Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(545 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(226 produits)
- HSP(179 produits)
- Intégrine(249 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(124 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
Affichez 10 plus de sous-catégories
3860 produits trouvés pour "Cycle cellulaire/point de contrôle"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
N3-[(Pyrid-4-yl)methyl]uridine
N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, may have antiepileptic properties and aid in researching anticonvulsants and anxiolytics.Formule :C15H17N3O6Couleur et forme :SolidMasse moléculaire :335.31Guanosine triphosphate
CAS :Guanosine triphosphate (GTP), a native nucleotide, and its derivatives may serve as specific inhibitors against COVID-19 [1].Formule :C10H16N5O14P3Couleur et forme :SolidMasse moléculaire :523.18RA-V
RA-V is a natural product that can be used as a reference standard.Formule :C160H202N24O41Couleur et forme :SolidMasse moléculaire :3117.5Chrysomycin A
CAS :Chrysomycin A is an antibiotic that can be derived from Streptomyces.Formule :C28H28O9Couleur et forme :SolidMasse moléculaire :508.52PDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.Formule :C17H12F3NO2Couleur et forme :SolidMasse moléculaire :319.2783'-Deoxy-GTP trisodium
3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.
Couleur et forme :Odour SolidFuzapladib
CAS :Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.
Formule :C15H20F3N3O3SDegré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :379.4dCeMM3
CAS :dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.
Formule :C14H11ClN4OSDegré de pureté :98.48% - 99.41%Couleur et forme :SolidMasse moléculaire :318.78Censavudine
CAS :Censavudine (OBP-601) is an HIV-1/2 treatment and prevention drug, a reverse transcriptase inhibitor with EC50 of 30-890 nM.Formule :C12H12N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.23Heliquinomycin
CAS :Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.Formule :C33H30O17Couleur et forme :SolidMasse moléculaire :698.586CDK4/6-IN-5
CAS :CDK4/6-IN-5 inhibits CDK4/6; Ki: 0.2 nM (CDK4/D1) & 4.4 nM (CDK6/D3). (WO2019207463A1, A93)Formule :C22H28ClFN6O4SCouleur et forme :SolidMasse moléculaire :527.01DHFR-IN-11
DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.Couleur et forme :Odour SolidCarboxy pyridostatin trifluoroacetate salt
Carboxy pyridostatin trifluoroacetate salt exhibits higher molecular specificity for RNA over DNA G4s.Formule :C37H35F3N10O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :820.73Filanesib TFA
CAS :Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.
Formule :C22H23F5N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.55'-O-DMT-rI
CAS :5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1].Formule :C31H30N4O7Couleur et forme :SolidMasse moléculaire :570.59JB300
CAS :JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formule :C43H45ClFN7O10SCouleur et forme :SolidMasse moléculaire :906.375Sarecycline hydrochloride
CAS :Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.Formule :C24H30ClN3O8Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :523.965'-O-TBDMS-dA
CAS :5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
Formule :C16H27N5O3SiCouleur et forme :SolidMasse moléculaire :365.509WAY-647802
CAS :WAY-647802 is a CDK inhibitor.Formule :C11H14N4O3Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :250.25Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Formule :C13H20N2O6Couleur et forme :SolidMasse moléculaire :300.308JH-XVI-178
CAS :JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.Formule :C22H22ClN7OCouleur et forme :SolidMasse moléculaire :435.92Bz-rC Phosphoramidite
CAS :Bz-rC Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.Formule :C52H66N5O9PSiCouleur et forme :SolidMasse moléculaire :964.185XT17
XT17 is an anthrone compound with broad-spectrum antibacterial activity, exerting its effects by disrupting the cell wall and inhibiting DNA synthesis. It demonstrates weak hemolytic activity, low cytotoxicity to mammalian cell lines, and a low rate of resistance development. Additionally, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies confirm that XT17 forms a stable complex with bacterial gyrase. XT17 is suitable for research in the field of anti-infective agents.Couleur et forme :Odour Solid16,16-dimethyl Prostaglandin A1
CAS :16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.Formule :C22H36O4Couleur et forme :SolidMasse moléculaire :364.526GSK270822A
CAS :GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.Formule :C24H20N4O2Degré de pureté :98.64% - 99.78%Couleur et forme :SolidMasse moléculaire :396.44Ref: TM-T27467
1mg133,00€5mg314,00€10mg416,00€25mg632,00€50mg847,00€100mg1.134,00€200mg1.513,00€1mL*10mM (DMSO)323,00€CDK12-IN-6
CAS :CDK12-IN-6, a pyrazolotriazine, strongly inhibits CDK12 (IC50 1.19 μM at 2 mM ATP), but not CDK2/Cyclin E or CDK9/Cyclin T1 (both IC50 >20 μM).Formule :C20H21F2N9Couleur et forme :SolidMasse moléculaire :425.448αVβ8-IN-1
CAS :αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).Formule :C25H32ClN5O4Couleur et forme :SolidMasse moléculaire :502.01EC0488
CAS :EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity.Formule :C65H98N16O34SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1679.63(1S,3R,5R)-PIM447 dihydrochloride
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).Formule :C24H25Cl2F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.385-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS :5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.Formule :C22H31N3O5SiCouleur et forme :SolidMasse moléculaire :445.58Nitrosofolic acid
CAS :Nitrosofolic acid is a folic acid derivaive.Formule :C19H18N8O7Couleur et forme :SolidMasse moléculaire :470.40Gly-Arg-Gly-Asp-Ser
CAS :Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.Formule :C17H30N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.47TTK/PLK1-IN-1
CAS :TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.Formule :C30H33N7O2Degré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :523.63SP27
CAS :SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].Formule :C40H40F2N12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :806.82Adenosine Dialdehyde (ADOX)
CAS :Adenosine Dialdehyde, a purine analogue, inhibits SAHH (Ki=3.3 nM), and shows strong anti-tumor effects in vivo.Formule :C10H11N5O4Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :265.23Ref: TM-T22231
5mg52,00€10mg66,00€25mg88,00€50mg155,00€100mg225,00€200mg335,00€500mg565,00€1mL*10mM (DMSO)57,00€5'-O-DMT-N2-DMF-dG
CAS :5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, finds application in deoxyribonucleic acid (DNA) or nucleic acid synthesis.Formule :C34H36N6O6Couleur et forme :SolidMasse moléculaire :624.698GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Formule :C21H22N6O2Couleur et forme :SolidMasse moléculaire :390.44Cdk2/Cyclin Inhibitory Peptide I
CDK2, a Ser/Thr kinase, is akin to yeast cdc28 and human Cdk1, crucial for cell division.Formule :C111H196N48O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2571.05Mumefural
CAS :Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.
Formule :C12H12O9Couleur et forme :SolidMasse moléculaire :300.22DHODH-IN-16
CAS :DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).Formule :C24H25FN4O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :436.483'-Deoxyuridine-5'-triphosphate trisodium
3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).Formule :C9H12N2Na3O14P3Couleur et forme :SoildMasse moléculaire :534.08Cy5-dATP
Cy5-dATP is a Cy5 -labeled dATP . Cy5-dATP can be incorporated into a DNA primer [1] [2] .
Formule :C47H58N7O19P3S2Couleur et forme :SolidMasse moléculaire :1182.05Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.Formule :C21H25FN4O2Couleur et forme :SolidMasse moléculaire :384.45UnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.Formule :C39H35NO10C6H15NCouleur et forme :SolidMasse moléculaire :778.346555'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.Formule :C44H49F2N4O7PCouleur et forme :SolidMasse moléculaire :814.855-Iminodaunorubicin
CAS :5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.Formule :C27H30N2O9Couleur et forme :SolidMasse moléculaire :526.54CDK4/6-IN-23
CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.Formule :C32H34FN7O4Couleur et forme :SolidMasse moléculaire :599.6555'(R)-C-Methyl-5-fluorouridine
5’(R)-C-Methyl-5-fluorouridine, a uridine analogue, possesses potential antiepileptic properties.Formule :C10H13FN2O6Couleur et forme :SolidMasse moléculaire :276.22Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Formule :C25H41N11O8SCouleur et forme :SolidMasse moléculaire :655.727PROTAC CDK9 degrader-7
CAS :PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (Formule :C43H50Cl2N8O9Couleur et forme :SoildMasse moléculaire :893.81Rifalazil
CAS :Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Formule :C51H64N4O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :941.075'-O-DMT-Bz-rC
CAS :5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.Formule :C37H35N3O8Couleur et forme :SolidMasse moléculaire :649.69Cytarabine triphosphate
CAS :Ara-CTP, active Cytarabine metabolite, inhibits DNA synthesis, predicts leukemic chemosensitivity.Formule :C9H16N3O14P3Couleur et forme :SolidMasse moléculaire :483.16STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Degré de pureté :97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :Odour LiquidChk1-IN-6
CAS :Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.
Formule :C16H18F3N7Couleur et forme :SolidMasse moléculaire :365.364Aclacinomycin A
CAS :Aclacinomycin A has a wide range of applications in life science related research.Formule :C42H53NO15Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :811.87Flurocitabine HCl
CAS :Fluorocitabine HCl, a cytarabine analog, hydrolyzes into ara-FC and ara-FU, showing antitumor effects in leukemia and solid cancers.Formule :C9H11ClFN3O4Degré de pureté :99.23% - 99.76%Couleur et forme :SoildMasse moléculaire :279.655'-O-TBDMS-Bz-dA
CAS :5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.Formule :C23H31N5O4SiCouleur et forme :SolidMasse moléculaire :469.617PROTAC CDK9 degrader-8
PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].Formule :C44H52Cl2N10O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :903.85Ac-dA Phosphoramidite
CAS :Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.Formule :C42H50N7O7PCouleur et forme :SolidMasse moléculaire :795.878Barasertib
CAS :AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formule :C26H31FN7O6PDegré de pureté :99.92% - 99.97%Couleur et forme :SolidMasse moléculaire :587.543'-β-C-Methyl-2-thiouridine
3’-β-C-Methyl-2-thiouridine, a purine nucleoside analog, exhibits extensive antitumor activity, particularly against indolent lymphoid malignancies.Formule :C10H14N2O5SCouleur et forme :SolidMasse moléculaire :274.29N7-Methyl-2'-O-(2-methoxyethyl) guanosine
N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Formule :C14H21N5O6Couleur et forme :SolidMasse moléculaire :355.35ONX 0801 trisodium
CAS :ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Formule :C32H30N5Na3O10Couleur et forme :SolidMasse moléculaire :713.58AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61α2β1 Integrin Ligand Peptide
CAS :The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFormule :C14H22N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.35Erythromycin lactobionate
CAS :Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.Formule :C49H89NO25Couleur et forme :SolidMasse moléculaire :1092.233N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS :N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Formule :C21H35N12O17P3Couleur et forme :SolidMasse moléculaire :820.498-NH2-ATP
CAS :8-NH2-ATP is an inactive derivative of adenosine triphosphate (ATP), synthesized from 8-NH2-Ado.Formule :C10H17N6O13P3Couleur et forme :SolidMasse moléculaire :522.205-Caroxy uracil-1-yl acetic acid benzyl ester
5-Caroxy uracil-1-yl acetic acid benzyl ester, a purine analog, inhibits DNA synthesis and induces apoptosis to combat lymphoid cancers.Formule :C14H12N2O6Couleur et forme :SolidMasse moléculaire :304.256-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
6-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue with broad antitumor activity, particularly againstFormule :C10H15N7O4Couleur et forme :SolidMasse moléculaire :297.27Rev 2'-O-MOE-C(Bz)-5'-amidite
'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Formule :C49H58N5O10PCouleur et forme :SolidMasse moléculaire :907.99XY028-133
CAS :XY028-133 is a PROTAC-based CDK4/6 degrader for the study of tumors.
Formule :C53H67N11O7SDegré de pureté :97.11%Couleur et forme :SolidMasse moléculaire :1002.237-TFA-ap-7-Deaza-ddA
CAS :Compound 19c is a nucleotide derivative for DNA sequencing dye terminators.Formule :C16H16F3N5O3Couleur et forme :SolidMasse moléculaire :383.3311-(β-D-Xylofuranosyl)-N6-Isopentenyladenine
1-(β-D-Xylofuranosyl)-N6-Isopentenyladenine is an adenosine analog.Formule :C15H21N5O4Couleur et forme :SolidMasse moléculaire :335.365'-O-DMT-ibu-dC
CAS :5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.Formule :C34H37N3O7Couleur et forme :SolidMasse moléculaire :599.67N1-Methylpseudouridine-5′-triphosphate tetralithium
N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.Formule :C10H13Li4N2O15P3Couleur et forme :SolidMasse moléculaire :521.9N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-deoxycytidine
N4-Acetyl-5’-O-(4,4’-dimethoxytrityl)-5-methyl-2’-deoxycytidine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolentFormule :C33H35N3O7Couleur et forme :SolidMasse moléculaire :585.65DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Couleur et forme :Odour SolidIRE1α kinase-IN-6
CAS :IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM.Formule :C25H23Cl2FN6O3S2Couleur et forme :SolidMasse moléculaire :609.52Adenosine-2-carboxy methyl amide
Adenosine-2-carboxy methyl amide: a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis.Formule :C12H16N6O5Couleur et forme :SolidMasse moléculaire :324.29LDV
CAS :α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.Formule :C48H70N10O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :979.13Psammaplin A
CAS :Psammaplin A: marine-derived, inhibits HDAC/DNA methyltransferases, strong DAC1 blocker (IC50=0.9nM), antimicrobial against Gram-positive bacteria, anticancer.Formule :C22H24Br2N4O6S2Couleur et forme :SolidMasse moléculaire :664.38KWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Formule :C33H31ClF3N9O4Couleur et forme :SolidMasse moléculaire :710.105NUAK1-IN-1
NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formule :C25H30N6OCouleur et forme :SolidMasse moléculaire :430.545Nusinersen
CAS :Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.Degré de pureté :98.62%Couleur et forme :SolidSNX7
CAS :SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Formule :C15H14N2ODegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :238.282'-Deoxy-2'-fluoro-l-uridine
CAS :2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.Formule :C9H11FN2O5Couleur et forme :SolidMasse moléculaire :246.198-Chloro-2'-O-methyl inosine
8-Chloro-2’-O-methyl inosine, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Formule :C11H13ClN4O5Couleur et forme :SolidMasse moléculaire :316.72'-Deoxy-2'-fluoro-N3-[3-(tert-butoxycarbonyl) amino]propyluridine
2’-Deoxy-2’-fluoro-N3-[3-(tert-butoxycarbonyl)amino]propyluridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolentFormule :C17H26FN3O7Couleur et forme :SolidMasse moléculaire :403.4PKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Formule :C24H26FN5O2Couleur et forme :SolidMasse moléculaire :435.49Antibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Couleur et forme :Odour Solidm7GpppCmpG
CAS :m7GpppCmpG, a trinucleotide cap analogue, enables RNA manufacturing with cap 0 or cap 1 structures.Formule :C31H43N13O25P4Couleur et forme :SolidMasse moléculaire :1121.642'-O-Acetyl-5'-O-benzoyl-3'-O-(2-methoxyethyl) uridine
2’-O-Acetyl-5’-O-benzoyl-3’-O-(2-methoxyethyl) uridine, an analog of uridine known for its potential antiepileptic properties, is utilized in researchingFormule :C21H24N2O9Couleur et forme :SolidMasse moléculaire :448.42Guanosine 5'-triphosphate trisodium salt hydrate
CAS :5'-GTP trisodium salt hydrate activates G proteins and is a precursor for DNA/RNA synthesis.Formule :C10H18N5NaO15P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.185wrwyar-NH2 TFA
wrwyar-NH2 (TFA) serves as the control peptide for wrwycr-NH2.Couleur et forme :Odour Solid3'Ome-m7GpppAmpG
CAS :3'Ome-m7GpppAmpG is a trinucleotide cap with LNA, boosting translation; useful in mRNA vaccines and gene therapy.Formule :C33H45N15O24P4Couleur et forme :SolidMasse moléculaire :1159.69TFMU-ADPr triethylamine
TFMU-ADPr triethylamine is a substrate for PARG activity measurement, releasing a fluorophore to indicate PAR hydrolase activity.Formule :C25H26F3N5O16P2·5C6H15NCouleur et forme :SolidMasse moléculaire :1024.42CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Formule :C24H22FN7O2Couleur et forme :SolidMasse moléculaire :459.48Pseudouridimycin
CAS :Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.Formule :C17H26N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.44
