Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
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HDAC-IN-50
CAS :<p>HDAC-IN-50, a potent FGFR/HDAC inhibitor (IC50: 0.18-13 nM), induces apoptosis, cell cycle arrest, and shows anti-tumor activity.</p>Formule :C31H41N7O4Couleur et forme :SolidMasse moléculaire :575.7PD-1/PD-L1-IN-22
CAS :<p>PD-1/PD-L1-IN-22 is a small molecule inhibitor of PD-1/PD-L1 protein-protein interactions that blocks PD-1/PD-L1 interactions (IC50: 0.732 μM).</p>Formule :C25H26BrClN2O3Couleur et forme :SolidMasse moléculaire :517.84Nirogacestat dihydrobromide
CAS :<p>Potent γ-secretase inhibitor; IC50: 1.2 nM (cell), 6.2 nM (cell-free); lowers Aβ in mice/guinea pigs' brain, CSF, plasma.</p>Formule :C27H43Br2F2N5OCouleur et forme :SolidMasse moléculaire :651.48Cerivastatin
CAS :<p>Cerivastatin is an HMG-CoA reductase inhibitor with anticancer and lipid-lowering effects and can be used to study primary hyperlipidemia.</p>Formule :C26H34FNO5Degré de pureté :97.80% - 99.56%Couleur et forme :SolidMasse moléculaire :459.55BRD4 Inhibitor-18
CAS :<p>BRD4 Inhibitor-18: potent (IC50: 110 nM), impairs MV-4-11 cell growth, disrupts G0/G1 phase, and induces apoptosis.</p>Formule :C26H26ClN3O3SCouleur et forme :SolidMasse moléculaire :496.021-Stearoyl-2-Adrenoyl-sn-glycero-3-PC
CAS :<p>1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC (PC(18:0/22:4)) acts as a cyclin-dependent kinase (CDK) inhibitor, promoting apoptosis and restricting the proliferation of various cancer cell lines [1].</p>Formule :C48H88NO8PCouleur et forme :SolidMasse moléculaire :838.19Pivanex
CAS :<p>Pivanex, an oral HDAC inhibitor, targets metastasis, angiogenesis, reduces Bcr-Abl protein, and promotes apoptosis.</p>Formule :C10H18O4Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :202.25Antitumor agent-110
CAS :<p>Antitumor Agent-110 (Compound 13), an imidazotetrazine anticancer agent, exhibits excellent permeability.</p>Formule :C10H6N6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.26Antitumor agent-92
CAS :<p>Antitumor Agent-92, a derivative of Icaritin, halts cell cycle, triggers cell death, and is promising for liver cancer study.</p>Formule :C33H41NO10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :611.68Lepadin H
CAS :<p>Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancing</p>Formule :C26H45NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.64Mezigdomide
CAS :<p>Mezigdomide (CC-92480) is a potent, novel cereblon E3 ubiquitin ligase modulator (CELMoD) that acts as a molecular glue.Cost-effective and quality-assured.</p>Formule :C32H30FN5O4Degré de pureté :97.21% - 99.68%Couleur et forme :SolidMasse moléculaire :567.61TL02-59
CAS :<p>TL02-59: Fgr inhibitor (IC50=0.03nM), also targets Lyn (0.1nM), Hck (160nM), halts acute myelogenous leukemia growth.</p>Formule :C32H34F3N5O4Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :609.64Thaspine acetate
CAS :<p>Thaspine: inhibits topoisomerase IB, reduces VEGF, stops endothelial cell growth via PI3K/MAPK pathways.</p>Formule :C22H23NO8Couleur et forme :SolidMasse moléculaire :429.425IM156
CAS :<p>IM156, a Metformin derivative, activates AMPK, enhances cognition in aging animals, and inhibits OXPHOS in solid tumor research.</p>Formule :C13H16F3N5ODegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :315.29Ro 41-5253
CAS :<p>Ro 41-5253 is a RARα antagonist with antitumor activity that inhibits the proliferation of ZR-75.1 estrogen receptor-positive breast cancer cells.</p>Formule :C28H36O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.65EGFR kinase inhibitor 1
CAS :<p>Potent EGFR blocker; acts on WT, L858R/T790M (IC50: 1.7 nM), less on T790M/C797S; stalls cell cycle, induces apoptosis, deters metastasis.</p>Formule :C30H31N7O2Couleur et forme :SolidMasse moléculaire :521.61Tubulin polymerization-IN-56
CAS :<p>Tubulin Polymerization-IN-56 (compound 8l), an indazole derivative, potently inhibits tubulin polymerization by targeting the colchicine site, which induces</p>Formule :C22H22ClN3O3Couleur et forme :SolidMasse moléculaire :411.88AMRI-59
CAS :<p>AMRI-59 is a potent inhibitor of PrxI with anti-tumor activity.</p>Formule :C25H27N3O2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :401.5eIF4A3-IN-18
CAS :<p>eIF4A3-IN-18, a silvestrol analogue with EC50s: 0.8/35/2 nM, inhibits eIF4F complex and is cytotoxic (LC50: 0.06 nM) for cancer research.</p>Formule :C29H28N2O6Couleur et forme :SolidMasse moléculaire :500.54CHM-1
CAS :<p>CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity.</p>Formule :C16H10FNO3Degré de pureté :99.839%Couleur et forme :SolidMasse moléculaire :283.25Q-VD(OMe)-OPh
CAS :<p>Q-VD-OPh: broad-spectrum, non-toxic caspase inhibitor; cost-effective, specific for apoptotic inhibition.</p>Formule :C27H27F2N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.52WF-210
CAS :<p>WF-210 is an effective activator of procaspase-3 that acts by inducing apoptosis in cancer cells and reducing tumor growth.</p>Formule :C41H38FN7O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :791.85Siremadlin (R Enantiomer)
CAS :<p>Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53.</p>Formule :C26H24Cl2N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :555.41HDAC-IN-59
CAS :<p>HDAC-IN-59 (compound 13a), a potent histone deacetylase (HDAC) inhibitor, enhances intracellular reactive oxygen species (ROS) production, induces DNA damage,</p>Formule :C20H25NO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :391.42HDAC-IN-53
CAS :<p>HDAC-IN-53 inhibits HDAC1-3 with IC50s: 47, 125, 450 nM. Inactive on class II HDACs; triggers apoptosis; reduces tumor growth in mice.</p>Formule :C23H20ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.9Antitumor agent-97
CAS :<p>Antitumor agent-97 (compound 42), an anticancer agent, effectively inhibits proliferation and autophagy in MGC 803 cells, induces apoptosis, and enhances ROS</p>Formule :C24H34O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.52Boserolimab
CAS :<p>Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.</p>Couleur et forme :LiquidMI-219
CAS :<p>MI-219 is a human double minute 2 (HDM2) inhibitor.</p>Formule :C27H32Cl2FN3O4Couleur et forme :SolidMasse moléculaire :552.47WYE-132
CAS :<p>WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.</p>Formule :C27H33N7O4Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :519.6Falcarindiol
CAS :<p>Falcarindiol: Activates PPARγ, boosts ABCA1, induces apoptosis/autophagy, has anti-inflammatory/anticancer effects.</p>Formule :C17H24O2Couleur et forme :SolidMasse moléculaire :260.37FHND5071
CAS :<p>FHND5071, a potent and selective RET kinase inhibitor, exerts antitumor effects through the inhibition of RET autophosphorylation and may be utilized for tumor</p>Formule :C30H30D3N9OCouleur et forme :SolidMasse moléculaire :538.66viFSP1
CAS :<p>viFSP1, a species-independent FSP1 inhibitor, effectively induces ferroptosis in FSP1-dependent cells by targeting the highly conserved NAD(P)H binding pocket of FSP1, directly inhibiting its activity. This action results in lipid peroxidation and exhibits anticancer activity [1].</p>Formule :C16H17N3O3SCouleur et forme :SolidMasse moléculaire :331.39Deoxynybomycin
CAS :<p>Deoxynybomycin, a selective anti-tumor agent, inhibits topoisomerase I and induces apoptosis.</p>Formule :C16H14N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29MP7
CAS :<p>MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).</p>Formule :C28H22F2N4O4Degré de pureté :99.84% - 99.89%Couleur et forme :SolidMasse moléculaire :516.5Ataquimast
CAS :<p>Ataquimast is used in curing advanced receptor-positive breast cancer.</p>Formule :C11H14ClN3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :239.7LY303511 hydrochloride
CAS :<p>LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.</p>Formule :C19H20Cl2N2O2Couleur et forme :SolidMasse moléculaire :379.28JNJ-1013
CAS :<p>JNJ-1013 is a selective IRAK1 PROTAC degrader with an IC50 of 72 nM ,antiproliferative and proapoptotic, increases cleaved-PARP expression.</p>Formule :C46H55N9O7SDegré de pureté :99.596%Couleur et forme :SolidMasse moléculaire :878.05Lepadin E
CAS :<p>Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway.</p>Formule :C26H47NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.66CHMFL-FLT3-122
CAS :<p>CHMFL-FLT3-122 is a potent and orally available FLT3 kinase inhibitor used to treat FLT3-ITD positive acute myeloid leukemia.</p>Formule :C26H29N7O2Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :471.55BMS-561392 formate
CAS :<p>BMS-561392 formate, the formate derivative of BMS-561392, functions as a TNF alpha-converting enzyme (TACE) inhibitor and an ADAM17 blocker. It is utilized in the research of inflammatory bowel disease [1] [2].</p>Formule :C28H34N4O6Couleur et forme :SolidMasse moléculaire :522.59Bcl-2-IN-13
CAS :<p>Bcl-2-IN-13 is a potent inhibitor of Bcl-2, exhibiting an IC50 of 17 nM, and holds potential for use in cancer research [1].</p>Formule :C42H44ClN7O6S3Couleur et forme :SolidMasse moléculaire :874.49JMJD3/HDAC-IN-1
CAS :<p>Compound A5b, also known as JMJD3/HDAC-IN-1, is a dual inhibitor that targets both JMJD3 (Jumonji domain-containing protein demethylase 3) and HADC1 (histone</p>Formule :C21H30N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.5NWP-0476
CAS :<p>NWP-0476 is a modified BCL-2/BCL-xL inhibitor with enhanced specificity for BCL-xL, suitable for research on relapsed T-acute lymphoblastic leukemia (T-ALL) [1</p>Formule :C47H53ClN8O8SCouleur et forme :SolidMasse moléculaire :925.49SCH79797 dihydrochloride
CAS :<p>SCH79797 dihydrochloride is a PAR1 antagonist with IC50 70 nM, Ki 35 nM, antiproliferative, and pro-apoptotic properties.</p>Formule :C23H27Cl2N5Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :444.4SW IV-52
CAS :<p>SW IV-52 is an XIAP-inhibitor that acts as a second mitochondria-derived activator of caspases (SMAC) mimetic.</p>Formule :C25H39ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :479.05PARP-1-IN-3
CAS :<p>PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-</p>Formule :C21H17BrN2O3Degré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :425.28Ac-VAD-CHO
CAS :<p>Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of</p>Formule :C14H23N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.35PARP1-IN-14
CAS :<p>PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM.</p>Formule :C28H24FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.53BMS-561392
CAS :<p>BMS-561392 (DPC333) is a tumor necrosis factor-α ( TNF-α) Invertase inhibitor.</p>Formule :C27H32N4O4Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :476.57Met-F-AEA
CAS :<p>Met-F-AEA is a metabolically stable analogue of anandamine that exhibits antitumor activity by inhibiting cell growth through the activation of apoptosis [1].</p>Formule :C23H38FNOCouleur et forme :SolidMasse moléculaire :363.561Atiprimod dimaleate
CAS :<p>Atiprimod Dimaleate is a JAK2 inhibitor.</p>Formule :C30H52N2O8Couleur et forme :SolidMasse moléculaire :568.74HM90822
CAS :<p>HM90822 is an IAP antagonist that inhibits XIAP and cIAP1/2 protein expression, induces IAP ubiquitination and promotes proteasome-dependent IAP degradation.</p>Formule :C30H36ClF2N7O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :632.1ERα antagonist 1
CAS :<p>ERα antagonist 1 is a selective, potent, covalent estrogen receptor alpha (ERα) antagonist that blocks the cell cycle of MCF-7 cells in G0/G1 phase and induces</p>Formule :C33H32N2O5SCouleur et forme :SolidMasse moléculaire :568.68HDAC/JAK/BRD4-IN-1
CAS :<p>HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4.</p>Formule :C24H28N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.52HDAC1/CDK7-IN-1
CAS :<p>HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively.</p>Formule :C33H32ClN7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :626.11Mcl-1 inhibitor 13
CAS :<p>Mcl-1 Inhibitor 13 (Example 9), with a Ki of 8.2 nM, serves as an MCL-1 inhibitor suitable for cancer research [1].</p>Formule :C47H45ClFN7O6Couleur et forme :SolidMasse moléculaire :858.35APE1-IN-2
CAS :<p>APE1-IN-2 (AP1), a Pt(IV) proagent, targets APE1 protein, induces DNA damage, and triggers apoptosis with anticancer effects.</p>Formule :C9H12Cl2N4O5PtDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :522.21SD 1008
CAS :<p>SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. SD 1008 inhibits activation of STAT3, JAK2, and Src.</p>Formule :C18H19NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.35CDC801
CAS :<p>CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.</p>Formule :C23H24N2O5Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :408.45JHU395
CAS :<p>JHU395, an oral prodrug of glutamine antagonist DON, shows stable antitumor effects on MPNST in vitro and vivo.</p>Formule :C22H29N3O7Degré de pureté :99.15% - 99.26%Couleur et forme :SolidMasse moléculaire :447.48VU0661013
CAS :<p>VU0661013 is an effective and selective inhibitor of MCL-1.</p>Formule :C39H39Cl2N5O4Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :712.66PARP1/2/TNKS1/2-IN-1
CAS :<p>PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has anti-tumor activity and induces apoptosis.</p>Formule :C35H31FN6O5Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :634.66KSQ-4279
CAS :<p>KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma,</p>Formule :C27H25F3N8ODegré de pureté :99.76% - 99.79%Couleur et forme :SoildMasse moléculaire :534.54MC4033
CAS :<p>MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1].</p>Formule :C16H13N3O3Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :295.29GCN2-IN-7
CAS :<p>GCN2-IN-7 is an inhibitor of the environmental sensing protein GCN2 with antitumor activity for the study of melanoma.</p>Formule :C22H23BrN8OSDegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :527.44Elobixibat
CAS :<p>Elobixibat (A 3309) blocks IBAT in mice/humans/dogs (IC50: 0.13/0.53/5.8 nM); used for constipation research.</p>Formule :C36H45N3O7S2Degré de pureté :97.43% - 98.03%Couleur et forme :SolidMasse moléculaire :695.89Nanatinostat
CAS :<p>Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, for HDAC1/2/3 .anti-proliferation apoptosis.</p>Formule :C20H19FN6O2Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :394.4LB42708
CAS :<p>LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).</p>Formule :C30H27BrN4O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :555.47PP5-IN-1
CAS :<p>PP5-IN-1 is a serine/threonine protein phosphatase-5 (PP5) inhibitor with potential anticancer activity that induces apoptosis in cancer cells.</p>Formule :C18H18N2O3SDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :342.41Ac-DEVD-CHO
CAS :<p>Ac-DEVD-CHO is a specific Caspase-3 inhibitor (Ki: 230 pM).Ac-DEVD-CHO has an inhibitory effect in SLNT-induced apoptosis.</p>Formule :C20H30N4O11Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :502.47CDDO-2P-Im
CAS :<p>CDDO-2P-Im shows chemopreventive effect and reduces the size and severity of the lung tumors in the mouse lung cancer model.</p>Formule :C39H46N4O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :618.81GP 1a
CAS :<p>GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.</p>Formule :C23H22Cl2N4ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :441.35RH01386
CAS :<p>RH01386, a small molecule, prevents ER stress in β cells, inhibits proapoptotic genes, and may treat type 2 diabetes by restoring insulin secretion.</p>Formule :C18H15F3N4O3SDegré de pureté :99.16% - 99.67%Couleur et forme :SolidMasse moléculaire :424.4NSC697923
CAS :<p>NSC-697923 inhibits UBE2N, triggers p53-dependent and JNK-mediated apoptosis, blocks DNA damage and NF-κB signaling in neuroblastoma cells.</p>Formule :C11H9NO5SDegré de pureté :97% - 99.71%Couleur et forme :SolidMasse moléculaire :267.26ZNL 02-096
CAS :<p>ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar</p>Formule :C42H45N11O6Degré de pureté :99.02% - 99.84%Couleur et forme :SolidMasse moléculaire :799.88M3541
CAS :<p>M3541: an oral ATM inhibitor with antitumor effects, hinders DNA repair and promotes cancer cell death.</p>Formule :C23H17FN6O2Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :428.42AZA197
CAS :<p>AZA197 (AZA-197) is a selective Cdc42 inhibitor.</p>Formule :C24H36N6Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :408.58Tefinostat
CAS :<p>Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor.</p>Formule :C28H37N3O5Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :495.61CPI-360
CAS :<p>CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.</p>Formule :C25H31N3O4Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :437.53CDDO-3P-Im
CAS :<p>CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion.</p>Formule :C39H46N4O3Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :618.81Alrizomadlin
CAS :<p>Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines.Cost-effective and quality-assured.</p>Formule :C34H38Cl2FN3O4Degré de pureté :98.41% - 99.47%Couleur et forme :SolidMasse moléculaire :642.59DuP-697
CAS :<p>DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1.Cost-effective and quality-assured.</p>Formule :C17H12BrFO2S2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :411.31HM43239
CAS :<p>HM43239: oral FLT3 inhibitor; IC50: FLT3 WT 1.1nM, ITD 1.8nM, D835Y 1.0nM; blocks p-STAT5/p-ERK; affects SYK, JAK1/2, TAK1; halts leukemia cell growth.</p>Formule :C29H33ClN6Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :501.07SMO-IN-5
<p>SMO-IN-5 (Compound 25(B31)) is an effective inhibitor of smoothened (SMO), which suppresses the Hedgehog (Hh) signaling pathway. This compound inhibits cellular proliferation and induces apoptosis, demonstrating antitumor activity.</p>Formule :C25H24N6OCouleur et forme :SolidMasse moléculaire :424.5NCAO
CAS :<p>N-ω-chloroacetyl-L-ornithine (NCAO) serves as a powerful reversible competitive inhibitor of ornithine decarboxylase (ODC), displaying cytotoxic and antiproliferative properties against various tumor cell lines, with EC50 values spanning from 1 to 50.6 µM. In vitro studies reveal that NCAO promotes Apoptosis and restricts tumor cell migration. Additionally, it demonstrates significant antitumor efficacy in a mouse model, targeting both solid and ascitic tumors using the myeloma (Ag8) cell line. NCAO holds promise in the development of antitumor agents.</p>Formule :C7H13ClN2O3Couleur et forme :SolidMasse moléculaire :208.64Ferrostatin-1 diyne
CAS :<p>Ferrostatin-1 diyne (Fer-1 diyne) (compound 2) serves as an inhibitor of ferroptosis, accumulating in cellular lysosomes, mitochondria, and the endoplasmic reticulum. It notably inhibits ferroptosis independently of lysosomal and mitochondrial activity.</p>Formule :C18H22N2O2Couleur et forme :SolidMasse moléculaire :298.38Silvestrol
CAS :<p>Silvestrol is a eukaryotic translation initiation factor 4A inhibitor. Silvestrol causes autophagy and caspase-mediated apoptosis.</p>Formule :C34H38O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.66PD-L1-IN-1
<p>PD-L1-IN-1, potent PD-L1 inhibitor with 115 nM IC50, suppresses tumors, boosts immune response, and spares healthy cells.</p>Formule :C21H23N5O2Couleur et forme :SolidMasse moléculaire :377.44TFCP2L1-IN-1
CAS :<p>TFCP2L1-IN-1 is a TFCP2L1 transcription factor inhibitor that regulates cell proliferation and promotes antitumor effect of Sorafenib by STAT3/NANOG pathway.</p>Formule :C15H13BrN2OSDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :349.25Keap1-Nrf2-IN-4
<p>Keap1-Nrf2-IN-4 hinders MGC-803 cell growth (IC50=2.55μM), migration, and induces apoptosis with low toxicity.</p>Formule :C26H34N2OCouleur et forme :SolidMasse moléculaire :390.56BRD-K20733377
CAS :<p>BRD-K20733377 is a Bcl-2 inhibitor that exhibits selective cytotoxicity toward senescent cells, specifically inhibiting the activity of etoposide-induced senescent IMR-90 cells with an IC50 of 10.7 μM. Additionally, BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21, and KI67 in aged mouse models.</p>Formule :C23H18N4O3SCouleur et forme :SolidMasse moléculaire :430.48Lonitoclax
CAS :<p>Lonitoclax is an inhibitor of B-cell lymphoma 2 (Bcl-2). It demonstrates antitumor activity in B-cell and myeloid malignancy models comparable to Venetoclax. Lonitoclax holds potential for research in relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma, and certain low-grade lymphomas.</p>Formule :C43H45ClN4O5Couleur et forme :SolidMasse moléculaire :733.294Tandutinib sulfate
CAS :<p>Tandutinib (MLN518) sulfate is an effective and selective inhibitor of FLT3, with an IC50 value of 0.22 μM. It also inhibits c-Kit and PDGFR, displaying IC50 values of 0.17 μM and 0.20 μM respectively. This compound can be utilized in the treatment of acute myeloid leukemia and has the capability to cross the blood-brain barrier.</p>Formule :C31H44N6O8SCouleur et forme :SolidMasse moléculaire :660.78MDK-3345
CAS :<p>MDK-3345 is a reversible covalent inhibitor for Mcl-1.</p>Formule :C36H34BN3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :631.48Microtubule inhibitor 2
<p>Microtubule inhibitor 2: potent, selective, oral, induces ferroptosis, strong antitumor effect.</p>Formule :C20H23NO7Couleur et forme :SolidMasse moléculaire :389.4(Rac)-Idroxioleic acid sodium
CAS :<p>(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic derivative of oleic acid (OA) that binds to the plasma membrane, altering lipid composition. This compound exhibits antitumor properties.</p>Formule :C18H33NaO3Couleur et forme :SolidMasse moléculaire :320.44PIM-1/HDAC-IN-1
<p>PIM-1/HDAC-IN-1 (4d): inhibits PIM-1 (IC50: 343.87nM), HDAC1 (63.65nM), HDAC6 (62.39nM); induces apoptosis in MCF-7 cells.</p>Formule :C22H19N3O3Couleur et forme :SolidMasse moléculaire :373.4Top/HDAC-IN-3
CAS :<p>Top/HDAC-IN-3 (Compound 31) is a dual inhibitor of Topoisomerase and HDAC with oral activity. It induces DNA damage by elevating reactive oxygen species (ROS) levels, consequently inhibiting the clonal formation and migration of cancer cells, and triggering apoptosis (Apoptosis) and cell cycle arrest. Top/HDAC-IN-3 demonstrates a significant antitumor effect in NSCLC models, exhibiting a tumor growth inhibition (TGI = 77.5%, 100 mg/kg) superior to that of the HDAC inhibitor SAHA and the combination of SAHA with the topoisomerase inhibitor Irinotecan.</p>Formule :C24H25N3O5Couleur et forme :SolidMasse moléculaire :435.47YCW-E11
CAS :<p>YCW-E11 is an antiapoptotic Bcl-2 family proteins inhibitor.</p>Formule :C25H21Cl2N3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :594.49HR-19011
CAS :<p>HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.</p>Formule :C25H19F6N3O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :523.43DWP-05195
CAS :<p>DWP-05195 is a TRPV1 antagonist capable of inhibiting pain signal transduction. Additionally, it induces ER stress-dependent apoptosis in human ovarian cancer cells via the ROS-p38-CHOP pathway.</p>Formule :C18H10BrF3N4Couleur et forme :SolidMasse moléculaire :419.2microRNA-21-IN-1
CAS :<p>microRNA-21-IN-1: microRNA inhibitor, curbs HeLa/HCT-116 growth (IC50: 5.5/2.8 μM), induces HeLa apoptosis, elevates PTEN/EGR1/SLIT2, for cancer research.</p>Formule :C30H37FN6O3Couleur et forme :SolidMasse moléculaire :548.65Urease-IN-20
CAS :<p>Urease-IN-20 (compound XBP2) is an inhibitor of Helicobacter pylori (H. pylori), with an IC50 of 0.14 μM for H. pylori inhibition. It effectively decreases apoptosis in GES-1 cells infected with H. pylori and reduces levels of ROS and γH2AX. Urease-IN-20 also demonstrates significant gastric mucosal protective effects, making it suitable for H. pylori research.</p>Formule :C14H8FNO2SeCouleur et forme :SolidMasse moléculaire :320.18STAT3-IN-12
CAS :<p>STAT3-IN-12,STAT3 signaling inhibitor. Blocks IL-6-induced JAK/STAT3 activation. Induces apoptosis. Used in HCC and esophageal cancer research.</p>Formule :C28H30N4O2Degré de pureté :99.19%Couleur et forme :SoildMasse moléculaire :454.56Verrucarin A
CAS :<p>Verrucarin A, a mycotoxin from Myrothecium verrucaria, inhibits protein synthesis, leukemia growth, and triggers apoptosis.</p>Formule :C27H34O9Couleur et forme :SolidMasse moléculaire :502.55Pan-Trk-IN-3
<p>Pan-Trk-IN-3: potent Trk inhibitor (IC50: 2-26 nM), effective against drug-resistant mutants, induces apoptosis, anti-tumor effects.</p>Formule :C29H31ClN8O3Couleur et forme :SolidMasse moléculaire :575.06NLRP3-IN-72
CAS :<p>NLRP3-IN-72 (Compound 2) is a benzimidazole derivative. It exhibits anti-inflammatory and antioxidant properties, with an IC50 of 0.3 μM for NLRP3 IL-1β, a PD50 of 0.4 μM for protection against cell pyroptosis, and an EC50 of 0.6 μM for inducing HO-1.</p>Formule :C19H20FN5OCouleur et forme :SolidMasse moléculaire :353.393BRD-K44839765
CAS :<p>BRD-K44839765 selectively targets Bcl-2, exhibiting an IC50 of 5.6 μM in IMR-90 cells. This compound is also orally active.</p>Formule :C23H19N3O2S2Couleur et forme :SolidMasse moléculaire :433.55Topo I-IN-1
<p>Topo I-IN-1 (14d) is a powerful Topo I inhibitor with antitumor effects and DNA intercalation, inducing apoptosis.</p>Formule :C20H14BrN3O2Couleur et forme :SolidMasse moléculaire :408.25PD-1/PD-L1-IN-16
<p>PD-1/PD-L1-IN-16 is a potent inhibitor of PD-1/PD-L1 (IC50: 53.2 nM) and has shown research potential for tumour immunotherapy.</p>Formule :C34H30N4O4Couleur et forme :SolidMasse moléculaire :558.63Ferroptosis-IN-15
CAS :<p>Ferroptosis-IN-15 (compound 12) serves as an effective inhibitor of ferroptosis, exhibiting EC50 values of 0.76 μM and 0.67 μM in A375 cells and 786-O cells, respectively. It acts as a potential iron chelator and radical-scavenging antioxidant.</p>Formule :C17H14O5Couleur et forme :SolidMasse moléculaire :298.294-Hydroxyresveratrol
CAS :<p>4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene) is a resveratrol analog that variably induces the expression of pro-apoptotic genes such as p53 and Bax. It triggers apoptosis in SV40 virus-transformed WI38 cells (WI38VA), but not in WI38 cells. Additionally, 4-Hydroxyresveratrol significantly increases the expression of p53, GADD45, and Bax genes in WI38VA cells, while suppressing the expression of the bcl-2 gene.</p>Formule :C14H12O4Couleur et forme :SolidMasse moléculaire :244.243Topoisomerase I/II inhibitor 3
<p>Topoisomerase I/II inhibitor 3 suppresses cell growth and induces apoptosis in liver cancer by blocking PI3K/Akt/mTOR.</p>Formule :C24H24N2O4Couleur et forme :SolidMasse moléculaire :404.46ZIF-8
CAS :<p>ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.</p>Formule :C4H6N2ZnCouleur et forme :SolidMasse moléculaire :147.513APD-94
CAS :<p>APD-94 is a dual inhibitor targeting tubulin and Bmi-1. It disrupts the normal polymerization of tubulin and suppresses the expression of Bmi-1. This compound induces cell cycle arrest at the G2/M phase and triggers apoptosis, thereby inhibiting cancer cell proliferation. Additionally, APD-94 inhibits the growth of HT29 cell xenograft tumors in NOD/SCID mice and is applicable to colorectal cancer research.</p>Formule :C18H17N3O4Couleur et forme :SolidMasse moléculaire :339.345MTX-216
CAS :<p>MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.</p>Formule :C22H14Cl2FN5O2SCouleur et forme :SolidMasse moléculaire :502.348M3258
CAS :<p>LMP7-IN-1 may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer, is an inhibitor of</p>Formule :C17H20BNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.16Spicamycin
CAS :<p>Spicamycin can be used as a potent inducer of differentiation of human myeloid leukemia cells (HL-60) and murine myeloid leukemia cells (M1).</p>Formule :C30H51N7O7Couleur et forme :SolidMasse moléculaire :621.77DNMT1-IN-5
CAS :<p>DNMT1-IN-5 (Compound 55) is an inhibitor of DNMT, specifically targeting DNMT1 and DNMT3A, with IC50 values of 2.42 μM and 14.4 μM, respectively. It demonstrates antiproliferative effects across various cancer cell lines (TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226, and HCT116) with IC50 values ranging from 0.19 to 2.37 μM. The compound induces G2/M phase cell cycle arrest and apoptosis in TMD-8 and DOHH2 cells. Additionally, DNMT1-IN-5 exhibits antitumor efficacy in a TMD-8 xenograft mouse model.</p>Formule :C24H32FN7Couleur et forme :SolidMasse moléculaire :437.556Antitumor agent-54
<p>Compound C11 inhibits 14-3-3η protein (KD: 35 μM), targets liver cancer cells, blocks G1-S phase, and induces apoptosis.</p>Formule :C29H32N2O3Couleur et forme :SolidMasse moléculaire :456.58STAT3-IN-9
<p>STAT3-IN-9 hinders STAT3 at Tyr705, doesn't affect STAT1 Tyr701, induces apoptosis, and arrests cells in G2/M phase.</p>Formule :C22H21N3O4Couleur et forme :SolidMasse moléculaire :391.42LL-Z 1640-4
CAS :<p>A signal-specific JNK/p38 pathway and TAK 1 inhibitor</p>Formule :C19H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.39PDEδ/NAMPT IN-1
CAS :<p>PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) with a dissociation constant (KD) of 0.410 nM and nicotinamide phosphoribosyltransferase (NAMPT) with an inhibitory concentration (IC50) of 2.21 nM. It disrupts KRAS-related signaling by inhibiting NAMPT's role in the synthesis of nicotinamide adenine dinucleotide (NAD+), consequently inducing apoptosis in pancreatic cancer cells with KRAS mutations. This compound holds potential for research in KRAS-mutant pancreatic cancer.</p>Formule :C26H30N4O4SCouleur et forme :SolidMasse moléculaire :494.61PI3Kα-IN-8
<p>PI3Kα-IN-8 is a selective inhibitor of PI3Kα (IC50: 0.012 μM).</p>Formule :C26H27BrN4O2Couleur et forme :SolidMasse moléculaire :507.42Tubulin polymerization-IN-3
<p>Tubulin polymerization-IN-3 is a potent inhibitor of microtubulin polymerization (IC50: 3.84 μM) and induces apoptosis in colon cancer cells.</p>Formule :C20H20ClN5O3Couleur et forme :SolidMasse moléculaire :413.86Casein kinase 1δ-IN-29
CAS :<p>Casein kinase1δ-IN-29 (Compound 18) is an inhibitor that targets p38α and casein kinase 1 (CK1), exhibiting inhibitory effects on p38α, CK1δ, and CK1ε with IC50 values of 0.041 µM, 0.005 µM, and 0.447 µM, respectively. This compound causes cell cycle arrest at the subG1 phase and induces apoptosis in AC1-M88 cells.</p>Formule :C26H23FN4O4SCouleur et forme :SolidMasse moléculaire :506.549Pim-1 kinase inhibitor 2
CAS :<p>Compound 13, a potent Pim-1 inhibitor, induces apoptosis with potential for cancer research.</p>Formule :C24H14N4O3Couleur et forme :SolidMasse moléculaire :406.39IMB5046
CAS :<p>IMB5046 is a microtubule inhibitor that induces apoptosis (cell death) by obstructing the G2/M phase of the cell cycle. It possesses antitumor properties.</p>Formule :C19H20N2O5SCouleur et forme :SolidMasse moléculaire :388.438MRK003
CAS :<p>MRK003, a γ-secretase inhibitor, induces apoptosis, halts cell growth in myeloma/NHL, and affects notch signaling and PI3K/Akt pathway.</p>Formule :C25H31F6N3O2SCouleur et forme :SolidMasse moléculaire :551.59S100A2-p53-IN-1
CAS :<p>S100A2-p53-IN-1 inhibits S100A2-p53 in pancreatic cancer, stunting MiaPaCa-2 cell growth at 1.2-3.4 μM.</p>Formule :C20H20F6N2O4SCouleur et forme :SolidMasse moléculaire :498.44EGFR-IN-161
CAS :<p>EGFR-IN-161 (Compound DD-8) is a potent and reversible inhibitor of the L858R/T790M/C797S mutant EGFR kinase, with an IC50 value of 0.87 nM. EGFR-IN-161 effectively inhibits tumor cell apoptosis, G1 phase arrest, and migration.</p>Formule :C33H36Cl2N8O2Couleur et forme :SolidMasse moléculaire :647.597Anticancer agent 54
<p>Anticancer agent 54 blocks cell cycle in G0/G1, induces apoptosis, and fights cancer via DNA embedding and ROS.</p>Formule :C33H36N6Couleur et forme :SolidMasse moléculaire :516.68Caspase-3-IN-2
CAS :<p>Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.</p>Formule :C10H6ClNO5Couleur et forme :SolidMasse moléculaire :255.611Anticancer agent 65
CAS :<p>Anticancer agent 65: Effective on A549 cells, IC50 1.07 μM, halts S phase, triggers apoptosis, elevates p53/p21, causes ROS and MMP collapse.</p>Formule :C36H63NO5Couleur et forme :SolidMasse moléculaire :589.89HDL-16
CAS :<p>HDL-16 is a highly effective P2Y14R antagonist with anti-colitis effects, targeting P2Y14R in intestinal epithelial cells to alleviate ulcerative colitis.</p>Formule :C14H11BrN2ODegré de pureté :97.58%Couleur et forme :SolidMasse moléculaire :303.15MTDH-SND1 blocker 2
CAS :<p>MTDH-SND1 blocker 2 (compound C19) is an effective MTDH-SND1 inhibitor with an IC50 value of 487 nM. It binds to the SND1 protein with a Kd of 279 nM and can degrade the SND1 protein. Additionally, MTDH-SND1 blocker 2 exhibits antiproliferative activity and induces apoptosis, showing potential for breast cancer research.</p>Formule :C18H12FN3O2SCouleur et forme :SolidMasse moléculaire :353.37Bim-IN-1
<p>Bim-IN-1 is a potent inhibitor of Bim expression with low toxicity, Bim-IN-1 reduces Bim expression levels with little inhibition of protein kinase A.</p>Formule :C19H20Cl2FNO2SCouleur et forme :SolidMasse moléculaire :416.34NSD2-IN-1
CAS :<p>NSD2-IN-1: potent, selective NSD2-PWWP1 inhibitor, IC50 0.11 μM, induces gene expression changes, apoptosis, cell cycle arrest.</p>Formule :C29H31N5Couleur et forme :SolidMasse moléculaire :449.59PD-1/PD-L1-IN-17
<p>PD-1/PD-L1-IN-17 (Compound P20) is a potent PD-1/PD-L1 inhibitor (IC50: 26.8 nM).</p>Formule :C23H20ClN3O4Couleur et forme :SolidMasse moléculaire :437.88BCL6-IN-9
CAS :<p>BCL6-IN-9 (compound 1) is a potent inhibitor of B-cell lymphoma 6 protein (BCL6) (IC50: 3.9 nM) and can be used to study cancer.</p>Formule :C22H18ClF2N5O2Couleur et forme :SolidMasse moléculaire :457.86FAK-IN-4
<p>FAK-IN-4 (Compound 7d) has anticancer activities that can induce cell apoptosis. FAK-IN-4 is potential inhibitor of FAK [1].</p>Formule :C20H22N4OCouleur et forme :SolidMasse moléculaire :334.41GGTI298
CAS :<p>GGTI298 is a potent GGTase I inhibitor; IC50 3μM for Rap1A, >20μM for Ha-Ras.</p>Formule :C27H33N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :479.63AQX-435
CAS :<p>AQX-435 activates SHIP1, inhibits PI3K in BCR signaling, induces apoptosis in B cells, and slows lymphoma growth.</p>Formule :C27H34N2O4Couleur et forme :SolidMasse moléculaire :450.57CRT0066101
CAS :<p>CRT0066101 is a potent, orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM, and 2 nM for PKD1, PKD2, and PKD3, respectively [1]. Additionally, it inhibits PIM2 with an IC 50 of approximately 135.7 nM and demonstrates anticancer effects [2].</p>Formule :C18H22N6OCouleur et forme :SolidMasse moléculaire :338.41Topoisomerase I/II inhibitor 4
<p>Topoisomerase I/II inhibitor 4 halts cell growth and spread, induces apoptosis, and is used in liver cancer research.</p>Formule :C27H21N5O6Couleur et forme :SolidMasse moléculaire :511.49Bomedemstat hydrochloride
<p>Bomedemstat (IMG-7289) hydrochloride, an oral LSD1 inhibitor, has anticancer properties, blocking cell growth and triggering apoptosis.</p>Formule :C28H35ClFN7O2Couleur et forme :SolidMasse moléculaire :556.08Flonoltinib sulfate
CAS :<p>Flonoltinib maleate is an orally active dual inhibitor of JAK2/FLT3, with IC50 values of 0.7 nM for JAK2, 4 nM for FLT3, 26 nM for JAK1, and 39 nM for JAK3. It exhibits anticancer properties.</p>Formule :C25H36FN7O5SCouleur et forme :SolidMasse moléculaire :565.661Samuraciclib hydrochloride hydrate
<p>Samuraciclib (CT7001) is a potent oral CDK7 inhibitor (IC50: 41 nM) with anti-breast cancer properties.</p>Formule :C22H35ClN6O3Couleur et forme :SolidMasse moléculaire :521.7T0080
CAS :<p>T0080 is an FPR-1 antagonist. It reduces apoptosis (Apoptosis) and inhibits the production of reactive oxygen species (ROS) and pro-inflammatory cytokines (TNF-α and IL-1β) in plaque macrophages within ApoE−/− mouse models, thereby slowing the progression of atherosclerosis.</p>Formule :C24H22F3N3O3Couleur et forme :SolidMasse moléculaire :457.45Autophagy inducer 7
CAS :<p>Autophagyinducer 7 (Compound SSA) serves as an inducer of autophagy (Autophagy) and apoptosis (Apoptosis). It stimulates autophagy by inhibiting Akt/mTOR signaling and the expression of downstream proteins. Additionally, Autophagyinducer 7 suppresses DNA synthesis and causes G0-G1 cell cycle arrest, ultimately inhibiting the growth of tumor cells.</p>Formule :C24H27FN2OSCouleur et forme :SolidMasse moléculaire :410.547Enpp-1-IN-25
CAS :<p>Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.</p>Formule :C15H21N5O4SCouleur et forme :SolidMasse moléculaire :367.423MI-888 TFA
CAS :<p>MI-888 (TFA) is an orally active inhibitor of the MDM2-p53 interaction with a Ki of 0.44 nM. It can induce rapid, complete, and durable tumor regression in xenograft mouse models.</p>Formule :C30H33Cl2F4N3O5Couleur et forme :SolidMasse moléculaire :662.5GP130-IN-1
CAS :<p>GP130-IN-1 (compound 49) is an effective inhibitor of GP130, demonstrating significant in vitro anti-tumor activity and higher selectivity compared to Bazedoxifene. It induces ultrastructural changes in cells, leading to a time-dependent arrest of the cell cycle at the G0/G1 phase, and triggers both apoptosis and autophagy. GP130-IN-1 is useful for research on triple-negative breast cancer.</p>Formule :C21H10F5NO3Couleur et forme :SolidMasse moléculaire :419.30TI17
CAS :<p>TI17 is a selective TRIP13 inhibitor with anticancer activity and inhibits proliferation of multiple myeloma (MM) cells</p>Formule :C23H22N2O3Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :374.43CCT369260
CAS :<p>CCT369260 (compound 1), an orally active inhibitor targeting B-cell lymphoma 6 (BCL6), demonstrates anti-tumor efficacy with an IC50 value of 520 nM [1].</p>Formule :C24H31ClF2N6O2Couleur et forme :SolidMasse moléculaire :508.99DL-Buthionine-(S,R)-sulfoximine hydrochloride
<p>DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent and specific glutamylcysteine synthetase biosynthesis inhibitor</p>Formule :C8H19ClN2O3SCouleur et forme :SolidMasse moléculaire :258.77eIF4A3-IN-4
<p>eIF4A3-IN-4 is a novel inhibitor of eIF4A (IC50: 8.6 μM).</p>Formule :C24H20N2O5Couleur et forme :SolidMasse moléculaire :416.43SL-176
CAS :<p>SL-176, a WIP1 inhibitor, when combined with GSK-J4, can induce cell cycle arrest and apoptosis (apoptosis), thereby inhibiting tumor growth both in vitro and in vivo.</p>Formule :C24H48O4Si2Couleur et forme :SolidMasse moléculaire :456.806Antitumor agent-37
<p>Antitumor agent-37: strong anti-growth, anti-spread, induces DNA damage, apoptosis via Bcl-2/Bax/caspase3, boosts immune response.</p>Formule :C16H18Cl2N2O4PtCouleur et forme :SolidMasse moléculaire :568.32TAS-117 hydrochloride
<p>TAS-117 HCl: potent oral Akt inhibitor (Akt1 IC50: 4.8nM, Akt2: 1.6nM, Akt3: 44nM), boosts anti-myeloma effects, induces cell death.</p>Formule :C26H25ClN4O2Couleur et forme :SolidMasse moléculaire :460.96TrxR-IN-8
CAS :<p>TrxR-IN-8 (Compound 6f) is a selective inhibitor of TrxR with an IC50 of 10.2 μM. It induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species, reducing intracellular thiols, and lowering the glutathione/glutathione disulfide ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells.</p>Formule :C16H16INO2Couleur et forme :SolidMasse moléculaire :381.21MLS-0053105
CAS :<p>MLS-0053105, a chloromaleimide, functions as a selective inhibitor of BFL-1, exhibiting an IC50 of 0.4 µM against Bfl-1/F-Bid. Its inhibitory potency is over tenfold lower for Bcl-W, Bcl-2, and Bcl-XL, and it shows no activity against Bcl-B and Mcl-1.</p>Formule :C15H14Cl3N3O2Couleur et forme :SolidMasse moléculaire :374.65Casuarinin
CAS :<p>Casuarinin, an ellagitannin found in pomegranates and certain Casuarina/Stachyurus plants, is a carbonic anhydrase inhibitor and astringent.</p>Formule :C41H28O26Couleur et forme :SolidMasse moléculaire :936.65PARP1-IN-12
<p>PARP1-IN-12: potent PARP1 inhibitor, IC50 2.99 nM, triggers cell apoptosis, G2/M arrest, induces DSBs in BRCA-deficient cells.</p>Formule :C43H56FN5O5Couleur et forme :SolidMasse moléculaire :741.93CDK2/9-IN-1
CAS :<p>CDK2/9-IN-1 (compound 20a) is an orally active dual inhibitor of CDK2 and CDK9, with IC50 values of 0.004 μM and 0.009 μM for CDK2 and CDK9, respectively. It induces apoptosis by regulating G2/M cell cycle arrest and exhibits antitumor activity.</p>Formule :C14H14N6O2S2Couleur et forme :SolidMasse moléculaire :362.43mTOR/HDAC6-IN-1
<p>mTOR/HDAC6-IN-1 inhibits HDAC6 (IC50: 56 nM) & mTOR (IC50: 133.7 nM), may treat TNBC by inducing autophagy and apoptosis.</p>Formule :C20H20ClN5O2Couleur et forme :SolidMasse moléculaire :397.86PD-1/PD-L1-IN-30
CAS :<p>PD-1/PD-L1-IN-30: Cancer research inhibitor with 0.018 μM IC50.</p>Formule :C29H28F3NO5Couleur et forme :SolidMasse moléculaire :527.53PARP/NAMPT-IN-1
CAS :<p>PARP/NAMPT-IN-1 (Compound 13j) is a dual-target inhibitor of PARP and NAMPT, with IC50 values of 0.8 nM for PARP1 and 18 nM for NAMPT. It suppresses breast cancer cell proliferation and migration, inducing apoptosis. PARP/NAMPT-IN-1 is applicable for research on triple-negative breast cancer.</p>Formule :C34H36FN7O3Couleur et forme :SolidMasse moléculaire :609.693Sabialimon P
CAS :<p>Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.</p>Formule :C31H50O4Couleur et forme :SolidMasse moléculaire :486.73hCAIX/XII-IN-1
<p>hCAIX/XII-IN-1: potent CAIX inhibitor (KI=0.48μM), CAXII (KI=0.83μM), antiproliferative, induces apoptosis in MCF-7 cells.</p>Formule :C19H11NO5S2Couleur et forme :SolidMasse moléculaire :397.42ERK1/2 inhibitor 11
<p>ERK1/2 inhibitor 11 (compound L6) is a dual inhibitor of ERK1/2 that promotes the accumulation of DSBs and the degradation of ERK1/2 expression. This compound decreases BCL-2 levels and induces DNA damage by inhibiting PARP and ERK1/2. Additionally, ERK1/2 inhibitor 11 activates caspase 3 to induce apoptosis.</p>Formule :C15H19N5O2SCouleur et forme :SolidMasse moléculaire :333.41HDAC-IN-81
CAS :<p>HDAC-IN-81 (Compound 11g) is an HDAC inhibitor capable of effectively inhibiting HDAC1 with an IC50 value of 4.5 nM. Additionally, it exhibits anticancer activity by inhibiting cell proliferation and can induce cell apoptosis (apoptosis).</p>Formule :C20H27N3O3Couleur et forme :SolidMasse moléculaire :357.45Antitumor agent-58
<p>Antitumor agent-58 suppresses tumor growth, colony formation, cell migration, and induces mitochondrial dysfunction in MGC-803 cells.</p>Formule :C27H28F3N9SCouleur et forme :SolidMasse moléculaire :567.63Sinulatumolin E
CAS :<p>Sinulatumolin E, a terpenoid, inhibits TNF-α (IC 50: 3.6 μM); has anti-inflammatory properties.</p>Formule :C15H22O2Couleur et forme :SolidMasse moléculaire :234.33Top/HDAC-IN-1
<p>Top/HDAC-IN-1: Dual Top/HDAC inhibitor, potent against HDAC1-3,6,8 and HCT116 cells; blocks G2 phase, induces apoptosis.</p>Formule :C29H27N5O4Couleur et forme :SolidMasse moléculaire :509.56BRD4/CK2-IN-1
CAS :<p>BRD4/CK2-IN-1 is a small-molecule inhibitor targeting BRD4 and CK2, inducing apoptosis and autophagy-related cell death.</p>Formule :C29H30ClN5O5Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :564.03Lometrexol hydrate
CAS :<p>Lometrexol hydrate, an antipurine antifolate, inhibits GARFT and purine synthesis, leading to cancer cell apoptosis without causing DNA breaks.</p>Formule :C21H27N5O7Couleur et forme :SolidMasse moléculaire :461.475DX3-234
CAS :<p>DX3-234 is a OXPHOS inhibitor that acts by inhibiting complex I in the mitochondrial ETC,for cancers dependent on aerobic metabolism, such as pancreatic cancer.</p>Formule :C25H35N5O6S2Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :565.71Nitrovin
CAS :<p>Nitrovin is an antimicrobial growth promoter that induces ROS-mediated non-apoptotic and quasi-apoptotic cell death by targeting TrxR1. It exhibits anticancer activity with IC50 values ranging from 1.31 to 6.60 μM for both tumor and normal cells.</p>Formule :C14H12N6O6Couleur et forme :SolidMasse moléculaire :360.28Bafilomycin C1
CAS :<p>vacuolar H+-ATPases (V-ATPases) inhibitor</p>Formule :C39H60O12Degré de pureté :98%Couleur et forme :Light Tan SolidMasse moléculaire :720.89Nenocorilant
CAS :<p>Nenocorilant (Relacorilant) is an orally active glucocorticoid receptor (GR) antagonist (Ki: 0.15 nM). Nenocorilant can be used to study tumours.</p>Formule :C26H21F4N7O3SCouleur et forme :SolidMasse moléculaire :587.55Belotecan
CAS :<p>Belotecan (CKD-602) inhibits DNA topoisomerase I, blocks cell cycle, induces apoptosis, and is a camptothecin-derived anticancer agent.</p>Formule :C25H27N3O4Couleur et forme :SolidMasse moléculaire :433.5RWJ-56110
CAS :<p>protease-activated receptor-1 (PAR1) antagonist</p>Formule :C41H43Cl2F2N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :790.73(S)-Purvalanol B
CAS :<p>(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is an inhibitor of cyclin-dependent kinase(CDK) .</p>Formule :C20H25ClN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.9AB8939
CAS :<p>AB8939 is a potent small-molecule inhibitor of microtubule/tubulin polymerization, exhibiting antitumor activity (with tumor cell proliferation inhibition IC50≤10 nM). It effectively circumvents resistance mechanisms mediated by P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis.</p>Formule :C22H24N4O3Couleur et forme :SolidMasse moléculaire :392.451RSK-IN-2
CAS :<p>RSK-IN-2 (Compound 3e) is an inhibitor of RSK, showing IC50 values of 37.89 nM for RSK2, 30.78 nM for RSK1, 20.51 nM for RSK3, and 91.28 nM for RSK4. It suppresses tumor cell proliferation, induces apoptosis, and causes cell cycle arrest at the G2/M phase.</p>Formule :C25H30ClN7O3Couleur et forme :SolidMasse moléculaire :512.004HAC-Y6
CAS :<p>HAC-Y6 exerts its anticancer effects by inducing cell cycle arrest. It prompts apoptosis in COLO 205 cells with an IC50 of 0.52 µM.</p>Formule :C23H22N2O4Couleur et forme :SolidMasse moléculaire :390.43Antitumor agent-78
<p>Antitumor agent-78 blocks GPx-4, raises COX2, triggers apoptosis, halts EMT, and stifles cancer cell growth and migration.</p>Couleur et forme :SoildFosizensertib
CAS :<p>Fosizensertib is an inhibitor of RIP-1 kinase and is used in research related to ulcerative colitis.</p>Formule :C22H21F2N4O5PCouleur et forme :SolidMasse moléculaire :490.397PROTAC FKBP Degrader-3
CAS :<p>PROTAC FKBP Degrader-3, with FKBP and VHL binding groups linked, is a potent FKBP degrader.</p>Formule :C68H90N6O17SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1295.54PI3K-IN-35
CAS :<p>PI3K-IN-35 (6l) selectively inhibits PI3K-α, β, δ (IC50: 13.98, 7.22, 10.94 μM), blocks G2/M phase, induces apoptosis, and is useful in leukemia research.</p>Formule :C25H23N7O2Couleur et forme :SolidMasse moléculaire :453.5Antitumor agent-202
CAS :<p>Antitumor agent-202 is a stabilizer of the p53Y220C mutant, selectively inhibiting the proliferation of tumor cells carrying the p53Y220C mutation. It is applicable for research focused on cancers associated with the p53 Y220C mutation.</p>Formule :C17H13NOCouleur et forme :SolidMasse moléculaire :247.291AKT-IN-3
CAS :<p>AKT-IN-3: potent oral Akt inhibitor with low hERG blockage. IC50: 1.4-1.7 nM for Akt1-3. Inhibits AGC kinases like PKA, PKC.</p>Formule :C23H23Cl2F2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :526.36WF-47-JS03
<p>WF-47-JS03: RET kinase inhibitor, crosses blood-brain barrier, 500x more selective for KDR, IC50: 1.7 nM in Ba/F3 cells, 5.3 nM in LC-2/ad lung cancer cells.</p>Formule :C30H38N6O2Couleur et forme :SolidMasse moléculaire :514.66Mcl-1 inhibitor 21
CAS :<p>Mcl-1 inhibitor21 (Example 1-36) is an Mcl-1 inhibitor with an IC50 of 328 nM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it applicable for cancer research.</p>Formule :C32H33N3O4Couleur et forme :SolidMasse moléculaire :523.622FTO-IN-13
CAS :<p>FTO-IN-13 (compound 8t) is a potent FTO inhibitor with antiproliferative properties. It induces apoptosis (cell apoptosis) and reduces the expression of Bcl-2 and Caspase 3 active proteins. Additionally, FTO-IN-13 lowers the expression of MYC and CEBPA genes and demonstrates anticancer activity.</p>Formule :C18H12Br2N2O4Couleur et forme :SolidMasse moléculaire :480.107Mcl-1 inhibitor 22
CAS :<p>Mcl-1 inhibitor22 (Example 36) is an MCL-1 inhibitor that suppresses its anti-apoptotic function by blocking the interaction between MCL-1 and pro-apoptotic proteins. It exhibits antiproliferative activity against various cancer cell lines and can be utilized for cancer research.</p>Formule :C33H33ClFN3O4Couleur et forme :SolidMasse moléculaire :590.084TRPM7-IN-1
CAS :<p>TRPM7-IN-1 (compound SUD) is a benzamide-urea derivative and an effective inhibitor of TRPM7. This compound induces cell cycle arrest and apoptosis in MCF-7 and BGC-823 cells, reducing their migration capabilities. It decreases vimentin expression while increasing E-cadherin expression. TRPM7-IN-1 reduces TRPM7-like currents and inhibits TRPM7 expression by activating the PI3K/Akt signaling pathway. This compound shows potential as a therapeutic agent for reducing breast and gastric cancer metastasis by targeting TRPM7 expression and activity.</p>Formule :C23H25N5O3Couleur et forme :SolidMasse moléculaire :419.48L-threo-Sphingosine C-18
CAS :<p>L-threo-Sphingosine C-18 is a protein kinase C inhibitor.</p>Formule :C18H37NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :299.49ASTX295
CAS :<p>ASTX295 is a selective mouse double minute 2 (MDM2) antagonist with an IC50 value of less than 1 nM. It specifically inhibits the interaction between MDM2 and p53, reactivating wild-type (WT) TP53, which subsequently induces the expression of related transcriptional targets, leading to cell death and cell cycle arrest. ASTX295 holds potential for research in lymphoid malignancies such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and T-cell lymphoma.</p>Formule :C33H34Cl2FNO6Couleur et forme :SolidMasse moléculaire :630.531
