Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(137 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(94 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6231 produits trouvés pour "Apoptose"
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TNF-α-IN-9
CAS :TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.Formule :C17H14O4Degré de pureté :99.21%Couleur et forme :SoildMasse moléculaire :282.29Citreoviridin
CAS :Citreoviridin from Penicillium citreoviride blocks brain Na+/K+-ATPase; boosts Na+/K+- and Mg2+-ATPase in microsomes dose-dependently.Formule :C23H30O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.48Nrf2 activator-9
Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-densityFormule :C26H27N5O4Couleur et forme :SolidMasse moléculaire :473.52MDM2/4-p53-IN-2
MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.Formule :C25H17Cl3FN3O3Couleur et forme :SolidMasse moléculaire :532.78Inuviscolide
CAS :Inuviscolide induces apoptosis, G2/M arrest in melanoma, and has anti-cancer, anti-inflammatory effects.Formule :C15H20O3Couleur et forme :SolidMasse moléculaire :248.32XIAP BIR2/BIR2-3 inhibitor-3
CAS :XIAP BIR2/BIR2-3 Inhibitor-3 functions as a dual inhibitor targeting both BIR2 and BIR2-3 domains, exhibiting potent activity with IC50 values below 1 nM. This compound is utilized in cancer research [1].Formule :C86H106N18O16S2Couleur et forme :SolidMasse moléculaire :1712Enpp/Carbonic anhydrase-IN-2
CAS :Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.Formule :C23H24FNO4SDegré de pureté :99.46%Couleur et forme :SoildMasse moléculaire :429.5Ref: TM-T77631
1mg44,00€5mg90,00€1mL*10mM (DMSO)96,00€10mg145,00€25mg236,00€50mg338,00€100mg460,00€200mg622,00€RIPK2-IN-2
CAS :RIPK2-IN-2, a RIP2 kinase PROTAC inhibitor, blocks proinflammatory signaling in autoinflammatory diseases.Formule :C53H65FN14O7S2Couleur et forme :SolidMasse moléculaire :1093.3YB-0158
CAS :YB-0158 inhibits Wnt, targets colorectal CSCs, disrupts Sam68/Src, induces apoptosis, and has anti-cancer properties.Formule :C32H32N7Na2O7PCouleur et forme :SolidMasse moléculaire :703.59CSN5-IN-2
CSN5-IN-2 (Compound 31) is a CSN5 inhibitor with an IC50 of 0.36 μM. It increases Cullin 1 neddylation levels in cancer cells and downregulates the expression of RAD51 and PD-L1. CSN5-IN-2 exhibits antitumor activity, which is enhanced when used in combination with Talazoparib.Couleur et forme :Odour SolidEGFR T790M/L858R-IN-2
EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.Formule :C28H28FN7OCouleur et forme :SolidMasse moléculaire :497.57Pipernonaline
CAS :Pipernonaline is a useful organic compound for research related to life sciences. The catalog number is T124000 and the CAS number is 88660-10-0.Formule :C21H27NO3Couleur et forme :SolidMasse moléculaire :341.451PD-L1-IN-5
PD-L1-IN-5 (X22) is an orally active PD-L1 inhibitor with an IC50 of 785.6 nM, demonstrating antitumor activity in vivo.PROTAC EGFR degrader 9
CAS :PROTACEGFRdegrader 9 (Compound C6) is an orally active, CRBN-based PROTAC EGFR degrader. It has a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTACEGFRdegrader 9 demonstrates effective degradation activity against various EGFR mutants while not affecting EGFRWT.
Formule :C45H48F3N9O6SMasse moléculaire :899.98Nemorosone
CAS :Nemorosone, a PPAP from C. rosea, inhibits neuroblastoma and pancreatic cancer cell growth, induces apoptosis, and reduces mouse xenograft tumors.Formule :C33H42O4Couleur et forme :SolidMasse moléculaire :502.695GDCNF-11
CAS :GDCNF-11, an HSP90-based HIM-PROTACGPX4 degrader, facilitates the ubiquitination and degradation of GPX4 through the HSP90 chaperone complex. This reduction in endogenous GPX4 induces ferroptosis in HT-1080 cells, with a DC50 value of 0.08 μM.Formule :C48H53Cl2N13O5SCouleur et forme :SolidMasse moléculaire :994.99CDK9-IN-36
CDK9-IN-36 (Compound T7) is a potent, selective, and metabolically stable CDK9 inhibitor with an IC50 value of 1.2 nM. It effectively suppresses the proliferation of Osimertinib-resistant NSCLC cells by downregulating Mcl-1, reducing colony formation, and inducing apoptosis. Additionally, CDK9-IN-36 exhibits antitumor activity in xenograft models.Formule :C30H33F2N5O4Couleur et forme :SolidMasse moléculaire :565.61Sterigmatocystine
CAS :Sterigmatocystine, a G1 phase and DNA synthesis inhibitor, curbs p21 and is a mycotoxin precursor from Aspergillus versicolor.Formule :C18H12O6Degré de pureté :98%Couleur et forme :Pale-Yellow Crystals Pale Yellow SolidMasse moléculaire :324.28PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withCouleur et forme :Odour SolidRef: TM-L1300
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderCXCR4-IN-2
CXCR4-IN-2 (compound A1), a potent bifunctional fluorinated small molecule, inhibits CXCR4 and exhibits anticancer properties by exerting cytotoxicity (IC 50:Formule :C21H20F6N4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.47EGFR-IN-144
EGFR-IN-144 (Compound 4B) inhibits EGFR (IC50=0.639 µg/mL) and tubulin polymerization (IC50=7.339 µg/mL). It exhibits cytotoxicity in various cancer cells with a GI50 at the nanomolar level. EGFR-IN-144 reduces the expression of mTOR, TNF-α, and IL-6, causes G1/S phase cell cycle arrest, and induces apoptosis.Formule :C20H17Cl2N3O3Couleur et forme :SolidMasse moléculaire :418.273CYP51/PD-L1-IN-2
CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.Formule :C25H23N7O3Couleur et forme :SolidMasse moléculaire :469.5PROTAC EGFR degrader 6
CAS :PROTAC EGFR degrader 6 effectively degrades EGFR Del19 in HCC827 cells (DC50=45.2 nM) and induces apoptosis and G1 arrest.Formule :C49H57FN12O5Couleur et forme :SolidMasse moléculaire :913.052,2-Dimethyl-2,3-dihydrobenzofuran-7-ol
CAS :2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol inhibits the proliferation of the THP-1 cell line and anti-infective Leishmania and Toxoplasma gondii RH.Formule :C10H12O2Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :164.20PPA-904 FA
PPA-904 FA is a cationic photosensitizer with antimicrobial activity that can be used to study chronic leg ulcers and diabetic foot ulcers.Formule :C29H43N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :497.74Golimumab
CAS :Golimumab (CNTO-148), an anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anti-cancer activity, can be used to prevent inflammation and cartilage.Couleur et forme :LiquidMasse moléculaire :146.93 kDaAcetyl coenzyme A
CAS :Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways in the tricarboxylic acid cycle, fatty acid synthesisFormule :C23H38N7O17P3SDegré de pureté :91.68%Couleur et forme :SolidMasse moléculaire :809.57Verproside
CAS :Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.Formule :C22H26O13Couleur et forme :SolidMasse moléculaire :498.437Antitumor agent-145
CAS :Compound Ir5 (Antitumor agent-145) serves as a tumor inhibitor characterized by significant fluorescence and mitochondrial targeting. It promotes anti-cancer activity by inducing necroptosis and stimulating the necroptosis-related immune response [1].Formule :C44H34IrN5OSCouleur et forme :SolidMasse moléculaire :873.06Etanercept
CAS :Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.
Degré de pureté :98%Couleur et forme :LiquidN-Acetylpsychosine
CAS :N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties.
Formule :C26H49NO8Couleur et forme :SolidMasse moléculaire :503.67EGFR-PK/JNK-2-IN-1
EGFR-PK/JNK-2-IN-1 (Compound 6c) is a dual inhibitor of EGFR-PK and JNK-2, with IC50 values of 2.7 and 3.0 μM, respectively. It can induce apoptosis and cause cell cycle arrest at various stages. This compound is applicable in cancer research.Formule :C22H17ClN4O3SMasse moléculaire :452.07099Flavopiridol
CAS :Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Formule :C21H20ClNO5Degré de pureté :97.74% - 99.99%Couleur et forme :SolidMasse moléculaire :401.84Macrophage-activating lipopeptide 2 TFA
Macrophage-activating lipopeptide 2 TFA (MALP-2 TFA) is a diacylglycerol lipopeptide and TLR-2/TLR-6 agonist activates immune cell responses macrophages,Formule :C99H167N19O30S·xC2HF3O2Degré de pureté :97.56%Couleur et forme :SolidMasse moléculaire :2135.56 (free base)PDE4B-IN-4
PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.Formule :C26H27N5O5Couleur et forme :SolidMasse moléculaire :489.52Thalidomide-NH-amido-C6-NH2 hydrochloride
Thalidomide-NH-amido-C6-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, designed for the synthesis of PROTAC.Formule :C21H28ClN5O5Masse moléculaire :465.1779Narasin
CAS :Narasin inhibits dengue virus, treats coccidiosis without harm to cells, and induces cancer cell apoptosis.Formule :C43H72O11Couleur et forme :SolidMasse moléculaire :765.03Thalidomide-O-C5-acid
CAS :Thalidomide-O-C5-acid, a synthesized E3 ligase linker, merges cereblon and PROTAC tech.Formule :C19H20N2O7Couleur et forme :SolidMasse moléculaire :388.376W1131 TFA
W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.Formule :C25H20F3N5O6Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :543.45Ref: TM-T80847
1mL*10mM (DMSO)À demander1mg92,00€5mg188,00€10mg311,00€25mg628,00€50mg1.008,00€100mg1.596,00€Aphidicolin
CAS :Aphidicolin blocks DNA synthesis, hinders herpes virus growth, and stimulates apoptosis in leukemia cells; it's a mold-derived DNA polymerase inhibitor.Formule :C20H34O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :338.48Etoposide phosphate disodium
CAS :Etoposide phosphate disodium, a prodrug of etoposide, is a powerful anticancer drug inhibiting DNA topoisomerase II.
Formule :C29H31Na2O16PCouleur et forme :SolidMasse moléculaire :712.5SB 699551
CAS :SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.Formule :C34H45N3ODegré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :511.74Ref: TM-T23325L
1mg190,00€5mg471,00€10mg662,00€25mg1.036,00€50mg1.429,00€100mg1.821,00€200mg2.489,00€HMGB1-IN-1
HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/Formule :C57H75N3O15Couleur et forme :SolidMasse moléculaire :1042.22Liensinine Perchlorate
CAS :Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
Formule :C37H43ClN2O10Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :711.2FOXO4-DRI
CAS :FOXO4-DRI: a peptide blocking FOXO4/p53 interaction; induces senescent cells' apoptosis.Formule :C228H388N86O64Couleur et forme :SolidMasse moléculaire :5358.06PUMA BH3
PUMA BH3 activates Bak, binds Bcl-2; triggers apoptosis via cytochrome C release; Kd 26 nM.Formule :C128H202N42O43SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3049.3(-)-Mcl-1 inhibitor 21
CAS :(-)-Mcl-1 inhibitor 21 (Example 1-38) is an Mcl-1 inhibitor with an IC50 of 7.51 μM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.
Formule :C32H33N3O4Couleur et forme :SolidMasse moléculaire :523.622Nargenicin
CAS :Nargenicin: a macrolide antibiotic effective against S. aureus, MRSA, M. luteus; inhibits bacterial DnaE and reduces inflammation and leukemia cell growth.Formule :C28H37NO8Couleur et forme :SolidMasse moléculaire :515.6UM4118
CAS :UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier used in the study of acute myeloid leukemia.Formule :C15H11N3ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :249.27Fluoxetine-Conjugated Platinum(IV) prodrug-1
Fluoxetine-Conjugated Platinum(IV) prodrug-1 is an eEF2K inhibitor that can hinder the proliferation of cancer cells, induce DNA damage, and cause cell cycle arrest at the S phase, leading to apoptosis (Apoptosis). It also promotes the accumulation of reactive oxygen species (ROS) and disrupts mitochondrial function. This prodrug inhibits the migration and invasion of TNBC cells by suppressing MMP-2 activity and induces autophagy in TNBC cells through AMPK activation. In the 4T1-Luc mouse model, it exhibits antitumor activity and triggers immune suppression. Fluoxetine-Conjugated Platinum(IV) prodrug-1 is relevant for research in triple-negative breast cancer (TNBC).Formule :C21H28Cl2F3N3O5PtCouleur et forme :SolidMasse moléculaire :724.1006
