Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
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SP27
<p>SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].</p>Formule :C40H40F2N12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :806.826-O-Methyl-2'-O-methylinosine
<p>6-O-Methyl-2’-O-methylinosine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formule :C12H16N4O5Couleur et forme :SolidMasse moléculaire :296.28Heliquinomycin
CAS :<p>Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.</p>Formule :C33H30O17Couleur et forme :SolidMasse moléculaire :698.586N6-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl) adenosine
<p>N6-Benzoyl-3'-O-DMT-adenosine is a purine analog with antitumor effects by hindering DNA synthesis and inducing apoptosis.</p>Formule :C41H41N5O8Couleur et forme :SolidMasse moléculaire :731.79(1S,3R,5R)-PIM447 dihydrochloride
<p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>Formule :C24H25Cl2F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.3812R-LOX-IN-2
CAS :<p>12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.</p>Formule :C19H13NODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :271.31Mulnitorsen
CAS :<p>Mulnitorsen acts as an inhibitor of antisense non-coding mitochondrial RNA (ASncmtRNA) synthesis and serves as an antitumor agent [1].</p>Formule :C172H217N74O82P17S17Couleur et forme :SolidMasse moléculaire :5704.662'-Deoxy-2'-fluorouridine 5'-monophosphate triethyl ammonium
<p>2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits extensive antitumor effects against indolent lymphoid</p>Formule :C21H42FN4O7PCouleur et forme :SolidMasse moléculaire :512.553'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
<p>3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolent lymphoid</p>Formule :C38H43N5O9Couleur et forme :SolidMasse moléculaire :713.785'-O-DMT-N4-Ac-2'-F-dC
CAS :<p>5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formule :C32H32FN3O7Couleur et forme :SolidMasse moléculaire :589.61Chrysomycin A
CAS :<p>Chrysomycin A is an antibiotic that can be derived from Streptomyces.</p>Formule :C28H28O9Couleur et forme :SolidMasse moléculaire :508.52Deoxythymidine-5'-triphosphate sodium hydrate
<p>dTTP sodium hydrate, a DNA synthesis component, is a nucleoside triphosphate.</p>Formule :C10H17N2O14P3·xNa·xH2OCouleur et forme :SolidMasse moléculaire :C10H17N2O14P3.xNa.xH2ODG1
<p>DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressing</p>Formule :C19H17N5O5SCouleur et forme :SolidMasse moléculaire :427.43Mumefural
CAS :<p>Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.</p>Formule :C12H12O9Couleur et forme :SolidMasse moléculaire :300.22m7GpppCpG
CAS :<p>m7GpppCpG, a trinucleotide cap analogue, is used for synthesizing RNA with cap 0 or cap 1 structures.</p>Formule :C30H41N13O25P4Couleur et forme :SolidMasse moléculaire :1107.61CDK2-IN-7
CAS :<p>CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).</p>Formule :C24H30N6O4SCouleur et forme :SolidMasse moléculaire :498.6CW-2
<p>CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).</p>Formule :C43H42Cl2FN11O10PtCouleur et forme :SolidMasse moléculaire :1156.212515-(2-Hydroxyethyl)-2',3'-di-O-toluoyl-2'-deoxyuridine
<p>5-(2-Hydroxyethyl)-2',3'-di-O-toluoyl-2'-deoxyuridine, a purine nucleoside analog, exhibits widespread antitumor activity specifically against indolent lymphoid</p>Formule :C27H28N2O8Couleur et forme :SolidMasse moléculaire :508.52JB300
CAS :<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Formule :C43H45ClFN7O10SCouleur et forme :SolidMasse moléculaire :906.3755-Iminodaunorubicin
CAS :<p>5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.</p>Formule :C27H30N2O9Couleur et forme :SolidMasse moléculaire :526.54TTK/PLK1-IN-1
CAS :<p>TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.</p>Formule :C30H33N7O2Degré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :523.63Nogalamycin
CAS :<p>Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.</p>Formule :C39H49NO16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.8125'-O-TBDMS-dA
CAS :<p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formule :C16H27N5O3SiCouleur et forme :SolidMasse moléculaire :365.5095'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
<p>5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.</p>Formule :C44H49F2N4O7PCouleur et forme :SolidMasse moléculaire :814.85WAY-647802
CAS :<p>WAY-647802 is a CDK inhibitor.</p>Formule :C11H14N4O3Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :250.25Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Formule :C21H25FN4O2Couleur et forme :SolidMasse moléculaire :384.45Anticancer agent 263
<p>Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.</p>Formule :C13H20N2O6Couleur et forme :SolidMasse moléculaire :300.3086-Methoxypurine-9-β-D-5'(R)-C-methylriboside
<p>6-Methoxypurine-9-β-D-5’(R)-C-methylriboside, an analog of hypoxanthine—a purine base predominantly found in muscle tissue and a metabolite generated when</p>Formule :C12H16N4O5Couleur et forme :SolidMasse moléculaire :296.28Obtustatin
<p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>Formule :C184H284N52O57S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4393.0713-TP
<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>Formule :C12H19F2N6O12P3Couleur et forme :SolidMasse moléculaire :570.23Rachelmycin
CAS :<p>Rachelmycin, a potent antibiotic and antitumor agent from Streptomyces zelensis, binds to DNA's minor groove.</p>Formule :C37H33N7O8Couleur et forme :SolidMasse moléculaire :703.712wrwycr-NH2 TFA
<p>wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.</p>Couleur et forme :Odour SolidBz-rC Phosphoramidite
CAS :<p>Bz-rC Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>Formule :C52H66N5O9PSiCouleur et forme :SolidMasse moléculaire :964.185DNA Gyrase-IN-6
<p>Agent 138: soluble benzothiazole, inhibits DNA gyrase/topoisomerase IV, targets Gram+ & Gram- bacteria, binds plasma proteins.</p>Formule :C18H16Cl2N4O4SCouleur et forme :SolidMasse moléculaire :455.32EC0488
CAS :<p>EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity.</p>Formule :C65H98N16O34SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1679.63Biotin-PEG8-Vidarabine
<p>Biotin-PEG8-Vidarabine is an antiviral PEG linker targeting herpes and varicella zoster with adenosine analog Vidarabine.</p>Formule :C36H60N8O13SCouleur et forme :SolidMasse moléculaire :844.973,6-DMAD hydrochloride
<p>3,6-DMAD hydrochloride functions as an inhibitor for the IRE1α-XBP1 pathway within the unfolded protein response mechanism.</p>Formule :C22H31N5xHClDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.525-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS :<p>5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.</p>Formule :C22H31N3O5SiCouleur et forme :SolidMasse moléculaire :445.585'-O-DMT-2'-O-TBDMS-Ac-rC
CAS :<p>5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formule :C38H47N3O8SiCouleur et forme :SolidMasse moléculaire :701.892N4-(n-Palmitoyl)-4'-azido-2'-deoxy-2'-fluoro-arabinocytidine
<p>N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a cytidine nucleoside analog.</p>Formule :C25H41FN6O5Couleur et forme :SolidMasse moléculaire :524.63Pseudorabies virus-IN-1
<p>Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.</p>Formule :C27H23ClF2N4O2Couleur et forme :SolidMasse moléculaire :508.947ONX 0801 trisodium
CAS :<p>ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.</p>Formule :C32H30N5Na3O10Couleur et forme :SolidMasse moléculaire :713.58Ficellomycin
CAS :<p>Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.</p>Formule :C13H24N6O3Couleur et forme :SolidMasse moléculaire :312.37Ganodermaones B
<p>Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .</p>Formule :C21H26O5Couleur et forme :SolidMasse moléculaire :358.43Nitrosofolic acid
CAS :<p>Nitrosofolic acid is a folic acid derivaive.</p>Formule :C19H18N8O7Couleur et forme :SolidMasse moléculaire :470.405'-O-DMT-2'-O-TBDMS-Bz-rC
CAS :<p>5'-O-DMT-2'-O-TBDMS-Bz-rC, a modified nucleoside, is utilized in the synthesis of DNA or RNA.</p>Formule :C43H49N3O8SiCouleur et forme :SolidMasse moléculaire :763.95R-BC154 acetate
<p>R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.</p>Formule :C56H65N9O14S3Couleur et forme :SolidMasse moléculaire :1184.36L-5-Methyluridine
CAS :<p>L-5-Methyluridine, an L-configuration of 5-Methyluridine, is an endogenous methylated nucleoside present in human fluids.</p>Formule :C10H14N2O6Couleur et forme :SolidMasse moléculaire :258.23EFdA-TP tetraammonium
<p>EFdA-TP tetraammonium is a potent HIV-1 RT inhibitor and DNA synthesis blocker, acting as an ICT or DCT.</p>Formule :C12H27N9O12P3Couleur et forme :SolidMasse moléculaire :601.312'-Deoxy-2'-fluoroguanosine 5'-monophosphate triethyl ammonium
<p>2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits broad antitumor activity specifically targeting indolent</p>Formule :C22H43FN7O7PCouleur et forme :SolidMasse moléculaire :567.59
