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Apoptose

Apoptose

Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.

Sous-catégories appartenant à la catégorie "Apoptose"

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5599 produits trouvés pour "Apoptose"

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  • NiCur
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    NiCur

    CAS :
    <p>NiCur is an effective and selective inhibitor of CBP histone acetyltransferase (HAT), with an IC50 of 0.35 μM.</p>
    Formule :C22H16N2O
    Degré de pureté :99.22%
    Couleur et forme :Solid
    Masse moléculaire :324.38

    Ref: TM-T60888

  • WB436B
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    WB436B

    CAS :
    <p>WB436B, a highly selective STAT3 inhibitor, effectively targets and inhibits STAT3-Tyr705 phosphorylation along with the expression of STAT3 target genes. It exhibits cytotoxic effects on pancreatic cancer cells by inducing apoptosis. Furthermore, WB436B suppresses tumor growth and metastasis in pancreatic cancer mouse models, thereby prolonging the survival of tumor-bearing mice.</p>
    Formule :C21H20N6O3S
    Couleur et forme :Solid
    Masse moléculaire :436.49

    Ref: TM-T200318

  • GPX4 activator 2
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    GPX4 activator 2

    CAS :
    <p>GPX4 Activator 2 (Compound C3) serves as an activator of GPX4 and exhibits cardioprotective effects by inhibiting cellular iron death (ferroptosis) with an efficacy concentration (EC50) of 7.8 μM. It is used in the study of myocardial damage.</p>
    Formule :C20H26N6O2S
    Couleur et forme :Solid
    Masse moléculaire :414.52

    Ref: TM-T200148

  • PF-7006
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    PF-7006

    CAS :
    <p>PF-7006, an Mps1 kinase inhibitor, exhibits a Ki value of 0.27 nM and an IC50 value of 2.5 nM. It disrupts cell cycle checkpoints by inhibiting the catalytic activity of Mps1, reduces histone H3 levels, and shortens the duration of mitosis, thereby inducing apoptosis (Apoptosis) in cancer cells. When used in combination with Palbociclib, the tolerance of cancer cells to PF-7006 is enhanced. PF-7006 is applicable for research on breast cancer.</p>
    Formule :C22H26N8O2
    Couleur et forme :Solid
    Masse moléculaire :434.49

    Ref: TM-T200142

  • MC3629
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    MC3629

    CAS :
    <p>MC3629, an inhibitor of the histone methyltransferase (EZH2), exhibits antitumor activity. This compound effectively inhibits the proliferation and self-renewal of SHH MB cancer cells while inducing cell apoptosis (apoptosis). MC3629 is also useful in research on tumor aggressiveness and resistance.</p>
    Formule :C19H20N4O2
    Couleur et forme :Solid
    Masse moléculaire :336.39

    Ref: TM-T200181

  • Gallium 8-Hydroxyquinolinate
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    Gallium 8-Hydroxyquinolinate

    CAS :
    <p>Gallium 8-Hydroxyquinolinate is an inducer of apoptosis that initiates both p53-dependent and independent cell death in cancer cells through the induction of Ca2+ signaling transduction. In addition to its apoptotic properties, this compound's nanostructures exhibit excellent optical performance, making it suitable for use in tumor research.</p>
    Formule :C27H18GaN3O3
    Couleur et forme :Solid
    Masse moléculaire :502.17

    Ref: TM-T200246

  • SPI-001
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    SPI-001

    CAS :
    <p>SPI-001 is a selective inhibitor of PPM1D (IC50=0.48 µM) that exhibits anticancer activity. The compound inhibits the phosphatase activity of PPM1D in human breast cancer cells overexpressing PPM1D and enhances the phosphorylation of p53. Additionally, SPI-001 suppresses cell proliferation by inducing apoptosis.</p>
    Formule :C30H60O4Si2
    Couleur et forme :Solid
    Masse moléculaire :540.97

    Ref: TM-T89868

  • XSJ05
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    XSJ05

    CAS :
    <p>XSJ05, a derivative of camptothecin (CPT), exhibits anti-cancer activity by inhibiting topoisomerase I (Topo I). This compound induces DNA double-strand breaks, leading to DNA damage. Furthermore, XSJ05 stifles the growth of colorectal cancer (CRC), halts the cell cycle in the G2/M phase, and induces apoptosis.</p>
    Formule :C29H25N5O4S
    Couleur et forme :Solid
    Masse moléculaire :539.60

    Ref: TM-T200042

  • PD-1/PD-L1-IN-55
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    PD-1/PD-L1-IN-55

    CAS :
    <p>PD-1/PD-L1-IN-55 (compound D6) is a potent PD-1/PD-L1 inhibitor with an IC50 of 4.8 nM. It enhances IFN-γ secretion and decreases the proportion of late apoptosis due to PD-L1.</p>
    Formule :C25H23ClN2O3
    Couleur et forme :Solid
    Masse moléculaire :434.92

    Ref: TM-T207534

  • ASTX295
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    ASTX295

    CAS :
    <p>ASTX295 is a selective mouse double minute 2 (MDM2) antagonist with an IC50 value of less than 1 nM. It specifically inhibits the interaction between MDM2 and p53, reactivating wild-type (WT) TP53, which subsequently induces the expression of related transcriptional targets, leading to cell death and cell cycle arrest. ASTX295 holds potential for research in lymphoid malignancies such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and T-cell lymphoma.</p>
    Formule :C33H34Cl2FNO6
    Couleur et forme :Solid
    Masse moléculaire :630.531

    Ref: TM-T206682

  • Le logo de CymitQuimica
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    VEGFR-2-IN-11

    <p>VEGFR-2-IN-11 is a potent inhibitor of VEGFR-2 (IC50: 60.27 nM) with an IC50 value of 60.27 nM, which induces apoptosis and has anticancer activity.</p>
    Formule :C29H22BrN5S
    Couleur et forme :Solid
    Masse moléculaire :552.49

    Ref: TM-T63900

  • HDAC/PSMD14-IN-1
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    HDAC/PSMD14-IN-1

    CAS :
    <p>HDAC/PSMD14-IN-1 is a derivative of gambogic acid. It serves as an orally active dual inhibitor targeting PSMD14 and HDAC1, with IC50 values of 238.7 nM and 141.2 nM, respectively. The compound exhibits significant cytotoxicity against ESCC cell lines (IC50: 30-250 nM) and effectively reverses epithelial-mesenchymal transition (EMT). Additionally, HDAC/PSMD14-IN-1 can induce apoptosis. In KYSE30 cell xenograft models in mice, it displays antitumor activity. HDAC/PSMD14-IN-1 is useful for researching esophageal cancer treatment.</p>
    Formule :C20H24N4O3S2
    Couleur et forme :Solid
    Masse moléculaire :432.56

    Ref: TM-T207215

  • TAI-95
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    TAI-95

    CAS :
    <p>TAI-95 is an inhibitor of highly expressed cancer protein 1 (Hec1).</p>
    Formule :C24H23N5O3S2
    Couleur et forme :Solid
    Masse moléculaire :493.60

    Ref: TM-T70649

  • JR5-26B
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    JR5-26B

    CAS :
    <p>JR5-26B is an orally active apoptosis (apoptosis) inducer. It induces cell death via copper-mediated apoptosis and necroptosis (necroptosis). JR5-26B exhibits antiproliferative activity against MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2 cells, with IC50 values of 0.6, 4.4, 8.0, 1.1, and 3.4 μM, respectively.</p>
    Formule :C19H17FN6O
    Couleur et forme :Solid
    Masse moléculaire :364.38

    Ref: TM-T207308

  • VDR agonist 1
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    VDR agonist 1

    CAS :
    <p>Compound 28 is a nonsteroidal VDR agonist with 690 nM potency, inducing cell cycle arrest and apoptosis in MCF-7 cells.</p>
    Formule :C32H51N3O2
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :509.77

    Ref: TM-T13292

  • RIPK1-IN-28
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    RIPK1-IN-28

    CAS :
    <p>RIPK1-IN-28 (compound 13) is an orally active inhibitor of RIPK1. It exhibits inhibitory effects on human I2.1 and Hepa1-6 cells, with IC50 values of 0.4 and 1.2 nM, respectively.</p>
    Formule :C27H24N4O4
    Couleur et forme :Solid
    Masse moléculaire :468.504

    Ref: TM-T204483

  • PLK1-IN-13
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    PLK1-IN-13

    CAS :
    <p>PLK1-IN-13 is a selective, orally active PLK1 inhibitor with an IC50 of 0.27 nM. It also inhibits PLK2 (IC50: 12.72 nM) and PLK3 (IC50: 4.12 nM). PLK1-IN-13 induces cell cycle arrest at the G2 phase, promotes apoptosis, and downregulates the transcription of the cancer-associated oncogene c-MYC. This compound inhibits tumor growth and is applicable for research in acute myeloid leukemia (AML).</p>
    Formule :C29H39N9O2S
    Couleur et forme :Solid
    Masse moléculaire :577.744

    Ref: TM-T206596

  • Topo II/HDAC-IN-2
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    Topo II/HDAC-IN-2

    CAS :
    <p>Topo II/HDAC-IN-2 (8d) demonstrates remarkable dual inhibitory effects on Topo II and HDAC, and also induces apoptosis [1].</p>
    Formule :C17H20N4O3S
    Couleur et forme :Solid
    Masse moléculaire :360.43

    Ref: TM-T87549

  • Pim-1 kinase inhibitor 10
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    Pim-1 kinase inhibitor 10

    CAS :
    <p>Pim-1 Kinase Inhibitor 10 (compound 13a) acts as both a competitive and non-competitive inhibitor of PIM-1/2 kinase, promoting cell apoptosis and displaying anticancer properties. Additionally, this compound triggers the activation of caspase 3/7 [1].</p>
    Formule :C21H13N3O3
    Couleur et forme :Solid
    Masse moléculaire :355.35

    Ref: TM-T87212

  • Z-VAD
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    Z-VAD

    CAS :
    <p>Z-VAD is an irreversible pan-caspase inhibitor, suppressing multiple caspases including caspase-3, -6, -7, -8, and -9. Z-VAD induces autophagy in tumour cells.</p>
    Formule :C20H27N3O8
    Degré de pureté :98.961%
    Couleur et forme :Solid
    Masse moléculaire :437.44

    Ref: TM-T89262