Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(226 produits)
- HSP(179 produits)
- Intégrine(249 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(124 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
Affichez 10 plus de sous-catégories
3864 produits trouvés pour "Cycle cellulaire/point de contrôle"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Formule :C25H41N11O8SCouleur et forme :SolidMasse moléculaire :655.7275'-O-DMT-Bz-rC
CAS :5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.Formule :C37H35N3O8Couleur et forme :SolidMasse moléculaire :649.69Cytarabine triphosphate
CAS :Ara-CTP, active Cytarabine metabolite, inhibits DNA synthesis, predicts leukemic chemosensitivity.Formule :C9H16N3O14P3Couleur et forme :SolidMasse moléculaire :483.16STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Degré de pureté :97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :Odour LiquidRifalazil
CAS :Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Formule :C51H64N4O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :941.07Aclacinomycin A
CAS :Aclacinomycin A has a wide range of applications in life science related research.Formule :C42H53NO15Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :811.87Flurocitabine HCl
CAS :Fluorocitabine HCl, a cytarabine analog, hydrolyzes into ara-FC and ara-FU, showing antitumor effects in leukemia and solid cancers.Formule :C9H11ClFN3O4Degré de pureté :99.23% - 99.76%Couleur et forme :SoildMasse moléculaire :279.655'-O-TBDMS-Bz-dA
CAS :5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.Formule :C23H31N5O4SiCouleur et forme :SolidMasse moléculaire :469.617Chk1-IN-6
CAS :Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.
Formule :C16H18F3N7Couleur et forme :SolidMasse moléculaire :365.364Ac-dA Phosphoramidite
CAS :Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.Formule :C42H50N7O7PCouleur et forme :SolidMasse moléculaire :795.878Barasertib
CAS :AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formule :C26H31FN7O6PDegré de pureté :99.92% - 99.97%Couleur et forme :SolidMasse moléculaire :587.543'-β-C-Methyl-2-thiouridine
3’-β-C-Methyl-2-thiouridine, a purine nucleoside analog, exhibits extensive antitumor activity, particularly against indolent lymphoid malignancies.Formule :C10H14N2O5SCouleur et forme :SolidMasse moléculaire :274.29N7-Methyl-2'-O-(2-methoxyethyl) guanosine
N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Formule :C14H21N5O6Couleur et forme :SolidMasse moléculaire :355.35ONX 0801 trisodium
CAS :ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Formule :C32H30N5Na3O10Couleur et forme :SolidMasse moléculaire :713.58PROTAC CDK9 degrader-8
PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].Formule :C44H52Cl2N10O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :903.85α2β1 Integrin Ligand Peptide
CAS :The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFormule :C14H22N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.35Erythromycin lactobionate
CAS :Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.Formule :C49H89NO25Couleur et forme :SolidMasse moléculaire :1092.233N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS :N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Formule :C21H35N12O17P3Couleur et forme :SolidMasse moléculaire :820.498-NH2-ATP
CAS :8-NH2-ATP is an inactive derivative of adenosine triphosphate (ATP), synthesized from 8-NH2-Ado.Formule :C10H17N6O13P3Couleur et forme :SolidMasse moléculaire :522.205-Caroxy uracil-1-yl acetic acid benzyl ester
5-Caroxy uracil-1-yl acetic acid benzyl ester, a purine analog, inhibits DNA synthesis and induces apoptosis to combat lymphoid cancers.Formule :C14H12N2O6Couleur et forme :SolidMasse moléculaire :304.256-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
6-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue with broad antitumor activity, particularly againstFormule :C10H15N7O4Couleur et forme :SolidMasse moléculaire :297.27Rev 2'-O-MOE-C(Bz)-5'-amidite
'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Formule :C49H58N5O10PCouleur et forme :SolidMasse moléculaire :907.99XY028-133
CAS :XY028-133 is a PROTAC-based CDK4/6 degrader for the study of tumors.
Formule :C53H67N11O7SDegré de pureté :97.11%Couleur et forme :SolidMasse moléculaire :1002.237-TFA-ap-7-Deaza-ddA
CAS :Compound 19c is a nucleotide derivative for DNA sequencing dye terminators.Formule :C16H16F3N5O3Couleur et forme :SolidMasse moléculaire :383.331AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.615'-O-DMT-ibu-dC
CAS :5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.Formule :C34H37N3O7Couleur et forme :SolidMasse moléculaire :599.67N1-Methylpseudouridine-5′-triphosphate tetralithium
N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.Formule :C10H13Li4N2O15P3Couleur et forme :SolidMasse moléculaire :521.9N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-deoxycytidine
N4-Acetyl-5’-O-(4,4’-dimethoxytrityl)-5-methyl-2’-deoxycytidine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolentFormule :C33H35N3O7Couleur et forme :SolidMasse moléculaire :585.65DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Couleur et forme :Odour SolidIRE1α kinase-IN-6
CAS :IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM.Formule :C25H23Cl2FN6O3S2Couleur et forme :SolidMasse moléculaire :609.52Adenosine-2-carboxy methyl amide
Adenosine-2-carboxy methyl amide: a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis.Formule :C12H16N6O5Couleur et forme :SolidMasse moléculaire :324.29LDV
CAS :α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.Formule :C48H70N10O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :979.131-(β-D-Xylofuranosyl)-N6-Isopentenyladenine
1-(β-D-Xylofuranosyl)-N6-Isopentenyladenine is an adenosine analog.Formule :C15H21N5O4Couleur et forme :SolidMasse moléculaire :335.36Psammaplin A
CAS :Psammaplin A: marine-derived, inhibits HDAC/DNA methyltransferases, strong DAC1 blocker (IC50=0.9nM), antimicrobial against Gram-positive bacteria, anticancer.Formule :C22H24Br2N4O6S2Couleur et forme :SolidMasse moléculaire :664.38NUAK1-IN-1
NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formule :C25H30N6OCouleur et forme :SolidMasse moléculaire :430.545Nusinersen
CAS :Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.Degré de pureté :98.62%Couleur et forme :SolidSNX7
CAS :SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Formule :C15H14N2ODegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :238.282'-Deoxy-2'-fluoro-l-uridine
CAS :2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.Formule :C9H11FN2O5Couleur et forme :SolidMasse moléculaire :246.198-Chloro-2'-O-methyl inosine
8-Chloro-2’-O-methyl inosine, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Formule :C11H13ClN4O5Couleur et forme :SolidMasse moléculaire :316.72'-Deoxy-2'-fluoro-N3-[3-(tert-butoxycarbonyl) amino]propyluridine
2’-Deoxy-2’-fluoro-N3-[3-(tert-butoxycarbonyl)amino]propyluridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolentFormule :C17H26FN3O7Couleur et forme :SolidMasse moléculaire :403.4KWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Formule :C33H31ClF3N9O4Couleur et forme :SolidMasse moléculaire :710.105Antibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Couleur et forme :Odour SolidPKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Formule :C24H26FN5O2Couleur et forme :SolidMasse moléculaire :435.492'-O-Acetyl-5'-O-benzoyl-3'-O-(2-methoxyethyl) uridine
2’-O-Acetyl-5’-O-benzoyl-3’-O-(2-methoxyethyl) uridine, an analog of uridine known for its potential antiepileptic properties, is utilized in researchingFormule :C21H24N2O9Couleur et forme :SolidMasse moléculaire :448.42Guanosine 5'-triphosphate trisodium salt hydrate
CAS :5'-GTP trisodium salt hydrate activates G proteins and is a precursor for DNA/RNA synthesis.Formule :C10H18N5NaO15P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.185wrwyar-NH2 TFA
wrwyar-NH2 (TFA) serves as the control peptide for wrwycr-NH2.Couleur et forme :Odour Solid3'Ome-m7GpppAmpG
CAS :3'Ome-m7GpppAmpG is a trinucleotide cap with LNA, boosting translation; useful in mRNA vaccines and gene therapy.Formule :C33H45N15O24P4Couleur et forme :SolidMasse moléculaire :1159.69TFMU-ADPr triethylamine
TFMU-ADPr triethylamine is a substrate for PARG activity measurement, releasing a fluorophore to indicate PAR hydrolase activity.Formule :C25H26F3N5O16P2·5C6H15NCouleur et forme :SolidMasse moléculaire :1024.42CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Formule :C24H22FN7O2Couleur et forme :SolidMasse moléculaire :459.48m7GpppCmpG
CAS :m7GpppCmpG, a trinucleotide cap analogue, enables RNA manufacturing with cap 0 or cap 1 structures.Formule :C31H43N13O25P4Couleur et forme :SolidMasse moléculaire :1121.64
