Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5600 produits trouvés pour "Apoptose"
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Keap1-Nrf2-IN-4
<p>Keap1-Nrf2-IN-4 hinders MGC-803 cell growth (IC50=2.55μM), migration, and induces apoptosis with low toxicity.</p>Formule :C26H34N2OCouleur et forme :SolidMasse moléculaire :390.56Lonitoclax
CAS :<p>Lonitoclax is an inhibitor of B-cell lymphoma 2 (Bcl-2). It demonstrates antitumor activity in B-cell and myeloid malignancy models comparable to Venetoclax. Lonitoclax holds potential for research in relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma, and certain low-grade lymphomas.</p>Formule :C43H45ClN4O5Couleur et forme :SolidMasse moléculaire :733.294GRP78-IN-1
<p>GRP78-IN-1 binds to GRP78 protein, inhibits cell growth, and triggers apoptosis in breast cancer; has -8.07 kcal/mol binding energy.</p>Formule :C21H23FO3Couleur et forme :SolidMasse moléculaire :342.4EGFR-IN-47
<p>EGFR-IN-47: strong oral EGFRL858R/T790M/C797S blocker, induces cell death; promising for NSCLC research. IC50: 0.01 μM.</p>Formule :C29H35N7Couleur et forme :SolidMasse moléculaire :481.64Spliceostatin A
CAS :<p>Spliceostatin A is an anticancer agent and splicing inhibitor that induces apoptosis by inducing cell cycle arrest in the G1 and G2/M phases.</p>Formule :C28H43NO8Degré de pureté :94.66%Couleur et forme :SolidMasse moléculaire :521.643FAK-IN-4
<p>FAK-IN-4 (Compound 7d) has anticancer activities that can induce cell apoptosis. FAK-IN-4 is potential inhibitor of FAK [1].</p>Formule :C20H22N4OCouleur et forme :SolidMasse moléculaire :334.41CRT0066101
CAS :<p>CRT0066101 is a potent, orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM, and 2 nM for PKD1, PKD2, and PKD3, respectively [1]. Additionally, it inhibits PIM2 with an IC 50 of approximately 135.7 nM and demonstrates anticancer effects [2].</p>Formule :C18H22N6OCouleur et forme :SolidMasse moléculaire :338.41PIM1-IN-3
<p>PIM1-IN-3 (HL8) selectively blocks PIM1, induces Colo320 cell apoptosis, and may be researched for cancer.</p>Formule :C27H25BrN6OCouleur et forme :SolidMasse moléculaire :529.43Samuraciclib hydrochloride hydrate
<p>Samuraciclib (CT7001) is a potent oral CDK7 inhibitor (IC50: 41 nM) with anti-breast cancer properties.</p>Formule :C22H35ClN6O3Couleur et forme :SolidMasse moléculaire :521.7GP130-IN-1
CAS :<p>GP130-IN-1 (compound 49) is an effective inhibitor of GP130, demonstrating significant in vitro anti-tumor activity and higher selectivity compared to Bazedoxifene. It induces ultrastructural changes in cells, leading to a time-dependent arrest of the cell cycle at the G0/G1 phase, and triggers both apoptosis and autophagy. GP130-IN-1 is useful for research on triple-negative breast cancer.</p>Formule :C21H10F5NO3Couleur et forme :SolidMasse moléculaire :419.30DX3-234
CAS :<p>DX3-234 is a OXPHOS inhibitor that acts by inhibiting complex I in the mitochondrial ETC,for cancers dependent on aerobic metabolism, such as pancreatic cancer.</p>Formule :C25H35N5O6S2Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :565.71GNE684
CAS :<p>GNE684 inhibits RIP1; Ki app: 21 nM (human), 189 nM (mouse), 691 nM (rat).</p>Formule :C23H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.48TI17
CAS :<p>TI17 is a selective TRIP13 inhibitor with anticancer activity and inhibits proliferation of multiple myeloma (MM) cells</p>Formule :C23H22N2O3Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :374.43DAPK1-IN-1
CAS :<p>DAPK1-IN-1 (compound 10) is an inhibitor of Death-associated protein kinase 1 (DAPK1), with a dissociation constant (Kd) of 0.63 μM. It is utilized in the study of Alzheimer's disease.</p>Formule :C15H11BrO4Couleur et forme :SolidMasse moléculaire :335.15Topoisomerase I/II inhibitor 8
CAS :<p>TopoisomeraseI/II inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of TopoisomeraseI/II that induces DNA damage and activates PARP-1, leading to the activation of RIPK1, RIPK3, and MLKL, ultimately causing necroptosis. It shows significant anticancer activity by effectively targeting cancer cell nuclei and inducing cell death through necroptosis, offering substantial clinical potential in overcoming resistance in cancer treatment.</p>Formule :C14H11Br2NO5S2Couleur et forme :SolidMasse moléculaire :497.179Minnelide
CAS :<p>Minnelide is a prodrug of triptolide,and shows potent antitumor activity in a number of tumor types.</p>Formule :C21H25Na2O10PDegré de pureté :98.49% - 99.59%Couleur et forme :SolidMasse moléculaire :514.37RET-IN-1
CAS :<p>RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively).</p>Formule :C29H31N9O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.61Bayer-18
CAS :<p>Bayer-18 is an inhibitor of TYK2. It inhibits the viability of anaplastic large cell lymphoma cells, including K299, SR786, Mac1, and Mac2a, with an IC50 ranging from 2-3 µM. Additionally, Bayer-18 induces apoptosis in K299 and SR786 cells.</p>Formule :C19H27FN6O2Couleur et forme :SolidMasse moléculaire :390.46Tubulin polymerization-IN-9
CAS :<p>Tubulin-IN-9 inhibits tubulin (IC50: 1.82 μM), halts K562 cells in G2/M, induces apoptosis, and has anti-cancer effects.</p>Formule :C19H19NO5SeCouleur et forme :SolidMasse moléculaire :420.32Antiproliferative agent-4
<p>Antiproliferative agent-4 suppresses cancer cell growth with low toxicity, inhibits tumors in mice, and induces apoptosis in EC109 cells.</p>Formule :C29H35ClO8Couleur et forme :SolidMasse moléculaire :547.04
