Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6190 produits trouvés pour "Apoptose"
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CDK2-IN-32
CDK2-IN-32 (Compound 5g) is a selective CDK2 inhibitor with an IC50 of 0.21 μM. It exhibits cytotoxicity towards Vero cells with an IC50 of 28.52 μM.Formule :C18H13Cl2N5O2Couleur et forme :SolidMasse moléculaire :402.23Chol-CTPP
Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.Formule :C144H263N3O53Couleur et forme :SolidMasse moléculaire :2884.62STK17A/B-IN-1 hydrochloride
STK17A/B-IN-1 hydrochloride is a potent, selective, orally active inhibitor of STK17A/B, displaying an IC50 value of 23 nM against STK17A. It is utilized in the research of tumors.Formule :C26H28ClN7OCouleur et forme :SolidMasse moléculaire :490.00SZU-B6
CAS :SZU-B6, a PROTAC degrader, targets and degrades SIRT6 with DC50 values of 45 nM in SK-HEP-1 cells and 154 nM in Huh-7 cells. It inhibits the proliferation of SK-HEP-1 cells with an IC50 of 1.51 μM and suppresses colony formation in both SK-HEP-1 and Huh-7 cell lines. Additionally, SZU-B6 induces apoptosis in SK-HEP-1 cells and causes cell cycle arrest at the G2/M phase. It demonstrates anti-tumor activity in murine models.Formule :C29H32FN7O6Couleur et forme :SolidMasse moléculaire :593.61MK-4166
MK-4166 is a humanized IgG1 agonistic monoclonal antibody targeting GITR. It is capable of enhancing the proliferation of both naive T lymphocytes and tumor-infiltrating T lymphocytes.Echitamine chloride
CAS :Echitamine chloride, an alkaloid in Alstonia scholaris, has anti-cancer properties and inhibits pancreatic lipase (IC50: 10.92 µM).Formule :C22H29ClN2O4Couleur et forme :SolidMasse moléculaire :420.93Mcl-1 antagonist 1
CAS :Mcl-1 antagonist 1 is a Mcl-1 protein antagonist.Formule :C41H54ClF2N5O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :850.42Thalidomide-O-amido-C3-COOH
CAS :Thalidomide-O-amido-C3-COOH is a cereblon ligand-linker for PROTACs, melding Thalidomide with a standard linker.Formule :C19H19N3O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.37Ac-LEVD-CHO
CAS :Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].Formule :C22H36N4O9Couleur et forme :SolidMasse moléculaire :500.54Sarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+Formule :C38H44O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :692.75WKYMVM TFA
CAS :WKYMVm is a selective FPR2 agonist with high affinity, which was identified through screening of a synthetic peptide library.Formule :C43H62F3N9O9S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :970.135,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin
CAS :5,10,15,20-Tetrakis(4-methoxyphenyl)porphyrin is a capable of forming complexes with metal ions and exhibit phototoxicity towards Hep-2 cells.Formule :C48H38N4O4Couleur et forme :SolidMasse moléculaire :734.84Topoisomerase I inhibitor 17
CAS :TopoisomeraseI inhibitor 17 (Compound 7h) is an inhibitor of TopoisomeraseI (Top1). It reduces DDX5 and reverses the locking effect of DDX5 on Top1 activity. This compound induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. It triggers apoptosis by decreasing anti-apoptotic proteins XIAP, Bcl-2, and Survivin, while increasing pro-apoptotic proteins Bax and γH2AX. Moreover, TopoisomeraseI inhibitor 17 halts progression at the G2/M checkpoint, leading to cell cycle arrest. It significantly impairs colorectal cancer cell colony formation and migration, and effectively reduces tumor size in human PDX tumor mouse models.Formule :C28H21FN2O7Couleur et forme :SolidMasse moléculaire :516.47Ub4ix
CAS :Ub4ix, a DUB/26S proteasome inhibitor, safeguards K48-linked Ub chains against cleavage by deubiquitinating enzymes (DUBs) and inhibits the proteasomal degradation of Ub-tagged proteins. Additionally, it diminishes the viability of Hela cells and triggers apoptosis, exhibiting an IC 50 value of 1.6 μM.Formule :C84H106N18O23SCouleur et forme :SolidMasse moléculaire :1767.91Aviculin
CAS :Aviculin, a lignan glycoside, exhibits anticancer properties by inducing apoptosis in breast cancer cells with an IC50 of 75.47 μM.Formule :C26H34O10Couleur et forme :SolidMasse moléculaire :506.54Tizanidine
CAS :Tizanidine, an α2-adrenergic receptor agonist, suppresses the release of neurotransmitters from central nervous system (CNS) noradrenergic neurons.Formule :C9H8ClN5SDegré de pureté :99.11%Couleur et forme :White SolidMasse moléculaire :253.71WK369
WK369 is an innovative small molecule inhibitor of BCL6, demonstrating remarkable bioactivity against ovarian cancer by inducing cell cycle arrest and triggering apoptosis. It binds directly to the BCL6-BTB domain, obstructing the interaction between BCL6 and SMRT, which results in the reactivation of p53, ATR, and CDKN1A.Formule :C19H20FN5O2Masse moléculaire :369.1601Pamlectabart
Pamlectabart is a humanised antibody targeting TNFRSF17/BCMA, (ADC) Pamlectabart tismanitin multiple myeloma.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :145.20 kDaPomalidomide-C5-Dovitinib
CAS :Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC that links Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity inFormule :C39H38FN9O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :747.77155H1
155H1 (Compound 11) is a stapled peptide that covalently binds to hMcl1 (172-323) with an IC50 of 18 nM.Formule :C79H120FN19O23SMasse moléculaire :1753.85092
