Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(5 produits)
- Caspase(151 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(105 produits)
- PDK(9 produits)
- PERK(26 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(58 produits)
- c-RET(61 produits)
- p53(63 produits)
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6048 produits trouvés pour "Apoptose"
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Apoptosis inducer 26
Apoptosisinducer 26 (compound [AgCl(dap2SH)(PPh3)2]) is a mononuclear Ag(I) ligand-based autophagy inducer that exhibits antibacterial and anticancer activities against various bacterial strains and cancer cell lines. This compound facilitates the accumulation of Ag(I) ions in the periphery of bacteria, effectively inhibiting the growth of both Gram-positive (+) and Gram-negative (-) bacteria. Additionally, Apoptosisinducer 26 can intercalate between the base pairs of CT DNA, inducing apoptosis in A549 cells. It also possesses radical scavenging properties, which helps prevent oxidative stress.Formule :C40H36AgClN4P2SCouleur et forme :SolidMasse moléculaire :810.07Thalidomide-O-C2-acid
CAS :Thalidomide-O-C2-acid: E3 ligase ligand-linker for PROTAC, with cereblon-derived Thalidomide component.Formule :C16H14N2O7Couleur et forme :SolidMasse moléculaire :346.2916Photosensitizer-3
CAS :Photosensitizer-3, generates single-linear oxygen upon near-infrared light excitation in combination with FAP,potent and selective killing cancer cells.Formule :C29H33ClI2N2O3Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :746.85LS-106
LS-106 is an orally active, effective epidermal growth factor receptor (EGFR) inhibitor displaying antitumor activity both in vitro and in vivo. It inhibits the kinase activities of EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S, with IC50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, demonstrating stronger inhibition than Osimertinib. LS-106 induces cell apoptosis (Apoptosis), suppresses the proliferation of tumor cells carrying EGFR19del/T790M/C797S, and results in significant tumor reduction in a C797S mutant xenograft model.Formule :C24H28BrClN5OPCouleur et forme :SolidMasse moléculaire :548.84Sterigmatocystine
CAS :Sterigmatocystine, a G1 phase and DNA synthesis inhibitor, curbs p21 and is a mycotoxin precursor from Aspergillus versicolor.Formule :C18H12O6Degré de pureté :98%Couleur et forme :Pale-Yellow Crystals Pale Yellow SolidMasse moléculaire :324.28Enterodiol
Enterodiol is a natural product that can be used as a reference standard.Formule :C18H22O4Couleur et forme :SolidMasse moléculaire :302.37p38α inhibitor 6
p38α inhibitor6 (compound 19) is a p38α inhibitor with an IC50 value of 0.68 μM. It induces apoptosis, arrests the cell cycle in the G0 and G2/M phases, reduces TNF-α concentration, upregulates the expression of the tumor suppressor gene p53, increases the Bax/BCL-2 ratio, and activates caspase3/7.Couleur et forme :Odour SolidZX782
ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.Formule :C39H48ClN5O8Couleur et forme :SolidMasse moléculaire :750.28Albanol B
CAS :Albanol B, from mulberries, combats Alzheimer's, bacteria, and oxidation, hinders cancer growth, and triggers cell arrest and apoptosis.Formule :C34H22O8Couleur et forme :SolidMasse moléculaire :558.53AUNP-12
CAS :AUNP-12, a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.Formule :C142H226N40O48Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3261.55Pexelizumab
CAS :Pexelizumab is a humanized antibody targeting C5 to inhibit apoptosis and treat cerebral IR injury and myocardial infarction.Couleur et forme :LiquidWaltonitone
CAS :Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.Formule :C30H48O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.7Enniatin complex
CAS :Enniatin complex: fungal cyclohexadepsipeptides inhibit enzymes, induce cancer cell apoptosis, and have ionophoric, antibiotic, and hypolipidemic effects.Degré de pureté :98%Couleur et forme :SolidFerroptosis-IN-13
Ferroptosis-IN-13 (compound NY-26) is an inhibitor of ferroptosis. It effectively suppresses RSL3-induced ferroptosis in 786-O cells, with an EC50 value of 62 nM.Formule :C32H30F2N4O3Couleur et forme :SolidMasse moléculaire :556.602Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
CAS :Cereblon ligand for PROTAC R&D; has E3 ligase, alkylC1-PEG3-alkylC3 linker, terminal amine. Part of Arvinas-licensed tool molecules.Formule :C25H35ClN4O9Couleur et forme :SolidMasse moléculaire :571.02Violacein
CAS :Violacein, a purple antibacterial and antiprotozoal compound from C. violaceum, effective against Gram-positive bacteria and P. falciparum.
Formule :C20H13N3O3Couleur et forme :SolidMasse moléculaire :343.34Ch282-5
CAS :Ch282-5, an orally active inhibitor targeting the Bcl-2 protein, promotes mitochondria-dependent apoptosis (Apoptosis) by disrupting mitophagy and the mTOR pathway. It demonstrates antiproliferative effects on colorectal cancer cells, effective both in vitro and in vivo, while also inhibiting metastasis. Further, Ch282-5 augments Oxaliplatin-induced autophagy (Autophagy) by downregulating Mcl-1 protein and raising platelet count, which helps mitigate the adverse effects of Navitoclax.Formule :C34H34N2Na2O14S2Couleur et forme :SolidMasse moléculaire :804.75MYC-RIBOTAC
MYC-RIBOTAC, a ribonuclease-targeting chimera (RIBOTAC) specific to the MYC internal ribosome entry site (IRES), comprises an MYC mRNA-binding element tetheredFormule :C55H58N10O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1067.17DB2115 tertahydrochloride
CAS :DB2115 (tertahydrochloride) inhibits PU.1, key in leukemia; potential for cancer research.
Formule :C32H34Cl4N8O2Couleur et forme :SolidMasse moléculaire :704.48AMG-7209
CAS :AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.Formule :C37H41Cl2FN2O7SCouleur et forme :SolidMasse moléculaire :747.7
