Apoptose

Lestaurtinib (CEP 701) is a FLT3 inhibitor that inhibits the phosphorylation of RPTKs and can be used to study leukemia.

Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

Tamoxifen-d5 is a deuterium labeled Tamoxifen.

Necrostatin 2 is a RIPK1 inhibitor that can be used to study inner ear disorders such as sudden deafness, dizziness and tinnitus.

Prexasertib dimesylate is a selective CHK1 inhibitor with K i 0.9 nM, blocks CHK2 & RSK1, induces DNA breakage, and has potent anti-tumor effects.

Forodesine inhibits lymphocyte growth and induces apoptosis in leukemic cells; oral purine nucleoside phosphorylase blocker; IC50: 0.48-1.57 nM.

Degarelix is a peptide and selective GnRH (human gonadotropin-releasing hormone) receptor antagonist prostate cancer by lowering testosterone levels.

SU11652 is an effective and competitive receptor tyrosine kinase (RTK) inhibitor, including VEGFR, FGFR, PDGFR, and Kit.

Chiisanoside is a useful organic compound for research related to life sciences. The catalog number is T123983 and the CAS number is 89354-01-8.

Zinc pyrithione (Standard) is an analytical standard and reference sample. Zinc pyrithione (OM-1563) disrupts membrane transport by inhibiting proton pumps.

AK-778-XXMU is an ID2 antagonist with a KD value of 129 nM.AK-778-XXMU has potential antitumor and anticancer activity and can be used for the study of gliomas.

Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM.

J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in

SLF is a synthetic ligand for FKBP12 and increases Ca2+ efflux and protein synthesis.

SLC7A11-IN-1 is an SLC7A11 inhibitor with antiproliferative activity, inhibiting cell invasion and metastasis, useful for research on neurological diseases.

ML291 triggers UPR, causing apoptosis in solid cancers by activating PERK/eIF2a/CHOP pathway and reducing leukemia cells.

Mardepodect hydrochloride (Mardepodect HCl) is a PDE10A inhibitor.Mardepodect hydrochloride upregulates genes encoding specific growth factors.

MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.

Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis, inhibiting SARS-CoV-2 and COVID-19.

(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor with neuroprotective activity that induces apoptosis.

Thioridazine: an antipsychotic, anti-anxiety drug, blocks dopamine D2, PI3K-Akt-mTOR; halts angiogenesis, kills cancer cells, targets CSCs.

U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.

Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.

BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM).

Ripretinib (DCC-2618) is an orally bioavailable inhibitor of KIT and PDGFRA.

Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to

SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.

Dehydroeffusol: anti-cancer, anxiolytic, sedative; halts gastric cancer growth via ER stress and apoptosis.

Anisomycin (NSC-76712), an antibiotic from Streptomyces, blocks protein/DNA synthesis by targeting peptidyl transferase/80S ribosomes.

Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene

MFCD01917484: A thiophene derivative with ligand, catalyst, and photosensitizer roles, used in biochemical research and drug development.

BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM).

Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis.

Antineoplaston A10 (NSC-648539) is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.

GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.

SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.

dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.

CCF642 (AC1LYELL) is a novel PDI-inhibiting compound with antimyeloma activity.

Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon

4-Methyldaphnetin (DHMC) is a potent inhibitor of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals.

Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor

Phytosphingosine: anticancer phospholipid; triggers apoptosis in cancer cells via caspase 8 activation and Bax translocation.

PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.