ribosomal subunit. It is a white crystalline powder that is soluble in methanol and acetonitrile. 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4 - one binds to the ribosome and interferes with protein synthesis by inhibiting the release of aminoacyl tRNA from the ribosome. The drug has been shown to have antibacterial activity against Gram positive and Gram negative bacteria. 3-(2) Chloroethyl)-2-methyl 6,7</p>

<p>Beta-Asp-(9)-Semaglutide is a semaglutide impurity. The amino acid at position 9 has been replaced by the beta-aspartic acid (also known as isoaspartic, isoAsp, β-Asp or beta-Asp). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>Methylisothiourea is a label that can be used to identify cells in vivo. It is a fluorescent molecule that is activated by the presence of cytokines, such as IL-1β and TNF-α. Methylisothiourea has been used to evaluate corneal epithelial cells for their response to injury. The effect of Methylisothiourea on the tissue was assessed by histology and evaluated by the presence of cytokine concordance with the fluorescence intensity. Reconstitution experiments were conducted in vitro using human tissues. It was found that Methylisothiourea was not toxic at concentrations up to 500 μM and that it did not interfere with DNA synthesis or cell division at concentrations up to 10 mM.</p>

<p>N-Methyl-3-(4-naphthol)-3-(2-thienyl) propanamine hydrochloride is a custom synthesis that has been shown to be a metabolite of naphthalene. It has been used as an impurity standard for N-methyl-3-(4-naphthol)-2-[(5-nitrofuran-2-yl)methyl] propanamine and in metabolism studies.</p>

<p>O3-Desethyl apremilast is an experimental drug product that belongs to the class of drug products. This drug product has been shown to be a natural, synthetic and analytical impurity in API. It is also an impurity standard for HPLC analysis. O3-Desethyl apremilast can be used in research and development, as well as niche applications in the pharmaceutical industry.</p>

<p>Ceftazidime impurity B is a ceftazidime impurity that is found in the drug Ceftazidime. Ceftazidime is an antibiotic that belongs to the group of cephalosporin antibiotics and inhibits bacterial growth by inhibiting cell wall synthesis. Ceftazidime impurity B has been shown to be toxic to gram-positive bacteria, such as Enterococcus faecium and Staphylococcus aureus, but not to gram-negative bacteria, such as Escherichia coli. In addition, it has been shown to have no effect on the IL-2 receptor of T cells or the binding of penicillin-binding protein. It has also been shown to be safe for injection into mice and rats in toxicity studies.</p>

<p>Bis-[[2-aminoethyl]thio]methane is a custom synthesis, drug product, niche, Metabolite, Drug development, Natural, pharmacopoeia and API impurity. This chemical is CAS No. 22907-27-3 and has the molecular weight of 249.00 g/mol. It can be synthesized in the laboratory using the following methods: HPLC standard, Research and Development and Impurity standard. The chemical is an analytical standard with a purity of 99%. This chemical can be used as analytical reagent or in research and development of drugs.</p>

<p>Trazodone Hydrochloride Impurity G is a synthetic compound that is an impurity found in Trazodone Hydrochloride, CAS No. 77893-17-6. This compound has the following physical properties: MW = 284.27, mp = 227-229°C, [α] D = -33.5° (c 1.0 in water), and UV max (λ max ) = 228 nm. It has been shown that this compound is not metabolized by human enzymes and is found to be natural. It can be used as a standard for HPLC analysis of Trazodone Hydrochloride Impurities A-F with the following retention times: 8.7 min for Impurity A, 9.2 min for Impurity B, 9.9 min for Impurity C, 10.4 min for Impurity D, 11.1 min for Impurity E, and 12.3 min for Impurity F.BR&gt;BR</p>

<p>The product is an impurity that is used as a standard in HPLC analysis. It is a natural metabolite of olmesartan, which is a drug marketed for the treatment of hypertension. The purity levels are high and the material has been shown to be stable with respect to decomposition in the presence of light, heat, or alkali. This compound has also been used in metabolism studies and as an analytical reference material.</p>

<p>3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one is a triazine derivative that is used as an analytical reagent and intermediate. It has been used as a wastewater analysis method to measure the concentration of carbamazepine. 3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one has also been shown to be useful in developing analytical methods for clinical trials. 3DCTKP has also been used to test the matrix effect of carbamazepine by analyzing it in different matrices such as water and human plasma.</p>

<p>4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid is a white to off-white solid that is soluble in water. It is used as an impurity standard for drug product and as a custom synthesis for research and development. This compound is metabolized by oxidation to form an alcohol and carboxylic acid. The oxidation products are excreted in the urine. 4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid has been used for metabolism studies with human liver microsomes.</p>

<p>Soluble in Chloroform &amp; in Methanol Confirmed<br>Insoluble in Wate</p>

<p>Amiodarone N-oxide HCl is a class III antiarrhythmic drug that acts by slowing the heart rate and prolonging the time between heartbeats. It has been shown to be effective in treating atrial fibrillation, ventricular fibrillation, and atrial flutter. Amiodarone N-oxide HCl has significant cytotoxicity, which can lead to cardiomyopathy and myocardial infarcts. Due to its long half life, amiodarone can accumulate in the body and cause side effects such as pulmonary toxicity, gastrointestinal bleeding, thyroid dysfunction, or liver damage. It is not recommended for use in patients with structural heart disease or those taking nonsteroidal anti-inflammatory drugs (NSAIDs) because of an increased risk of adverse events.</p>

<p>8-Fluoro-2,2-dimethyl-9-(4-methyl-1-piperazinyl)-6-oxo-2H,6H-oxazolo[5,4,3-ij]quinoline-5-carboxylic acid is a synthetic drug product. It has been shown to be metabolized by CYP3A4 and CYP3A5 into an impurity that is not detectable with HPLC. 8FQCA is also studied for its pharmacological effects on the metabolic pathways of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and cyclooxygenase 2 (COX2).</p>

<p>a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-alpha-ethyl-3,4-dimethoxy-benzeneacetonitrile is a new inhibitor of the human p glycoprotein (Pgp). It has been shown to inhibit the function of Pgp in vitro and in vivo. This compound is structurally related to other known inhibitors of Pgp, such as verapamil. The topological similarity between these compounds can be rationalized by the fact that they all have a two methyleneoxy ring system with an alpha ethyl side chain. The substructural similarity can be explained by the presence of three contiguous hydroxyl groups on the benzene ring and two methyl groups on the alpha ethyl side chain.</p>

(S)-Ethyl 2-ethoxy-4-[[[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]amino]carbonyl]methyl]benzoate is an intermediate in the synthesis of repaglinide. It is a reagent that reacts with ethylamine and carbodiimide hydrochloride to form a urea derivative. This urea derivative is then reacted with filtration to give the desired product, which is recrystallized from dichloromethane solution. The (S)-ethyl 2-ethoxy-4-[(N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]amino)carbonyl]-methyl benzoate can be converted into the ester, phenylacetic acid, through hydrolytic reaction.

<p>N-[(1R)-1-(1-Naphthalenyl)ethyl]carbamic acid 3-[3-(trifluoromethyl)phenyl]propyl] ester is a drug product. It is a synthetic substance that is used in the development of new drugs and for research and development. This impurity standard is used as an analytical reference in the testing of other compounds. N-[(1R)-1-(1-Naphthalenyl)ethyl]carbamic acid 3-[3-(trifluoromethyl)phenyl]propyl] ester has been shown to be a metabolite of CAS No. 915979-44-1, which is also known as N-[(2S)-2-[[5-[3-(Trifluoromethoxy)phenoxy]-2-pyridinyl]methyl]-2,5-dioxopyrrolidin-1-yl]-3,</p>

<p>Lisdexamfetamine dimesylate impurity C is a research and development chemical with CAS No. 1207-0284-00-6 that belongs to the class of drugs. It is a custom synthesis, high purity, pharmacopoeia grade drug product that exhibits analytical properties similar to the drug product. Lisdexamfetamine dimesylate impurity C has been shown to be a metabolite of lisdexamfetamine dimesylate and is used for metabolism studies.</p>

<p>N4-Acetyl sulfadoxine is a drug that is used to treat urinary tract infections in women and children. It is also used to treat bacterial infections of the skin, lungs, and joints. N4-Acetyl sulfadoxine may be effective against prostatitis caused by E. coli or Mycoplasma pneumoniae by inhibiting the production of prostaglandins. This drug works by binding to dihydropteroate synthase, which prevents folic acid from being incorporated into the bacterial cell wall, thereby inhibiting bacterial growth.</p>

<p>N-[5-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-3-yl]-2,3-dichlorobenzamide is a pharmaceutical dosage form that is titrated to achieve the desired therapeutic effect. It is used to treat epilepsy and bipolar disorder. Lamotrigine binds to sodium channels in nerve cells and blocks their opening. This prevents the influx of sodium ions that are necessary for neuronal transmission. Lamotrigine has been shown to have an anticonvulsant effect by reducing the frequency of seizures in patients with epilepsy.</p>

<p>Please enquire for more information about 6-Hydroxy chlorzoxazone β-D-glucuronide lithium salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Intermediate in the synthesis of ribavirin</p>

<p>Tenofovir disoproxil related compound B is a peptidyl prodrug that is metabolized by esterases to tenofovir. It has been shown to be an effective agent against Mycobacterium tuberculosis and other bacterial species. Tenofovir disoproxil related compound B was also found to inhibit protein synthesis in Mycobacterium avium and Mycobacterium smegmatis, but not in Escherichia coli. This drug binds to the ribosome's 30S subunit, which blocks the binding of aminoacyl-tRNA and prevents the formation of peptide bonds. The mechanism of action for this drug is similar to that of the antibiotic erythromycin.</p>

<p>N-Cyano-N'-methyl-N''-[2-[(5-methyl-1H-imidazol-4-yl)methylsulphinyl]ethyl]guanidine is an acetylcholinesterase inhibitor that is used to treat Alzheimer's disease. It has been shown to be safe and effective in clinical studies with a number of populations. The drug binds to the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. This action prevents the breakdown of acetylcholine, leading to increased levels of this chemical in the brain and improved function. NCAEMG has also been found to increase uptake of drugs by proximal tubules in humans, which may be due to its ability to inhibit cimetidine metabolism.</p>

<p>Nisoxetine is a norepinephrine (NE) reuptake inhibitor that is used as an antidepressant. It has been shown to be a potent and selective NE reuptake inhibitor with a high affinity towards the NE transporter in rat brain synaptosomes, with potency several times higher than that of tricyclic antidepressants. Nisoxetine's major advantage over other antidepressants is its high efficiency, which makes it suitable for large-scale production. The synthesis of nisoxetine involves two steps: 1) reaction of 3-[methyl(phenylmethyl)amino]-1-phenyl-1-propanone hydrochloride with toluene to form the corresponding methyl ester and 2) hydrogenation of the methyl ester to form nisoxetine. This synthesis is efficient, stable, and chiral due to the use of bimetallic catalysts.</p>

<p>1,3-Bis(p-chlorobenzylidene)amino]guanidine hydrochloride (1,3-BCBGAH) is a method for the determination of p-hydroxybenzoic acid in reaction solutions. It is used as an analytical reagent in the analysis of p-hydroxybenzoic acid in pharmaceuticals and other organic chemicals. The matrix effect can be reduced by adding quillaja saponaria to the extraction solution. The main application of this compound is for the detection of resistant mutants in infectious diseases such as liver lesions and tissue infection. 1,3-BCBGAH has also been shown to be effective against robenidine and polymyxin B., with a more favorable toxicity profile than maduramicin ammonium or anhydrous sodium.</p>

<p>Cefazolin impurity A is a by-product in the synthesis of Cefazolin, which is a drug product. It has CAS No. 30246-33-4 and is used as an impurity standard for analytical purposes. The Impurity Standard is also known as Metabolite A. Research and Development (R&amp;D) studies are needed to identify the appropriate analytical impurities for this API, which will be reported on Pharmacopoeia's List of Impurities for reference. The high purity and custom synthesis of this API makes it ideal for use in R&amp;D studies, HPLC standards, or niche markets.<br>CAS No.: 30246-33-4<br>Synonyms: Metabolite A<br>Formula: C11H14N2O5S <br>Molecular weight: 289.24 g/mol <br>Appearance: white solid powder</p>

<p>Impurity arising druring the synthesis of ranitidine</p>

<p>(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a drug used to treat depression. It is an antidepressant drug that inhibits the reuptake of serotonin and norepinephrine in the brain by blocking their transport into the nerve cells. The drug acts as a weak inhibitor of monoamine oxidase (MAO). It also has an effect on bladder function. This compound is synthesized from 1-phenyl-2,5-dihydrothiazole by way of a sequence of reactions that includes the formation of an amine salt via reaction with phosphorus pentoxide and chloroacetic acid followed by conversion to the chloride with thionyl chloride.</p>

<p>Risedronate sodium hydrate is a polymorphic, water-soluble salt of risedronate. It has been used in the treatment of osteoporosis and Paget's disease of bone. Risedronate sodium hydrate binds to calcium ions in the body and prevents them from being deposited in bone tissue. This drug also cross-links collagen fibers in the bone matrix, which increases mineralization and decreases the risk of fracture by strengthening the bones. The monosodium salt form of risedronate is soluble in water and is used as an analytical reagent for determining ionic strength or pH. It has been shown to inhibit ionotropic gelation, which may be due to its polyphosphoric acid content. Risedronate sodium hydrate is a polymorphic, water-soluble salt of risedronate that has been used in the treatment of osteoporosis and Paget's disease of bone. Risedronate sodium hyd</p>

<p>Regadenoson Impurity 29 is a synthetic impurity of the drug Regadenoson that has been used in Metabolism studies, Natural, API impurity, Custom synthesis, Impurity standard, Synthetic, Drug development, Research and Development. It is a high purity analytical standard that can be used as a CAS No. 16033-28-6 HPLC standard or as a High purity pharmacopoeia.</p>

<p>Please enquire for more information about Minocycline EP Impurity H including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pteroic acid is a synthetic compound that is an analog of the natural amino acid phenylalanine. It has been shown to inhibit protein synthesis and may be useful for the treatment of cancer. Pteroic acid can be activated by the addition of trifluoroacetic acid and reacts with metal ions such as nickel, cobalt, copper, and zinc. It also binds to receptors on tubule cells in kidney tissue. This binding inhibits the enzyme carbonic anhydrase II, which catalyzes the conversion of carbon dioxide to bicarbonate in these cells. The inhibition of this enzyme results in a decrease in bicarbonate concentration within these cells, leading to cell death.</p>

<p>Dideiodo amiodarone is a noncompetitive inhibitor of the enzyme, which is expressed in the human heart. It has been shown to interact with the benzofuran derivatives that are responsible for the antiarrhythmic effects of amiodarone. The inhibitory potency of dideiodo amiodarone is dose-dependent and constant. This drug has shown no competitive inhibition against any other analogs, such as quinidine or digitoxin. Dideiodo amiodarone inhibits the enzyme by binding to an allosteric site on the enzyme molecule. This site does not bind any other analogs, such as quinidine or digitoxin, and therefore it does not compete for this site.</p>

<p>2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate (CDFMP) is a potent antitumor agent that has been shown to have a strong anti-angiogenic effect. It inhibits the cancer cell's production of microvessels and interferes with the formation of new blood vessels from pre-existing ones, which can be used to deliver chemotherapy drugs to the tumor. CDFMP is synthesized by reacting 2'-deoxy-2',2'-difluorocytidine with phosphoric acid and then converting it into the monophosphate form using phosphorus oxychloride. This drug is also resistant to platinum-based chemotherapy agents, making it a promising drug for patients who are resistant to other treatments.</p>

<p>Gliclazide is a sulfonylurea drug that is used to treat type 2 diabetes. The impurity F, which is an impurity standard, can be synthesized by reacting 1-chloro-2,6-difluoroaniline with sodium methoxide in methanol. It is also an API impurity found in the synthesis of gliclazide and can be custom synthesized for research and development purposes. Gliclazide impurity F has a CAS number of 1076198-18-9 and the molecular formula C8H4ClF3NOS. This product has a purity of &gt;99% and is classified as synthetic. It has been shown to have pharmacopoeia activity and can also be used for niche applications such as drug development.</p>

<p>Intermediate for tiotropium bromide synthesis</p>

<p>Atorvastatin diepoxide is an analytical standard for the drug atorvastatin that is used in the development of pharmaceuticals. It is synthesized by reacting atorvastatin with epichlorohydrin, which produces a diepoxide derivative. This synthetic molecule can be used as an impurity standard for HPLC analysis. The CAS number for atorvastatin diepoxide is 887470-43-1.</p>

<p>2-(4-Butylphenyl)propionic acid (p-butylhydratropic acid) is a known impurity of ibuprofen (Ibuprofen impurity B) which derives from an impurity present in the isobutylbenzene starting material and 2-(4-butylphenyl)propionic acid. p-Butylhydratropic acid is therefore used as a reference analytical standard.</p>

<p>Ciprofloxacin impurity A is an analog of ciprofloxacin and is a pharmaceutical preparation that belongs to the class of fluoroquinolones. It has been shown to be active against P. aeruginosa and other gram-negative bacteria in wastewater treatment systems. Ciprofloxacin impurity A is activated by ethylene diamine and can be eluted with acidic solvents. It also inhibits tumor cell line growth through adsorption mechanism and is used as a drug for cancer chemoprevention in combination with malic acid.</p>

<p>5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulphonyl]-1H-benzimidazole N-oxide is a cyclic sulfoxide that has shown to be a potent inhibitor of gastric acid secretion. It is an important intermediate in the synthesis of esomeprazole magnesium, a proton pump inhibitor used to treat gastroesophageal reflux disease and other gastrointestinal disorders. 5-Methoxy-2-[(4-methoxy 3,5 dimethyl 2 pyridinyl) methyl] sulphonyl]-1H benzimidazole N oxide is also known as (RS)-N-[4-(4′ methoxyphenyl)-3,5 dimethylpyrazol -2 - ylmethyl] methanesulfonamide. This compound has been shown to have a polymorphic form with two different</p>

<p>N-Methyl zonisamide is a drug that is an impurity in Zonisamide. It is an analog of the drug and has been used as a research and development standard for Zonisamide. N-Methyl zonisamide can be synthesized from the corresponding nitrobenzene, aminobenzene, and formaldehyde. The synthesis can be performed by converting nitrobenzene to aminobenzene with sodium hydroxide in methanol, followed by conversion to N-methyl zonisamide with formaldehyde in ethanol. Pharmacopoeia standards for this compound are available from Sigma Aldrich, which can be purchased from our website.</p>

<p>Tirzepatide impurity.</p>

<p>4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carbox ylic acid sodium salt is a research and development compound that is synthesized using the drug product synthesis method. This compound belongs to the class of Impurity standards, which are used for quality control in analytical chemistry. The CAS number for this compound is 879097–59–3, and the molecular formula is C26H34N6O4S. The molecular weight of this compound is 564.49 g/mol. 4-(1-Hydroxy-1-methylethyl)-2-propyl-[1-[2'-[(1,3,5 -tris(triphenylmethyl</p>

<p>Please enquire for more information about (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(2,3-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hy droxyethoxy)-1,2-cyclopentanediol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Duloxetine succinamide is a chromatographic, solid, acidic compound. It has been synthesized by reacting (S)-duloxetine hydrochloride with succinic anhydride in the presence of triethylamine and acetonitrile. The reaction mixture was purified by high-performance liquid chromatography to produce the desired product. The purity of the compound was confirmed by postulating that it should have a reversed-phase HPLC profile similar to that of duloxetine succinate. Duloxetine succinamide is not soluble in water and is insoluble in organic solvents such as acetone, chloroform, ether, or benzene. The compound is stable at room temperature but decomposes when heated at higher temperatures. !--

<p>D-Ser(11)-Semaglutide is a semaglutide impurity. The amino acid at position 11 has been replaced by the D-form of the amino acid D-serine (D-Ser). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>7-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one is a palladium catalyst that can be used in a Buchwald reaction. This reaction is an industrially scalable process that has been developed to produce high yields of valuable organic compounds from inexpensive starting materials. The catalytic cycle involves the formation of the palladium species Pd(0) followed by its oxidative addition to an alkyl halide. This addition leads to the formation of a palladium(II) species and subsequent reductive elimination of hydrogen halide. 7-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one is used as a catalyst in this process because it selectively reacts with electron rich aromatic substrates to form substituted benzoquinones or phenols. The product distribution is determined by the reactivity of the substrate and the relative rates of competing reactions. Impurities are formed during synthesis due to</p>

<p>Natriuretic hormone; induces uterine contraction and lactation</p>

<p>N-[1-(R)-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamide is an impurity standard that is used in the manufacture of a drug product. This compound is not found in nature and has no known biological activity. It has been shown to be metabolized by CYP2D6, CYP2C8, and CYP2C9. The analytical impurity content of this compound should be less than 10% or 10 ppm as determined using HPLC methods.</p>

<p>4-(2,3,4-Trimethoxybenzyl)piperazine-1-carbaldehyde hydrochloride is a custom synthesis that is used as a drug product, impurity standard and metabolic studies. The compound has been shown to be metabolized via oxidation by cytochrome P450 enzymes. It also binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.</p>

<p>N-[[2'-(2H-Tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-Valine is a synthetic, nonstandardized HPLC standard that is used in drug development and metabolism studies. It is not available as a natural product, but can be made synthetically. N-[[2'-(2H-Tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-Valine has the CAS No. 676129-92-3 and impurity standards are available for this compound.</p>

<p>N-(2-Phenethyl)benzamide (NPEB) is a molecule that belongs to the group of reactive molecules. It has been shown to be toxic to gram-positive bacteria, such as Staphylococcus aureus and Bacillus subtilis, but not gram-negative bacteria such as Escherichia coli. NPEB also has been shown to have locomotor activity in animals, which may be due to its ability to inhibit the mitochondrial electron transport chain and inhibit ATP production. NPEB's biological properties are well characterized. FTIR spectroscopy showed that this molecule has an amide functional group and is a small molecule with a molecular weight of 176.4 g/mol. This molecule was also found to be able to bind to mitochondria in animals.</p>

<p>Trazodone hydrochloride impurity H is an impurity of the drug product Trazodone hydrochloride. It is a natural metabolite of Trazodone hydrochloride, which is synthesized in vivo by oxidation of the parent compound. Impurity H has been identified as a potential impurity standard for HPLC-UV analysis of Trazodone hydrochloride. The purity of this compound is 98.3% and it is available on a custom synthesis basis.</p>

<p>Simvastatin hydroxy acid ethyl ester is a solvated form of simvastatin, an investigational drug for the treatment of dyslipidemia. The ammonium salt was prepared by alcoholysis with ethanol. The elution process was carried out using an acetonitrile-water mixture and chromatography on silica gel. Preparation methods were investigated to determine the best preparative procedure that would yield pure material. This compound has been investigated as a possible therapeutic agent for the treatment of midbody diseases such as familial amyloidotic polyneuropathy and Alzheimer's disease.</p>

<p>4-Isobutyl-2-pyrrolidinone is a colorless liquid that belongs to the category of phosphites. It has a high boiling point, which makes it suitable for use in organic solvents and as a heat transfer agent. The thermodynamic properties of 4-Isobutyl-2-pyrrolidinone have been evaluated using the protonation theory. It can be protonated at either the nitrogen or the methyl group, and both forms are present in solution. This means that 4-Isobutyl-2-pyrrolidinone is acidic and can react with other compounds to form salts called lactams. There are two isomers of this compound: cis and trans. Both isomers exist in equilibrium; however, the cis isomer predominates at room temperature. The most common impurities of 4-Isobutyl-2-pyrrolidinone are dehydration products formed during synthesis or</p>

<p>Terbinafine is an antifungal agent that belongs to the family of medicines. It is used to treat fungal infections of the skin, nails and scalp. Terbinafine can also be used to treat other types of fungal infections, such as tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete's foot) and tinea capitis (scalp ringworm). Terbinafine dimer impurity dihydrochloride is a by-product of terbinafine hydrochloride that has been shown to have industrial applications as a dispersant or lubricant in industries such as papermaking.</p>

<p>11-Fluoro desloratadine is a metabolite of the antihistamine, loratadine. It has shown to be an analytical standard for HPLC, and impurity standard for pharmacopoeia. 11-Fluoro desloratadine is typically synthesized by reacting loratadine with fluorinating reagent such as N-fluorosuccinimide (NFSI) in the presence of a base catalyst such as sodium methoxide. 11-Fluoro desloratadine is also found in breast milk at concentrations of up to 1.2% of total loratadine concentration, which has been attributed to incomplete metabolism or passive transfer from mother to child.</p>

<p>Adefovir Dipivoxyl Impurity I is a white crystalline powder with a melting point of 232–234 °C. It is soluble in water, and insoluble in organic solvents. Adefovir Dipivoxyl Impurity I is used as an impurity standard for Adefovir Dipivoxyl and has been shown to be metabolized by CYP3A4 and UGT1A9. This impurity also has the potential to inhibit DNA synthesis in cells.</p>

<p>Tirzepatide impurity</p>

<p>Des-Glu(3)-semaglutide is a semaglutide-related impurity. This des-amino acid form has got the glutamic acid or glutamate (Glu) amino acid from position 3 removed from the peptide chain. Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist used for managing type 2 diabetes and obesity.</p>

<p>D-Glu(3)-Semaglutide is a semaglutide impurity. The amino acid at position 3 has been replaced by the D-form of the amino acid D-glutamic acid (D-Glu). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>Raloxifene N-oxide is a synthetic drug product that is used in the treatment of osteoporosis. It belongs to the family of selective estrogen receptor modulators (SERM). Raloxifene N-oxide has been shown to inhibit bone resorption and reduce the risk of vertebral fractures. It also has anti-estrogenic effects, which have been shown to be beneficial for prostate cancer patients who are receiving androgen deprivation therapy. Raloxifene N-oxide is an impurity in the synthesis of raloxifene, which is a drug product with CAS number 195454-31-0. The purity of this compound should be at least 99%.</p>

<p>Paracetamol Impurity L is a drug product that is used as an analytical standard for the impurity paracetamol. It is found in pharmaceuticals, such as acetaminophen, which is used to relieve pain and reduce fever. Paracetamol Impurity L is a natural compound and has been shown to be metabolically stable in humans. The CAS number for this compound is 619-25-4.</p>

<p>Tirzepatide impurity.</p>

<p>6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxaldehyde is a colorimetric reagent that can be used to detect Cl. It has been shown to react with Cl in the presence of an acidic solution and produce a red color. The reagent is stable in organic solvents, such as chloroform, but decomposes in water. 6-Chloro-4-(2-chlorophenyl)-2-quinazolinecarboxaldehyde is also used to detect chloride by titrimetric or polarographic methods.</p>

<p>Tirzepatide impurities.</p>

<p>Betamethasone EP Impurity I is a synthesized impurity of betamethasone. It is an impurity in the drug product that is used for the treatment of inflammation and allergies, as well as some skin conditions. The main physicochemical properties are: white powder, soluble in methanol, insoluble in water and acetone. This impurity can be obtained by synthetic methods or it can be formed by metabolic degradation of the parent drug.<br>The impurity has been shown to have a niche application in HPLC standards for analytical purposes and research and development of new drugs.</p>

<p>Please enquire for more information about Keto bisoprolol hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Rac-N-Demethylpromethazine hydrochloride is a racemic mixture of promethazine. It is an analytical reference material that is offered as a high purity API impurity standard, which can be used for HPLC analysis. Rac-N-Demethylpromethazine hydrochloride is also offered as a drug development and drug product impurity standard for the manufacture of drugs. The racemic mixture of promethazine has been shown to inhibit the growth of bacteria by competitive inhibition of bacterial enzymes. Rac-N-Demethylpromethazine hydrochloride acts on bacterial DNA gyrase and topoisomerase IV, which maintain the integrity of bacterial DNA by inhibiting the production of proteins vital for cell division. Rac-N-Demethylpromethazine hydrochloride has also been shown to have antiinflammatory properties in animal studies.</p>

<p>1-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethyl-2-(1-piperazinyl)ethoxyethanol is a synthetic drug that is used as an analytical reference standard and as an impurity standard for drug development. It is a metabolite of the benzodiazepine diazepam, which has been shown to produce significant changes in the activity of GABA receptors. This product has not been evaluated by the FDA and should be used in laboratory research only.</p>

<p>5-Methyl Zolpidem is a zolpidem tartrate that is used for the treatment of insomnia and as a sedative. It is an intermediate in the synthesis of zolpidem tartrate, which is synthesized from 5-methyl-1-(4-methoxybenzoyl)-1H-benzo[d]imidazole with potassium t-butoxide. The synthesis starts with the conversion of 5-methyl-1-(4-methoxybenzoyl)-1H-benzo[d]imidazole to 1-(4'-methylphenyl) benzene by reaction with methyl iodide followed by hydrolysis of the ester group to form 1-(4'-methylphenyl) benzene. The next step involves a nucleophilic substitution reaction using potassium t-butoxide to produce 1-(4'-methylphenyl) benzene t-butoxide, followed by reaction with methanol</p>

<p>Remdesivir impurity 13 is a metabolite of remdesivir, which is a drug product that is custom synthesized by us. This compound has been shown to be natural and can be found in the human body. Remdesivir impurity 13 has been studied extensively for its metabolic pathway and as a potential impurity standard for HPLC analysis.</p>

<p>Atorvastatin methyl ester is a statin drug that inhibits the synthesis of cholesterol and other lipids in the body. It is used to reduce high levels of low-density lipoprotein (LDL) cholesterol, which may lead to heart disease or stroke. Atorvastatin methyl ester has been shown to be effective in reducing the uptake of LDL cholesterol into cells by preventing the formation of LDL particles. This drug also decreases the production of biphosphate-containing phospholipids, which are essential for dendritic cell maturation. The crystalline polymorphs have been characterized by X-ray diffraction and microscopy. Impurities can be detected using ultraviolet spectroscopy, infrared spectroscopy, or nuclear magnetic resonance spectroscopy.</p>

<p>Isotopically labelled metabolite of telmisartan</p>

<p>1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester is a creatine kinase inhibitor that blocks the synthesis of creatine phosphate, which is an important energy source for muscle contraction. Creatine kinase inhibitors are used in the treatment of congestive heart failure and myocardial infarct. They also have vasodilatory effects on blood vessels and can be used to treat hypertension. The elimination rate of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester depends on its formulation: solid dispersions have a half life of about 3 hours whereas orally administered doses have a half life of about 8 hours.</p>

<p>4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine is an impurity standard of the drug product. It is a high purity synthetic compound with a niche in pharmacopoeia and drug development. 4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine has been shown to be a metabolite of the natural product.</p>

<p>Terbutaline Impurity D is a synthetic drug with the CAS number 94109-61-2. This product has been developed as an impurity standard for Terbutaline, which is a drug product that has been approved by the United States Pharmacopoeia (USP). Terbutaline Impurity D can be used to study the metabolism of Terbutaline in animals. It is also used to develop new drugs by chemists and other scientists.</p>

<p>Atorvastatin is a drug used for the treatment of hypercholesterolemia and cardiovascular diseases. Atorvastatin lactam, which is an impurity formed during the synthesis of atorvastatin, has been shown to inhibit cholesterol biosynthesis in a rat model. The in vivo metabolism of atorvastatin lactam was studied by HPLC-MS/MS and was found to be identical to that of the parent molecule. This impurity may be useful as a research and development or custom synthesis product, or as an impurity standard for HPLC analysis.</p>