Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6223 produits trouvés pour "Apoptose"
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Pamrevlumab
CAS :FG-3019 (Pamrevlumab), a human antibody, targets CTGF, potentially treating idiopathic pulmonary fibrosis.Degré de pureté :100% (SEC-HPLC) - >95.0% (SDS-PAGE)Couleur et forme :LiquidMasse moléculaire :150 kDaDiethanolamine hydrochloride
CAS :Diethanolamine hydrochloride is HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) and pregnane X receptor (PXR), p53 Estrogen receptor.Formule :C4H12ClNO2Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :141.6Thalidomide-PEG3-NH2
CAS :Thalidomide-PEG3-NH2: a cereblon-based E3 ligase ligand-linker for PROTAC tech.Formule :C19H23N3O7Couleur et forme :SolidMasse moléculaire :405.407BAG3/HSP70-IN-1
USP1-IN-11 (compound 38-P2) is a selective, reversible, and non-competitive inhibitor of USP1 (Ubiquitin-specific protease 1). It activates the DDR (DNA damage repair) pathway, leading to cell cycle arrest and apoptosis, thereby inhibiting cell survival. USP1-IN-11 increases sensitivity to Olaparib in drug-resistant cells and works synergistically with Andrographolide in cancer cells with functional BRCA. In the MDA-MB-436 xenograft model, USP1-IN-11 demonstrates significant dose-dependent antitumor activity.Formule :C28H39N7O4Couleur et forme :SolidMasse moléculaire :537.65Efaprinermin alfa
CAS :Efaprimermin alfa (OMP-336B11) is a human monoclonal antibody that targets TNFRSF18, and functions as a GITR ligand-Fc fusion protein [1].Couleur et forme :LiquidPKM2 modulator 1
PKM2 modulator 1 (compound C998) is an effective PKM2 inhibitor with antiproliferative activity. It induces apoptosis and holds potential for research in glioblastoma studies.Formule :C26H25N3O3Couleur et forme :SolidMasse moléculaire :427.5Topo I/II-IN-2
Topo I/II-IN-2 (Compound 3g) is an inhibitor of both Topo I and Topo II. It exhibits inhibitory activity against NCI-H446 and NCI-H1048 cells with IC50 values of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial apoptosis, disrupts mitochondrial function, and stimulates activity generation. Additionally, it inhibits the PI3K/Akt/mTOR pathway, effectively preventing the proliferation, invasion, and migration of small cell lung cancer (SCLC) cells in vitro.Formule :C25H26N2O4Couleur et forme :SolidMasse moléculaire :418.48Diafenthiuron
CAS :Diafenthiuron is a widely utilized thiourea-based pesticide that effectively hinders mitochondrial activity in insect pests.Formule :C23H32N2OSCouleur et forme :SolidMasse moléculaire :384.58Ranevetmab
CAS :Ranevetmab (NV-01), a caninized anti-NGF mAb, relieves pain in DJD research.Couleur et forme :LiquidAChE-IN-81
AChE-IN-81 (compound 22) is a reversible, selective inhibitor of AChE with an 80.0% inhibition rate and an IC50 of 3.7 μM. It binds to AChE with an affinity (Kd) of 5.37 μM. AChE-IN-81 effectively reduces apoptosis in zebrafish brain cells and shows potential neuroprotective activity in an H2O2-induced SH-SY5Y cell damage model.Formule :C37H54ClNO5Couleur et forme :SolidMasse moléculaire :628.28KRASG12C IN-16
KRASG12C IN-16 (Compound SK-17) is a selective, covalent, and orally active KRASG12C inhibitor. It can induce apoptosis and effectively prevent the activation of the MAPK and PI3K/mTOR signaling pathways. Additionally, KRASG12C IN-16 exhibits antitumor activity against pancreatic cancer.Formule :C28H35ClN8O2Couleur et forme :SolidMasse moléculaire :551.08Antagonist G
CAS :Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.Formule :C49H66N12O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :951.19BRD-810
CAS :BRD-810 is a highly selective MCL1 inhibitor (Kd=0.3 nM) capable of inducing tumour cell apoptosis, for haematological malignancies and solid tumours.Formule :C39H44ClFN4O5Degré de pureté :97.88%Couleur et forme :SolidMasse moléculaire :703.24Ref: TM-T89869
1mL*10mM (DMSO)À demander1mg665,00€5mg1.935,00€10mg3.087,00€25mg4.609,00€50mg6.201,00€Pacmilimab
CAS :Pacmilimab (CX-072) is a Probody immune checkpoint inhibitor targeting programmed death ligand 1 (PD-L1) with anti-tumor activity for the study of solid tumors.Degré de pureté :98.8% (SDS-PAGE); 96.3% (SEC-HPLC) - 98.8% (SDS-PAGE); 96.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :153.3 kDaDefNEtTrp
DefNEtTrp is an iron bis-chelating ligand composed of Def and Trp groups. It demonstrates potent broad-spectrum antiproliferative and cytotoxic effects in cancer cell lines. DefNEtTrp induces apoptosis and ferroptosis, exhibiting cytotoxicity with an IC50 value of 0.77 μM.Formule :C30H27N9O3SCouleur et forme :SolidMasse moléculaire :593.659KB02-SLF
KB02-SLF, a molecular glue, degrades nuclear FKBP12 by modifying E3 ligase DCAF16 and extends protein degradation.Formule :C50H65ClN4O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :949.52Atorolimumab
CAS :Atorolimumab (P3x22914G4), a monoclonal antibody, is employed in immunotherapies that target the programmed death-1 (PD-1) receptor [1].Couleur et forme :LiquidFosbretabulin [free base]
CAS :Fosbretabulin is a natural cis-stilbene that interferes with cellular tubulin dynamics and selectively destroys tumor blood vessels.
Formule :C18H21O8PCouleur et forme :SolidMasse moléculaire :396.33Aloeresin G
CAS :Aloeresin G, a chromone glycoside isolated from Aloe, exhibits a moderate inhibitory effect on TNFα-induced NF-κB transcriptional activity, evidenced by an IC50Formule :C29H30O10Couleur et forme :SolidMasse moléculaire :538.54QZ2135
QZ2135 (compound 20) is a PROTAC degrader that specifically targets RET and exhibits antitumor activity in vivo within a Ba/F3-KIF5B-RET-G810C xenograft mouse model. The compound demonstrates degradation activity with DC50 values of 4.7 nM (WT), 17.2 nM (V804M), and 73.8 nM (G810C) when targeting KIF5B-RET. QZ2135 is composed of the target protein ligand (red part) RETligand-3, the E3 ligase ligand (blue part) Lenalidomide-F, and the PROTAC Linker (black part) 7-Iodohept-1-yne, wherein the target protein ligand combined with the linker forms the conjugate RETLigand-Linker Conjugate-1.Formule :C53H54N12O4Couleur et forme :SolidMasse moléculaire :923.07Betamethasone
CAS :Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.Formule :C22H29FO5Degré de pureté :98% - 99.71%Couleur et forme :White Or Almost White Powder Solid CrystallineMasse moléculaire :392.46IPH10
IPH10 is an anticancer agent with strong antitumor effects in vivo and exhibits no liver or kidney toxicity. It significantly increases the reactive oxygen species (ROS) levels in tumor cells, decreases mitochondrial membrane potential, and induces apoptosis (apoptosis) in these cells.Formule :C32H33NO4Couleur et forme :SolidMasse moléculaire :495.61Rozibafusp alfa
CAS :Rozibafusp alfa is an IgG2-κ antibody that targets ICOSLG, combined with a TNFSF13B fusion protein [1].Couleur et forme :LiquidTelitacicept
CAS :Telitacicept (RC18), a fully human TACI-Fc fusion protein, acts as a dual inhibitor of B lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligandCouleur et forme :LiquidAXL/Angiokinase-IN-1
AXL/Angiokinase-IN-1 (compound 11b) is an inhibitor of AXL/triple angiokinase, with an IC50 of 3.75 nM for AXL expression. This compound suppresses epithelial-mesenchymal transition (EMT) in Bxpc-3 cells and prevents metastasis in lung cancer cells. Additionally, AXL/Angiokinase-IN-1 impairs the functions of vascular and fibroblast cells and induces apoptosis in both cancer and fibroblast cells. It is characterized by low toxicity and favorable metabolic stability.Formule :C31H34ClN5O2Couleur et forme :SolidMasse moléculaire :544.09Iparomlimab
CAS :Iparomlimab: anti-PD-1 IgG4κ antibody, targets PSB103 γ4/κ-chains, forms dimers, used in cancer research.Couleur et forme :LiquidP53R3
CAS :P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53Formule :C32H35Cl2N5O2Degré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :592.56Manelimab
CAS :Manelimab is a monoclonal antibody that inhibits programmed death-ligand 1 ( PD-L1 ) [1] .Couleur et forme :LiquidDD0-2363
DD0-2363 (Compound 32d) is a dual-target inhibitor of WDR5-MLL1/HDAC. It can suppress the proliferation of acute myeloid leukemia cells and induce apoptosis. With its antitumor properties, DD0-2363 is applicable for research on acute myeloid leukemia.Formule :C36H36ClFN6O4Couleur et forme :SolidMasse moléculaire :671.16Balstilimab
CAS :Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1 [1] .Couleur et forme :LiquidAnti-Mouse CD44 Antibody (IM7)
Anti-Mouse CD44 Antibody (IM7) is a monoclonal antibody targeting CD44 in mice.Degré de pureté :99%Couleur et forme :Odour LiquidMasse moléculaire :150 kDaβ-Amyloid (1-40) (rat)
CAS :Rat form of the beta-Amyloid (1-40) peptideFormule :C190H291N51O57SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4233.76FKBP12 ligand-1
CAS :FKBP12 ligand-1 is the target protein ligand for MC-25B, which is a PROTAC targeting FKBP12.Formule :C32H41NO9Couleur et forme :SolidMasse moléculaire :583.669R1-ICR-5
CAS :R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Formule :C54H70N8O7S2Couleur et forme :SolidMasse moléculaire :1007.31ZZM-1220
ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP.Formule :C25H29N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :447.53TPP-1 TFA
TPP-1 TFA is a high-affinity PD-L1 inhibitor (KD=95nM) that boosts T-cell function to curb tumor growth.Formule :C109H151F3N34O34S2Couleur et forme :SolidMasse moléculaire :2602.69Enlonstobart
CAS :Enlonstobart is a humanized IgG4-κ monoclonal antibody targeting PDCD1, functioning as both an immunostimulant and antineoplastic agent [1].Couleur et forme :LiquidAc-AAVALLPAVLLALLAP-YVAD-CHO
CAS :Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].Formule :C97H160N20O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1990.43Zeluvalimab
CAS :Zeluvalimab (AMG-404) is a monoclonal antibody designed to target the PD-1 receptor, and is utilized in cancer research [1].Couleur et forme :LiquidBGC4
BGC4 is a gold(III) complex based on biphenyl. It inhibits human recombinant thioredoxin reductase (TrxR) with an IC50 of 10.7 μM, exhibits cytotoxicity with an IC50 of 5.4 μM in MDA-MB-231 cells, and induces apoptosis. Additionally, BGC4 demonstrates antitumor activity in mouse models.Formule :C30H32AuClF3N3Couleur et forme :SolidMasse moléculaire :724.01SH-5
CAS :SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene productsFormule :C29H59O10PCouleur et forme :SolidMasse moléculaire :598.75Antagonist G TFA
Potent vasopressin blocker, Antagonist G TFA also mildly inhibits GRP & Bradykinin, triggers AP-1, enhances chemo response.Formule :C51H67F3N12O8SCouleur et forme :SolidMasse moléculaire :1065.21Atacicept
CAS :Atacicept (TACI-Ig) is a homodimeric fusion protein that inhibits B cell stimulation.Degré de pureté :97.9% (SDS-PAGE); 98.7% (SEC-HPLC) - 97.9% (SDS-PAGE); 98.7% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :35.36 kDaTaxamairin B
CAS :Taxamairin B is a potent anti-inflammatory compound that inhibits the expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and reduces theFormule :C22H24O4Couleur et forme :SolidMasse moléculaire :352.42MEDI-7352
MEDI-7352 is a human bispecific antibody targeting NGF/bNGF and TNF. It can be utilized in research focused on osteoarthritis (OA) pain.Couleur et forme :Odour LiquidCGP-74514
CAS :CGP-74514,CDK1 inhibitor (IC50=25 nM). Induces G2/M arrest, apoptosis. Used in bladder cancer research.Formule :C19H24ClN7Degré de pureté :98.54%Couleur et forme :SoildMasse moléculaire :385.89m7GpppAmpG
CAS :M7GpppAmpG is a trinucleotide 5′ cap analog, exhibiting capping efficiencies of 90% for the produced RNAs [1].Formule :C32H43N15O24P4Couleur et forme :SolidMasse moléculaire :1145.66Lenercept
CAS :Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].Couleur et forme :LiquidSM-164 Hydrochloride (957135-43-2 free base)
SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.Formule :C62H85ClN14O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1157.88(E/Z)-Eltrombopag 13C4
CAS :(E/Z)-Eltrombopag 13C4 is a mix of E/Z isotopologues, both 13C-labeled TPO receptor agonists for thrombocytopenia.Formule :C25H22N4O4Couleur et forme :SolidMasse moléculaire :446.444
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