Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(115 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(227 produits)
- HSP(180 produits)
- Intégrine(268 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(126 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3904 produits trouvés pour "Cycle cellulaire/point de contrôle"
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TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Formule :C37H50F2N12O13Couleur et forme :SolidMasse moléculaire :908.86PROTAC CDK9 degrader-5
CAS :PROTAC CDK9 degrader-5 selectively degrades CDK9 isoforms 42, 55 with DC50 of 0.10μM, 0.14μM via proteasome.Formule :C42H48Cl2N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :879.78AV-153
CAS :AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.Formule :C14H19NNaO6Couleur et forme :SolidMasse moléculaire :320.297JB170
CAS :JB170 is a specific Aurora A degradator. Alisertib and Thalidomide, induces S-phase arrest in cell growth and inhibits the non-catalytic function.Formule :C48H44ClFN8O11Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :963.36Rev 2'-O-MOE-C(Bz)-5'-amidite
'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Formule :C49H58N5O10PCouleur et forme :SolidMasse moléculaire :907.9912R-LOX-IN-2
CAS :12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.Formule :C19H13NODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :271.312'-Deoxy-2'-fluoro-l-uridine
CAS :2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.Formule :C9H11FN2O5Couleur et forme :SolidMasse moléculaire :246.19(+)-Glaucarubinone
(+)-Glaucarubinone is a natural product that can be used as a reference standard.Formule :C25H34O10Couleur et forme :SolidMasse moléculaire :494.5373'-β-C-ethynyl-N6-iso-pentenyl adenosine
3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine is an adenosine analog.Formule :C17H21N5O4Couleur et forme :SolidMasse moléculaire :359.38PROTAC CDK9 degrader-6
CAS :PROTAC CDK9 degrader-6 targets and degrades CDK9 isoforms via proteasome, with DC50 of 0.10μM and 0.14μM.Formule :C42H49Cl2N9O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :878.87-TFA-ap-7-Deaza-ddG
CAS :Compound 19d, a nucleotide derivative, is used to make thiotriphosphate dye terminators for DNA sequencing.Formule :C16H16F3N5O4Couleur et forme :SolidMasse moléculaire :399.33N4-Benzoyl-2'-deoxy-2'-fluoro-β-D-arabinocytidine
N4-Benzoyl-2’-deoxy-2’-fluoro-β-D-arabinocytidine, a purine nucleoside analog, exhibits widespread antitumor activity, particularly against indolent lymphoidFormule :C16H16FN3O5Couleur et forme :SolidMasse moléculaire :349.31α-Methyl-DL-aspartic acid
CAS :α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.Formule :C5H9NO4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :147.13(E/Z)-ZINC09659342
CAS :(E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.
Formule :C23H15F3N2O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :440.37CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Formule :C19H19N7O2Couleur et forme :SolidMasse moléculaire :377.16002MTH1 ligand 1
CAS :MTH1 ligand 1 functions as a target protein ligand for MTH1, and is utilized in the synthesis of PROTACaTAG 2139.Formule :C23H18N4O3Couleur et forme :SolidMasse moléculaire :398.41DENV-IN-2
CAS :DENV-IN-2 inhibits dengue virus replication (EC50: 0.016 nM), affects all serotypes (EC50: 0.013-0.029 nM). Derived from WO2018215315A1 6AB.Formule :C29H26ClF3N2O6Couleur et forme :SolidMasse moléculaire :590.98C16Y
CAS :C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Formule :C78H115N17O17Couleur et forme :SolidMasse moléculaire :1562.85Olsutamig
CAS :Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. It is capable of binding simultaneously to PSMA on tumor cell surfaces and CD3E on T cell surfaces, leading to significant activation of T cells and the specific destruction of prostate cancer cells.Couleur et forme :LiquidRS-1
CAS :RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.Formule :C20H16Br2N2O3SDegré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :524.23Ref: TM-T6972
2mg34,00€5mg49,00€10mg69,00€25mg105,00€50mg142,00€100mg187,00€200mg280,00€1mL*10mM (DMSO)56,00€PROTAC CDK9 degrader-11
CAS :PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Formule :C39H48Cl2N10O5Couleur et forme :SolidMasse moléculaire :807.768N1-Methyl-2'-deoxy-2'-fluoroarabinoguanosine
Nucleoside Derivatives - Fluoro-modified nucleosides; N-Methylated alkylated nucleosidesCouleur et forme :SoildRef: TM-TNU0546
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demanderms2i6A
CAS :ms2i6A is a mitochondrial tRNA-specific modification, which regulates efficient mitochondrial translation and energy metabolism in mammals.Formule :C16H23N5O4SCouleur et forme :SolidMasse moléculaire :381.452',3',5'-Tri-O-benzoyl-5-iodouridine
CAS :Nucleoside Derivatives - Halo-Nucleosides, 5-Modified pyrimidine nucleosidesFormule :C30H23IN2O9Couleur et forme :SolidMasse moléculaire :682.42Ref: TM-TNU0905
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander2,6-Bis(4-morpholinyl)-9-b-D-ribofuranosyl-9H-purine
Nucleoside Derivatives –6-Subtituted nucleosides；2-Substituted nucleosidesCouleur et forme :SoildRef: TM-TNU1411
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander5-Iodo-2'-O-methylcytidine
CAS :5-Iodo-2'-O-methylcytidine is a Halo-nucleoside; 2'-O-Methyl nucleoside.Formule :C10H14IN3O5Couleur et forme :SolidMasse moléculaire :383.14Ref: TM-TNU0018
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander2-Amino-6-methythio-9-(β-D-ribofuranosyl)-9H-purine
CAS :2-Amino-6-methythio-9-(beta-D-ribofuranosyl)-9H-purine is a Nucleoside Derivative - 6-Modified purine nucleoside; Thio-nucleoside.Formule :C11H15N5O4SCouleur et forme :SolidMasse moléculaire :313.33Ref: TM-TNU0491
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander5-Phenylcytidine
CAS :5-Phenylcytidine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside.Formule :C15H17N3O5Couleur et forme :SolidMasse moléculaire :319.31Ref: TM-TNU0150
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander2-Chloro-6-methoxypurine -9-β-D-(2'-deoxy-2'-fluoro)-arabinoriboside
CAS :Fluoro-modified nucleoside; Halo-nucleoside; 2/6/8-Modified purine nucleoside; Arabino-nucleoside;Formule :C11H12ClFN4O4Couleur et forme :SolidMasse moléculaire :318.69Ref: TM-TNU0104
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander8-Benzyloxy-2'-deoxyguanosine
CAS :8-Benzyloxy-2'-deoxyguanosine is a Nucleoside Derivative - 8-Modified purine nucleoside.Formule :C17H19N5O5Couleur et forme :SolidMasse moléculaire :373.36Ref: TM-TNU0931
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-[5-(propyn-1-yl)pyridin-3-yl]purine
CAS :9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-[5-(propyn-1-yl)pyridin-3-yl]purine is a Nucleoside Derivative - Fluoro-modified nucleoside, 6-Modified purineFormule :C18H16FN5O3Couleur et forme :SolidMasse moléculaire :369.35Ref: TM-TNU0735
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander5-Methyl-2-thio-xylo-uridine
CAS :Nucleoside Derivatives - Xylo-nucleosides; Thio-nucleosidesFormule :C10H14N2O5SCouleur et forme :SolidMasse moléculaire :274.29Ref: TM-TNU0433
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander2'-Deoxy-N4,N4-dimethylcytidine
CAS :2'-Deoxy-N4,N4-dimethylcytidine is a Nucleoside Derivative - N-Methylated nucleoside.Formule :C11H17N3O4Couleur et forme :SolidMasse moléculaire :255.27Ref: TM-TNU1206
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander2-Chloro-2'-C-methyl-6-N,N-dimethyladenosine
CAS :2’-C-Methyl nucleoside; Halo-nucleoside; 2/6/8-Modified purine nucleosideFormule :C13H18ClN5O4Couleur et forme :SolidMasse moléculaire :343.77Ref: TM-TNU0111
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander5'-O-DMT-dT
CAS :5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative that finds utility in oligonucleotide synthesis.Formule :C31H32N2O7Couleur et forme :White PowderMasse moléculaire :544.595'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-uridine
CAS :Nucleoside Derivatives - Didehydro-nucleosidesFormule :C11H12N2O5Couleur et forme :SolidMasse moléculaire :252.22Ref: TM-TNU0993
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine
CAS :Nucleoside Derivatives - 5-Modified pyrimidine nucleosideFormule :C31H32N2O9Couleur et forme :SolidMasse moléculaire :576.59Ref: TM-TNU0852
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander8-Chloro-2'-β-C-methyl inosine
CAS :Nucleoside Derivatives - 2’-Modified nucleosides; 8-Modified purine nucleosides; Halo-nucleosidesFormule :C11H13ClN4O5Couleur et forme :SolidMasse moléculaire :316.7Ref: TM-TNU0553
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander7-Cyclopropylmethyl-7,8-dihydro-8-oxo-9-(b-D-xylofuranosyl) guanine
CAS :Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; N-Methylated alkylated nucleosidesFormule :C14H19N5O6Couleur et forme :SolidMasse moléculaire :353.33Ref: TM-TNU0388
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander2-Amino-2'-deoxyadenosine
CAS :2-Amino-2'-deoxyadenosine is a deoxyribonucleoside used for the oligonucleotide synthesis.Formule :C10H14N6O3Couleur et forme :SolidMasse moléculaire :266.265-Hydroxymethyl xylo-uridine
CAS :Nucleoside Derivatives - Xylo-nucleosides; 5-Modified pyrimidine nucleosidesFormule :C10H14N2O7Couleur et forme :SolidMasse moléculaire :274.23Ref: TM-TNU0484
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander5-(2-Hyroxyethyl)-2'-deoxyuridine
CAS :5-(2-Hyroxyethyl)-2'-deoxyuridine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside.Formule :C11H16N2O6Couleur et forme :SolidMasse moléculaire :272.25Ref: TM-TNU1280
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander5'-DMT-3'-TBDMS-Bz-rA
CAS :5'-DMT-3'-TBDMS-Bz-rA is a nucleoside with protective and modification effects.Formule :C44H49N5O7SiCouleur et forme :SolidMasse moléculaire :787.975-O-benzoyl-1,2-O-isopropylidene-α-D-erythro-pent-3-ulofuranose
CAS :5-O-benzoyl-1,2-O-isopropylidene-alpha-D-erythro-pent-3-ulofuranose is a Carbohydrate; Used for modified nucleoside.Formule :C15H16O6Couleur et forme :SolidMasse moléculaire :292.28Ref: TM-TNU0608
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demanderN1-Propargylpseudouridine
CAS :N1-Propargylpseudouridine is a Nucleoside Derivative - C-nucleoside; N-Alkylated nucleoside.Formule :C12H14N2O6Couleur et forme :SolidMasse moléculaire :282.25Ref: TM-TNU0079
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander3'-O-(2-Azidoethyl)adenosine
Nucleoside Derivatives - 3’-Modified nucleosides; Azido-nucleosidesCouleur et forme :SoildRef: TM-TNU0177
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander2'-Deoxy-2'-fluoroarabino inosine
CAS :2'-Deoxy-2'-fluoroarabino inosine is a Nucleoside Derivative - 2'-Modified nucleoside, Fluoro-modified nucleoside.Formule :C10H11FN4O4Couleur et forme :SolidMasse moléculaire :270.22Ref: TM-TNU1502
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demanderMethotrexate Diglutamate
CAS :Methotrexate Diglutamate Small molecule compound present in the liver that acts as a partially purified human dihydrofolate reductase inhibitor.Formule :C25H29N9O8Degré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :583.552-Chloro-9-[(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)]-9H-purine
CAS :2-Chloro-9-[(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)]-9H-purine is a Nucleoside Derivative - Halo-nucleoside, 6-Deaminopurine nucleoside.Formule :C16H17ClN4O7Couleur et forme :SolidMasse moléculaire :412.78Ref: TM-TNU1210
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demanderN1-Methyl-2'-deoxy-2'-fluoroarabinoadenosine
N1-Methyl-2'-deoxy-2'-fluoroarabinoadenosine is a Nucleoside Derivative - 2'-Modified nucleoside, N-Methylated/alkylated nucleoside, Fluoro-modified nucleoside.Couleur et forme :SoildRef: TM-TNU0544
5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander500mgÀ demander
![9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-[5-(propyn-1-yl)pyridin-3-yl]purine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTNU0735.webp&w=3840&q=75)
![2-Chloro-9-[(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)]-9H-purine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTNU1210.webp&w=3840&q=75)
