Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(114 produits)
- PDK(9 produits)
- PERK(24 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(65 produits)
- c-RET(61 produits)
- p53(63 produits)
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6111 produits trouvés pour "Apoptose"
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BRD9 ligand-5
CAS :BRD9 Ligand-5 (Compound 172-11) serves as a ligand for the target protein in PROTAC applications. It is utilized in the synthesis of CFT8634.Formule :C17H19NO4Couleur et forme :SolidMasse moléculaire :301.34TNF-α/IL-1β-IN-1
TNF-α/IL-1β-IN-1 (compound 11a) is an anti-inflammatory agent that effectively reduces the expression of TNF-α and IL-1β, inhibits oxidative stress and myocardial cell apoptosis, and demonstrates significant activity against septic myocardial injury. Additionally, it improves myocardial blood flow in vivo.Formule :C41H58N2O7Couleur et forme :SolidMasse moléculaire :690.91EGFR-IN-169
EGFR-IN-169 is an epidermal growth factor receptor (EGFR) inhibitor derived from ginsenoside, with an IC50 of 5.19 μM. It disrupts colorectal cancer cell migration and growth by inhibiting the EGFR-mediated RalA/EMT pathway. With an IC50 of 4.46 μM against HCT-116 cells and a selectivity index (SI) of 16.92, EGFR-IN-169 also inhibits CDKs, induces G0/G1 cell cycle arrest, and suppresses cell migration and invasion. Additionally, EGFR-IN-169 reduces mitochondrial membrane potential, induces apoptosis and reactive oxygen species (ROS) production. It is applicable in cancer research, particularly for colorectal cancer.Couleur et forme :Odour SolidNargenicin
CAS :Nargenicin: a macrolide antibiotic effective against S. aureus, MRSA, M. luteus; inhibits bacterial DnaE and reduces inflammation and leukemia cell growth.Formule :C28H37NO8Couleur et forme :SolidMasse moléculaire :515.6Thalidomide-PEG4-NH2 hydrochloride
CAS :Thalidomide-PEG4-NH2 HCl, a cereblon ligand-linker for PROTAC.Formule :C21H28ClN3O8Couleur et forme :SolidMasse moléculaire :485.92Thalidomide-O-C8-NH2 hydrochloride
CAS :Thalidomide-derived cereblon ligand with PROTAC linker as an E3 ligase ligand-linker conjugate, in hydrochloride form.Formule :C21H28ClN3O5Couleur et forme :SolidMasse moléculaire :437.92ERK1/2 inhibitor 13
ERK1/2 inhibitor 13 (Compound 21y) is an orally bioavailable ERK inhibitor that targets ERK1 and ERK2, with IC50 values of 91.71 nM and 97.87 nM, respectively. It effectively suppresses the proliferation of cancer cell lines MCF-7, 4T1, MDA-MB-468, and HCC1970 with IC50 values of 0.67 μM, 2.76 μM, 2.15 μM, and 1.68 μM, respectively. Additionally, it inhibits cancer cell migration, induces apoptosis and autophagy in MCF-7 cells, and demonstrates anti-tumor and anti-metastatic effects in a 4T1 xenograft mouse model.Formule :C36H29BrF6N4OCouleur et forme :SolidMasse moléculaire :727.54Satratoxin G
CAS :Satratoxin G, from Stachybotrys chartarum, triggers apoptosis in nasal and brain OSNs.Formule :C29H36O10Couleur et forme :SolidMasse moléculaire :544.597IDOi-Pt(IV) prodrug-1
IDOi-Pt(IV) prodrug-1 (Compound 10) is an IDOi-Pt(IV) prodrug that suppresses IDO expression. It induces apoptosis, reduces mitochondrial membrane potential, and inhibits tumor cell migration and invasion. Additionally, IDOi-Pt(IV) prodrug-1 triggers reactive oxygen species-mediated endoplasmic reticulum stress and the secretion of damage-associated molecular patterns (DAMPs), leading to immunogenic cell death (ICD). Compared to cisplatin, IDOi-Pt(IV) prodrug-1 exhibits relatively high efficiency and low toxicity in its antitumor activity.Formule :C21H26Cl3N3O6PtSCouleur et forme :SolidMasse moléculaire :749.96Cardanol (C15:1)
CAS :Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells.Formule :C21H34ODegré de pureté :98.48% - 99.77%Couleur et forme :SolidMasse moléculaire :302.49Ref: TM-TN3594
1mg92,00€2mg135,00€5mg259,00€10mg371,00€25mg583,00€50mg800,00€100mgÀ demander1mL*10mM (DMSO)268,00€ZMF-24
ZMF-24 is an anti-triple-negative breast cancer (TNBC) agent that exhibits IC50 values of 0.22 μM and 0.44 μM against BT-549 and MDA-MB-231 TNBC cell proliferation, respectively. It targets the eukaryotic translation initiation factor 3 subunit D (EIF3D), disrupting TNBC's energy supply by inhibiting glycolysis. Additionally, ZMF-24 induces TNBC cell apoptosis (apoptosis) by stimulating sustained endoplasmic reticulum stress.Couleur et forme :Odour SolidThalidomide-O-amido-PEG2-C2-NH2
CAS :Thalidomide-O-amido-PEG2-C2-NH2, which combines an E3 ligase ligand with a linker, serves as an immunomodulator for cancer treatment.Formule :C21H26N4O8Couleur et forme :SolidMasse moléculaire :462.459Thevetiaflavone
CAS :Thevetiaflavone, a natural flavonoid from W. indica, blocks LDH leakage, boosting cell survival.Formule :C16H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :284.26Human membrane-bound PD-L1 polypeptide
CAS :Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].Formule :C85H140N26O36SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2134.24HPOB
CAS :HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.Formule :C17H18N2O4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :314.345-LOX-IN-8
5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory properties. It suppresses IL-6, IL-1β, TNF-α, and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. Additionally, 5-LOX-IN-8 decreases the disease activity index in DSS colitis models. This compound is applicable for research in inflammatory bowel disease (IBD).Couleur et forme :Odour SolidHellebrin
CAS :Cytotoxic and antiproliferative effects of Hellebrin on breast and lung cancer cells.Formule :C36H52O15Couleur et forme :SolidMasse moléculaire :724.79MitoEbselen-2 chloride
CAS :MitoEbselen-2 mitigates radiation, cuts lipid hydroperoxides, blocks cell death, and boosts survival in irradiated mice.Formule :C35H30ClN2O2PSeCouleur et forme :SolidMasse moléculaire :656.01DS-5272
CAS :DS-5272 is a potent and orally active inhibitor of p53-MDM2 interaction.Formule :C34H38Cl2F2N6O2SCouleur et forme :SolidMasse moléculaire :703.67BM-1074
CAS :BM-1074 is a potent and highly efficacious inhibitor of Bcl-2/Bcl-xL with Ki value of < 1nM [1].Formule :C50H57ClN8O7S3Couleur et forme :SolidMasse moléculaire :1013.69
