Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(227 produits)
- HSP(180 produits)
- Intégrine(269 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(126 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3904 produits trouvés pour "Cycle cellulaire/point de contrôle"
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3'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolent lymphoidFormule :C38H43N5O9Couleur et forme :SolidMasse moléculaire :713.785'-O-DMT-N4-Ac-2'-F-dC
CAS :5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.Formule :C32H32FN3O7Couleur et forme :SolidMasse moléculaire :589.615'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.Formule :C44H49F2N4O7PCouleur et forme :SolidMasse moléculaire :814.85α2β1 Integrin Ligand Peptide TFA
α2β1 Integrin Ligand Peptide TFA interacts with the integrin receptor on the cell membrane and enters the cell to mediate extracellular signaling.It is aFormule :C16H23F3N4O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.37Lorutengitide
CAS :Lorutengitide is a transcription-regulating peptide with antiproliferative activity.Formule :C30H50N8O12Couleur et forme :SolidMasse moléculaire :714.764Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.Formule :C21H25FN4O2Couleur et forme :SolidMasse moléculaire :384.45CDK2-IN-43
CDK2-IN-43 (Compound 3a) is a CDK2-cyclin E2 inhibitor with an IC50 value of 6.0 nM. It is applicable to cancer research.Formule :C19H27N7OCouleur et forme :SolidMasse moléculaire :369.464[pThr3]-CDK5 Substrate
CAS :[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate.[pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM[1].Formule :C53H100N15O15PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1218.4313-TP
13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.Formule :C12H19F2N6O12P3Couleur et forme :SolidMasse moléculaire :570.23(1S,3R,5R)-PIM447 dihydrochloride
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).Formule :C24H25Cl2F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.38CDK7-IN-21
CAS :CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor [1] .Formule :C33H36FN9O2Couleur et forme :SolidMasse moléculaire :609.7Trimethoprim hydrochloride
CAS :Trimethoprim hydrochloride: oral, broad-spectrum antibiotic, DHFR inhibitor, treats UTIs, shigellosis, pneumocystis pneumonia, may block Influenza A with zinc.Formule :C14H19ClN4O3Couleur et forme :SolidMasse moléculaire :326.78Obtustatin
Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.Formule :C184H284N52O57S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4393.07CDK4/6-IN-5
CAS :CDK4/6-IN-5 inhibits CDK4/6; Ki: 0.2 nM (CDK4/D1) & 4.4 nM (CDK6/D3). (WO2019207463A1, A93)Formule :C22H28ClFN6O4SCouleur et forme :SolidMasse moléculaire :527.01Gly-Arg-Gly-Asp-Ser
CAS :Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.Formule :C17H30N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.47Solidagonic acid
CAS :Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.Formule :C22H34O4Couleur et forme :SolidMasse moléculaire :362.5Rev 2'-O-MOE-A(Bz)-5'-amidite
'Rev 2’-O-MOE-A(Bz)-5’-amidite is a nucleoside analog specifically categorized within the purine subset, renowned for its wide-ranging antitumor efficacyFormule :C50H58N7O9PCouleur et forme :SolidMasse moléculaire :932.01MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Couleur et forme :Odour SolidMYC-IN-2
CAS :MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.Formule :C25H17N3O2SCouleur et forme :SolidMasse moléculaire :423.49Pseudorabies virus-IN-1
Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.Formule :C27H23ClF2N4O2Couleur et forme :SolidMasse moléculaire :508.947ONX 0801 trisodium
CAS :ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Formule :C32H30N5Na3O10Couleur et forme :SolidMasse moléculaire :713.58DHFR-IN-11
DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.Couleur et forme :Odour SolidHDAC-IN-85
HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.Formule :C24H27FN4O5Couleur et forme :SolidMasse moléculaire :470.49BIO5192 hydrate
BIO5192 hydrate: potent α4β1 inhibitor, binds selectively (Kd<10 pM, IC50=1.8 nM), boosts murine HSPC mobilization 30x.Couleur et forme :SolidN4-(n-Palmitoyl)-4'-azido-2'-deoxy-2'-fluoro-arabinocytidine
N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a cytidine nucleoside analog.Formule :C25H41FN6O5Couleur et forme :SolidMasse moléculaire :524.63WAY-322243
CAS :WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.Formule :C18H18N2O2SDegré de pureté :99.88%Couleur et forme :SoildMasse moléculaire :326.41Ganodermaones B
Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .Formule :C21H26O5Couleur et forme :SolidMasse moléculaire :358.433'-β-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine
3’-Beta-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine is an adenosine analog.Formule :C20H18F3N5O4Couleur et forme :SolidMasse moléculaire :449.38L-5-Methyluridine
CAS :L-5-Methyluridine, an L-configuration of 5-Methyluridine, is an endogenous methylated nucleoside present in human fluids.Formule :C10H14N2O6Couleur et forme :SolidMasse moléculaire :258.23S-MGB-234
CAS :S-MGB-234 treats AAT, effective against T. congolense and T. vivax, no cross-resistance or shared transport with diamidines.Formule :C30H32N8O4Couleur et forme :SolidMasse moléculaire :568.638EFdA-TP tetraammonium
EFdA-TP tetraammonium is a potent HIV-1 RT inhibitor and DNA synthesis blocker, acting as an ICT or DCT.Formule :C12H27N9O12P3Couleur et forme :SolidMasse moléculaire :601.31Evybactin
Evybactin: a selective DNA gyrase inhibitor for Mycobacterium tuberculosis (MIC 0.25 µg/mL), first of its kind.Formule :C64H89N21O21Couleur et forme :SolidMasse moléculaire :1488.52DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Couleur et forme :Odour SolidFF-10502
CAS :FF-10502, a pyrimidine analog of Gemcitabine, inhibits DNA polymerases α/β, targeting dormant cancer cells.Formule :C9H12FN3O3SCouleur et forme :SolidMasse moléculaire :261.27N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS :N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Formule :C21H35N12O17P3Couleur et forme :SolidMasse moléculaire :820.49STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Degré de pureté :97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :Odour LiquidMasse moléculaire :145.12 kDaRNA splicing modulator 1
CAS :RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].Formule :C19H20N6OSCouleur et forme :SolidMasse moléculaire :380.47R-1479
CAS :R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system.Formule :C9H12N6O5Degré de pureté :98.11% - 99.95%Couleur et forme :SolidMasse moléculaire :284.23Ref: TM-TQ0162
1mg104,00€5mg258,00€10mg358,00€25mg595,00€50mg842,00€100mg1.134,00€200mg1.521,00€1mL*10mM (DMSO)318,00€AD16
CAS :AD16 (Acetamide) acts as an inhibitor of LINE-1 retrotransposon endonuclease, exhibiting an IC50 value of 4.7 μM. It decreases LINE-1 retrotransposition in senescent cells and mitigates the resulting DNA damage and inflammation.Formule :C24H20N14O3S2Couleur et forme :SolidMasse moléculaire :616.64CBP501 Affinity Peptide
CAS :CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].Formule :C68H119N21O25SCouleur et forme :SolidMasse moléculaire :1662.86Apcin A HCL
CAS :Apcin A HCL is an Apcin-derived APC inhibitor that binds Cdc20 and hinders ubiquitination, useful for synthesizing PROTAC CP5V.
Formule :C10H15Cl4N5O2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :379.07Bimosiamose disodium
CAS :Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.Formule :C46H52Na2O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :906.88RP-1664
CAS :RP-1664,PLK4 inhibitor (IC50=3 nM). Disrupts centriole biogenesis. Antitumor activity in breast cancer, neuroblastoma.Formule :C23H24F2N8O2SDegré de pureté :99.04%Couleur et forme :SoildMasse moléculaire :514.55dCeMM3
CAS :dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.
Formule :C14H11ClN4OSDegré de pureté :98.48% - 99.41%Couleur et forme :SolidMasse moléculaire :318.785'-O-TBDMS-Bz-dA
CAS :5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.Formule :C23H31N5O4SiCouleur et forme :SolidMasse moléculaire :469.617(S)-DI-87
CAS :(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor，reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.Formule :C23H30N6O3S2Degré de pureté :99.42%Couleur et forme :SoildMasse moléculaire :502.655'(R)-C-Methyl-5-fluorouridine
5’(R)-C-Methyl-5-fluorouridine, a uridine analogue, possesses potential antiepileptic properties.Formule :C10H13FN2O6Couleur et forme :SolidMasse moléculaire :276.22ROCK-IN-32
CAS :ROCK-IN-32 is an effective Rho-kinase inhibitor.Formule :C20H17Cl2N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.27Aclacinomycin A
CAS :Aclacinomycin A has a wide range of applications in life science related research.Formule :C42H53NO15Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :811.87CPS2
CAS :CPS2: potent, selective PROTAC CDK2 degrader. IC50=24nM, targets acute myeloid leukemia research.Formule :C38H42N12O10S2Couleur et forme :SolidMasse moléculaire :890.94
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