Apoptose

<p>Thalidomide-O-amido-C4-NH2 is a thalidomide cereblon ligand-linker used for PROTAC synthesis as an E3 ligase.</p>

<p>5-(N,N-Hexamethylene)-amiloride (5-HMA) is an amiloride derivative that inhibits TRPA1-mediated calcium signaling (IC50: 35 μM). It functions as an inhibitor of the Na+/H+ exchanger (NHE) with Ki values ranging from 0.013 to 2.4 μM for various NHE isoforms. Additionally, 5-HMA blocks ASIC3 channels by 51% at 20 μM.</p>

<p>KT-474 (KYM-001) is a PROTAC degrader targeting IRAK4 with antitumor activity for the study of autoimmune diseases.</p>

<p>Propylparaben sodium, a plant-based preservative used in cosmetics, pharma, and food, hinders follicle growth and sperm health.</p>

<p>5-Methoxyuridine (Mo5U) is an antitumor purine analog that inhibits DNA synthesis and induces apoptosis in lymphatic cancers.</p>

<p>(Rac)-Apremilast D5 is a deuterium-labeled version of the enantiomer (R)-Apremilast, also known as (R)-CC-10004, which itself is one specific form of Apremilast</p>

<p>3,4,5-Trihydroxycinnamic acid decyl ester is an anti-obesity agent that inhibits lipid absorption and pancreatic lipase (EC50 ≈ 0.9μM).</p>

<p>BCL6-IN-5 is a highly effective inhibitor of BCL6. It exhibits a pIC50 value of 5.82.</p>

Saquinavir mesylate (Ro 31-8959/003) is an Inhibitor of HIV Proteaseused in antiretroviral therapy

<p>Busulfan-d8 (Sulphabutin-d8) is the 2H-labeled Busulfan. Busulfan is an anticancer agent with immunosuppressive and myeloablative chemotherapy activities.</p>

(Rac)-Hesperetin, a racemic flavanone, inhibits human UGT activity and triggers apoptosis via p38 MAPK activation.

<p>Prexasertib dimesylate is a selective CHK1 inhibitor with K i 0.9 nM, blocks CHK2 &amp; RSK1, induces DNA breakage, and has potent anti-tumor effects.</p>

Triclabendazole (Standard) is the standard substance of Triclabendazole, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Triclabendazole (CGA89317) has been used in trials studying Parasitic Disease.

<p>AZD-5991, an antitumor compound, is a highly selective, potent and direct MCL-1 inhibitor, rapid apoptosis by Bak-dependent mitochondrial apoptotic pathway.</p>

<p>AK-778-XXMU is an ID2 antagonist with a KD value of 129 nM.AK-778-XXMU has potential antitumor and anticancer activity and can be used for the study of gliomas.</p>

<p>SC144 hydrochloride: oral gp130 inhibitor, blocks Stat3 and gene expression, triggers apoptosis in ovarian cancer cells.</p>

<p>Benzyl selenocyanate is a chemopreventive agent that effectively inhibits chemically induced tumors at both initiation and postinitiation stages in animal models. It acts as a potent inhibitor of DNA (cytosine-5)-methyltransferase (Mtase) with an IC50 of 8.4 μM.</p>

<p>Hematoporphyrin monomethyl ether is a porphyrin photosensitizer that can be used in studies of port wine stains.</p>

<p>PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour .</p>

<p>Degarelix is a peptide and selective GnRH (human gonadotropin-releasing hormone) receptor antagonist prostate cancer by lowering testosterone levels.</p>

<p>Thioridazine: an antipsychotic, anti-anxiety drug, blocks dopamine D2, PI3K-Akt-mTOR; halts angiogenesis, kills cancer cells, targets CSCs.</p>

<p>Methopterin shows the activation and bone resorption function of murine osteoclasts.</p>

<p>Sodium cyclamate is a carbonic anhydrase inhibitor, artificial sweetener, with anticonvulsant properties, and used in cancer research.</p>

<p>Celosin K (compound 8), isolated from Semen Celosiae seeds, effectively inhibits t-BHP-induced neuronal injury.</p>

<p>Acyclovir-d4 is a deuterated compound of Acyclovir. Acyclovir has a CAS number of 59277-89-3. Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.</p>

<p>Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.</p>

<p>MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.</p>

<p>Cobimetinib hemifumarate is a potent and selective MEK1 inhibitor with an IC50 value of 4.2 nM for MEK1.</p>

<p>Isovalerylcarnitine (3-methylbutyrylcarnitine) is a selective effective calpain activator that can promote cell apoptosis and is related to isovaleric acidemia.</p>

<p>Batabulin sodium, an antitumor compound, disrupts microtubules, alters cell shape, halts cell cycle, and induces apoptosis.</p>

4-Benzoyl-L-phenylalanine is an L-phenylalanine derivative and optically active amino acid.

<p>Diuron is an orally active benzoylurea herbicide. Diuron inhibits the production of ATP and NADH,, ROS and cancer.</p>

<p>Rutin trihydrate is a natural flavonoid with antioxidant, anti-inflammatory, anti-diabetic, and anti-cancer benefits, plus heart and brain protection.</p>

<p>Tubastatin A is a potent HDAC6 inhibitor with IC50 of 15 nM.</p>

<p>LG100268 is a selective, and oral RXR agonist，inducing transcriptional activation in adipocytes; inhibits keratin 17 increases PD-L1 expression.</p>

<p>Forodesine inhibits lymphocyte growth and induces apoptosis in leukemic cells; oral purine nucleoside phosphorylase blocker; IC50: 0.48-1.57 nM.</p>

<p>6-Formylpterin (Pterin-6-aldehyde) is an inhibitor of Xanthine Oxidase, which induces ROS generation and apoptosis in HL-60 cells.</p>

<p>Metronidazole-d4 is a deuterium labeled compound isotopic tracing.Metronidazole is an antibiotic and antiprotozoal oral and BBB penetration anaerobic bacteria.</p>

<p>Necrostatin 2 is a RIPK1 inhibitor that can be used to study inner ear disorders such as sudden deafness, dizziness and tinnitus.</p>

<p>Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast.</p>

<p>(-)-Apomorphine hydrochloride hydrate is a broad-spectrum dopamine agonist and ferroptosis inhibitor.</p>

<p>Amifostine thiol (WR-1065), an active Amifostine metabolite, is a radioprotective cytoprotectant that activates p53 via JNK pathway.</p>

<p>Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].</p>