Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
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RECTAS-2.0
CAS :<p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G>A mutation, intended for research in Fabry disease.</p>Formule :C18H17ClN4O4Couleur et forme :SolidMasse moléculaire :388.8052'-O-MOE-UTP
CAS :<p>2'-O-MOE-UTP is a nucleotide analog employed in the synthesis of oligonucleotides.</p>Formule :C12H21N2O16P3Couleur et forme :SolidMasse moléculaire :542.22CB 30900
CAS :<p>CB30900 is a novel and effective thymidylate synthase inhibitor.</p>Formule :C31H32FN5O9Couleur et forme :SolidMasse moléculaire :637.61Cimpuciclib tosylate
CAS :<p>Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.</p>Formule :C37H43FN8O4SCouleur et forme :SolidMasse moléculaire :714.85Aurora/LIM kinase-IN-1
<p>Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.</p>Formule :C16H20N6OCouleur et forme :SolidMasse moléculaire :312.37MU1409
CAS :<p>MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.</p>Formule :C20H14BrN3O3SCouleur et forme :SolidMasse moléculaire :456.312Bersiporocin
CAS :<p>Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.</p>Formule :C15H19Cl2N3ODegré de pureté :98.88% - 99.79%Couleur et forme :SolidMasse moléculaire :328.24CDK5-IN-2
CAS :<p>CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor that acts on CDK5/p25 (IC50: 0.2 nM) and CDK2/CycA (IC50: 23 nM).</p>Formule :C29H28FN5OCouleur et forme :SolidMasse moléculaire :481.56DIDS
CAS :<p>DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.</p>Formule :C16H10N2O6S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.52Dencatistat
CAS :<p>Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.</p>Formule :C24H27N7O5SDegré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :525.58Xanthosine-5'-Triphosphate trisodium
CAS :<p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>Formule :C10H12N4Na3O15P3Couleur et forme :SolidMasse moléculaire :590.111PROTAC CDK12/13 Degrader-1
<p>PROTAC CDK12/13 Degrader-1 (7f) selectively degrades CDK12/13 at nanomolar potency, targeting breast cancer.</p>Couleur et forme :SolidCDK8-IN-5
CAS :<p>CDK8-IN-5: potent CDK8 inhibitor, IC50=72 nM, boosts IL-10 by 43%, may aid inflammatory bowel disease research.</p>Formule :C26H22N2O4Couleur et forme :SolidMasse moléculaire :426.46Adafosbuvir
CAS :<p>Adafosbuvir has antiviral activity.</p>Formule :C22H29FN3O10PCouleur et forme :SolidMasse moléculaire :545.4573-IN-PP1
CAS :<p>3-IN-PP1: PKD inhibitor (IC50: 94-108 nM for PKD1/2/3), broad anticancer agent for research.</p>Formule :C17H18N6Couleur et forme :SolidMasse moléculaire :306.36MtTMPK-IN-2
CAS :<p>MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).</p>Formule :C23H24ClN3O3Couleur et forme :SolidMasse moléculaire :425.91WEE1/PKMYT1-IN-1
CAS :<p>WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.</p>Formule :C16H16N4O3Couleur et forme :SolidMasse moléculaire :312.3232′-F-UDP
CAS :<p>2′-F-UDP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>Formule :C9H13FN2O11P2Couleur et forme :SolidMasse moléculaire :406.15PCNA-IN-1
CAS :<p>PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.</p>Formule :C19H18I3NO3Couleur et forme :SolidMasse moléculaire :689.065OSI-7904L free acid
CAS :<p>OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.</p>Formule :C27H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :500.5Dyrk1A/α-synuclein-IN-1
<p>Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).</p>Formule :C20H21N5O3SCouleur et forme :SolidMasse moléculaire :411.482′-OMe-GDP
CAS :<p>2′-OMe-GDP is a nucleotide analog utilized for the synthesis of oligonucleotides.</p>Formule :C11H17N5O11P2Couleur et forme :SolidMasse moléculaire :457.23CDK1-IN-5
<p>CDK1-IN-5 is a selective inhibitor for CDK1 (IC50: 42.19 nM), CDK2, CDK5, halting cancer cell growth.</p>Formule :C27H26ClN5OSCouleur et forme :SolidMasse moléculaire :504.05APE1-IN-3
CAS :<p>APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.</p>Formule :C17H16O4Couleur et forme :SolidMasse moléculaire :284.31Cdc7-IN-8
CAS :<p>Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)</p>Formule :C19H21N5O2Couleur et forme :SolidMasse moléculaire :351.40CHK1 inhibitor
CAS :<p>CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.</p>Formule :C17H21BrN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.28TREX1-IN-4
CAS :<p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>Formule :C24H19ClN6O4Couleur et forme :SolidMasse moléculaire :490.8982-CEES
CAS :<p>2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.</p>Formule :C4H9ClSCouleur et forme :SolidMasse moléculaire :124.632ddCTP trisodium
<p>ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.</p>Formule :C9H13N3Na3O12P3Couleur et forme :SolidMasse moléculaire :517.1DDO-6079
CAS :<p>DDO-6079 is an efficient CDC37 inhibitor. It suppresses the HSP90-CDC37 and CDC37-CDK4/6 chaperone complexes by binding to an allosteric site on CDC37. Additionally, DDO-6079 reduces the thermal stability of CDK6.</p>Formule :C18H13ClN2O3Couleur et forme :SolidMasse moléculaire :340.7611-Oxahomoaminopterin
CAS :<p>11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.</p>Formule :C20H21N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :455.42L 734217
CAS :<p>L 734217 is an antagonist of the fibrinogen receptor.</p>Formule :C18H31N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :353.46GR 122222X
CAS :<p>GR 122222X is an inhibitor of topoisomerase II.</p>Formule :C26H35N5O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.65Z4P
CAS :<p>Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB), inhibited glioblastoma growth and recurrence in combination with Temozolomide.</p>Formule :C19H24N2O2Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :312.41WEE1-IN-10
CAS :<p>WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.</p>Formule :C28H30Cl2N8ODegré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :565.5BAY-364
CAS :<p>BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+</p>Formule :C23H19N3O4Couleur et forme :SolidMasse moléculaire :401.41CDK9-IN-11
CAS :<p>CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].</p>Formule :C20H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.43DL-Alanosine
CAS :<p>DL-Alanosine is an amino acid analog with antitumor activity.</p>Formule :C3H7N3O4Couleur et forme :SolidMasse moléculaire :149.105CHK1-IN-4
CAS :<p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>Formule :C18H18BrN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.29YKL-1-116
CAS :<p>YKL-1-116 is an effective, selective, and covalent CDK7 inhibitor.</p>Formule :C34H38N8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :606.72Zeltociclib
CAS :<p>Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.</p>Formule :C18H20F3N4O2PCouleur et forme :SolidMasse moléculaire :412.346Ladirubicin
CAS :<p>Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.</p>Formule :C29H31NO11SCouleur et forme :SolidMasse moléculaire :601.62TY-011
CAS :<p>TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.</p>Formule :C18H16ClN5Couleur et forme :SolidMasse moléculaire :337.812'-(2-Nitrobenzyl)-ATP
CAS :<p>2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.</p>Formule :C17H21N6O15P3Couleur et forme :SolidMasse moléculaire :642.30c-Myc inhibitor 4
<p>Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.</p>Formule :C26H33FN6O3Couleur et forme :SolidMasse moléculaire :496.58GTSE1-IN-1
CAS :<p>GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.</p>Formule :C21H24FN7Couleur et forme :SolidMasse moléculaire :393.46CDK/HDAC-IN-1
<p>CDK/HDAC-IN-1 inhibits CDK2/4/6 & HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.</p>Formule :C20H18N4O4Couleur et forme :SolidMasse moléculaire :378.38PD-L1-IN-7
CAS :<p>PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.</p>Formule :C46H50N6O7Couleur et forme :SolidMasse moléculaire :798.93HPH-15
CAS :<p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>Formule :C19H31N3S4Couleur et forme :SolidMasse moléculaire :429.73(E)-Antiviral agent 67
CAS :<p>(E)-Antiviral agent 67 (compound PC6) is a pyrazolone-based antiviral compound that exhibits inhibitory activity against RNA-dependent RNA polymerase.</p>Formule :C19H19N3OCouleur et forme :SolidMasse moléculaire :305.374TREX1-IN-3
CAS :<p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>Formule :C24H19ClN6O4Couleur et forme :SolidMasse moléculaire :490.898SCH-1473759
CAS :<p>SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).</p>Formule :C20H26N8OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.54SR121566A
CAS :<p>SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).</p>Formule :C20H25N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.51Epolactaene
CAS :<p>Epolactaene: neuritogenic, inhibits mammalian DNA polymerases & human DNA topoisomerase II.</p>Formule :C21H27NO6Couleur et forme :SolidMasse moléculaire :389.44Dyrk1A-IN-1
<p>Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.</p>Formule :C23H20N4O3SCouleur et forme :SolidMasse moléculaire :432.49CDK2-IN-8
<p>CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.</p>Formule :C22H25N5O3Couleur et forme :SolidMasse moléculaire :407.47Cdc7-IN-11
CAS :<p>Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.</p>Formule :C20H22F2N4O2SCouleur et forme :SolidMasse moléculaire :420.48MU147
CAS :<p>MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.</p>Formule :C19H13N3O3SCouleur et forme :SolidMasse moléculaire :363.39CDK2-IN-40
CAS :<p>CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.</p>Formule :C16H21N7O2Couleur et forme :SolidMasse moléculaire :343.384FT3967385
<p>FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.</p>Formule :C21H19N5O2Couleur et forme :SolidMasse moléculaire :373.41CLK1/2-IN-1
CAS :<p>CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.</p>Formule :C21H20F3N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.42CDK8-IN-11 hydrochloride
<p>CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.</p>Formule :C19H16ClF3N4O2Couleur et forme :SolidMasse moléculaire :424.8p38α inhibitor 9
CAS :<p>p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.</p>Formule :C27H24FN3O3Couleur et forme :SolidMasse moléculaire :457.496USP7-IN-10
CAS :<p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>Formule :C26H29ClN4O3SCouleur et forme :SolidMasse moléculaire :513.05L-I-OddU
CAS :<p>L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).</p>Formule :C8H9IN2O5Couleur et forme :SolidMasse moléculaire :340.07FT709
CAS :<p>FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.</p>Formule :C23H22N4O7SCouleur et forme :SolidMasse moléculaire :498.51SF0166
CAS :<p>SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.</p>Formule :C23H27F2N5O4Couleur et forme :SolidMasse moléculaire :475.49LN-439A
CAS :<p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>Formule :C24H26FN3O4Couleur et forme :SolidMasse moléculaire :439.48DNA polymerase-IN-6
CAS :<p>DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.</p>Formule :C26H28ClFN8O4Couleur et forme :SolidMasse moléculaire :571.003CDK1-IN-3
<p>CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.</p>Formule :C28H25ClF3N5O2Couleur et forme :SolidMasse moléculaire :555.98And1 degrader 1
CAS :<p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>Formule :C26H27Cl2N3OCouleur et forme :SolidMasse moléculaire :468.42WRN inhibitor 13
CAS :<p>WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.</p>Formule :C16H20N2O5SCouleur et forme :SolidMasse moléculaire :352.405PD-1-IN-17
CAS :<p>PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.</p>Formule :C13H22N6O7Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :374.35LIMK1 inhibitor 1
CAS :<p>LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.</p>Formule :C12H15N3S2Couleur et forme :SolidMasse moléculaire :265.398DNA Gyrase-IN-1
<p>DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.</p>Formule :C24H24FN7O6Couleur et forme :SolidMasse moléculaire :525.49GR 83895
CAS :<p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>Formule :C29H39N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.745'-DMT-5-F-2'-dU Phosphoramidite
CAS :<p>5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.</p>Formule :C39H46FN4O8PCouleur et forme :SolidMasse moléculaire :748.777CDK9 autophagic degrader 1
CAS :<p>CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.</p>Formule :C34H39N7O4S2Couleur et forme :SolidMasse moléculaire :673.848KL-50
CAS :<p>KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.</p>Formule :C7H7FN6O2Couleur et forme :SolidMasse moléculaire :226.17LNA-GDP
CAS :<p>LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>Formule :C11H15N5O11P2Couleur et forme :SolidMasse moléculaire :455.217-Methylguanosine 5′-monophosphate
CAS :<p>7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.</p>Formule :C11H16N5O8PCouleur et forme :SolidMasse moléculaire :377.25CDK2-IN-39
CAS :<p>CDK2-IN-39 (compound 4) is a CDK2 inhibitor.</p>Formule :C14H15N3O4SCouleur et forme :SolidMasse moléculaire :321.352CDK4/6-IN-3
CAS :<p>CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.</p>Formule :C25H31FN8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.57MtTMPK-IN-8
<p>MtTMPK-IN-8 inhibits MtbTMPK, has low cytotoxicity, shows 0.78-9.4 μM activity against Mycobacterium, useful for tuberculosis research.</p>Formule :C24H24N6O7Couleur et forme :SolidMasse moléculaire :508.48Metesind Glucuronate
CAS :<p>Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.</p>Formule :C29H34N4O10SCouleur et forme :SolidMasse moléculaire :630.67AB25583
CAS :<p>AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.</p>Formule :C22H17ClN4O3SCouleur et forme :SolidMasse moléculaire :452.91LIMK1 inhibitor 2
CAS :<p>LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.</p>Formule :C10H11N3OSCouleur et forme :SolidMasse moléculaire :221.279MKLP2-IN-1
CAS :<p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>Formule :C23H19BrFN3O2Couleur et forme :SolidMasse moléculaire :468.318Antibacterial agent 110
<p>Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).</p>Formule :C22H21N5O4SCouleur et forme :SolidMasse moléculaire :451.5CDK4/9-IN-1
CAS :<p>CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.</p>Formule :C22H34N6O2Couleur et forme :SolidMasse moléculaire :414.544Antiangiogenic agent 2
<p>Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.</p>Formule :C26H26FN3O4Couleur et forme :SolidMasse moléculaire :463.5Valopicitabine dihydrochloride
CAS :<p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Formule :C15H25ClN4O6Couleur et forme :SolidMasse moléculaire :392.84CDK7-IN-17
CAS :<p>CDK7-IN-17, a pyrimidine-based CDK7 inhibitor, shows promise for various cancers, especially with abnormal transcription.</p>Formule :C24H26F3N6OPCouleur et forme :SolidMasse moléculaire :502.47JY-3-094
CAS :<p>JY-3-094 is a selective Myc inhibitor that targets the hydrophobic domain of Myc and inhibits the formation of the Myc-Max heterodimer, with an IC50 of 33 μM, and can be used for cancer research.</p>Formule :C13H8N4O5Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :300.23CDK7/12-IN-1
CAS :<p>CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.</p>Formule :C25H34N8OCouleur et forme :SolidMasse moléculaire :462.598-Oxo-dATP
CAS :<p>8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.</p>Formule :C10H12Li4N5O13P3Couleur et forme :SolidMasse moléculaire :530.9135-Methylcytosine hydrochloride
CAS :<p>5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.</p>Formule :C5H8ClN3OCouleur et forme :SolidMasse moléculaire :161.59IIP0943
CAS :<p>IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.</p>Formule :C26H28N6O3SCouleur et forme :SolidMasse moléculaire :504.60412(S)-HETE
CAS :<p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.47NSC 641396
CAS :<p>NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.</p>Formule :C18H13NO3Couleur et forme :SolidMasse moléculaire :291.301Sovesudil hydrochloride
<p>Sovesudil (PHP-201) HCl: potent local ROCK inhibitor; targets ROCK I/II (IC50: 3.7/2.3 nM); lowers IOP, non-congesting.</p>Formule :C23H23ClFN3O3Couleur et forme :SolidMasse moléculaire :443.9CDK12/13 ligand 1
CAS :<p>ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.</p>Formule :C26H26BrN5OCouleur et forme :SolidMasse moléculaire :504.42Dyrk1A/B-IN-1
<p>Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.</p>Formule :C21H17N3O2S2Couleur et forme :SolidMasse moléculaire :407.51Polθ-IN-6
CAS :<p>Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.</p>Formule :C25H23N3O3SCouleur et forme :SolidMasse moléculaire :445.53BRD-7880
CAS :<p>BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.</p>Formule :C32H38N4O7Couleur et forme :SolidMasse moléculaire :590.67WRN inhibitor 12
CAS :<p>WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.</p>Formule :C33H33ClF3N9O5Couleur et forme :SolidMasse moléculaire :728.12Lobucavir
CAS :<p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>Formule :C11H15N5O3Couleur et forme :SolidMasse moléculaire :265.27NRTT-IN-1
CAS :<p>NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.</p>Formule :C28H24FN5O5Couleur et forme :SolidMasse moléculaire :529.519DNA Gyrase-IN-13
CAS :<p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>Formule :C15H21N3O3SCouleur et forme :SolidMasse moléculaire :323.41RMS-07
CAS :<p>RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.</p>Formule :C35H40N8O2Couleur et forme :SolidMasse moléculaire :604.74D-G23
CAS :<p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>Formule :C19H22N4O3Couleur et forme :SolidMasse moléculaire :354.403P162-0948
CAS :<p>P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. It reduces cell migration and the expression of EMT-related proteins in the A549 human alveolar epithelial cell line. Furthermore, P162-0948 decreases Smad phosphorylation, indicating disruption of the TGF-β/Smad signaling pathway, making it a promising compound for pulmonary fibrosis research.</p>Formule :C20H15FN4O2Couleur et forme :SolidMasse moléculaire :362.357GSK3335103
CAS :<p>GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.</p>Formule :C27H36FN3O4Couleur et forme :SolidMasse moléculaire :485.59Dyrk1A-IN-12
CAS :<p>Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).</p>Formule :C22H16FN3O2SCouleur et forme :SolidMasse moléculaire :405.4455-Iminodaunorubicin hydrochloride
CAS :<p>5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.</p>Formule :C27H31ClN2O9Couleur et forme :SolidMasse moléculaire :563.00CDK2 degrader 4
CAS :<p>CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.</p>Formule :C23H26ClN3O5Couleur et forme :SolidMasse moléculaire :459.923LZ9
CAS :<p>LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.</p>Formule :C17H11F3N4O2Couleur et forme :SolidMasse moléculaire :360.29MtTMPK-IN-7
<p>MtTMPK-IN-7 inhibits MtbTMPK (IC50: 47 μM), active against M. brevis (MIC: 2.3-4.7 μM), useful for tuberculosis research.</p>Formule :C27H29ClN6O3Couleur et forme :SolidMasse moléculaire :521.01Rhodblock 1a
CAS :<p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>Formule :C20H16N2O2Couleur et forme :SolidMasse moléculaire :316.353CDK2/4-IN-2
CAS :<p>CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.</p>Formule :C18H20F3N7O3S2Couleur et forme :SolidMasse moléculaire :503.52Kolavenic acid analog
CAS :<p>KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.</p>Formule :C25H38O4Couleur et forme :SolidMasse moléculaire :402.57Zalunfiban dihydrochloride
<p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>Formule :C16H20Cl2N8O2SCouleur et forme :SolidMasse moléculaire :459.35MtTMPK-IN-9
<p>MtTMPK-IN-9 moderately inhibits MtbTMPK (IC50: 48 μM), has submicromolar Mycobacterium activity, and is non-toxic, aiding tuberculosis research.</p>Formule :C25H26N6O7Couleur et forme :SolidMasse moléculaire :522.51(R)-CSN5i-3
CAS :<p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>Formule :C28H29F2N5O2Degré de pureté :99.76% - 99.97%Couleur et forme :SolidMasse moléculaire :505.56WRN inhibitor 11
CAS :<p>WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.</p>Formule :C34H35ClF3N9O5Couleur et forme :SolidMasse moléculaire :742.15LY 254155
CAS :<p>LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.</p>Formule :C19H23N5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.48LNA-GTP
CAS :<p>LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.</p>Formule :C11H16N5O14P3Couleur et forme :SolidMasse moléculaire :535.194,5'-Dimethylangelicin-NHS
<p>NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.</p>Formule :C21H19NO7SCouleur et forme :SolidMasse moléculaire :429.44DYRKs-IN-1 hydrochloride
CAS :<p>DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.</p>Formule :C30H31Cl2N7O4Couleur et forme :SolidMasse moléculaire :624.52DNA gyrase B-IN-1
<p>DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.</p>Formule :C23H18ClF3N6O4SCouleur et forme :SolidMasse moléculaire :566.94α5β1 integrin agonist-1
CAS :<p>α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.</p>Formule :C24H26FN5O9Couleur et forme :SolidMasse moléculaire :547.49(R)-Atuveciclib
CAS :<p>Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].</p>Formule :C18H18FN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.43RAD51-IN-7
CAS :<p>RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)</p>Formule :C25H31N5O4S2Couleur et forme :SolidMasse moléculaire :529.67DNA ligase-IN-2
CAS :<p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is >64 μg/mL.</p>Formule :C13H8FN3O3Couleur et forme :SolidMasse moléculaire :273.219AR-13324 M1 metabolite
CAS :<p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>Formule :C19H19N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.37Methyl 3-oxodecanoate
CAS :<p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>Formule :C11H20O3Couleur et forme :SolidMasse moléculaire :200.275DS96432529
<p>DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.</p>Formule :C18H26N4O3SCouleur et forme :SoildMasse moléculaire :378.49CDK9-IN-13
<p>CDK9-IN-13 is a potent and selective CDK inhibitor (IC50<3 nM). CDK9-IN-13 has a very short half-life in rodents.</p>Formule :C27H35N5O2Couleur et forme :SolidMasse moléculaire :461.62'-O-MOE-GMP
CAS :<p>2'-O-MOE-GMP is a nucleotide analogue that can be utilized in the synthesis of oligonucleotides.</p>Formule :C13H20N5O9PCouleur et forme :SolidMasse moléculaire :421.30Chk1-IN-5
CAS :<p>Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.</p>Formule :C18H18FN7O2Couleur et forme :SolidMasse moléculaire :383.38CDK9-IN-38
CAS :<p>CDK9-IN-38 (compound 14) is a CDK9 inhibitor with IC50 values of 1.2 nM for wild-type CDK9 and 3.3 nM for the L156F mutant. It effectively inhibits tumor growth both in vitro and in vivo.</p>Formule :C22H23N5O3SCouleur et forme :SolidMasse moléculaire :437.515CDK6-IN-1
CAS :<p>CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.</p>Formule :C30H23N5Couleur et forme :SolidMasse moléculaire :453.54N-Isobutyryl-2', 3'-acetyl-guanosine
CAS :<p>N-Isobutyryl-2', 3'-acetyl-guanosine is a derivative of guanosine.</p>Formule :C18H23N5O8Couleur et forme :SolidMasse moléculaire :437.404CYP2C19-IN-1
<p>CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.</p>Formule :C26H26N2O6SCouleur et forme :SolidMasse moléculaire :494.56CDK7-IN-31
CAS :<p>CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.</p>Formule :C27H32F5N6O2PCouleur et forme :SolidMasse moléculaire :598.55T-2513 hydrochloride
CAS :<p>T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.</p>Formule :C25H28ClN3O5Couleur et forme :SolidMasse moléculaire :485.96CHK-IN-1
CAS :<p>CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.</p>Formule :C18H19ClFN5OSDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :407.89Hesperadin hydrochloride
<p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12LNA-AMP
CAS :<p>LNA-AMP is a nucleotide analog used in the synthesis of oligonucleotides.</p>Formule :C11H14N5O7PCouleur et forme :SolidMasse moléculaire :359.23CDK1-IN-7
CAS :<p>CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.</p>Formule :C23H19ClN4O3Couleur et forme :SolidMasse moléculaire :434.88CDK8-IN-9
<p>CDK8-IN-9, potent CDK8 inhibitor (IC50: 48.6 nM), curbs tumor growth, useful for colorectal cancer research.</p>Couleur et forme :SolidDyrk1A-IN-2
<p>Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.</p>Formule :C27H32N6O4Couleur et forme :SolidMasse moléculaire :504.58Dmf-dg
CAS :<p>Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a nucleoside of deoxyguanosine (dG) with a dimethylaminomethylene (DMF) base protection, employed in the synthesis of oligonucleotides.</p>Formule :C13H18N6O4Couleur et forme :SolidMasse moléculaire :322.32UMPK ligand 1
CAS :<p>UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).</p>Formule :C15H22N4O5SCouleur et forme :SolidMasse moléculaire :370.4242'-F-CDP
CAS :<p>2'-F-CDP is a nucleotide analog that can be utilized in the synthesis of oligonucleotides.</p>Formule :C9H14FN3O10P2Couleur et forme :SolidMasse moléculaire :405.17β-catenin-IN-8
CAS :<p>β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.</p>Formule :C15H12ClN3O2SCouleur et forme :SolidMasse moléculaire :333.79PLK1-IN-5
CAS :<p>PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].</p>Formule :C28H39N7O3Couleur et forme :SolidMasse moléculaire :521.65(Rac)-Plevitrexed
CAS :<p>(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).</p>Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.53INX-315
CAS :<p>INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.</p>Formule :C19H21N7O3SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :427.48Dyrk1A-IN-8
CAS :<p>Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.</p>Formule :C17H21N3OCouleur et forme :SolidMasse moléculaire :283.37CHK1-IN-11
CAS :<p>CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.</p>Formule :C20H22N8O2Couleur et forme :SolidMasse moléculaire :406.44CDK2 degrader 6
CAS :<p>CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.</p>Formule :C23H22F5N5O3Couleur et forme :SolidMasse moléculaire :511.44LNA-CTP
CAS :<p>LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>Formule :C10H16N3O14P3Couleur et forme :SolidMasse moléculaire :495.17RNAP-σ interaction inhibitor-2
CAS :<p>RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor targeting the interaction between RNA polymerase and the sigma factor. It demonstrates inhibitory activity against S. aureus with a minimum inhibitory concentration (MIC) of 2 µg/mL.</p>Formule :C27H19Cl3N2O6S2Couleur et forme :SolidMasse moléculaire :637.939Antiviral agent 67
CAS :<p>Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.</p>Formule :C19H19N3OCouleur et forme :SolidMasse moléculaire :305.374CD 10899
CAS :<p>CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].</p>Formule :C34H50N8O4Couleur et forme :SolidMasse moléculaire :634.81iPAF1C
CAS :<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formule :C27H26BrFN4OCouleur et forme :SolidMasse moléculaire :521.42CDK1-IN-6
<p>CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.</p>Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.432,5-Di-tert-butyl-1,4-benzoquinone
CAS :<p>2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.</p>Formule :C14H20O2Couleur et forme :SolidMasse moléculaire :220.31Mps1-IN-8
CAS :<p>Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].</p>Formule :C35H47N8O6PCouleur et forme :SolidMasse moléculaire :706.77WRN inhibitor 7
CAS :<p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>Formule :C27H23N3O6Couleur et forme :SolidMasse moléculaire :485.49N-Nitrosonornicotine
CAS :<p>N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.</p>Formule :C9H11N3OCouleur et forme :SolidMasse moléculaire :177.2DB18
CAS :<p>DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].</p>Formule :C24H18ClN7O3Couleur et forme :SolidMasse moléculaire :487.9VPC-80051
CAS :<p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>Formule :C16H13F2N3OCouleur et forme :SolidMasse moléculaire :301.291LIMK-IN-2
CAS :<p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>Formule :C28H27N5O2Couleur et forme :SolidMasse moléculaire :465.555'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine
CAS :<p>5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine is a nucleoside synthesized through oxime ring-opening at the 5' position and methylation at the 2' position. In chemotaxis assays, 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine demonstrates tissue affinity.</p>Formule :C36H39N5O8Couleur et forme :SolidMasse moléculaire :669.724TMX-3013
CAS :<p>TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.</p>Formule :C17H14BrFN6O3SCouleur et forme :SolidMasse moléculaire :481.3PKMYT1-IN-2
CAS :<p>PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].</p>Formule :C22H19N5O2Couleur et forme :SolidMasse moléculaire :385.42PLK1-IN-11
CAS :<p>PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.</p>Formule :C12H11N5OCouleur et forme :SolidMasse moléculaire :241.2492'-O-MOE-GTP
CAS :<p>2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>Formule :C13H22N5O15P3Couleur et forme :SolidMasse moléculaire :581.26PKMYT1-IN-7
CAS :<p>PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.</p>Formule :C17H18FN5O3Couleur et forme :SolidMasse moléculaire :359.355PolQi1
CAS :<p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>Formule :C18H14ClF5N4O2Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :448.77NusB-IN-1
<p>NusB-IN-1 (22r) is an oral bacterial rRNA inhibitor, effective against MRSA and VRSA.</p>Formule :C21H16N2O3Couleur et forme :SolidMasse moléculaire :344.36ROCK-IN-11
CAS :<p>ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.</p>Formule :C22H20N4O4SCouleur et forme :SolidMasse moléculaire :436.484WEE1-IN-11
CAS :<p>WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.</p>Formule :C26H29FN8OS2Couleur et forme :SolidMasse moléculaire :552.69PPA-037
CAS :<p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>Formule :C25H27N7Couleur et forme :SolidMasse moléculaire :425.53WEE1 degrader 1
<p>WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.</p>Formule :C30H31N5O3Couleur et forme :SolidMasse moléculaire :509.6CDK2-IN-18
CAS :<p>CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].</p>Formule :C21H23N7O2SCouleur et forme :SolidMasse moléculaire :437.52Haspin-IN-1
<p>Haspin-IN-1 blocks haspin (IC50: 119 nM) and inhibits CLK1, DYRK1A, CDK9 with potential as an anticancer drug.</p>Formule :C12H8N4O2SCouleur et forme :SolidMasse moléculaire :272.28Uridine 3',5'-diphosphate
CAS :<p>Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].</p>Formule :C9H14N2O12P2Couleur et forme :SolidMasse moléculaire :404.16Dyrk1A-IN-4
CAS :<p>Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.</p>Formule :C14H13F3N6Couleur et forme :SolidMasse moléculaire :322.29DHX9-IN-9
CAS :<p>DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].</p>Formule :C21H21ClFN5O3S2Couleur et forme :SolidMasse moléculaire :510Plevitrexed
CAS :<p>Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor & reduced folate carrier, treats gastric cancer.</p>Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.532′-O-MOE-CMP
CAS :<p>2′-O-MOE-CMP is a nucleotide analogue utilized in the synthesis of oligonucleotides.</p>Formule :C12H20N3O9PCouleur et forme :SolidMasse moléculaire :381.28RAD51-IN-8
<p>RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.</p>Formule :C16H14Cl2FN3O2Couleur et forme :SolidMasse moléculaire :370.21CIB-L43
CAS :<p>CIB-L43 is a oral TRBP inhibitor, inhibit miR-21, increase PTEN and Smad7, and block the AKT and TGF-β，inhibit proliferation and migration.</p>Formule :C15H16N2O3SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :304.36Cdc7-IN-18
CAS :<p>Cdc7-IN-18 (1-2) inhibits CDC7 enzyme (IC50: 1.29 nM) and COLO205 cell proliferation (IC50: 53.62 nM).</p>Formule :C19H21N5OSCouleur et forme :SolidMasse moléculaire :367.47Polθ-IN-8
CAS :<p>Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.</p>Formule :C22H22ClN7O3SCouleur et forme :SolidMasse moléculaire :499.97Cdc7-IN-19
CAS :<p>Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC 50 of 1.49 nM [1].</p>Formule :C19H21N5O2Couleur et forme :SolidMasse moléculaire :351.40CDK8-IN-14
CAS :<p>CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01μM in MOLM-13 cells and 0.03±0.01μM in MV4-11 cells [1].</p>Formule :C18H13N3O2Couleur et forme :SolidMasse moléculaire :303.31
