Immunologie et Inflammation
Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"
- RCC(140 produits)
- CXCR(153 produits)
- Paroi cellulaire(5 produits)
- Récepteur IL(108 produits)
- IκB/IKK(59 produits)
- LTR(3 produits)
- MALT(24 produits)
- MRP(6 produits)
- NADPH-oxydase(1 produits)
- NF-κB(445 produits)
- NOD(17 produits)
- NOS(62 produits)
- Nrf2(82 produits)
- PGE Synthase(31 produits)
- ROS(70 produits)
- TGF-beta/Smad(59 produits)
- TLR(74 produits)
- Thioredoxine(12 produits)
- gp120/CD4(4 produits)
Affichez 11 plus de sous-catégories
3269 produits trouvés pour "Immunologie et Inflammation"
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ROS inducer 8
<p>ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.</p>Formule :C26H31FN6O6Couleur et forme :SolidMasse moléculaire :542.56Keap1-Nrf2-IN-25
Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor with an IC50 of 0.55 μM and exhibits a Keap1 binding affinity (Kd of 0.50 μM). This compound activates Nrf2, reducing reactive oxygen species (ROS) and pro-inflammatory cytokines (IL-1β, IL-6). Additionally, Keap1-Nrf2-IN-25 provides protective effects against DSS-induced colitis.Formule :C25H28N2O6SCouleur et forme :SolidMasse moléculaire :484.565STING agonist-3 trihydrochloride
STING agonist-3 is a selective, non-nucleotide small-molecule with anti-tumor properties and potential in cancer therapy.Formule :C37H45Cl3N12O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :860.19CRX 527
CAS :<p>CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.</p>Formule :C81H151N2O19PCouleur et forme :SolidMasse moléculaire :1488.04Basiliximab
CAS :Basiliximab: chimeric IgG1 antibody inhibiting interleukin-2 receptor, used for kidney transplant immunosuppression.Degré de pureté :SDS-PAGE:94.1%;SEC-HPLC:95.3%Couleur et forme :LiquidMasse moléculaire :144.01 kDa(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA
CAS :<p>(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA ((6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-coenzyme A) acts as an NLRX1 modulator. This compound shows potential for research into immune and metabolism-related diseases.</p>Formule :C45H70N7O17P3SCouleur et forme :SolidMasse moléculaire :1106.06Keap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Formule :C17H21Cl2N2O5PS3Couleur et forme :SolidMasse moléculaire :531.434Carotuximab
CAS :<p>Carotuximab (DE-122), an antibody, inhibits CD105 to reduce angiogenesis, inflammation, and tumor growth.</p>Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :144.8 kDaVEN-02XX
<p>VEN-02XX is an orally active NLRP3 inhibitor capable of penetrating the brain. It effectively suppresses the release of IL-1β and IL-18, with IC50 values of 0.3 and 0.28 μM, respectively. In the 5XFAD/Rubicon KO mouse model, VEN-02XX aids in restoring memory and cognition, inhibits microgliosis, and alleviates neuroinflammation and tau protein pathology. This compound is valuable for Alzheimer's disease (AD) research.</p>Formule :C18H16ClF3N4OCouleur et forme :SolidMasse moléculaire :396.79Aloenin aglycone
CAS :<p>Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate.</p>Formule :C13H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.232,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside
CAS :<p>2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside that is commonly found in the bulbs of</p>Formule :C20H27Cl3O12Couleur et forme :SolidMasse moléculaire :565.78AMG-424
<p>AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 and CD3E. It effectively kills cancer cells that express CD38, stimulates T cell proliferation, and reduces cytokine release. AMG-424 exhibits antitumor activity in mouse cancer models with bone marrow invasion and induces peripheral B cell depletion in cynomolgus monkeys. It is used in studies of multiple myeloma. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3.</p>Couleur et forme :Odour LiquidAspulvinone O
CAS :<p>Aspulvinone O, from P. variotti, is an antioxidant with anticancer properties, inhibits GOT1, and reduces SW1990 pancreatic tumor growth in mice.</p>Formule :C27H28O6Couleur et forme :SolidMasse moléculaire :448.515Fletikumab
CAS :<p>Fletikumab (NNC0109-0012) is a monoclonal antibody against IL-20 that is often used as an IL-20 inhibitor.Fletikumab is used in the study of rheumatoid</p>Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.48 kDaFLY26
FLY26 is a selective partial antagonist of GluN2B, with an IC50 value of 0.64 μM. FLY26 inhibits the GluN2B subunit of NMDA receptors, reducing calcium ion influx and reactive oxygen species (ROS) production. It also activates the BDNF/TrkB/CREB neuroprotective signaling pathway, mitigating excitotoxicity and mitochondrial dysfunction. FLY26 holds potential for treating neurological deficits caused by cerebral ischemia-reperfusion injury.Formule :C22H23N5O3Couleur et forme :SolidMasse moléculaire :405.18009Anti-PSMA Antibody
<p>Anti-PSMA Antibody is a humanized IgG1 monoclonal antibody targeting PSMA. It serves as the antibody component of the ADC molecule ARX517.</p>Couleur et forme :Odour LiquidBuChE-IN-20
<p>BuChE-IN-20 is a selective hBuChE inhibitor (IC50= 0.13 μM) with the ability to cross the blood-brain barrier (BBB). This compound, a derivative of L-Tryptophan, exhibits neuroprotective effects by inhibiting nitric oxide (NO) production and reducing reactive oxygen species (ROS) levels. It effectively suppresses the self-aggregation of amyloid-beta (Aβ) peptides and is applicable in Alzheimer's disease research.</p>Couleur et forme :Odour SolidFITC-labeled ODN 1018 sodium
<p>FITC-labeled ODN 1018 (sodium), a TLR-9 agonist oligodeoxynucleotide, facilitates the assessment of CpG ODN cellular uptake and localization through confocal</p>Couleur et forme :SolidMasse moléculaire :8171E7766 diammonium salt
CAS :<p>E7766 diammonium salt, a macrocycle-bridged STING agonist, exhibits a dissociation constant (Kd) of 40 nM, demonstrating potent pan-genotypic and antitumor</p>Formule :C24H32F2N12O8P2S2Couleur et forme :SolidMasse moléculaire :780.661-Hydroxy-ibuprofen
CAS :1-Hydroxy Ibuprofen, a metabolite in P. australis, targets COX-1/COX-2 with IC50s: 13 μM/370 μM.Formule :C13H18O3Couleur et forme :SolidMasse moléculaire :222.2802
