Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(109 produits)
- PDK(9 produits)
- PERK(26 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(64 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6100 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Tubulin polymerization-IN-79
Tubulin polymerization-IN-79 (Compound C20) acts as an inhibitor of microtubule polymerization. It exhibits significant antiproliferative activity against esophageal cancer cells, such as KYSE450 (IC50=0.36 μM) and EC-109 (IC50=0.63 μM). In esophageal cancer cells, Tubulin polymerization-IN-79 occupies the colchicine binding site, disrupting the microtubule network's integrity, activating the Hippo signaling pathway, downregulating the oncogenic protein YAP, and inducing G2/M phase arrest and apoptosis. This compound shows promise for esophageal cancer research.Couleur et forme :Odour SolidPROTAC c-Met degrader-5
PROTACc-Met degrader-5 (Compound D19) is an orally active c-Met PROTAC degrader, with a DC50 of 0.42 nM in EBC-1 cells and 0.32 nM in Hs746T cells. It effectively induces apoptosis, causes G1 cell cycle arrest, and inhibits cell migration and invasion. This compound shows strong antiproliferative and degradative effects on c-Met-dependent cancer cells and those resistant to Tepotinib.Couleur et forme :Odour SolidBAD (103-127) (human)
CAS :BAD (103-127) human peptide from BH3 domain, blocks Bcl-xL, 800x more binding than 16-mer.Formule :C137H212N42O39SCouleur et forme :SolidMasse moléculaire :3103.52CQ627
CQ627 is a molecular glue that targets the degradation of RIOK2. It effectively recruits the E3 ubiquitin ligase RNF126, inducing the proteasomal degradation of RIOK2 via the ubiquitin-proteasome system (UPS) in MOLT4 leukemia cell lines, with a DC50 value of 410 nM. Additionally, CQ627 induces apoptosis in a dose-dependent manner in these cells, blocking the cell cycle at the G2/M phase, and exhibits antiproliferative activity across various cancer cell lines. It also demonstrates in vivo anticancer activity in MOLT4 xenograft mouse models.Formule :C36H27F4N7O4Couleur et forme :SolidMasse moléculaire :697.638VEGFR-2-IN-61
VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.Formule :C27H25N5OCouleur et forme :SolidMasse moléculaire :435.52DP-15
CAS :DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]Formule :C42H44ClN9O5SCouleur et forme :SolidMasse moléculaire :822.374Ono 3403
CAS :Ono 3403, a synthetic serine protease inhibitor, blocks TNF-alpha, NO production, and has antitumor properties.Formule :C26H31N3O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :545.6Bcl-2/Mcl-1-IN-4
Bcl-2/Mcl-1-IN-4 (compound 20) acts as a dual inhibitor targeting Bcl-2 (Ki=0.49 μM) and Mcl-1 (Ki=0.51 μM). This compound effectively suppresses cancer cell proliferation and induces apoptosis in U937 cells. It is utilized in cancer research.Couleur et forme :Odour Solid8(E),10(E),12(Z)-Octadecatrienoic Acid
CAS :Conjugated PUFA in C. officinalis oil, anticancer, inhibits Caco-2 growth and PG biosynthesis, induces DLD-1 apoptosis.Formule :C18H30O2Couleur et forme :SolidMasse moléculaire :278.436TTQ-SA
TTQ-SA is a near-infrared spiraling aggregation-induced emitter capable of converting near-infrared light (NIR) into thermal energy, resulting in thermal damage and death of tumor cells. In cancer cells MF-7, TTQ-SA shows cell uptake and targeting capabilities. TTQ-SA binds with DNAzyme to inhibit the expression of the survivin gene, enhancing the sensitivity of tumor cells to photothermal therapy.Formule :C78H53N7SCouleur et forme :SolidMasse moléculaire :1120.37RecQ helicase-IN-1
Frangulin B (Compd 11g) exhibits anticancer properties and acts as an effective RecQ helicase inhibitor. It induces apoptosis in both HCT-116 and MDA-MB-231 cells and can arrest HCT-116 cells in the G2/M phase.Formule :C25H21N3O3Masse moléculaire :411.15829ZLDI-8
CAS :ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
Formule :C24H23N3O3SDegré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :433.52Aviculin
CAS :Aviculin, a lignan glycoside, exhibits anticancer properties by inducing apoptosis in breast cancer cells with an IC50 of 75.47 μM.Formule :C26H34O10Couleur et forme :SolidMasse moléculaire :506.54Insect repellent M 3535
CAS :Insect repellent M 3535 is a bug repellant.Formule :C11H21NO3Couleur et forme :Colorless To Slightly Yellowish Liquid SolidMasse moléculaire :215.29HMGB1-IN-2
HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM inFormule :C53H71N3O11Couleur et forme :SoildMasse moléculaire :926.14XIAP ligand-Linker Conjugate 2
XIAPligand-Linker Conjugate 2 is an E3 ubiquitin ligase ligand-linker conjugate (E3 ligase Ligand-linker conjugate) that includes the XIAPBIR2 ligand XB2M54 and a linker. It is utilized in the synthesis of PROTACGNE-1567.Couleur et forme :Odour SolidPROTAC PI3Kδ degrader-1
PROTACPI3Kδ degrader-1 is a covalent PI3Kδ-targeting PROTAC degrader that targets lysine, with a DC50 of 3.98 nM. It exhibits potent antiproliferative activity and selective PI3Kδ inhibition (IC50: 8 nM). Additionally, PROTACPI3Kδ degrader-1 effectively degrades p-AKT, induces cell cycle arrest in the G1 phase, and promotes apoptosis and autophagy. It also significantly suppresses tumor growth in the SU-DHL-6 xenograft mouse model.Couleur et forme :Odour SoliddASK1-VHL
dASK1-VHL is an orally active PROTAC degrader targeting ASK1. It effectively binds to VHL, promoting the selective degradation of ASK1. By reducing ASK1 protein levels, dASK1-VHL inhibits the activation of p38 MAPK and decreases liver lipid content, offering new insights for MASH research.Couleur et forme :Odour SolidSB-T-1214
CAS :SB-T-1214 (SBT) is a taxane-based drug known for its ability to effectively suppress the expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induce apoptosis in drug-resistant tumorigenic CD133+/CD44+ colon cancer spheroids. In Pgp+ DLD-1 human colon tumor xenograft mouse models, SB-T-1214 successfully inhibits tumor growth. This compound is relevant for anti-tumor research, particularly against drug-resistant tumors such as colon, pancreatic, and renal cancers.Formule :C45H59NO15Couleur et forme :SolidMasse moléculaire :853.95Chetomin
CAS :Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar
Formule :C31H30N6O6S4Degré de pureté :98%Couleur et forme :Off-White To Fawn SolidMasse moléculaire :710.87
