Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(5 produits)
- Caspase(151 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(105 produits)
- PDK(9 produits)
- PERK(26 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(58 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6048 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Z-DQMD-FMK
CAS :Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
Formule :C29H40FN5O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :685.72Sotigalimab
CAS :Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with anticancer activity for the study of metastatic pancreatic cancer.Degré de pureté :98.50% - 98.50%Couleur et forme :LiquidTectorigenin sodium sulfonate
CAS :Tectorigenin sodium sulfonate, a derivative of tectorigenin, is synthesized through sulfonation with sulfuric acid followed by neutralization in saturatedFormule :C16H11NaO9SCouleur et forme :SolidMasse moléculaire :402.31Anticancer agent 136
Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM), exhibits an IC50 value of 3.38 μM against human dermal fibroblasts (HDF) andFormule :C40H50N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :742.86RWJ-56110 dihydrochloride
CAS :RWJ-56110 dihydrochloride is a potent PAR-1 inhibitor (IC50=0.44μM), blocking platelet aggregation, angiogenesis, and induces apoptosis. No PAR-2/3/4 effect.Formule :C41H44Cl3F2N7O3Couleur et forme :SolidMasse moléculaire :827.2Ecdysone
CAS :Ecdysone is a major steroid hormone in insects and herbs.Formule :C27H44O6Degré de pureté :99.22%Couleur et forme :PowderMasse moléculaire :464.63WEHI-3773
WEHI-3773 is an inhibitor of the interaction between VDAC2 and either BAK or BAX. It prevents BAX-mediated apoptosis (Apoptosis) by blocking the recruitment of BAX to the mitochondria through VDAC2. Conversely, WEHI-3773 promotes BAK-mediated apoptosis (Apoptosis) by limiting VDAC2's inhibitory sequestration of BAK. This compound shows promise for research in the field of cancer therapy.Couleur et forme :Odour SolidALK/ROS1 inhibitor 2e HCL
(R)-1-(2-((2-MeO-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(CF3O)benzyl)piperidine-3-carboxamide HCl is anti-apoptotic and anti-cancer.Formule :C30H36ClF3N6O3Degré de pureté :98.66%Couleur et forme :SoildMasse moléculaire :621.09Z-LEHD-fmk
CAS :Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor andFormule :C32H43FN6O10Degré de pureté :96.13%Couleur et forme :SolidMasse moléculaire :690.72Human membrane-bound PD-L1 polypeptide
CAS :Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].Formule :C85H140N26O36SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2134.24MK-4688
CAS :MK-4688 is an efficient inhibitor of the HDM2-p53 protein-protein interaction.Formule :C28H32ClN7O3Couleur et forme :SolidMasse moléculaire :550.06(Iso)-Z-VAD(OMe)-FMK
CAS :(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.Formule :C22H30FN3O7Degré de pureté :97.10%Couleur et forme :SoildMasse moléculaire :467.49c-JUN peptide
CAS :Peptide from c-Jun (33-57) blocks JNK binding, inhibits phosphorylation, upregulates p21, and induces HeLa cell apoptosis.
Formule :C121H210N36O34SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2743.55PARP1-IN-16
PARP1-IN-16 (compound 12a) serves as a potent PARP1 inhibitor, exhibiting an IC50 value of 1.89 nM.Degré de pureté :98%Couleur et forme :Odour SolidTNF-α (46-65), human
CAS :Human TNF alpha (46-65) peptide.Formule :C110H172N24O30Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2310.69Topo I/II-IN-2
Topo I/II-IN-2 (Compound 3g) is an inhibitor of both Topo I and Topo II. It exhibits inhibitory activity against NCI-H446 and NCI-H1048 cells with IC50 values of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial apoptosis, disrupts mitochondrial function, and stimulates activity generation. Additionally, it inhibits the PI3K/Akt/mTOR pathway, effectively preventing the proliferation, invasion, and migration of small cell lung cancer (SCLC) cells in vitro.Formule :C25H26N2O4Couleur et forme :SolidMasse moléculaire :418.48HX009
HX009 is a bispecific antibody that targets PD1 and CD47, though its binding to CD47 is attenuated. HX009 functions by blocking PD1/CD47 and can be utilized in research related to non-Hodgkin lymphoma (NHL).Couleur et forme :Odour LiquidIDOi-Pt(IV) prodrug-1
IDOi-Pt(IV) prodrug-1 (Compound 10) is an IDOi-Pt(IV) prodrug that suppresses IDO expression. It induces apoptosis, reduces mitochondrial membrane potential, and inhibits tumor cell migration and invasion. Additionally, IDOi-Pt(IV) prodrug-1 triggers reactive oxygen species-mediated endoplasmic reticulum stress and the secretion of damage-associated molecular patterns (DAMPs), leading to immunogenic cell death (ICD). Compared to cisplatin, IDOi-Pt(IV) prodrug-1 exhibits relatively high efficiency and low toxicity in its antitumor activity.Formule :C21H26Cl3N3O6PtSCouleur et forme :SolidMasse moléculaire :749.96ERK1/2 inhibitor 13
ERK1/2 inhibitor 13 (Compound 21y) is an orally bioavailable ERK inhibitor that targets ERK1 and ERK2, with IC50 values of 91.71 nM and 97.87 nM, respectively. It effectively suppresses the proliferation of cancer cell lines MCF-7, 4T1, MDA-MB-468, and HCC1970 with IC50 values of 0.67 μM, 2.76 μM, 2.15 μM, and 1.68 μM, respectively. Additionally, it inhibits cancer cell migration, induces apoptosis and autophagy in MCF-7 cells, and demonstrates anti-tumor and anti-metastatic effects in a 4T1 xenograft mouse model.Formule :C36H29BrF6N4OCouleur et forme :SolidMasse moléculaire :727.54PERK-IN-6
CAS :PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Formule :C23H22N6ODegré de pureté :99.62% - 99.92%Couleur et forme :SolidMasse moléculaire :398.46
