Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
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Isocytosine
CAS :<p>Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formule :C4H5N3OCouleur et forme :White To Off-White SolidMasse moléculaire :111.1PAT-LM1
<p>PAT-LM1 is a human monoclonal antibody that targets NRB54/NONO. It is applicable in the study of hematological malignancies.</p>Couleur et forme :Odour LiquidMps1-IN-6
<p>Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].</p>Formule :C35H39N9O3Couleur et forme :SolidMasse moléculaire :633.74RNA splicing modulator 3
CAS :<p>RNA Splicing Modulator 3 (Compound 236) is an effective RNA splicing modulator, exhibiting an AC50 value of less than 100 nM [1].</p>Formule :C19H20N6OSCouleur et forme :SolidMasse moléculaire :380.47MRK-952
<p>MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.</p>Formule :C20H20ClF3N6Couleur et forme :SolidMasse moléculaire :436.861N3,5-Dimethyl-2'-O-(2-methoxyethyl) uridine
<p>N3,5-Dimethyl-2’-O-(2-methoxyethyl) uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formule :C14H22N2O7Couleur et forme :SolidMasse moléculaire :330.33Stigmatellin
CAS :<p>Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.</p>Formule :C30H42O7Couleur et forme :SolidMasse moléculaire :514.65N1-Methyl-2'-β-C-methyl adenosine
<p>N1-Methyl-2’-beta-C-methyl adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formule :C12H17N5O4Couleur et forme :SolidMasse moléculaire :295.29CDK5-IN-1
CAS :<p>CDK5-IN-1: Potent CDK5 inhibitor (<10 nM) used in kidney disease research.</p>Formule :C24H25FN6O3SCouleur et forme :SolidMasse moléculaire :496.56Rev dC(Bz)-5'-amidite
<p>Rev dC(Bz)-5'-amidite, a purine nucleoside analog with antitumor effects, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.</p>Formule :C46H52N5O8PCouleur et forme :SolidMasse moléculaire :833.916-Thioguanosine
CAS :<p>6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside and low molecular weight gel.6-Thioguanosine has immunosuppressive properties.</p>Formule :C10H13N5O4SDegré de pureté :97.05%Couleur et forme :Yellow-Green PowderMasse moléculaire :299.31Remdesivir nucleoside monophosphate
CAS :<p>Remdesivir metabolite, antiviral nucleoside analog, effective against SARS-CoV and MERS-CoV.</p>Formule :C12H14N5O7PCouleur et forme :SolidMasse moléculaire :371.24Sarecycline hydrochloride
CAS :<p>Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.</p>Formule :C24H30ClN3O8Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :523.96Uridine triphosphate 13C9,15N2 sodium
CAS :<p>Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.</p>Formule :C9H1415N2NaO15P3Couleur et forme :SolidMasse moléculaire :517.04Rifalazil
CAS :<p>Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.</p>Formule :C51H64N4O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :941.07m7GpppApG
CAS :<p>M7GpppApG is a trinucleotide mRNA 5' cap analog utilized for in vitro RNA synthesis [1].</p>Formule :C31H41N15O24P4Couleur et forme :SolidMasse moléculaire :1131.64Xanthosine-5'-Triphosphate
CAS :<p>Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.</p>Formule :C10H15N4O15P3Couleur et forme :SolidMasse moléculaire :524.164Subquinocin
<p>Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.</p>Formule :C20H27N3O4SCouleur et forme :SolidMasse moléculaire :405.172235-Methylcytidine 5′-triphosphate trisodium
<p>5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, while</p>Formule :C10H15N3Na3O14P3Couleur et forme :SolidMasse moléculaire :563.13Etrolizumab
CAS :<p>MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.</p>Degré de pureté :98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Couleur et forme :LiquidPKMYT1-IN-3
<p>PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.</p>Formule :C24H26FN5O2Couleur et forme :SolidMasse moléculaire :435.49AB-3PRGD2
CAS :<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formule :C137H215IN30O45SCouleur et forme :SolidMasse moléculaire :3161.325'-O-DMT-N2-DMF-dG
CAS :<p>5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, finds application in deoxyribonucleic acid (DNA) or nucleic acid synthesis.</p>Formule :C34H36N6O6Couleur et forme :SolidMasse moléculaire :624.698SD49-7
CAS :<p>SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.</p>Formule :C18H14N2O3Degré de pureté :99.91%Couleur et forme :SoildMasse moléculaire :306.322-Methylbutyrylcarnitine chloride
<p>2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.</p>Formule :C12H24ClNO4Couleur et forme :SolidMasse moléculaire :281.78N4-(3,3,3-Trifluoropropanoyl)cytidine
<p>N4-(3,3,3-Trifluoropropanoyl)cytidine, a cytidine analog, inhibits DNA methyltransferases, possibly anti-metabolic and anti-cancer.</p>Formule :C12H14F3N3O6Couleur et forme :SolidMasse moléculaire :353.25AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61Emicoron
CAS :<p>Importazole is an inhibitor of the transport receptor importin-β. It specifically inhibits importin-β likely by altering its interaction with RanGTP.</p>Formule :C52H58N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :831.05Pseudouridimycin
CAS :<p>Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.</p>Formule :C17H26N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.44HEMTAC WEE1 degrader-1
CAS :<p>HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.</p>Formule :C57H71N15O6Couleur et forme :SolidMasse moléculaire :1062.27Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Formule :C25H41N11O8SCouleur et forme :SolidMasse moléculaire :655.727DSPE-PEG1000-cRGD
<p>DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.</p>Couleur et forme :Odour Solid2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
CAS :<p>dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.</p>Formule :C10H14N5Na2O8PCouleur et forme :SolidMasse moléculaire :409.202RNA splicing modulator 2
CAS :<p>RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .</p>Formule :C20H21N5OSCouleur et forme :SolidMasse moléculaire :379.48c(phg-isoDGR-(NMe)k) TFA
<p>C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].</p>Formule :C29H42F3N9O9Couleur et forme :SolidMasse moléculaire :717.691-(β-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine
<p>1-(β-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine is an adenosine analog.</p>Formule :C18H18F3N5O4Couleur et forme :SolidMasse moléculaire :425.363,5'-Bis(O-t-butyldimethylsilyl)-2'-O-methyl-5-methyl cytidine
<p>3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine, a cytidine analog, inhibits DNA methyltransferases (e.g., Zebularine), exhibiting potential anti</p>Formule :C23H45N3O5Si2Couleur et forme :SolidMasse moléculaire :499.79CDK7-IN-2 hydrochloride hydrate
CAS :<p>CDK7-IN-2 HCl hydrate is a potent, specific CDK7 enzyme inhibitor with significant anti-cancer effects.</p>Formule :C26H42ClN7O4Couleur et forme :SolidMasse moléculaire :552.12αVβ8-IN-1
CAS :<p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>Formule :C25H32ClN5O4Couleur et forme :SolidMasse moléculaire :502.01WAY-230563
CAS :<p>WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cells</p>Formule :C17H12N2O2SDegré de pureté :98.40%Couleur et forme :SolidMasse moléculaire :308.35CDK2/PIM1-IN-1
<p>CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.</p>Couleur et forme :Odour SolidCy5-dATP
<p>Cy5-dATP is a Cy5 -labeled dATP . Cy5-dATP can be incorporated into a DNA primer [1] [2] .</p>Formule :C47H58N7O19P3S2Couleur et forme :SolidMasse moléculaire :1182.05JH-XVI-178
CAS :<p>JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.</p>Formule :C22H22ClN7OCouleur et forme :SolidMasse moléculaire :435.92huATN-658
<p>huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.</p>Couleur et forme :Odour LiquidEesperamicin A1
CAS :<p>Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.</p>Formule :C59H80N4O22S4Couleur et forme :SolidMasse moléculaire :1325.54Tirandamycin A
<p>Tirandamycin A is a useful organic compound for research related to life sciences and the catalog number is T124996.</p>Formule :C22H27NO7Couleur et forme :SolidMasse moléculaire :417.458Erythromycin A dihydrate
CAS :<p>Erythromycin dihydrate, a macrolide antibiotic from Streptomyces erythreus, targets 50S ribosomal subunits, blocking protein synthesis.</p>Formule :C37H69NO14Couleur et forme :SolidMasse moléculaire :751.94Psammaplin A
CAS :<p>Psammaplin A: marine-derived, inhibits HDAC/DNA methyltransferases, strong DAC1 blocker (IC50=0.9nM), antimicrobial against Gram-positive bacteria, anticancer.</p>Formule :C22H24Br2N4O6S2Couleur et forme :SolidMasse moléculaire :664.38Chk1-IN-6
CAS :<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Formule :C16H18F3N7Couleur et forme :SolidMasse moléculaire :365.364m7Gpppm6AmpG
CAS :<p>m7Gpppm6AmpG, a trinucleotide mRNA 5’ cap analog, facilitates RNA synthesis in vitro [1].</p>Formule :C33H45N15O24P4Couleur et forme :SolidMasse moléculaire :1159.69SP27
<p>SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].</p>Formule :C40H40F2N12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :806.826-O-Methyl-2'-O-methylinosine
<p>6-O-Methyl-2’-O-methylinosine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formule :C12H16N4O5Couleur et forme :SolidMasse moléculaire :296.28Heliquinomycin
CAS :<p>Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.</p>Formule :C33H30O17Couleur et forme :SolidMasse moléculaire :698.586N6-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl) adenosine
<p>N6-Benzoyl-3'-O-DMT-adenosine is a purine analog with antitumor effects by hindering DNA synthesis and inducing apoptosis.</p>Formule :C41H41N5O8Couleur et forme :SolidMasse moléculaire :731.79(1S,3R,5R)-PIM447 dihydrochloride
<p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>Formule :C24H25Cl2F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.3812R-LOX-IN-2
CAS :<p>12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.</p>Formule :C19H13NODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :271.31Mulnitorsen
CAS :<p>Mulnitorsen acts as an inhibitor of antisense non-coding mitochondrial RNA (ASncmtRNA) synthesis and serves as an antitumor agent [1].</p>Formule :C172H217N74O82P17S17Couleur et forme :SolidMasse moléculaire :5704.662'-Deoxy-2'-fluorouridine 5'-monophosphate triethyl ammonium
<p>2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits extensive antitumor effects against indolent lymphoid</p>Formule :C21H42FN4O7PCouleur et forme :SolidMasse moléculaire :512.553'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
<p>3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolent lymphoid</p>Formule :C38H43N5O9Couleur et forme :SolidMasse moléculaire :713.785'-O-DMT-N4-Ac-2'-F-dC
CAS :<p>5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formule :C32H32FN3O7Couleur et forme :SolidMasse moléculaire :589.61Chrysomycin A
CAS :<p>Chrysomycin A is an antibiotic that can be derived from Streptomyces.</p>Formule :C28H28O9Couleur et forme :SolidMasse moléculaire :508.52Deoxythymidine-5'-triphosphate sodium hydrate
<p>dTTP sodium hydrate, a DNA synthesis component, is a nucleoside triphosphate.</p>Formule :C10H17N2O14P3·xNa·xH2OCouleur et forme :SolidMasse moléculaire :C10H17N2O14P3.xNa.xH2ODG1
<p>DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressing</p>Formule :C19H17N5O5SCouleur et forme :SolidMasse moléculaire :427.43Mumefural
CAS :<p>Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.</p>Formule :C12H12O9Couleur et forme :SolidMasse moléculaire :300.22m7GpppCpG
CAS :<p>m7GpppCpG, a trinucleotide cap analogue, is used for synthesizing RNA with cap 0 or cap 1 structures.</p>Formule :C30H41N13O25P4Couleur et forme :SolidMasse moléculaire :1107.61CDK2-IN-7
CAS :<p>CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).</p>Formule :C24H30N6O4SCouleur et forme :SolidMasse moléculaire :498.6CW-2
<p>CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).</p>Formule :C43H42Cl2FN11O10PtCouleur et forme :SolidMasse moléculaire :1156.212515-(2-Hydroxyethyl)-2',3'-di-O-toluoyl-2'-deoxyuridine
<p>5-(2-Hydroxyethyl)-2',3'-di-O-toluoyl-2'-deoxyuridine, a purine nucleoside analog, exhibits widespread antitumor activity specifically against indolent lymphoid</p>Formule :C27H28N2O8Couleur et forme :SolidMasse moléculaire :508.52JB300
CAS :<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Formule :C43H45ClFN7O10SCouleur et forme :SolidMasse moléculaire :906.3755-Iminodaunorubicin
CAS :<p>5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.</p>Formule :C27H30N2O9Couleur et forme :SolidMasse moléculaire :526.54TTK/PLK1-IN-1
CAS :<p>TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.</p>Formule :C30H33N7O2Degré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :523.63Nogalamycin
CAS :<p>Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.</p>Formule :C39H49NO16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.8125'-O-TBDMS-dA
CAS :<p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formule :C16H27N5O3SiCouleur et forme :SolidMasse moléculaire :365.5095'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
<p>5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.</p>Formule :C44H49F2N4O7PCouleur et forme :SolidMasse moléculaire :814.85WAY-647802
CAS :<p>WAY-647802 is a CDK inhibitor.</p>Formule :C11H14N4O3Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :250.25Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Formule :C21H25FN4O2Couleur et forme :SolidMasse moléculaire :384.45Anticancer agent 263
<p>Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.</p>Formule :C13H20N2O6Couleur et forme :SolidMasse moléculaire :300.3086-Methoxypurine-9-β-D-5'(R)-C-methylriboside
<p>6-Methoxypurine-9-β-D-5’(R)-C-methylriboside, an analog of hypoxanthine—a purine base predominantly found in muscle tissue and a metabolite generated when</p>Formule :C12H16N4O5Couleur et forme :SolidMasse moléculaire :296.28Obtustatin
<p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>Formule :C184H284N52O57S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4393.0713-TP
<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>Formule :C12H19F2N6O12P3Couleur et forme :SolidMasse moléculaire :570.23Rachelmycin
CAS :<p>Rachelmycin, a potent antibiotic and antitumor agent from Streptomyces zelensis, binds to DNA's minor groove.</p>Formule :C37H33N7O8Couleur et forme :SolidMasse moléculaire :703.712wrwycr-NH2 TFA
<p>wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.</p>Couleur et forme :Odour SolidBz-rC Phosphoramidite
CAS :<p>Bz-rC Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>Formule :C52H66N5O9PSiCouleur et forme :SolidMasse moléculaire :964.185DNA Gyrase-IN-6
<p>Agent 138: soluble benzothiazole, inhibits DNA gyrase/topoisomerase IV, targets Gram+ & Gram- bacteria, binds plasma proteins.</p>Formule :C18H16Cl2N4O4SCouleur et forme :SolidMasse moléculaire :455.32EC0488
CAS :<p>EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity.</p>Formule :C65H98N16O34SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1679.63Biotin-PEG8-Vidarabine
<p>Biotin-PEG8-Vidarabine is an antiviral PEG linker targeting herpes and varicella zoster with adenosine analog Vidarabine.</p>Formule :C36H60N8O13SCouleur et forme :SolidMasse moléculaire :844.973,6-DMAD hydrochloride
<p>3,6-DMAD hydrochloride functions as an inhibitor for the IRE1α-XBP1 pathway within the unfolded protein response mechanism.</p>Formule :C22H31N5xHClDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.525-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS :<p>5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.</p>Formule :C22H31N3O5SiCouleur et forme :SolidMasse moléculaire :445.585'-O-DMT-2'-O-TBDMS-Ac-rC
CAS :<p>5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formule :C38H47N3O8SiCouleur et forme :SolidMasse moléculaire :701.892N4-(n-Palmitoyl)-4'-azido-2'-deoxy-2'-fluoro-arabinocytidine
<p>N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a cytidine nucleoside analog.</p>Formule :C25H41FN6O5Couleur et forme :SolidMasse moléculaire :524.63Pseudorabies virus-IN-1
<p>Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.</p>Formule :C27H23ClF2N4O2Couleur et forme :SolidMasse moléculaire :508.947ONX 0801 trisodium
CAS :<p>ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.</p>Formule :C32H30N5Na3O10Couleur et forme :SolidMasse moléculaire :713.58Ficellomycin
CAS :<p>Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.</p>Formule :C13H24N6O3Couleur et forme :SolidMasse moléculaire :312.37Ganodermaones B
<p>Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .</p>Formule :C21H26O5Couleur et forme :SolidMasse moléculaire :358.43Nitrosofolic acid
CAS :<p>Nitrosofolic acid is a folic acid derivaive.</p>Formule :C19H18N8O7Couleur et forme :SolidMasse moléculaire :470.405'-O-DMT-2'-O-TBDMS-Bz-rC
CAS :<p>5'-O-DMT-2'-O-TBDMS-Bz-rC, a modified nucleoside, is utilized in the synthesis of DNA or RNA.</p>Formule :C43H49N3O8SiCouleur et forme :SolidMasse moléculaire :763.95R-BC154 acetate
<p>R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.</p>Formule :C56H65N9O14S3Couleur et forme :SolidMasse moléculaire :1184.36L-5-Methyluridine
CAS :<p>L-5-Methyluridine, an L-configuration of 5-Methyluridine, is an endogenous methylated nucleoside present in human fluids.</p>Formule :C10H14N2O6Couleur et forme :SolidMasse moléculaire :258.23EFdA-TP tetraammonium
<p>EFdA-TP tetraammonium is a potent HIV-1 RT inhibitor and DNA synthesis blocker, acting as an ICT or DCT.</p>Formule :C12H27N9O12P3Couleur et forme :SolidMasse moléculaire :601.312'-Deoxy-2'-fluoroguanosine 5'-monophosphate triethyl ammonium
<p>2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits broad antitumor activity specifically targeting indolent</p>Formule :C22H43FN7O7PCouleur et forme :SolidMasse moléculaire :567.59
