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Immunologie et Inflammation

Immunologie et Inflammation

Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.

Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"

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3269 produits trouvés pour "Immunologie et Inflammation"

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  • AhR agonist 8
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    AhR agonist 8

    CAS :
    <p>Compound 9, also known as AhR agonist 8, effectively activates the Aryl Hydrocarbon Receptor (AhR) with an EC50 of 0.154 nM. This compound is utilized in researching psoriasis and atopic dermatitis.</p>
    Formule :C17H15FN4O
    Couleur et forme :Solid
    Masse moléculaire :310.33

    Ref: TM-T89981

  • DEG-35
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    DEG-35

    CAS :
    DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).
    Formule :C25H21N3O5
    Couleur et forme :Solid
    Masse moléculaire :443.45

    Ref: TM-T207249

  • PVTX-405
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    PVTX-405

    CAS :
    PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a maximum degradation (Dmax) of 91%. It enhances degradation efficiency, significantly reduces off-target degradation, and minimizes hERG inhibition with an IC50 of 48 µM. PVTX-405 effectively inhibits MC38 tumor growth in Crbn391VC57BL/6 mouse xenograft models and shows superior synergistic anticancer effects when combined with immune checkpoint therapies (ICTs) such as anti-PD1 or anti-LAG3 antibodies.
    Formule :C30H31N5O4
    Couleur et forme :Solid
    Masse moléculaire :525.60

    Ref: TM-T211233

  • PSB-0963
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    PSB-0963

    CAS :
    PSB-0963 is a selective competitive extracellular 5'-nucleotidase (eN/CD73) inhibitor with a Ki value of 150 nM for rat extracellular 5'-nucleotidase. It exhibits greater selectivity compared to other extracellular nucleotidases (NTPDases 1-3) and P2Y receptors. PSB-0963 is applicable in cancer research.
    Formule :C28H17N2NaO5S
    Couleur et forme :Solid
    Masse moléculaire :516.50

    Ref: TM-T211796

  • Le logo de CymitQuimica
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    Cyclic-di-GMP sodium

    c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.
    Formule :C20H24N10NaO14P2
    Couleur et forme :Solid
    Masse moléculaire :713.08464

    Ref: TM-T64248

  • Ocipumaltib
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    Ocipumaltib

    CAS :
    Ocipumaltib (Example 2) is an inhibitor of mucosa-associated lymphoid tissue protein 1 (MALT1). It functions as an antineoplastic agent and is utilized in the study of cancer, infections, neurological disorders, and hematological diseases.
    Formule :C20H16ClF3N8O2
    Couleur et forme :Solid
    Masse moléculaire :492.84

    Ref: TM-T211708

  • Cbl-b-IN-1
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    Cbl-b-IN-1

    CAS :
    Cbl-b-IN-1 is a potent Cbl-b inhibitor (IC50 <100 nM) with potential anticancer activity for the study of intestinal inflammation.
    Formule :C29H34N6O2
    Degré de pureté :99.68%
    Couleur et forme :Solid
    Masse moléculaire :498.631

    Ref: TM-T37356

  • Indeno[1,2,3-cd]pyrene
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    Indeno[1,2,3-cd]pyrene

    CAS :
    Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon, exhibits moderate cytotoxicity to human alveolar epithelial cells (HPAEpiC). Additionally, it enhances allergic pulmonary inflammation responses through the activation of the aryl hydrocarbon receptor.
    Formule :C22H12
    Couleur et forme :Solid
    Masse moléculaire :276.33

    Ref: TM-T201817

  • Le logo de CymitQuimica
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    Anti-inflammatory agent 23

    Anti-inflammatory agent 23 blocks LPS-induced NO (IC50: 0.449 μM) and binds p65 well.
    Formule :C34H49NO6
    Couleur et forme :Solid
    Masse moléculaire :567.76

    Ref: TM-T64018

  • α-Hydroxy alprazolam
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    α-Hydroxy alprazolam

    CAS :
    α-Hydroxy alprazolam (U 40125), the primary metabolite of α-Hydroxy alprazolam, possesses pharmacological activity accounting for 60% of that of Alprazolam.
    Formule :C17H13ClN4O
    Couleur et forme :Solid
    Masse moléculaire :324.76

    Ref: TM-T201680

  • HTS05585
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    HTS05585

    CAS :
    HTS05585 (Compound Hit-1) is a selective inhibitor of macrophage migration inhibitory factor (MIF) with a Kd value of 0.29 μM determined by microscale thermophoresis (MST) and confirmed through isothermal titration calorimetry (ITC) at 0.32 μM. It suppresses the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) in macrophages induced by LPS, making it a promising candidate for the study of inflammatory diseases such as sepsis.
    Formule :C18H15N3O
    Couleur et forme :Solid
    Masse moléculaire :289.33

    Ref: TM-T210778

  • TNFα activity modulator 3
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    TNFα activity modulator 3

    CAS :
    <p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>
    Formule :C27H24F2N6O2
    Couleur et forme :Solid
    Masse moléculaire :502.52

    Ref: TM-T89932

  • RGT-068A
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    RGT-068A

    CAS :
    RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .
    Formule :C17H16ClN9O2
    Couleur et forme :Solid
    Masse moléculaire :413.82

    Ref: TM-T73389

  • NLRP3-IN-44
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    NLRP3-IN-44

    CAS :
    <p>NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.</p>
    Formule :C25H30N4O3
    Couleur et forme :Solid
    Masse moléculaire :434.53

    Ref: TM-T89953

  • IRAK4-IN-14
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    IRAK4-IN-14

    CAS :
    IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.
    Formule :C25H28FN9O
    Couleur et forme :Solid
    Masse moléculaire :489.55

    Ref: TM-T63278

  • cGAS-IN-4
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    cGAS-IN-4

    CAS :
    <p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>
    Formule :C19H18Cl2N4O3
    Couleur et forme :Solid
    Masse moléculaire :421.277

    Ref: TM-T204612

  • Le logo de CymitQuimica
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    NLRP3-IN-6

    <p>NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.</p>
    Formule :C18H15ClN2O4S3
    Couleur et forme :Solid
    Masse moléculaire :454.97

    Ref: TM-T62808

  • NLRP3-IN-57
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    NLRP3-IN-57

    <p>NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.</p>
    Formule :C44H60O7
    Couleur et forme :Solid
    Masse moléculaire :700.94

    Ref: TM-T201467

  • CYP1B1-IN-10
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    CYP1B1-IN-10

    CAS :
    CYP1B1-IN-10 (Compound 15C) is a highly selective inhibitor of human cytochrome P450 1B1 (hCYP1B1) with an IC50 value of 0.11 μM. It shows promise for use in research focused on hormone-dependent tumors, including breast and ovarian cancers.
    Formule :C23H18N2
    Couleur et forme :Solid
    Masse moléculaire :322.40

    Ref: TM-T212362

  • Itaconic acid prodrug-1
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    Itaconic acid prodrug-1

    CAS :
    Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid that efficiently delivers Itaconic acid to skin tissues upon oral administration. It exhibits immunomodulatory effects, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 is useful for research into alopecia areata and other inflammatory skin conditions.
    Formule :C15H22O10
    Couleur et forme :Solid
    Masse moléculaire :362.329

    Ref: TM-T204591