Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
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Camptothecin
CAS :<p>Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.</p>Formule :C20H16N2O4Degré de pureté :99.52% - 99.88%Couleur et forme :Solid PowderMasse moléculaire :348.35Riviciclib hydrochloride
CAS :<p>Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.</p>Formule :C21H20ClNO5·HClDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :438.3SAR405838
CAS :<p>MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.</p>Formule :C29H34Cl2FN3O3Degré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :562.5SU11274
CAS :<p>SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.</p>Formule :C28H30ClN5O4SDegré de pureté :98.62% - 99.53%Couleur et forme :Orange PowderMasse moléculaire :568.09W1131
CAS :<p>W1131 is a potent STAT3 inhibitor and ferroptosis trigger, reducing cancer progression and 5-FU resistance.</p>Formule :C23H19N5O4Couleur et forme :SolidMasse moléculaire :429.43Anticancer agent 63
CAS :<p>Compound 3h fights various cancers; most effective on MCF-7 (IC50 3.4 μM). Triggers apoptosis; alters Bcl-2, IL-2, Caspase-3 levels, has antioxidant effects.</p>Formule :C17H24F3NOSeCouleur et forme :SolidMasse moléculaire :394.33Caspase-3/7 activator 3
<p>Caspase-3/7 activator 3 triggers apoptosis with tumor selectivity and anti-proliferative effects.</p>Formule :C24H27NO5Couleur et forme :SolidMasse moléculaire :409.47(R)-eIF4A3-IN-2
CAS :<p>(R)-eIF4A3-IN-2, a weaker eIF4A3-IN-2 isomer, inhibits eIF4A3 selectively with 110 nM IC50.</p>Formule :C25H19Br2ClN4O2Couleur et forme :SolidMasse moléculaire :602.71RGB-286147
CAS :<p>RGB-286147 is a potent, selective, ATP-competitive Cdks inhibitor.</p>Formule :C23H22Cl2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.35HLI 373
CAS :<p>HLI373: potent Hdm2 (ubiquitin ligase) inhibitor, induces apoptosis in tumor cells, has antimalarial properties.</p>Formule :C18H23N5O2Couleur et forme :SolidMasse moléculaire :341.41Caspase-9 Inhibitor III
CAS :<p>Caspase-9 Inhibitor III (Ac-LEHD-cmk) blocks caspase-9, protects against ischemic heart damage.</p>Formule :C24H35ClN6O9Couleur et forme :SolidMasse moléculaire :587.02PI3Kδ-IN-10
CAS :<p>PI3Kδ-IN-10 is a highly potent and orally active PI3Kδ inhibitor (IC50= 2 nM).</p>Formule :C19H16ClN9Couleur et forme :SolidMasse moléculaire :405.84Tubulin polymerization-IN-13
CAS :<p>Compound 4f inhibits tubulin polymerization (IC50: 0.37 μM), induces apoptosis, and has notable anti-cancer properties.</p>Formule :C20H21NO6Couleur et forme :SolidMasse moléculaire :371.38Nec-3a
CAS :<p>Nec-3a, an analogue of Necrostatin-3, acts as a RIP1 inhibitor with an inhibition concentration (IC50) of 0.44 μM.</p>Formule :C21H18F4N2O4Couleur et forme :SolidMasse moléculaire :438.37HBV-IN-23
CAS :<p>HBV-IN-23: HBV replication inhibitor, IC50 0.58μM, affects resistant strains, induces HepG2 apoptosis, anti-HCC.</p>Formule :C25H27N3O3SCouleur et forme :SolidMasse moléculaire :449.57WK-298
CAS :<p>WK-298 is an effective MDM2/MDMX-p53 interaction inhibitor.</p>Formule :C35H38Cl2N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :629.62TRAF-STOP inhibitor 6877002
CAS :<p>TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.</p>Formule :C17H17NODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :251.32NU-8165
CAS :<p>NU-8165 is an MDM2-p53 protein-protein interaction inhibitor.</p>Formule :C24H22ClNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.89BP-1-108
CAS :<p>BP-1-108 is a potent and selective STAT5 inhibitor.</p>Formule :C32H38N2O6SCouleur et forme :SolidMasse moléculaire :578.72MCL-1/BCL-2-IN-3
CAS :<p>MCL-1/BCL-2-IN-3 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectiely.</p>Formule :C27H25BrN2O5SCouleur et forme :SolidMasse moléculaire :569.47Fomesafen
CAS :<p>Fomesafen (PP-021) is a diphenyl ether herbicide and an inhibitor of efficient and selective protoporphyrinogen IX oxidase (PPO).</p>Formule :C15H10ClF3N2O6SDegré de pureté :99.91% - 99.93%Couleur et forme :White Crystalline Solid Fomesafen Is A White Crystalline Solid Used As An HerbicideMasse moléculaire :438.76Dimethoate
CAS :<p>Dimethoate (L-395) is a systemic and contact insecticide for control of cattle grubs and certain other insect pests of farm animals.</p>Formule :C5H12NO3PS2Degré de pureté :99.74% - 99.91%Couleur et forme :White Crystalline SolidMasse moléculaire :229.26GZD856
CAS :<p>GZD856 is an orally bioavailable PDGFRα/β inhibitor (IC50s: 68.6 and 136.6 nM) with anti-lung cancer activities.</p>Formule :C29H27F3N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.56GL-331
CAS :<p>GL-331, a DNA topoisomerase II inhibitor, is used potentially for the treatment of small cell lung cancer and gastric cancer.</p>Formule :C27H24N2O9Couleur et forme :SolidMasse moléculaire :520.49Mitochonic Acid 35
CAS :<p>Mitochonic Acid 35 is a dual TNF-α and TGF-β1 inhibitor that acts by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation.</p>Formule :C19H19NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :341.36Xanthine oxidase-IN-6
<p>Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.</p>Formule :C29H34N2O15Couleur et forme :SolidMasse moléculaire :650.58PARP-2-IN-3
CAS :<p>PARP-2-IN-3 is used in the study of breast cancer as a PARP-2 inhibitor with antitumor activity that induces apoptosis (apoptosis) and necrosis in cancer cells.</p>Formule :C20H20ClN3O3Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :385.84Ki23057
CAS :<p>Ki23057, a FGFR2 inhibitor, boosts chemo effects in resistant gastric cancer, may work with SN38/PTX/VP16, enhancing apoptosis via ERCC1/p53 synergy.</p>Formule :C30H35N3O4Couleur et forme :SolidMasse moléculaire :501.62ABD56
CAS :<p>ABD56 inhibits osteoclast formation and activity in vitro and in vivo.</p>Formule :C17H18O3Couleur et forme :SolidMasse moléculaire :270.32CMLD012612
CAS :<p>CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).</p>Formule :C31H33N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :559.61Darinaparsin
CAS :<p>Darinaparsin, a dimethylated arsenic-glutathione compound, is cytotoxic to various cancer cells with diverse IC50 values and inhibits tumor growth in mice.</p>Formule :C12H22AsN3O6SCouleur et forme :SolidMasse moléculaire :411.31RIP1 kinase inhibitor 7
CAS :<p>RIP1 Kinase Inhibitor 7 (Compound 41) serves as a potent inhibitory agent for receptor interacting protein 1 kinase (RIP1) with an IC50 of under 100 nM.</p>Formule :C20H20FN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :337.39RS6212
CAS :<p>RS6212 is a specific lactate dehydrogenase (LDH) inhibitor (IC50=12.03 μ M）。 RS6212 shows strong anticancer activity in a variety of cancer cell lines.</p>Formule :C20H22N4O3SCouleur et forme :SolidMasse moléculaire :398.48MBC-11
CAS :<p>MBC-11: First bone-targeting bisphosphonate-etidronate conjugate with araC, may treat TIBD.</p>Formule :C11H20N3O14P3Degré de pureté :>99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :511.21Sibiriline
CAS :<p>Sibiriline is a Receptor-Interacting Protein Kinase 1 inhibitor that acts by preventing immune-dependent hepatitis.</p>Formule :C13H10N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :210.23Tubulin polymerization-IN-31
CAS :<p>Compound 4c, inhibits tubulin polymerization, IC50 3.64 μM, and induces cancer cell apoptosis.</p>Formule :C18H13ClFN3Couleur et forme :SolidMasse moléculaire :325.77CHMFL-ABL/KIT-155
CAS :<p>CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM).</p>Formule :C33H38F3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :609.68Anti-inflammatory agent 54
CAS :<p>Anti-inflammatory agent 54 (compound 9c), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression</p>Formule :C17H16N2O5Couleur et forme :SolidMasse moléculaire :328.32Thienopyridone
CAS :<p>Thienopyridone: potent, selective PRL phosphatase inhibitor, IC50s: 173/277/128 nM for PRL-1/2/3, induces apoptosis, anticancer.</p>Formule :C13H10N2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :242.3PIK-C98
CAS :<p>PIK-C98 is an inhibitor of PI3K that acts by displaying potent preclinical activity against multiple myeloma.</p>Formule :C16H10Cl2N2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.23Antitumor agent-62
CAS :<p>Antitumor agent-62 releases NO, inhibits cancer cell growth, triggers apoptosis, and halts cell cycle at G2/M.</p>Formule :C21H19N3O9SCouleur et forme :SolidMasse moléculaire :489.46BTK-IN-24
CAS :<p>BTK-IN-24 is a Bruton's tyrosine kinase (BTK) inhibitor with potential anticancer activity, and it can be used in the study of myeloproliferative disorders.</p>Formule :C26H19F4N5O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :509.46AKCI
CAS :<p>AKCI is a PPI inhibitor that acts by targeting the AURKC-IκBα interaction.</p>Formule :C19H27N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.46RETRA
CAS :<p>RETRA is an agent of anticancer that acts by exerting anticancer activity in Ewing's sarcoma cells independent of their TP53 status.</p>Formule :C11H12BrNO3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.25SB 706504
CAS :<p>SB 706504 is an effective p38 MAPK inhibitor that suppresses inflammatory gene expression in macrophages and inhibits TNFα production in COPD.</p>Formule :C24H19F3N8ODegré de pureté :98.686%Couleur et forme :SolidMasse moléculaire :492.46SHP2-IN-8
CAS :<p>SHP2-IN-8: reversible, selective SHP2 inhibitor; IC50=23 nM; induces AKT dephosphorylation and Hela cell apoptosis.</p>Formule :C17H21Cl2N5SCouleur et forme :SolidMasse moléculaire :398.35Flupenthixol
CAS :<p>Flupentixol is a typical antipsychotic drug of the thioxanthene class. Flupentixol is also used in low doses as an antidepressant.</p>Formule :C23H25F3N2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.52HDAC-IN-39
CAS :<p>HDAC-IN-39 inhibits HDAC1-3 (IC50: 1.07-2.27 μM), arrests G2/M phase, hinders microtubule polymerization, and is effective against drug-resistant cancers.</p>Formule :C27H26N4O4SCouleur et forme :SolidMasse moléculaire :502.58BMS-1166 hydrochloride
CAS :<p>"Motixafortide blocks CXCR4 with 1 nM potency. BMS-1166 hinders PD-1/PD-L1, boosting T cell activation, IC50: 1.4 nM."</p>Formule :C36H34Cl2N2O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :677.57Didesmethylrocaglamide
CAS :<p>Didesmethylrocaglamide, a Rocaglamide derivative, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor that exhibits strong growth-inhibitory effects,</p>Formule :C27H27NO7Couleur et forme :SolidMasse moléculaire :477.51OT-82
CAS :<p>OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.</p>Formule :C26H21FN4ODegré de pureté :98.91% - 99.315%Couleur et forme :SolidMasse moléculaire :424.47Antitumor agent-70
CAS :<p>Antitumor agent-70, a potent c-Kit kinase inhibitor, induces apoptosis with an IC50 of 0.12 μM, showing promise as a cancer therapy.</p>Formule :C21H18N4O2Couleur et forme :SolidMasse moléculaire :358.39LLL3
CAS :<p>LLL3 is a small molecule STAT3 inhibitor.</p>Formule :C16H10O4Couleur et forme :SolidMasse moléculaire :266.25RET-IN-6
CAS :<p>RET-IN-6 is a potent inhibitor of RET (IC50: 4.57 nM).</p>Formule :C30H29N7Couleur et forme :SolidMasse moléculaire :487.6cRIPGBM
CAS :<p>cRIPGBM induces apoptosis in GBM CSCs by targeting RIPK2, with an EC50 of 68 nM in GBM-1 cells.</p>Formule :C26H20FN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.45eIF4A3-IN-2
CAS :<p>eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 inhibitor with an IC50 of 110 nM.</p>Formule :C25H19Br2ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.71Metoprolol fumarate
CAS :<p>Metoprolol fumarate (CGP 2175C): selective β1-blocker with anti-inflammatory, antitumor, anti-angiogenic effects.</p>Formule :C34H54N2O10Couleur et forme :SolidMasse moléculaire :650.8Shield-2
CAS :<p>Shield-2 is a potent FKBP-derived destabilizing domain stabilizing ligand.</p>Formule :C35H51N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.8Anticancer agent 77
CAS :<p>Anticancer agent 77 exhibits anticancer effects and can be used extensively in synthetic and medicinal chemistry studies.</p>Formule :C25H30BrN7Couleur et forme :SolidMasse moléculaire :508.46AG-024322
CAS :<p>AG-024322 is a pan-CDK inhibitor with antitumor activity, induces apoptosis, and can be used in the study of metabolic diseases.</p>Formule :C23H20F2N6Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :418.44RIPK3-IN-2
CAS :<p>RIPK3-IN-2 is a RIP3 inhibitor that can be used in studies of diseases caused by or associated with activated necrotic pathways.</p>Formule :C21H16ClN3O2S2Couleur et forme :SolidMasse moléculaire :441.95VU0285655-1
CAS :<p>VU0285655-1, a PLD2 inhibitor, halts PLD2-deficient cell growth and protects against high glucose-induced cell death. Used in diabetic retinopathy research.</p>Formule :C25H27N5O2Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :429.51Mcl1-IN-1
CAS :<p>Mcl1-IN-1 is a myeloid cell factor 1 inhibitor (IC50=2.4 μM).</p>Formule :C23H18ClN3O4Couleur et forme :SolidMasse moléculaire :435.86Apoptosis inducer 10
CAS :<p>Apoptosis inducer 10 is a potent apoptosis inducer with anti-proliferative activity.</p>Formule :C27H46N2O2Couleur et forme :SolidMasse moléculaire :430.67Nutlin-1
CAS :<p>Nutlin-1 is a p53-MDM2 binding inhibitor, p-Glycoprotein (p-gp) transport substrate, and antitumor agent.</p>Formule :C32H34Cl2N4O4Couleur et forme :SolidMasse moléculaire :609.54HDAC1/2 and CDK2-IN-1
CAS :<p>Compound 14d inhibits HDAC1 (IC50=70.7μM), HDAC2 (23.1μM), CDK2 (0.80μM), blocks cell cycle, induces apoptosis, and shows in vivo anti-tumor effects.</p>Formule :C26H22ClN7OCouleur et forme :SolidMasse moléculaire :483.95673-A
CAS :<p>673-A inhibits ALDH1A, depletes ovarian CSCs, induces necroptosis, and reverses chemo resistance.</p>Formule :C15H13NOCouleur et forme :SolidMasse moléculaire :223.27GRI977143
CAS :<p>GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.</p>Formule :C22H17NO4SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :391.44SID 3712249
CAS :<p>SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544).</p>Formule :C17H21N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.4SKI-I
CAS :<p>SKI-I: Human sphingosine kinase inhibitor, IC50 1.2μM; hERK2 inhibitor, IC50 11μM; promotes tumor cell apoptosis.</p>Formule :C25H18N4O2Couleur et forme :SolidMasse moléculaire :406.44CDK1/2/4-IN-1
CAS :<p>CDK1/2/4-IN-1 inhibits CDKs (IC50: CDK1-1.47μM; CDK2-0.78μM; CDK4-0.87μM) and is useful in cancer studies, affecting apoptosis and the cell cycle.</p>Formule :C15H16N2O2SCouleur et forme :SolidMasse moléculaire :288.36Adapalene sodium salt
CAS :<p>Adapalene (CD 271; Differin) sodium salt is a synthetic retinoid and a Retinoic acid receptor agonist.</p>Formule :C28H28NaO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.519Dinoprost
CAS :<p>Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient.</p>Formule :C20H34O5Degré de pureté :97.94% - 98.04%Couleur et forme :White To Off-White Crystalline SolidMasse moléculaire :354.48Casein Kinase inhibitor A51
CAS :<p>Casein Kinase inhibitor A51 is a CK1α inhibitor with anticancer activity used in the study of breast and prostate cancer.</p>Formule :C18H25ClN6Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :360.88BR102375
CAS :<p>BR102375 is a non-TZD PPAR γ full agonist (EC50: 0.28 μM) for the treatment of type 2 diabetes.</p>Formule :C31H34N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :554.64ML132
CAS :<p>ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).</p>Formule :C22H28ClN5O5Couleur et forme :SolidMasse moléculaire :477.94MpsBAY2a
CAS :<p>carcinoma cell proliferation.</p>Formule :C29H28N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.57CDK8/19-IN-1
CAS :<p>CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).</p>Formule :C19H18N4O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.5Antitumor agent-44
CAS :<p>Antitumor agent-44 (Compound 5n) elicits potent antitumor effects by inducing disruption of mitochondrial homeostasis, cell cycle arrest, and apoptosis in human</p>Formule :C24H15N3O3Couleur et forme :SolidMasse moléculaire :393.39MCL-1/BCL-2-IN-4
CAS :<p>MCL-1/BCL-2-IN-4 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor.</p>Formule :C26H23BrN2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :555.44DCP-LA
CAS :<p>DCP-LA (FR236924), linoleic acid derivatives, selective and direct activation of PKCε.</p>Formule :C20H36O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.5Jolkinolide B
CAS :<p>Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud.</p>Formule :C20H26O4Degré de pureté :99.39% - 99.7%Couleur et forme :SolidMasse moléculaire :330.42MI-389
CAS :<p>MI-389 is a PROTAC degrader that induces the degradation of receptor tyrosine kinases (RTKs), useful for leukemia research.</p>Formule :C35H35FN6O6Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :654.69Pentabromophenol
CAS :<p>Pentabromophenol (NSC-5717) suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.</p>Formule :C6HBr5ODegré de pureté :99.83%Couleur et forme :Monoclinic Prisms From Acetic Acid; Needles From Alcohol Physical Description Light Brown Powder Insoluble In Water (Ntp 1992)Masse moléculaire :488.59MMP-9-IN-4
CAS :<p>MMP-9-IN-4 inhibits MMP-9 (IC50=7.46nM) and AKT (IC50=8.82nM), induces apoptosis and is used in cancer research.</p>Formule :C28H19F3N4O6Couleur et forme :SolidMasse moléculaire :564.47CCT373567
CAS :<p>CCT373567 is a potent degrader of the transcriptional repressor BCL6 (IC50: 2.9 nM) and exhibits anti-proliferative effects.</p>Formule :C26H29ClF2N6O3Couleur et forme :SolidMasse moléculaire :547EGFR-IN-46
CAS :<p>EGFR-IN-46: Potent EGFR/FAK inhibitor (IC50: 20.17 & 14.25 nM), curbs cancer cell growth, triggers apoptosis.</p>Formule :C27H32F3N3O3Couleur et forme :SolidMasse moléculaire :503.56DX2-201
CAS :<p>DX2-201 is a potent and selective inhibitor of oxidative phosphorylation (OXPHOS) complex I (IC50: 312 nM) and exhibits anticancer activity.</p>Formule :C18H28N2O6S2Couleur et forme :SolidMasse moléculaire :432.55Nampt-IN-3
CAS :<p>Nampt-IN-3 simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC (IC50s of 31 nM and 55 nM, respectively).</p>Formule :C29H25N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :503.55TJ08
CAS :<p>TJ08 has anticancer properties and can effectively induce G1/S phase blockade while promoting apoptosis in a variety of cancer cells.</p>Formule :C22H16FN3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :405.38FKGK 18
CAS :<p>FKGK 18: GVIA iPLA2 inhibitor, 99.9% at 0.091 fraction, selective, IC50 ~50 nM–3 μM, reduces blood glucose and diabetes in NOD mice.</p>Formule :C16H15F3OCouleur et forme :SolidMasse moléculaire :280.28Anticancer agent 164
CAS :<p>CML-IN-1, also known as compound 7 and compound 4, is a potent anticancer agent that demonstrates a strong induced-apoptosis effect in the human chronic myeloid</p>Formule :C21H23F3N8O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.58Telomerase-IN-4
CAS :<p>Telomerase-IN-4 is a potent inhibitor of telomerase with antiproliferative properties and induces apoptosis [1].</p>Formule :C21H18N4OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.52Anticancer agent 147
CAS :<p>Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS</p>Formule :C32H40BrN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :578.58Telomerase-IN-5
CAS :<p>Telomerase-IN-5 is a potent inhibitor of telomerase with antiproliferative properties, and it induces apoptosis [1].</p>Formule :C22H20N4OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.55Mutant p53 modulator-1
CAS :<p>Mutant p53 modulator-1 inhibits cancer with p53 mutations; see patent WO2021231474A1, compound 231B.</p>Formule :C27H32F4N8O2Couleur et forme :SolidMasse moléculaire :576.59Antitumor agent-83
<p>Antitumor agent-83 activates BAX protein, impedes tumor growth, triggers apoptosis, and is stable in vitro.</p>Formule :C29H30N6O2Couleur et forme :SolidMasse moléculaire :494.59(R)-STU104
CAS :<p>(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.</p>Formule :C18H18O4Degré de pureté :98.91% - 99.42%Couleur et forme :SolidMasse moléculaire :298.33Dipin
CAS :<p>Dipin is an Antineoplastic.</p>Formule :C12H24N6O2P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :346.31Topoisomerase I inhibitor 2
CAS :<p>ZML-8 selectively inhibits Top1, blocks G2/M phase, causes DNA damage, and induces apoptosis with anti-tumor properties.</p>Formule :C18H15NO3Couleur et forme :SolidMasse moléculaire :293.32Oxythiamine chloride HCl
CAS :<p>Oxythiamine chloride is a thiamine antagonist and anticancer agent that inhibits transketolase, affecting RNA/DNA synthesis and inducing apoptosis.</p>Formule :C12H17Cl2N3O2SCouleur et forme :SolidMasse moléculaire :338.25EC359
CAS :<p>EC359 is a Leukemia Inhibitory Factor Receptor (LIFR) inhibitor with anticancer activity for the study of leukemia and endometrial cancer.</p>Formule :C36H38F2O2Degré de pureté :98.11% - 98.11%Couleur et forme :SolidMasse moléculaire :540.68Simmiparib
CAS :<p>Simmiparib (SMOCL-9112) is a PARP1 and PARP2 inhibitor that promotes apoptosis.Simmiparib is used to study Parkinson's disease and melanoma.</p>Formule :C23H18F4N6O2Degré de pureté :99.05% - 99.51%Couleur et forme :SolidMasse moléculaire :486.42IM-54
CAS :<p>IM-54 is a cell-permeable, effective, and selective necrosis inhibitor.</p>Formule :C19H23N3O2Degré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :325.4Esuberaprost Sodium
CAS :<p>Famitinib (SHR1020), an oral drug, inhibits c-kit, VEGFR-2, and PDGFRβ (IC50: 2.3/4.7/6.6 nM) and triggers apoptosis in gastric cancer.</p>Formule :C23H27FN4O2Couleur et forme :SolidMasse moléculaire :410.48NSC260594
CAS :<p>NSC260594 is a chemical compound that promotes apoptosis by binding to the shallow groove of the Mcl-1 protein and suppressing its expression through down-</p>Formule :C29H24N6O3Couleur et forme :SolidMasse moléculaire :504.54Vin-C01
CAS :<p>Vin-C01, a potent protector of pancreatic β-cells (EC50=0.22μM), aids in type 2 diabetes research by preventing STZ-induced β-cell apoptosis.</p>Formule :C20H24N2OCouleur et forme :SolidMasse moléculaire :308.42VRT-043198
CAS :<p>VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.</p>Formule :C22H29ClN4O6Couleur et forme :SolidMasse moléculaire :480.94AK301
CAS :<p>AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM).</p>Formule :C19H21ClN2O2Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :344.84RIPK1-IN-15
CAS :<p>RIPK1-IN-15 (Compound 2.5) is a potent RIPK1 inhibitor that has the potential in neurodegenerative, autoimmune, and inflammatory diseases research [1].</p>Formule :C19H19N3O2Couleur et forme :SolidMasse moléculaire :321.37Verrucarin J
CAS :<p>Verrucarin J, a Myrothecium fungus metabolite, triggers apoptosis in some cancer cells and fights Candida, Mucor, and JUNV (IC50: 1.2 ng/mL).</p>Formule :C27H32O8Couleur et forme :SolidMasse moléculaire :484.54PD180970
CAS :<p>PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit.</p>Formule :C21H15Cl2FN4ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :429.27Mcl1-IN-3
CAS :<p>Mcl1-IN-3 is an Mcl1 inhibitor. It has an IC50 and Ki of 0.67 and 0.13 μM, respectively.</p>Formule :C27H22ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.93SKLB0565
CAS :<p>SKLB0565 inhibits tubulin and colorectal cancer growth (IC50: 0.012-0.081 μM), causes G2/M arrest, triggers apoptosis, and prevents HUVEC migration.</p>Formule :C20H25ClN6OCouleur et forme :SolidMasse moléculaire :400.91CEP-1612
CAS :<p>CEP-1612 inhibits protein breakdown, regulates cell cycles, apoptosis, boosts p21/p27 expression, and curbs lung cancer growth.</p>Formule :C35H53N7O7Couleur et forme :SolidMasse moléculaire :683.84SIRT6 activator 12q
CAS :<p>SIRT6 activator 12q: potent, selective, oral; IC50 - SIRT1: 171.20μM, SIRT6: 0.58μM; halts cell growth/migration, induces apoptosis, G2 arrest, anticancer.</p>Formule :C31H22N2O2Couleur et forme :SolidMasse moléculaire :454.52NSC114792
CAS :<p>NSC114792 is a selective JAK3 inhibitor.</p>Formule :C26H32N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.62BLM-IN-2
<p>BLM-IN-2: BLM inhibitor, IC50=0.8 μM; hinders CRC cell growth, invasion, cycle arrest, and death.</p>Formule :C33H38BrFN4OCouleur et forme :SolidMasse moléculaire :605.58HLI98C
CAS :<p>HLI98C is a HDM2 ubiquitin ligase inhibitor with anti-tumor activity.</p>Formule :C17H9ClN4O4Couleur et forme :SolidMasse moléculaire :368.73Cl-amidine
CAS :<p>Cl-amidine, an oral PAD inhibitor (IC50: 0.8-6.2 μM for PAD1/3/4), induces apoptosis in cancer cells.</p>Formule :C14H19ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.78Quinidine polygalacturonate
CAS :<p>Quinidine polygalacturonate: oral cytochrome P450db inhibitor, K+ channel blocker (IC50 19.9 μM), induces apoptosis, anti-arrhythmic, aids malaria research.</p>Formule :C26H34N2O9Couleur et forme :SolidMasse moléculaire :518.22643Caylin-2
CAS :<p>Nutlin-3 activates p53 by blocking MDM2. Caylin-2, a nutlin-3 analog with trifluoromethyl instead of chlorine, is 10x less potent with an 8 μM IC50.</p>Formule :C32H30F6N4O4Couleur et forme :SolidMasse moléculaire :648.6Cadein1
<p>Cadein1, an isoquinolinium derivative, induces G2/M phase delay and caspase-dependent apoptosis in cancer cells lacking functional p53.</p>Formule :C33H48F2INO2Couleur et forme :SolidMasse moléculaire :655.64BMS-37
CAS :<p>BMS-37 is a novel inhibitor of PD-1/PD-L1 immune checkpoint.</p>Formule :C27H32N2O4Couleur et forme :SolidMasse moléculaire :448.55GEM144
CAS :<p>GEM144: oral POLA1/HDAC11 inhibitor; boosts p53, p21; halts G1/S cycle; triggers cell death.</p>Formule :C28H31NO5Couleur et forme :SolidMasse moléculaire :461.55ATSP-7041
CAS :<p>ATSP-7041 is a novel potent and selective dual inhibitor of mdm2 (ki = 0.9 nm) and mdmx (ki = 7 nm)</p>Formule :C87H125N17O21Couleur et forme :SolidMasse moléculaire :1745.02PI3K inhibitor C 96
CAS :<p>PI3K inhibitor C 96 is an inhibitor of phosphatidylinositol 3-kinase. It shows effective activity against multiple myeloma in vitro and in vivo.</p>Formule :C11H8N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.26PD173952
CAS :<p>PD173952 is a Src kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.</p>Formule :C24H21Cl2N5O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :482.36RIPK1-IN-13
CAS :<p>RIPK1-IN-13 inhibits RIPK1 (IC50=1139 nM), potentially blocking necrosis and treating inflammation.</p>Formule :C21H20ClN3O3Couleur et forme :SolidMasse moléculaire :397.85CDK/HDAC-IN-2
CAS :<p>CDK/HDAC-IN-2 inhibits HDAC1,2,3, CDK1,2, induces G2/M arrest, apoptosis, and shows anti-tumor effects.</p>Formule :C25H20Cl2N6O3Couleur et forme :SolidMasse moléculaire :523.37TrxR inhibitor D9
CAS :<p>TrxR-IN-D9 is a novel inhibitor of thioredoxin reductase (TrxR).</p>Formule :C25H20AuOPSCouleur et forme :SolidMasse moléculaire :596.43Anticancer agent 56
CAS :<p>Anticancer agent 56 (4d) has potent action <3μM IC50 on various cancers, causing G2/M arrest and mitochondrial apoptosis via ROS and caspase activation.</p>Formule :C20H18ClN3O3Couleur et forme :SolidMasse moléculaire :383.83(S)-Erypoegin K
CAS :<p>(S)-Erypoegin K is a potent anticancer agent that demonstrates strong anti-proliferative activity against HL-60 cells and induces apoptosis.</p>Formule :C20H18O6Couleur et forme :SolidMasse moléculaire :354.35Apoptotic agent-3
CAS :<p>"Apoptotic agent-3 targets Bcl-2/Bax, activates caspase-3, and has anti-proliferative properties for cancer research."</p>Formule :C31H21N5OSCouleur et forme :SolidMasse moléculaire :511.6CCT373566
CAS :<p>CCT373566: potent BCL6 degrader, oral, IC50 2.2 nM; hinders cell growth in vitro & shrinks tumors in vivo.</p>Formule :C26H29ClF2N6O3Couleur et forme :SolidMasse moléculaire :547YLT205
CAS :<p>YLT205 is an inducer of apoptosis in human colorectal cells that acts by inhibiting tumor growth.</p>Formule :C16H12BrClN4O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.78MDM2-p53-IN-16
CAS :<p>MDM2-p53-IN-16 inhibits p53/MDM2 complex (IC 50 = 4.3 nM), triggers p53, causes GBM cell apoptosis, useful in cancer research.</p>Formule :C32H33N3O5Couleur et forme :SolidMasse moléculaire :539.62Tubulin polymerization-IN-22
CAS :<p>Tubulin polymerization-IN-22 inhibits tubulin (IC50=8.1μM), blocks G2/M phase, and triggers apoptosis.</p>Formule :C19H16O4Couleur et forme :SolidMasse moléculaire :308.33NF-κB-IN-5
CAS :<p>NF-κB-IN-5 (compound 4d) is an orally active NF-κB inhibitor.</p>Formule :C23H27N3O4Couleur et forme :SolidMasse moléculaire :409.48GLS1 Inhibitor-4
CAS :<p>GLS1 Inhibitor-4 (41e) has 11.86 nM IC50, strong binding, disrupts glutamine metabolism, induces apoptosis, and shows antitumor effects.</p>Formule :C29H27F3N10O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :668.72PDPOB
CAS :<p>PDPOB, a phenyl carboxylic acid derivative, may protect neurons from ischemic damage by reducing mitochondrial issues, oxidative stress, and cell death.</p>Formule :C15H20O5Couleur et forme :SolidMasse moléculaire :280.32(Rac)-Indoximod
CAS :<p>(Rac)-Indoximod, a robust IDO inhibitor, and IFN-γ combo reduce α-SMA hCM activity and boost apoptosis, aiding cardiac fibrosis.</p>Formule :C12H14N2O2Couleur et forme :SolidMasse moléculaire :218.25Anticancer agent 55
CAS :<p>Potent anticancer agent inhibits cell growth, migration, induces apoptosis; promising for prostate, breast cancer studies.</p>Formule :C28H21Br2FN2O2Couleur et forme :SolidMasse moléculaire :596.294CMC2.24
CAS :<p>CMC2.24 inhibits Ras and ERK1/2, fights pancreatic tumors in mice, blocks MMPs (IC50: 2-69 µM), and reduces osteoarthritis by stabilizing cartilage.</p>Formule :C26H21NO5Couleur et forme :SolidMasse moléculaire :427.45Antitumor agent-57
CAS :<p>Antitumor agent-57 (Compound 3o) is a potent NQO1-directed antitumor compound.</p>Formule :C20H15NO5Couleur et forme :SolidMasse moléculaire :349.34JS-K
CAS :<p>JS-K is a Nitric oxide donor. It has antiproliferative activity.</p>Formule :C13H16N6O8Couleur et forme :SolidMasse moléculaire :384.3AP23464
CAS :<p>AP23464 inhibits Src/Abl kinases, effective on imatinib-resistant CML cells (IC50=14nM), blocks cell cycle, induces apoptosis, not against T315I mutant.</p>Formule :C26H30N5O2PCouleur et forme :SolidMasse moléculaire :475.52CT1-3
CAS :<p>CT1-3 is a potent anti-cancer compound targeting JNK/Bcl-2 pathways, blocking EMT in HCCs, and is non-toxic to liver/kidneys in mice.</p>Formule :C25H29NO3S2Couleur et forme :SolidMasse moléculaire :455.63CZS-241
<p>CZS-241: Oral PLK4 inhibitor (IC50=2.6 nM), less potent TRKA blocker (IC50=2.74 μM), triggers apoptosis and S/G2 arrest, anti-leukemia, safe for normal cells.</p>Formule :C26H24ClF2N9OCouleur et forme :SolidMasse moléculaire :551.98AQX-016A
CAS :<p>AQX-016A, a potent SHIP1 agonist, is an oral analog of pelorol, 3x stronger, inhibits PI3K, TNFa, for inflammation research.</p>Formule :C22H32O2Couleur et forme :SolidMasse moléculaire :328.49PD-1/PD-L1-IN-20
CAS :<p>PD-1/PD-L1-IN-20 is a small molecule inhibitor of PD-1/PD-L1 protein-protein interaction.</p>Formule :C30H26BrClN2O3Couleur et forme :SolidMasse moléculaire :577.9Undecylprodigiosin
CAS :<p>Undecylprodigiosin is a classical cytotoxic immunosuppressant, suppressing immune functions. It also inhibits DNA synthesis.</p>Formule :C25H35N3OCouleur et forme :SolidMasse moléculaire :393.56Topoisomerase II inhibitor 11
CAS :<p>Topoisomerase II inhibitor 11 (compound 3d) is a potent inhibitor of Topoisomerase II (IC50: 2.89 μM).</p>Formule :C27H21BrCl2N2O2SCouleur et forme :SolidMasse moléculaire :588.34CAY10503
CAS :<p>CAY10503: proapoptotic, anti-growth agent; arrests cell cycle at G0-G1; IC50 = 7-23 μM; induces HL60 differentiation in 72 hours.</p>Formule :C18H14O3Couleur et forme :SolidMasse moléculaire :278.3c-Fms-IN-12
CAS :<p>c-Fms-IN-12 inhibits FMS/c-KIT, triggers A549 cell apoptosis, and has potential as a multi-cancer therapy.</p>Formule :C30H32N6O6Couleur et forme :SolidMasse moléculaire :572.61Antitumor agent-56
CAS :<p>Antitumor-56: Oral triptolide derivative; inhibits melanoma; anti-tumor, anti-inflammatory, NO-releasing properties.</p>Formule :C28H28N2O10SCouleur et forme :SolidMasse moléculaire :584.59CX-5011
CAS :<p>CX-5011, a CK2 inhibitor, induces Rac1 activation and promotes apoptosis, effectively causing cancer cell death [1] [2].</p>Formule :C20H12N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.33EGFR/BRAFV600E-IN-1
CAS :<p>EGFR/BRAFV600E-IN-1 inhibits EGFR (0.08 μM) & BRAFV600E (0.15 μM), affects A-549, MCF-7, Panc-1 & HT-29 (IC50: 0.79-1.3 μM).</p>Formule :C24H24ClN3O3Couleur et forme :SolidMasse moléculaire :437.92MDM2/XIAP-IN-3
CAS :<p>MDM2/XIAP-IN-3 (compound 3e), a dual inhibitor of MDM2/XIAP, diminishes MDM2 and XIAP protein levels while augmenting p53 expression, consequently suppressing</p>Formule :C29H30N2O5SCouleur et forme :SolidMasse moléculaire :518.62DNA topoisomerase II inhibitor 1
CAS :<p>Potent DNA topoisomerase II blocker; arrests cell cycle, induces apoptosis, anti-growth effects.</p>Formule :C28H24N4O3SCouleur et forme :SolidMasse moléculaire :496.58CS1
CAS :<p>CS1: potent topoisomerase II alpha inhibitor, broad-spectrum antitumor, low toxicity, anti-resistance, induces DNA damage, G2/M arrest, apoptosis.</p>Formule :C16H12O3Couleur et forme :SolidMasse moléculaire :252.26PI3K/Akt/mTOR-IN-2
CAS :<p>Potent PI3K/AKT/mTOR inhibitor, selective for MDA-MB-231 cells with IC50 of 2.29 μM; induces arrest and apoptosis.</p>Formule :C17H13F2NODegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :285.29Anti-inflammatory agent 55
CAS :<p>Compound 9j (anti-inflammatory agent 55), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression</p>Formule :C17H15N3O7Couleur et forme :SolidMasse moléculaire :373.32Anti-inflammatory agent 15
CAS :<p>Compound 29, anti-inflammatory and antimycobacterial, halts Mtb H37Rv and M299 growth; MIC50 at 2.3 and 7.8 μM. Blocks iNOS, TNF-α, IL-1β.</p>Formule :C17H20N2SCouleur et forme :SolidMasse moléculaire :284.42PDMP (hydrochloride)
CAS :<p>PDMP, a glucosylceramide synthase inhibitor with 4 stereoisomers, acts at 0.8μM; D-threo enantiomer also blocks lactosylceramide synthesis.</p>Formule :C23H39ClN2O3Couleur et forme :SolidMasse moléculaire :427.03Apoptosis inducer 8
CAS :<p>Apoptosis inducer 8 is a galectin-1 (gal-1)-mediated apoptosis inducer and a PET imaging agent that significantly reduces gal-1 protein levels and can be used</p>Formule :C29H22ClN5O2Couleur et forme :SolidMasse moléculaire :507.97MeOIstPyrd
CAS :<p>MeOIstPyrd is an anti-skin cancer agent that inhibits cell proliferation, migration, and spheroid formation through activation of the mitochondrial intrinsic</p>Formule :C14H16N4O2SCouleur et forme :SolidMasse moléculaire :304.37(S)-Elobixibat
CAS :<p>(S)-Elobixibat is the S-isomer of Elobixibat. It is an orally active inhibitor of Apical Sodium-Dependent Bile (IBAT) and can reduce LDL cholesterol, increase serum GLP-1, and promote colonic motility. This compound shows potential for treating metabolic syndrome and can be studied for constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors.</p>Formule :C36H45N3O7S2Couleur et forme :SolidMasse moléculaire :695.89ISC-4
CAS :<p>ISC-4 is an Akt inhibitor, which activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model.</p>Formule :C11H13NSeCouleur et forme :SolidMasse moléculaire :238.19RIPK1-IN-12
CAS :<p>RIPK1-IN-12: Strong RIPK1 blocker, hinders necroptosis; EC50=1.6 nM (human), 2.9 nM (mouse).</p>Formule :C24H26N4O3SCouleur et forme :SolidMasse moléculaire :450.55DRAK1/2-IN-1
CAS :<p>DRAK1/2-IN-1 is a potent inhibitor targeting both DRAK1 and DRAK2, displaying dissociation constants (Kd) of 1 µM and 6 µM, respectively.</p>Formule :C22H24N2O3SCouleur et forme :SolidMasse moléculaire :396.5PD-1/PD-L1-IN 5
CAS :<p>PD-1/PD-L1-IN 5 is a potent PD-1/PD-L1 protein/protein interaction inhibitor (IC50 ≤ 100 nM).</p>Formule :C22H18N4O3SCouleur et forme :SolidMasse moléculaire :418.47Justicidin B
CAS :<p>Justicidin B: anticancer, proapoptotic, inhibits bone resorption & platelets, antiviral, fungicidal, antiprotozoal.</p>Formule :C21H16O6Couleur et forme :SolidMasse moléculaire :364.35PI3K-IN-34
CAS :<p>PI3K-IN-34 targets PI3K-α/β/δ (IC50: 11.73/6.09/11.18 μM); potential leukemia research tool.</p>Formule :C23H22N6O3Couleur et forme :SolidMasse moléculaire :430.46hnRNPK-IN-1
CAS :<p>hnRNPK-IN-1 binds hnRNPK tightly (Kd 4.6-2.6 μM), disrupting c-myc transcription and inducing apoptosis in Hela cells.</p>Formule :C23H21N3O5Couleur et forme :SolidMasse moléculaire :419.43Caspase-3/7 activator 2
<p>Caspase-3/7 activator 2 triggers apoptosis with tumor selectivity and anti-proliferative properties.</p>Formule :C32H34N2O7Couleur et forme :SolidMasse moléculaire :558.62(Z)-4EGI-1
CAS :<p>(Z)-4EGI-1, a Z-isomer, inhibits eIF4E/eIF4G; binds eIF4E (IC50=43.5 μM, Kd=8.74 μM); anticancer properties.</p>Formule :C18H12Cl2N4O4SCouleur et forme :SolidMasse moléculaire :451.28ATAD2-IN-1
CAS :<p>ATAD2-IN-1 (compound 19f) serves as a potent ATAD2 inhibitor (IC 50: 0.27 μM), capable of inducing apoptosis. Additionally, it suppresses c-Myc activation and impedes the migration of BT-549 cells [1].</p>Formule :C22H26N6O5Couleur et forme :SolidMasse moléculaire :454.48Verticillin A
CAS :<p>Verticillin A, an apoptosis inducer, inhibits Leiomyosarcoma and Malignant peripheral nerve sheath tumor growth.</p>Formule :C30H28N6O6S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :696.84SK-7041
CAS :<p>SK-7041 is an effective HDAC inhibitor that acts by preferentially inhibiting class I HDAC1 and HDAC2.</p>Formule :C19H21N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :339.39GW-3333
CAS :<p>GW-3333 inhibits matrix metalloproteinases and TNF-Converting Enzyme, showing potential as an antiarthritic therapy.</p>Formule :C22H36N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.55VEGFR-2-IN-28
CAS :<p>VEGFR-2-IN-28 is a potent inhibitor of VEGFR-2 (IC50: 0.83 μM). VEGFR-2-IN-28 induces apoptosis and exhibits antitumor effects.</p>Formule :C26H17N7O7Couleur et forme :SolidMasse moléculaire :539.46BRD4 Inhibitor-15
CAS :<p>BRD4 Inhibitor-15 targets BRD4 with 18 nM IC50, induces apoptosis in 22RV1 cells, and lowers c-Myc, aiding prostate cancer research.</p>Formule :C22H21N3O2Couleur et forme :SolidMasse moléculaire :359.42VS 8
CAS :<p>VS 8: potent oral VEGFR-2 inhibitor, anti-angiogenic, induces cancer cell apoptosis & migration, acts on CSCs.</p>Formule :C26H20F3N3O3Couleur et forme :SolidMasse moléculaire :479.45Imofinostat
CAS :<p>Imofinostat (MPT0E028) is a selective, orally available pan-HDAC inhibitor with IC₅₀ values of 53.0/106.2/29.5 nM against HDAC1/HDAC2/HDAC6 in HCT116 cells.</p>Formule :C17H16N2O4SCouleur et forme :SolidMasse moléculaire :344.38CMLD012072
CAS :<p>CMLD012072 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor with potent anti-neoplastic activity. It can induce RNA clamping of eIF4A1 and eIF4A2.</p>Formule :C32H32N2O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.61MMPSI
CAS :<p>MMPSI (Caspase-3/7 Inhibitor I) is a caspase 3 and caspase 7 inhibitor that inhibits ischemic injury in cardiomyocytes and can be used to study cardioprotection</p>Formule :C14H16N2O5SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :324.35VU 0364739 hydrochloride
CAS :<p>VU 0364739 hydrochloride (VU 0364739 HCl) is a phospholipase D2 (PLD2) inhibitor that induces apoptosis and can be used in cancer research.</p>Formule :C26H28ClFN4O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :482.98Ivaltinostat
CAS :<p>CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.</p>Formule :C24H33N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :427.54TP-472
CAS :<p>TP-472 is a selective inhibitor of BRD9 (Kd: 33 nM).</p>Formule :C20H19N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :333.38GW7845
CAS :<p>GW7845, an L-tyrosine derivative, is a PPAR-γ agonist.</p>Formule :C29H28N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :500.54CSRM617
CAS :<p>CSRM617: selective ONECUT2 inhibitor, Kd 7.43 uM, binds OC2-HOX, induces apoptosis, tolerable in mouse prostate cancer model.</p>Formule :C10H13N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :255.23MEK-IN-5
CAS :<p>MEK-IN-5: strong MEK inhibitor and NO donor, reduces pMEK/pERK dose/time-dependently, triggers apoptosis in MDA-MB-231 cells.</p>Formule :C29H27FN4O10S2Couleur et forme :SolidMasse moléculaire :674.67HSP90-IN-13
CAS :<p>HSP90-IN-13 (5k): potent HSP90 inhibitor, IC50 25.07 nM, targets EGFR/VEGFR-2/Topo-2, blocks MCF-7 G2/M cycle, induces apoptosis.</p>Formule :C26H21N5O3SCouleur et forme :SolidMasse moléculaire :483.54NSC745885
CAS :<p>NSC745885 decreases EZH2, has selective cancer cell toxicity, and is studied for bladder and OSCC.</p>Formule :C14H6N2O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :266.27bpV(phen)
CAS :<p>bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).</p>Formule :C12H8KN2O5VDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.24MI-192
CAS :<p>MI-192: Selective HDAC2/3 inhibitor, IC50=30/16 nM, induces apoptosis in myeloid leukemia, potential in leukemia/anti-stroke treatment.</p>Formule :C24H21N3O2Couleur et forme :SolidMasse moléculaire :383.44Estramustine phosphate
CAS :<p>Estramustine phosphate can be used to treat prostatic neoplasms; also has radiation protective properties.</p>Formule :C23H32Cl2NO6PCouleur et forme :SolidMasse moléculaire :520.38DRI-C21041
CAS :<p>DRI-C21041 is a potent inhibitor of the CD40/CD40L interaction, demonstrating an inhibitory concentration 50 (IC50) value of 0.31 μM.</p>Formule :C30H21N3O7SCouleur et forme :SolidMasse moléculaire :567.57AG6033
CAS :<p>AG6033, a novel CRBN modulator, degrades GSPT1/IKZF1 and inhibits various tumors.</p>Formule :C30H23N5O4Couleur et forme :SolidMasse moléculaire :517.53
