Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(11 produits)
- Caspase(143 produits)
- FOXO1(3 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(139 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(90 produits)
- c-RET(58 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
5990 produits trouvés pour "Apoptose"
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PLK1-IN-13
CAS :PLK1-IN-13 is a selective, orally active PLK1 inhibitor with an IC50 of 0.27 nM. It also inhibits PLK2 (IC50: 12.72 nM) and PLK3 (IC50: 4.12 nM). PLK1-IN-13 induces cell cycle arrest at the G2 phase, promotes apoptosis, and downregulates the transcription of the cancer-associated oncogene c-MYC. This compound inhibits tumor growth and is applicable for research in acute myeloid leukemia (AML).Formule :C29H39N9O2SCouleur et forme :SolidMasse moléculaire :577.744PSP205
CAS :PSP205 is an effective anticancer agent with cytotoxic properties. It induces apoptosis and triggers autophagy mediated by ER stress. Furthermore, PSP205 enhances the expression of LC3BII protein and increases the expression of CHOP and spliced XBP1 at both mRNA and protein levels.Formule :C28H32ClN7O5S2Couleur et forme :SolidMasse moléculaire :646.181PBX-7011
CAS :PBX-7011, an active camptothecin derivative, binds to the DDX5 protein in cells and induces cell death through DDX5 protein degradation [1].Formule :C24H21N3O6Masse moléculaire :447.44Autophagy inducer 7
CAS :<p>Autophagyinducer 7 (Compound SSA) serves as an inducer of autophagy (Autophagy) and apoptosis (Apoptosis). It stimulates autophagy by inhibiting Akt/mTOR signaling and the expression of downstream proteins. Additionally, Autophagyinducer 7 suppresses DNA synthesis and causes G0-G1 cell cycle arrest, ultimately inhibiting the growth of tumor cells.</p>Formule :C24H27FN2OSCouleur et forme :SolidMasse moléculaire :410.547RIPK2-IN-6
CAS :RIPK2-IN-6 (Compound 15a) is an inhibitor of RIPK that specifically targets the phosphorylation of RIPK2, thereby suppressing the NF-κB and MAPK signaling pathways. It has demonstrated anti-inflammatory and anti-fibrotic activities in a mouse model of colitis induced by Dextran sodium sulfate.Formule :C26H21NO3Couleur et forme :SolidMasse moléculaire :395.45IMB5046
CAS :IMB5046 is a microtubule inhibitor that induces apoptosis (cell death) by obstructing the G2/M phase of the cell cycle. It possesses antitumor properties.Formule :C19H20N2O5SCouleur et forme :SolidMasse moléculaire :388.438RIPK1-IN-28
CAS :<p>RIPK1-IN-28 (compound 13) is an orally active inhibitor of RIPK1. It exhibits inhibitory effects on human I2.1 and Hepa1-6 cells, with IC50 values of 0.4 and 1.2 nM, respectively.</p>Formule :C27H24N4O4Couleur et forme :SolidMasse moléculaire :468.504VDR agonist 1
CAS :Compound 28 is a nonsteroidal VDR agonist with 690 nM potency, inducing cell cycle arrest and apoptosis in MCF-7 cells.Formule :C32H51N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.77Antitumor agent-100
CAS :Antitumor Agent-100 (compound A6) is a molecular gel and apoptosis inducer targeting PDE3A-SLFN12 with an IC50 of 0.3 μM, demonstrating potent antitumor activity. This orally available agent binds to the PDE3A enzyme pocket, recruiting and stabilizing SLFN12 which disrupts protein translation and induces apoptosis [1].Formule :C17H14ClN3OMasse moléculaire :311.77PD-L1/HDAC6-IN-1
CAS :PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 μM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ng·h/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.Formule :C27H33N3O3Couleur et forme :SolidMasse moléculaire :447.569VEGFR-2-IN-11
<p>VEGFR-2-IN-11 is a potent inhibitor of VEGFR-2 (IC50: 60.27 nM) with an IC50 value of 60.27 nM, which induces apoptosis and has anticancer activity.</p>Formule :C29H22BrN5SCouleur et forme :SolidMasse moléculaire :552.49MG28
CAS :<p>MG28 exhibits significant cytotoxic effects, likely stemming from its direct and potent DNA-damaging activity. The compound is utilized in cancer research.</p>Formule :C27H25NO3SCouleur et forme :SolidMasse moléculaire :443.56MRK003
CAS :MRK003, a γ-secretase inhibitor, induces apoptosis, halts cell growth in myeloma/NHL, and affects notch signaling and PI3K/Akt pathway.Formule :C25H31F6N3O2SCouleur et forme :SolidMasse moléculaire :551.59Fosizensertib
CAS :Fosizensertib is an inhibitor of RIP-1 kinase and is used in research related to ulcerative colitis.Formule :C22H21F2N4O5PCouleur et forme :SolidMasse moléculaire :490.397PROTAC FKBP Degrader-3
CAS :PROTAC FKBP Degrader-3, with FKBP and VHL binding groups linked, is a potent FKBP degrader.Formule :C68H90N6O17SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1295.54EGFR/VEGFR2-IN-3
CAS :EGFR/VEGFR2-IN-3 (compound 9) is an effective inhibitor of EGFR and VEGFR-2, demonstrating IC50 values of 0.129 µM for EGFR, 0.142 µM for VEGFR-2, and 3.428 µM for COX-2. This compound exhibits cytotoxic properties and induces cell apoptosis (apoptosis) as well as cell cycle arrest at the G2/M phase.Formule :C24H20ClN5O2S2Couleur et forme :SolidMasse moléculaire :510.03Tuspetinib dihydrochloride
CAS :Tuspetinib (HM43239) dihydrochloride is a selective FLT3 inhibitor with oral bioactivity, exhibiting IC50 values of 1.1 nM for FLT3 wild type, 1.8 nM for FLT3ITD mutant type, and 1.0 nM for FLT3D835Y mutant type. As a reversible type I inhibitor, it directly suppresses FLT3 kinase activity and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib dihydrochloride inhibits the proliferation of leukemia cells and induces apoptosis (apoptosis).Formule :C29H35Cl3N6Couleur et forme :SolidMasse moléculaire :573.99FKBP51-Hsp90-IN-2
CAS :FKBP51-Hsp90-IN-2 (Compound E08) functions as a selective inhibitor for the FKBP51 - Hsp90 protein-protein interaction, exhibiting IC 50 values of 0.4 µM for FKBP51 and 5 µM for FKBP52. Beyond its inhibitory actions, FKBP51-Hsp90-IN-2 enhances cellular energy metabolism and promotes neurite growth. This compound is utilized in the study of neurodegenerative diseases and cancer [1].Formule :C25H27N3O2SMasse moléculaire :433.57p53 Activator 11
CAS :P53 Activator 11 (compound A-1) is a highly effective p53 activator, demonstrating an EC50 value of 0.478 µM for p53 (Y220C). It holds potential for cancer research [1].Formule :C26H29N7O2SMasse moléculaire :503.62Antitumor agent-72
CAS :Antitumor agent-72 (compound 6w) is a potent anticancer agent that exhibits its anticancer activity by inducing apoptosis via caspase-3 activation and PARPFormule :C25H20ClNO6Couleur et forme :SolidMasse moléculaire :465.88
