
Cycle cellulaire/point de contrôle
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(115 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(227 produits)
- HSP(180 produits)
- Intégrine(269 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(126 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
3906 produits trouvés pour "Cycle cellulaire/point de contrôle"
TAK-960 dihydrochloride
TAK-960 dihydrochloride: oral PLK1 inhibitor, IC50 0.8 nM; also Hinders PLK2 and PLK3 (IC50s 16.9/50.2 nM); curbs cancer cell growth.Formule :C27H36Cl2F3N7O3Couleur et forme :SolidMasse moléculaire :634.52Ganciclovir hydrate
CAS :Ganciclovir hydrate: oral anti-cytomegalovirus; inhibits HSV 1/2, CMV, adenoviruses, FHV-1; brain-penetrating.Formule :C9H15N5O5Couleur et forme :SolidMasse moléculaire :273.249Netarsudil free base
CAS :Netarsudil (AR-11324), a ROCK inhibitor, treats glaucoma by increasing eye outflow and lowering IOP, with mild hyperemia as a side effect.Formule :C28H27N3O3Couleur et forme :SolidMasse moléculaire :453.53SNS-314
CAS :SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.Formule :C18H15ClN6OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.93CW-069
CAS :CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Formule :C23H21IN2O3Degré de pureté :97.52% - 99.52%Couleur et forme :SolidMasse moléculaire :500.33Ref: TM-T6209
1mg40,00€5mg86,00€10mg118,00€25mg205,00€50mg290,00€100mg409,00€500mg888,00€1mL*10mM (DMSO)94,00€THZ1 Hydrochloride
THZ1 Hydrochloride: selective covalent CDK7 inhibitor, IC50 of 3.2 nM; affects CDK12/13 & lowers MYC expression.Formule :C31H29Cl2N7O2Couleur et forme :SolidMasse moléculaire :602.51Chroman 1 dihydrochloride
Chroman 1 dihydrochloride: potent ROCK2 inhibitor (IC50: 1 pM), also affects ROCK1 (52 pM) and MRCK (150 nM).Formule :C24H30Cl2N4O4Couleur et forme :SolidMasse moléculaire :509.43Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.Formule :C25H31ClN6O2Couleur et forme :SolidMasse moléculaire :483.01LIMK-IN-22j
CAS :LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Formule :C20H21BrN8Degré de pureté :99.165%Couleur et forme :SolidMasse moléculaire :453.34Trimethoprim sulfate
CAS :Trimethoprim sulfate, a dihydrofolate reductase inhibitor, treats bacterial infections and sometimes malaria; may depress hematopoiesis.Formule :C28H38N8O10SCouleur et forme :SolidMasse moléculaire :678.72CX-5461 dihydrochloride
CX-5461 dihydrochloride: Oral Pol I inhibitor, HCT-116 (IC50: 142 nM), A375 (IC50: 113 nM), MIA PaCa-2 (IC50: 54 nM), weak on Pol II (IC50 ≥ 25 μM).Formule :C27H29Cl2N7O2SCouleur et forme :SolidMasse moléculaire :586.54Folinic acid calcium hydrate
CAS :Folinic acid (Leucovorin) calcium hydrate is a biofolic acid often used as a rescue agent with methotrexate (MTX) to reduce MTX-induced toxicity.Formule :C20H23CaN7O8Couleur et forme :SolidMasse moléculaire :529.523Ilorasertib
CAS :Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).Formule :C25H21FN6O2SDegré de pureté :96.17% - 97.49%Couleur et forme :SolidMasse moléculaire :488.54Simeprevir sodium
CAS :Simeprevir is a drug for the treatment and cure of hepatitis C.Formule :C38H46N5NaO7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.92APTO-253 HCl
CAS :APTO-253 (LOR-253/LT-253) is a small-molecule MTF-1 inhibitor with antitumor properties, reducing cyclin D1, hypoxia, and angiogenesis gene expression.Formule :C22H15ClFN5Couleur et forme :SolidMasse moléculaire :403.84HA-100 hydrochloride
CAS :HA-100 hydrochloride inhibits protein kinases PKG, PKA, PKC, MLC-kinase (IC50: 4-240 μM) and ROCK.Formule :C13H16ClN3O2SCouleur et forme :SolidMasse moléculaire :313.8LY3143921
CAS :LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Formule :C16H12FN5OCouleur et forme :SolidMasse moléculaire :309.3JSH-150
CAS :JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Formule :C24H33ClN6O2SDegré de pureté :99.96% - 99.96%Couleur et forme :SolidMasse moléculaire :505.08LY2880070
CAS :LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Formule :C19H23N7O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :381.43GNF2133 hydrochloride
CAS :GNF2133 hydrochloride: selective oral DYRK1A inhibitor (IC50: 0.0062 μM), boosts β-cell growth and insulin, potential for type 1 diabetes research.Formule :C24H31ClN6O2Couleur et forme :SolidMasse moléculaire :471.0HMN-214
CAS :HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.Formule :C22H20N2O5SDegré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :424.47Ref: TM-T2438
1mg38,00€2mg50,00€5mg80,00€10mg117,00€25mg207,00€50mg333,00€100mg477,00€500mg1.063,00€1mL*10mM (DMSO)87,00€TAK-960
CAS :TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.Formule :C27H34F3N7O3Degré de pureté :97.06%Couleur et forme :SolidMasse moléculaire :561.6Ref: TM-T7200
1mg60,00€2mg85,00€5mg114,00€10mg161,00€25mg279,00€50mg464,00€100mg672,00€1mL*10mM (DMSO)161,00€Cyclo(-RGDfK) TFA
CAS :Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Formule :C29H42F3N9O9Degré de pureté :98.99% - 99.54%Couleur et forme :SolidMasse moléculaire :717.69Seliciclib
CAS :Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Formule :C19H26N6ODegré de pureté :97.15% - 99.89%Couleur et forme :White To Off-White SolidMasse moléculaire :354.45InhA-IN-2
CAS :N-[3-(Aminomethyl)phenyl]-5-chloro-3-methyl-benzo[b]thiophene-2-sulfonamide inhibits InhA without KatG activation.Formule :C16H15ClN2O2S2Degré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :366.89Ref: TM-T9734
1mg93,00€5mg182,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)187,00€360A
CAS :360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
Formule :C27H23N5O2Degré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :449.5TH5487
CAS :TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)Formule :C19H18BrIN4O2Degré de pureté :98.38% - 98.73%Couleur et forme :SolidMasse moléculaire :541.18Ref: TM-T8119
1mg46,00€2mg59,00€5mg88,00€10mg152,00€25mg288,00€50mg520,00€100mg750,00€500mg1.521,00€1mL*10mM (DMSO)105,00€Mogroside I E1
CAS :Mogroside I E1 is a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener.Formule :C36H62O9Degré de pureté :98.62% - 99.71%Couleur et forme :SolidMasse moléculaire :638.87Protein kinase inhibitor 6
CAS :Protein kinase inhibitor 6 is a protein kinase inhibitor.Formule :C13H9FN2SDegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :244.29Ref: TM-T9779
2mg34,00€5mg52,00€10mg86,00€25mg163,00€50mg222,00€100mg324,00€200mg440,00€1mL*10mM (DMSO)52,00€AZD-5438
CAS :AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).Formule :C18H21N5O2SDegré de pureté :99.73% - 99.87%Couleur et forme :SolidMasse moléculaire :371.46PF-06873600
CAS :PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.Formule :C20H27F2N5O4SDegré de pureté :98.77% - 99.55%Couleur et forme :SolidMasse moléculaire :471.52Ref: TM-T8463
1mg54,00€5mg114,00€10mg178,00€25mg334,00€50mg557,00€100mg888,00€200mg1.198,00€1mL*10mM (DMSO)118,00€2'-Deoxy-2'-fluorocytidine
CAS :2'-Deoxy-2'-fluorocytidine is an nucleoside analog and inhibits of Crimean-Congo hemorrhagic fever virus (CCHFV) replication potently.Formule :C9H12FN3O4Degré de pureté :99.90%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :245.21GLPG0187
CAS :GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).Formule :C29H37N7O5SDegré de pureté :99.4% - 99.70%Couleur et forme :SolidMasse moléculaire :595.71Ref: TM-T4259
1mg44,00€5mg98,00€10mg144,00€25mg236,00€50mg350,00€100mg522,00€500mg1.134,00€1mL*10mM (DMSO)129,00€Roniciclib
CAS :Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.Formule :C18H21F3N4O3SDegré de pureté :98% - 98.63%Couleur et forme :SolidMasse moléculaire :430.44SCH900776
CAS :SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Formule :C15H18BrN7Degré de pureté :96.69% - 99.6%Couleur et forme :SolidMasse moléculaire :376.25Eprociclovir potassium
CAS :Eprociclovir potassium, 15x stronger than acyclovir, inhibits EHV1 and human herpesviruses, also treats herpetic keratitis effectively with eyedrops.Formule :C11H15KN5O3Couleur et forme :SolidMasse moléculaire :304.37DMTr-LNA-5MeU-3-CED-phosphoramidite
CAS :DMTr-LNA-5MeU-3-CED-phosphoramidite is a derivative of nucleoside.Formule :C41H49N4O9PDegré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :772.82SEL120-34A HCl
CAS :SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectivelyFormule :C15H19Br2ClN4Degré de pureté :98.13% - 98.47%Couleur et forme :SolidMasse moléculaire :450.6Amenamevir
CAS :Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mLFormule :C24H26N4O5SDegré de pureté :99.00% - 99.86%Couleur et forme :SolidMasse moléculaire :482.55Ref: TM-T4226
1mg34,00€5mg71,00€10mg92,00€25mg152,00€50mg222,00€100mg334,00€200mg494,00€1mL*10mM (DMSO)52,00€Dalpiciclib
CAS :Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.
Formule :C25H30N6O2Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :446.54CYC-116
CAS :CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not activeFormule :C18H20N6OSDegré de pureté :97.36% - 97.59%Couleur et forme :SolidMasse moléculaire :368.46Acelarin
CAS :Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.
Formule :C25H27F2N4O8PDegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :580.47POL1-IN-1
CAS :POL1-IN-1 (Compound 3A) 是一种RNA 聚合酶 1 POL1抑制剂,IC50值低于 0.5 uM。 它能有效抑制A375恶性黑色素瘤细胞系中RNA 聚合酶I 的转录。
Formule :C21H20N6Degré de pureté :98% - 98.01%Couleur et forme :SolidMasse moléculaire :356.42LXW7
CAS :LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (Formule :C29H48N12O12S2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :820.89BMS-3
CAS :BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Formule :C17H12Cl2F2N4OSDegré de pureté :99.31% - 99.81%Couleur et forme :SolidMasse moléculaire :429.276-O-Methyl Guanosine
CAS :6-O-Methyl Guanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.Formule :C11H15N5O5Degré de pureté :97.5%Couleur et forme :SolidMasse moléculaire :297.27Ispinesib
CAS :Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic
Formule :C30H33ClN4O2Degré de pureté :98% - 99.09%Couleur et forme :SolidMasse moléculaire :517.06Saccharin 1-methylimidazole
CAS :Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.Formule :C7H5NO3S·C4H6N2Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :265.29AZD-5597
CAS :AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent
Formule :C23H28FN7ODegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :437.51SP-146
SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).Formule :C25H20FN7ODegré de pureté :97.82%Couleur et forme :SolidMasse moléculaire :453.47Ref: TM-T8685
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)177,00€

