Immunologie et Inflammation
Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"
- RCC(136 produits)
- CXCR(147 produits)
- Paroi cellulaire(5 produits)
- Récepteur IL(113 produits)
- IκB/IKK(61 produits)
- LTR(3 produits)
- MALT(23 produits)
- MRP(6 produits)
- NADPH-oxydase(1 produits)
- NF-κB(445 produits)
- NOD(17 produits)
- NOS(63 produits)
- Nrf2(78 produits)
- PGE Synthase(31 produits)
- ROS(69 produits)
- TGF-beta/Smad(58 produits)
- TLR(66 produits)
- Thioredoxine(12 produits)
- gp120/CD4(4 produits)
Affichez 11 plus de sous-catégories
3035 produits trouvés pour "Immunologie et Inflammation"
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2-Guanidinobezimidazole
CAS :<p>2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB).</p>Formule :C8H9N5Couleur et forme :SolidMasse moléculaire :175.191IRAK4-IN-11
<p>IRAK4-IN-11 (compound 6) is a potent inhibitor of IRAK4 with an IC 50 of 0.008 μM. IRAK4-IN-11 exhibits cell pIRAK4 potencies with an IC 50 of 0.19 μM [1].</p>Formule :C16H19N7OCouleur et forme :SolidMasse moléculaire :325.37E 5090
CAS :<p>E5090 is a novel orally active inhibitor of IL-1 generation. It also has anti-inflammatory properties.</p>Formule :C19H20O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.36COX-2/PI3K-IN-2
<p>COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>Formule :C16H17N5O2Couleur et forme :SolidMasse moléculaire :311.34VISTA-IN-3
CAS :<p>VISTA-IN-3 (Compound A4), a potent small molecule inhibitor of VISTA, exhibits a dissociation constant (K D) of 0.49 μM. This compound effectively induces the release of IFN-γ cytokines and demonstrates synergistic enhancement of anti-cancer activity when combined with PD-L1 antibody [1].</p>Formule :C14H18N4O3Couleur et forme :SolidMasse moléculaire :290.32AMS-17
<p>AMS-17, a strong NLRP3 inhibitor, quells microglia activation and cytokines like caspase-1, TNF-α, IL-1β, iNOS in studies.</p>Formule :C15H13F3N4O3SCouleur et forme :SolidMasse moléculaire :386.35IL-17 modulator 5
CAS :<p>IL-17 modulator 5 is a IL-17 inhibitor, with an IC 50 of 1 nM .</p>Formule :C28H23F6N9O2Couleur et forme :SolidMasse moléculaire :631.53NLRP3-IN-29
CAS :<p>NLRP3-IN-29 (Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) with potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. It can be used for research on Alzheimer's disease [1].</p>Formule :C21H22N2O3SCouleur et forme :SolidMasse moléculaire :382.48(S,R,S)-AHPC-Boc derivative 1
CAS :<p>(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).</p>Formule :C28H40N4O6SCouleur et forme :SolidMasse moléculaire :560.705COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Formule :C19H19N3O4S2Couleur et forme :SolidMasse moléculaire :417.5SP11
CAS :<p>SP11 is a mitochondrial reactive oxygen species (ROS) inhibitor. It activates Fis1 with an IC50 of 9.4 µM by binding to Cys41 and enhances the translocation of Drp1 to mitochondria. SP11 is utilized for research into oxidative stress damage.</p>Formule :C18H19ClN2OSCouleur et forme :SolidMasse moléculaire :346.87Galectin-8-IN-1
<p>Galectin-8-IN-1 selectively binds galectin-8N with 48 μM affinity, 15x more than galectin-3.</p>Formule :C16H18N2O6Couleur et forme :SolidMasse moléculaire :334.32Amilo-5MER
CAS :<p>Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.</p>Formule :C23H40N6O9SCouleur et forme :SolidMasse moléculaire :576.664Nrf2 activator-2
<p>Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.</p>Formule :C20H17BrO3Couleur et forme :SolidMasse moléculaire :385.25cGAS-IN-2
CAS :<p>cGAS-IN-2 (compound 109) serves as a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), exhibiting an IC50 of 0.01512 μM against h-cGAS [1].</p>Formule :C16H18Cl2N2O2Couleur et forme :SolidMasse moléculaire :341.23Cryptopleurine
CAS :<p>Cryptopleurine is an inhibitor of gene products associated with cell proliferation, survival, invasion and angiogenesis. It acts by targeting the NF-κB pathway.</p>Formule :C24H27NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.48BIO-8169
CAS :<p>BIO-8169, a selective interleukin receptor-associated kinase 4 (IRAK 4) inhibitor, demonstrates potent activity with an IC 50 value of 0.23 nM. Exhibiting strong pharmacokinetic properties, BIO-8169 effectively reduces pro-inflammatory cytokine production and mitigates autoimmune encephalomyelitis in the EAE mouse model. Additionally, it has notable blood-brain penetration, evidenced by a rat Kpu,u of 0.7.</p>Formule :C24H27N5O4Couleur et forme :SolidMasse moléculaire :449.50CD73-IN-12
<p>CD73-IN-12, a compound from CN114437038A, shows strong anti-tumor activity by effectively inhibiting CD73 enzyme.</p>Formule :C17H14F2N4O2Couleur et forme :SolidMasse moléculaire :344.32Nitric oxide production-IN-2
CAS :<p>TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is an inhibitor of TLR4, JNK, and NF-κB. It suppresses NO production in LPS-stimulated RAW264.7 cells with an IC50 of 23.2 µM. By inhibiting TLR4 expression and reducing JNK phosphorylation, TLR4/JNK/NF-κB-IN-1 prevents NF-κB activation. This leads to a decrease in the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and the production of inflammatory mediators such as NO, PGE2, and TNF-α, thereby exhibiting anti-inflammatory activity. TLR4/JNK/NF-κB-IN-1 holds potential in the study of inflammatory diseases, including rheumatoid arthritis and various other inflammatory conditions.</p>Formule :C23H20O3Couleur et forme :SolidMasse moléculaire :344.403GB1490
CAS :<p>GB1490 is an orally administered galectin inhibitor, demonstrating Kd values of 0.4 μM for galectin-1 and 2.7 μM for galectin-3 [1].</p>Formule :C17H15Cl2FN4O4S2Couleur et forme :SolidMasse moléculaire :493.36IRAK4-IN-30
CAS :<p>IRAK4-IN-30 (Compound I) is an inhibitor of IRAK4, with an IC50 of 0.6 nM.</p>Formule :C27H33N5O5Couleur et forme :SolidMasse moléculaire :507.581Methoxyurea
CAS :<p>Methoxyurea (Compound 3) is a potential modulator of nitric oxide (NO) donors, interacting with hemoglobin forms such as oxyhemoglobin (OxyHb) and methemoglobin (MetHb). It holds promise for use in research on sickle cell disease (SCD).</p>Formule :C2H6N2O2Couleur et forme :SolidMasse moléculaire :90.081S-MTC acetate
CAS :<p>S-MTC acetate (S-Methyl-L-thiocitrulline acetate) serves as a potent inhibitor of inducible nitric oxide synthases and is especially effective in inhibiting the constitutive (neuronal) type rather than the inducible (endothelial) type.</p>Formule :C9H19N3O4SCouleur et forme :SolidMasse moléculaire :265.33meso-Zeaxanthin
CAS :<p>meso-Zeaxanthin accumulates in the central retina and, together with lutein and zeaxanthin, forms the macular pigment, which functions as a light filter. meso-Zeaxanthin can quench reactive oxygen species (ROS), thereby exhibiting antioxidant properties.</p>Formule :C40H56O2Couleur et forme :SolidMasse moléculaire :568.871TLR7/8 agonist 7
CAS :<p>TLR7/8 agonist 7 activates immune cells, useful in ISAC synthesis and immunity research.</p>Formule :C26H37N7O2Couleur et forme :SolidMasse moléculaire :479.62mPGES1-IN-4
CAS :<p>mPGES1-IN-4 (compound 32) is a multi-substituted pyrimidine compound acting as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and significantly suppresses acute inflammation models in vivo.</p>Formule :C27H25F2N3OCouleur et forme :SolidMasse moléculaire :445.50NLRP3-IN-53
CAS :<p>NLRP3-IN-53 (compound 1) is an NLRP3 inhibitor with an IC50 of 3.4nM.</p>Formule :C22H27N5O4Couleur et forme :SolidMasse moléculaire :425.48VS-15
CAS :<p>VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.</p>Formule :C29H27N5O3Couleur et forme :SolidMasse moléculaire :493.56Numidargistat
CAS :<p>CB-1158 is a potent and orally bioavailable inhibitor of arginase (IC50s: 86 and 296 nM for recombinant human arginase 1 and 2).</p>Formule :C11H22BN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :287.12COX-2/NO-IN-1
<p>COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.</p>Formule :C15H15NO3Couleur et forme :SolidMasse moléculaire :257.28(R)-cGAS-IN-4
CAS :<p>(R)-cGAS-IN-4 (Compound 77A*) is the R-enantiomer of cGAS-IN-4, which acts as an orally active inhibitor of cyclic GMP-AMP synthase-adenosine synthase (cGAS).</p>Formule :C19H18Cl2N4O3Couleur et forme :SolidMasse moléculaire :421.28trans-3-(3-Pyridyl)acrylic acid
CAS :<p>Trans-3-(3-Pyridyl)acrylic acid (compound 15) is a trans-3-aryl acrylic acid demonstrating antiviral activity against tobacco mosaic virus (TMV) [1].</p>Formule :C8H7NO2Couleur et forme :SolidMasse moléculaire :149.15NLRP3-IN-70
CAS :<p>NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.</p>Formule :C23H23NO5Couleur et forme :SolidMasse moléculaire :393.432TMV-IN-8
CAS :<p>TMV-IN-8 (compound 7d) is an anti-tobacco mosaic virus (TMV) agent with an antiviral EC50 of 157.6 μg/mL. TMV-IN-8 blocks the assembly of TMV by binding with coat protein (Kd = 0.7 μM) and suppresses TMV coat protein gene expression and biosynthesis process [1].</p>Formule :C26H22N6O4Couleur et forme :SolidMasse moléculaire :482.49TLR7 agonist 28
CAS :<p>TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.</p>Formule :C26H25N9O7Couleur et forme :SolidMasse moléculaire :575.533(R)-Ketoprofen
CAS :<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Formule :C16H14O3Couleur et forme :SolidMasse moléculaire :254.28DBMB
CAS :<p>DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.</p>Formule :C24H22N4OCouleur et forme :SolidMasse moléculaire :382.4586,2′,4′-Trimethoxyflavone
CAS :<p>6,2′,4′-Trimethoxyflavone is an AhR antagonist that does not demonstrate effective protection against ischemia-reperfusion injury in the brain of Sprague-Dawley rats.</p>Formule :C18H18O5Couleur et forme :SolidMasse moléculaire :314.332iNOs-IN-1
<p>iNOs-IN-1 (YPW) is a strong iNOS inhibitor with dose-dependent anti-inflammatory properties, reducing IL-6, iNOS, and NO levels.</p>Formule :C25H30N4O5Couleur et forme :SolidMasse moléculaire :466.53AhR agonist 2
<p>AhR agonist 2 is aryl hydrocarbon receptor (AhR) agonist,oral, inducing rapid nuclear enrichment of the AhR and facilitating skin barrier repair,psoriasis.</p>Formule :C12H7Br2N3Couleur et forme :SolidMasse moléculaire :353.01Factor B-IN-3
CAS :<p>Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.</p>Formule :C24H29N3O4Couleur et forme :SolidMasse moléculaire :423.5ND-2158
CAS :<p>ND-2158 is a potent and selective inhibitor of IRAK4.</p>Formule :C22H30N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.56mPGES-1-IN-1
<p>MPGES-1, potential anti-inflammatory drug target, has IC50 of 0.03 μM with mPGES-1-IN-1.</p>Formule :C21H14N4O2SCouleur et forme :SolidMasse moléculaire :386.43nNOS-IN-5
CAS :<p>nNOS-IN-5 (Compound 9) is a potent inhibitor of human neuronal nitric oxide synthase (nNOS) with a Ki of 22 nM. It exhibits remarkable selectivity, being 900 times more selective for human nNOS over endothelial nitric oxide synthase (eNOS). nNOS-IN-5 is applicable in research related to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.</p>Formule :C23H22N4OCouleur et forme :SolidMasse moléculaire :370.447NOD1/2 antagonist-1
CAS :<p>NOD1/2 antagonist-1 inhibits NOD1 (IC50 1.13 μM) and NOD2 (IC50 0.77 μM), enhances paclitaxel antitumor efficacy and is used to study innate immune signaling.</p>Formule :C32H28ClF5N4O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :663.03HPK1-IN-56
CAS :<p>HPK1-IN-56 (Compound A29) is an HPK1 inhibitor with an IC50 of 2.70 nM. It inhibits downstream p-SLP76 in Jurkat T cells with an IC50 of 8.1 nM. Additionally, HPK1-IN-56 induces IL-2 production in human PBMCs. This compound exhibits anticancer properties, enhancing T cell cytotoxicity and the antitumor efficacy of anti-PD-1 antibodies.</p>Formule :C24H26N8OCouleur et forme :SolidMasse moléculaire :442.516iNOS/PGE2-IN-1
<p>iNOS/PGE2-IN-1: iNOS/PGE2 inhibitor, reduces LPS-induced NO, low ulcer risk, anti-inflammatory.</p>Formule :C26H22ClN3O4Couleur et forme :SolidMasse moléculaire :475.92Rafutrombopag
CAS :<p>Rafutrombopag is a thrombopoietin (TPO) agonist.</p>Formule :C25H22N4O5Couleur et forme :SolidMasse moléculaire :458.47GNE-2256
CAS :<p>GNE-2256, also known as molecule 19, is an orally active compound that inhibits Interleukin 1 receptor-associated kinase 4 (IRAK4) with a K i of 1.4 nM and has</p>Formule :C24H27FN6O4Couleur et forme :SolidMasse moléculaire :482.51CDA-IN-3
CAS :<p>CDA-IN-3 (NCDI) is a chitin deacetylase (CDA) inhibitor with antiparasitic properties. It disrupts chitin metabolism in nematodes, increasing ROS levels within these organisms and causing cellular damage. CDA-IN-3 significantly inhibits all developmental stages of Caenorhabditis elegans and can be utilized in research focused on anti-infective applications.</p>Formule :C16H27N3O3S2Couleur et forme :SolidMasse moléculaire :373.534ASP-8731
CAS :<p>ASP8731 is a selective inhibitor of BACH1 that prevents inflammation and vascular occlusion, and induces fetal hemoglobin in sickle cell disease.</p>Formule :C20H21N5O4Couleur et forme :SolidMasse moléculaire :395.41ARG1-IN-1
CAS :<p>ARG1-IN-1 is a human arginase 1 inhibitor with an IC 50 of 29 nM.</p>Formule :C11H21BN2O4Couleur et forme :SolidMasse moléculaire :256.11CD73-IN-2
<p>CD73-IN-2 is a potent inhibitor of CD73 (IC50: 0.09 nM).</p>Formule :C17H25ClN5O7PCouleur et forme :SolidMasse moléculaire :477.84NLRP3/AIM2-IN-1
<p>NLRP3/AIM2-IN-1 is an inhibitor of thermal sepsis (IC50 = 3.136 ± 0.7667 μM).</p>Formule :C15H16BNO4Couleur et forme :SolidMasse moléculaire :285.1Galectin-3-IN-6
CAS :<p>Galectin-3-IN-6 (Compound 12) is an orally active galectin-3 (Gal-3) inhibitor, with an IC50 of 12 nM and a Kd of 13 nM for Gal-3. In a CCl4-induced mouse model of acute liver injury and fibrosis, Galectin-3-IN-6 significantly reduces fibrosis markers collagen-1 and α-smooth muscle actin (αSMA) by 64% and 71%, respectively, demonstrating notable anti-fibrotic activity. Galectin-3-IN-6 is applicable for research in fibrosis-related diseases, cancer, and cardiovascular disorders.</p>Formule :C28H29Cl2F3N4O6Couleur et forme :SolidMasse moléculaire :645.454SDH-IN-25
CAS :<p>SDH-IN-25 is an SDH inhibitor with an IC50 of 4.82 mg/L, demonstrating broad-spectrum and potent antifungal activity. By binding to SDH amino acid residues (TRP173, TYR58, and ARG43), it mimics the action mode of the commercial fungicide flutolanil. SDH-IN-25 induces changes in hyphal morphology, disrupts respiratory metabolism by binding to complex II, generates reactive oxygen species (ROS), and affects mitochondrial membrane potential (MMP) in hyphae. This compound is utilized in agricultural disease control research.</p>Formule :C19H15BrCl2N2O4Couleur et forme :SolidMasse moléculaire :486.143NOS-IN-2
<p>NOS-IN-2: potent, selective imidamide NOS inhibitor, IC50=20μM for iNOS, spares eNOS, low toxicity, useful in inflammation research.</p>Formule :C18H20F3N3O2Couleur et forme :SolidMasse moléculaire :367.37IRAK4-IN-9
CAS :<p>IRAK4-IN-9 is a potent IRAK4 inhibitor with an IC50 of 1.5 nM, promising for inflammatory, autoimmune diseases, and cancer research.</p>Formule :C22H25N7Couleur et forme :SolidMasse moléculaire :387.48STING agonist-7
<p>STING agonist-7 is an agonist of non-nucleotide STING that binds selectively to mouse STING but not human STING [1].</p>Formule :C17H12N4O4Couleur et forme :SolidMasse moléculaire :336.3BMY-25551
CAS :<p>BMY-25551, a Mitomycin A analog, exhibits cytotoxicity 8 to 20 times greater than Mitomycin C against both murine and human tumor cell lines. It is applicable in research pertaining to cancer and hematological disorders.</p>Formule :C17H21N3O7Couleur et forme :SolidMasse moléculaire :379.36TLR4/NF-κB/MAPK-IN-1
CAS :<p>TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways.</p>Formule :C19H25BrO6Couleur et forme :SolidMasse moléculaire :429.3IRAK4-IN-18
<p>IRAK4-IN-18: Potent IRAK4 inhibitor (IC50: 15 nM), reduces IL23 in cells, prevents rat arthritis.</p>Formule :C24H25FN6O3Couleur et forme :SolidMasse moléculaire :464.49ZM514
<p>ZM514 inhibits CD73 (hCD73 IC50: 1.39 μM, mCD73 IC50: 14.65 μM) with low cytotoxicity, suitable for cancer research.</p>Formule :C36H57NO4Couleur et forme :SolidMasse moléculaire :567.84(S)-MALT1-IN-5
CAS :<p>(S)-MALT1-IN-5: Potent MALT1 protease inhibitor, may help in abnormal T/B-cell signalling and MALT1-linked diseases.</p>Formule :C17H17ClF2N6O3Couleur et forme :SolidMasse moléculaire :426.80Carazostatin
CAS :<p>Carazostatin is an antioxidant, free radical scavenger, and potent lipid peroxidation inhibitor.</p>Formule :C20H25NODegré de pureté :98%Couleur et forme :Pale Yellow SolidMasse moléculaire :295.42Galectin-3-IN-2
<p>Galectin-3-IN-2 inhibits galactose lectin-3 (Gal-3) with an 8.3 μM IC50, impacting cancer-related metabolism.</p>Formule :C24H30FN3O10SCouleur et forme :SolidMasse moléculaire :571.57HEI3090
CAS :<p>HEI3090 is an activator of the P2X7R receptor. This compound enhances the production of IL-18 by stimulating dendritic cells that express P2X7R, which in turn promotes the production of IFN-γ by natural killer cells and CD4T cells within tumors, triggering a sustained anti-tumor response. Additionally, HEI3090 can be used to improve the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC).</p>Formule :C18H15Cl3N4O3Couleur et forme :SolidMasse moléculaire :441.70Glutathione monoethyl ester
CAS :<p>Glutathione monoethyl ester, a derivative of glutathione, can protect motor neuron cells (NSC-34) from TDP-43 pathology caused by mutations, which includes reducing aggregate formation, nuclear clearance, reactive oxygen species (ROS) production, and cell death.</p>Formule :C12H21N3O6SCouleur et forme :SolidMasse moléculaire :335.377NDT-30805
<p>NDT-30805, a triazolopyridine, blocks IL-1β in PBMC (IC50: 0.013μM) & NLRP3 inflammasome, for inflammation research.</p>Formule :C23H22N6SCouleur et forme :SolidMasse moléculaire :414.53Pelecopan
CAS :<p>Pelecopan (BCX9930), an oral complement factor D inhibitor, prevents hemolysis in PNH (IC50=14.3 nM).</p>Formule :C23H19FN2O4Couleur et forme :SolidMasse moléculaire :406.41Keap1-Nrf2-IN-5
CAS :<p>Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).</p>Formule :C23H30N4O6SCouleur et forme :SolidMasse moléculaire :490.57NLRP3-IN-69
CAS :<p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>Formule :C25H24O7Couleur et forme :SolidMasse moléculaire :436.454COX-2-IN-51
CAS :<p>COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.</p>Formule :C23H18F4O3SCouleur et forme :SolidMasse moléculaire :450.446BMS-986458
CAS :<p>BMS-986458 is a highly selective, orally active BCL6 PROTAC degrader. It specifically targets cereblon (CRBN) and the BCL6 N-terminal BTB domain to catalyze proximity-induced BCL6 degradation. BMS-986458 is applicable for research in B-cell non-Hodgkin lymphoma.</p>Formule :C32H34ClN9O3Couleur et forme :SolidMasse moléculaire :628.124STING-IN-11
CAS :<p>STING-IN-11 (Compound 42) is an orally active STING inhibitor with an IC50 of 37.8 nM. It impedes palmitoylation of the STING protein and the downstream signaling of STING, thereby inhibiting STING-mediated inflammation. STING-IN-11 demonstrates good in vivo safety and can be utilized for research on STING-related inflammatory and autoimmune diseases.</p>Formule :C21H20ClF2N3OCouleur et forme :SolidMasse moléculaire :403.853OP-5244
CAS :<p>OP-5244 has comparable potency to bisphosphonic acid series and targets CD73.</p>Formule :C19H29ClN5O9PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.89COX-2-IN-7
<p>COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.</p>Formule :C15H13N3O2S2Couleur et forme :SolidMasse moléculaire :331.41NLRP3-IN-78
CAS :<p>NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.</p>Formule :C12H5Cl2N3O4S2Couleur et forme :SolidMasse moléculaire :390.222HG-12-6
CAS :<p>HG-12-6 is a type II IRAK4 inhibitor, targeting its inactive form with an IC50 of 165 nM, and is used in autoimmunity and inflammation.</p>Formule :C29H27F3N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.62STAT1/3-IN-1
CAS :<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Formule :C28H25ClN6O5Couleur et forme :SolidMasse moléculaire :560.98820-Hydroxyvitamin D3
CAS :<p>20-Hydroxyvitamin D3 (20(OH)D3) is a hydroxy metabolite of vitamin D3. It functions as a ligand for the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor (LXR), and retinoic acid receptor-related orphan receptor (ROR). 20-Hydroxyvitamin D3 inhibits cell proliferation and induces differentiation. It is applicable in research on inflammatory and autoimmune diseases.</p>Formule :C27H44O2Couleur et forme :SolidMasse moléculaire :400.637AHR antagonist 5 hemimaleate
<p>Potent oral AHR antagonist with IC50 < 0.5 μM, hinders tumor growth with anti-PD-1.</p>Formule :C29H28FN7O4Couleur et forme :SolidMasse moléculaire :499.55CD73-IN-7
CAS :<p>CD73-IN-7: potent inhibitor of CD73, blocks adenosine production to treat tumors.</p>Formule :C13H11ClN4O2Couleur et forme :SolidMasse moléculaire :290.7Heme Oxygenase-2-IN-1
<p>Heme Oxygenase-2-IN-1 is a selective HO-2 inhibitor with IC50s: 14.9 μM (HO-1), 0.9 μM (HO-2).</p>Formule :C19H17N3O2Couleur et forme :SolidMasse moléculaire :319.36Hetrombopag olamine
CAS :<p>Hetrombopag olamine is a non-peptide thrombopoietin (TPO) receptor agonist with oral activity.</p>Formule :C29H36N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.63RuDiOBn
CAS :<p>RuDiOBn exhibits low antioxidant activity by scavenging DPPH and ABTS free radicals with scavenging rates of 13.2% and 5.9% at a concentration of 100 μg/mL. It inhibits collagen glycation and reduces the formation of advanced glycation end-products (AGE) with an IC50 of 2.45 μg/mL. RuDiOBn also enhances fibroblast proliferation and migration, stimulates collagen synthesis, and aids in skin repair and regeneration while inhibiting collagenase.</p>Formule :C29H22O7Couleur et forme :SolidMasse moléculaire :482.481MAO-B-IN-7
<p>MAO-B-IN-7 inhibits MAO-B/AChE, crossing the blood-brain barrier; IC50: 41/87 nM (h/eel AChE), 0.3 μM (MAO-B). Reduces oxidative stress and neuroinflammation.</p>Formule :C25H31NO4Couleur et forme :SolidMasse moléculaire :409.52ODN 21158
CAS :<p>ODN 21158 is a potent, non-cytotoxic inhibitor of G-modified TLR3 and TLR9. ODN 21158 dose-dependently inhibits IFN-α secretion.</p>Couleur et forme :SolidIRAK4-IN-14
CAS :<p>IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.</p>Formule :C25H28FN9OCouleur et forme :SolidMasse moléculaire :489.55NP3-146 sodium
CAS :<p>NP3-146 sodium is an inhibitor of the NLRP3 inflammasome.</p>Formule :C20H26ClN2NaO5SCouleur et forme :SolidMasse moléculaire :464.94NLRP3-IN-58
CAS :<p>NLRP3-IN-58 (Compound DS15) acts as an inhibitor of NLRP3 inflammasome activation, with an IC50 value of 3.85 μM, and is capable of inhibiting 33% of IL-1β release at a concentration of 10 μM.</p>Formule :C22H18ClN3O3SCouleur et forme :SolidMasse moléculaire :439.92IRAK4-IN-19
<p>IRAK4-IN-19, an IRAK4 inhibitor (IC50: 4.3 nM), hampers IL23 synthesis and arthritis progression.</p>Formule :C25H26F2N8OCouleur et forme :SolidMasse moléculaire :492.52C5aR-IN-3
CAS :<p>C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.</p>Formule :C36H40FN5O3Couleur et forme :SolidMasse moléculaire :609.73Ocadusertib
CAS :<p>Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).</p>Formule :C25H25N5O4Couleur et forme :SolidMasse moléculaire :459.50NLRP3-IN-56
CAS :<p>NLRP3-IN-56 (compound 062) is an inhibitor of NLRP3. It effectively suppresses the secretion of IL-1β in THP-1 cells, demonstrating an IC50 of 9.7 nM. NLRP3-IN-56 is useful for research into NLRP3-mediated symptoms and/or diseases.</p>Formule :C20H18ClN3O3Couleur et forme :SolidMasse moléculaire :383.83CD73-IN-13
<p>CD73-IN-13, a potent CD73 inhibitor, may be developed for tumor-related disease treatment.</p>Formule :C13H11F3N4O2Couleur et forme :SolidMasse moléculaire :312.25RGT-068A
CAS :<p>RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .</p>Formule :C17H16ClN9O2Couleur et forme :SolidMasse moléculaire :413.82OP-5244 sodium
<p>OP-5244 sodium: potent oral CD73 inhibitor (IC50: 0.25 nM), potential in cancer research by hindering adenosine, reversing immunosuppression.</p>Formule :C19H28ClN5NaO9PCouleur et forme :SolidMasse moléculaire :559.87oxLig-1
CAS :<p>OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).</p>Formule :C36H58O5Couleur et forme :SolidMasse moléculaire :570.84TLR7/8 antagonist 1
<p>Compound 16c, an imidazoquinoline, is a TLR7/8 agonist; IC50: 3.91 μM (TLR7), 2.19 μM (TLR8); targets TLR-2050 for disease treatment.</p>Formule :C24H27N5O2Couleur et forme :SolidMasse moléculaire :417.5Anti-inflammatory agent 6
<p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>Formule :C22H20O12Couleur et forme :SolidMasse moléculaire :476.39STING agonist-20
CAS :<p>STING agonist-20: potent, aids in XMT-2056 synthesis, used as a cancer vaccine adjuvant.</p>Formule :C36H39N11O8Couleur et forme :SolidMasse moléculaire :753.76MALT1-IN-11
CAS :<p>MALT1-IN-11: MALT1 inhibitor, IC50 <10-100 nM, reduces IL10, for cancer/autoimmune research.</p>Formule :C20H16F4N8OCouleur et forme :SolidMasse moléculaire :460.39TMC353121
CAS :<p>TMC353121 is an effective inhibitor of respiratory syncytial virus fusion (pEC50: 9.9).</p>Formule :C32H42N6O3Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :558.71YM-I-26
CAS :<p>YM-I-26 is a selective inhibitor of the NLRP3 inflammasome. This compound enhances the phagocytic activity of β-amyloid in murine microglial BV2 cells and reduces the production of IL-1β and IL-10. YM-I-26 is useful for research into inflammation-related immunomodulatory activities.</p>Formule :C28H33ClN2O5S2Couleur et forme :SolidMasse moléculaire :577.16COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Formule :C25H23N5O4S2Couleur et forme :SolidMasse moléculaire :521.61Nrf2 activator-6
CAS :<p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>Formule :C31H37ClFN5O5Couleur et forme :SolidMasse moléculaire :614.11AIM4
CAS :<p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>Formule :C25H23Br2N5O4Couleur et forme :SolidMasse moléculaire :617.289NOD1-IN-1
CAS :<p>NOD1/2-IN-1 (Compound 2) is a potent inhibitor of RIPK2 with an IC50 value of 0.65 nM as determined by the ADP-Glo assay. It selectively inhibits the NOD1 pathway, with an IC50 of 33 nM, effectively blocking the production of pro-inflammatory cytokines and thereby reducing inflammatory responses. This compound has potential applications in the research of colitis.</p>Formule :C16H14ClN3O3Couleur et forme :SolidMasse moléculaire :331.75G108
CAS :<p>G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.</p>Formule :C16H14Cl2N4O2Degré de pureté :99.13% - 99.75%Couleur et forme :SolidMasse moléculaire :365.21NOTA-FAPI
CAS :<p>NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.</p>Formule :C36H47F2N9O8Degré de pureté :99.748%Couleur et forme :SolidMasse moléculaire :771.81SLC7A11-IN-2
CAS :<p>SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.</p>Formule :C19H24N4O3Couleur et forme :SolidMasse moléculaire :356.42α-Gracinoic acid
CAS :<p>α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.</p>Formule :C29H42O4Couleur et forme :SolidMasse moléculaire :454.64SP4206
CAS :<p>SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)</p>Formule :C30H37Cl2N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :662.56CD73-IN-18
CAS :<p>CD73-IN-18 (compound 35j) is an orally effective inhibitor of the extracellular 5'-nucleotidase (CD73) enzyme. It can be utilized in anticancer research.</p>Formule :C20H17N5O3Couleur et forme :SolidMasse moléculaire :375.38SARM1-IN-4
CAS :<p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>Formule :C13H17F2N3O2Couleur et forme :SolidMasse moléculaire :285.29COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Formule :C19H14ClN5S2Couleur et forme :SolidMasse moléculaire :411.93LHC-165
CAS :<p>LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.</p>Formule :C29H32F2N3O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.55SMW139
CAS :<p>SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.</p>Formule :C19H21ClF3NO2Couleur et forme :SolidMasse moléculaire :387.824Antioxidant agent-3
<p>Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.</p>Formule :C18H14O8Couleur et forme :SolidMasse moléculaire :358.3Anti-inflammatory agent 102
CAS :<p>Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).</p>Formule :C16H16ClN3O3Couleur et forme :SolidMasse moléculaire :333.77NLRP3-IN-7
<p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>Formule :C18H15ClN2O4S3Couleur et forme :SolidMasse moléculaire :454.97cGAS-IN-4
CAS :<p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>Formule :C19H18Cl2N4O3Couleur et forme :SolidMasse moléculaire :421.277Cyclic-di-GMP sodium
<p>c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.</p>Formule :C20H24N10NaO14P2Couleur et forme :SolidMasse moléculaire :713.08464MALT1-IN-5
CAS :<p>MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.</p>Formule :C17H17ClF2N6O3Couleur et forme :SolidMasse moléculaire :426.80A-9758
CAS :<p>A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.</p>Formule :C25H23Cl2F3N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.36ABZI
CAS :<p>(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.</p>Formule :C23H24N6O3Masse moléculaire :432.48IRAK4-IN-12
<p>IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).</p>Formule :C24H31FN8OCouleur et forme :SolidMasse moléculaire :466.55IRAK4-IN-15
CAS :<p>IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.</p>Formule :C25H29FN10Couleur et forme :SolidMasse moléculaire :488.56Nrf2-ARE/hMAO-B/QR2 modulator 1
CAS :<p>Nrf2-ARE/hMAO-B/QR2 modulator 1 a resveratrol derivative activated the NRF2-ARE inhibit hMAO-B and QR2, promote hippocampal neurogenesis Alzheimer's disease .</p>Formule :C14H12N2O3Degré de pureté :98.5%Couleur et forme :SolidMasse moléculaire :256.26COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Formule :C31H32FN5O2SCouleur et forme :SolidMasse moléculaire :557.68COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Formule :C15H10ClIN2OCouleur et forme :SolidMasse moléculaire :396.61FAPI-74
CAS :<p>FAPI-74 is a PET (positron emission tomography) tracer involved in early FAPI-PET imaging.FAPI-74 can be used to study cancer tumors and degenerative diseases.</p>Formule :C36H49N9O8Couleur et forme :SolidMasse moléculaire :735.83Creatine ethyl ester
CAS :<p>Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.</p>Formule :C6H13N3O2Couleur et forme :SolidMasse moléculaire :159.186EGR-1-IN-3
CAS :<p>EGR-1-IN-3 (Compound 36) is an inhibitor of early growth response 1 (EGR-1) binding to DNA. It effectively suppresses the binding of EGR-1 to DNA and the expression of inflammation-related genes (such as TSLP, IL-31, IL-6, and CCL2) induced by TNFα. This compound is applicable to the study of inflammatory diseases.</p>Formule :C31H31N3O6SCouleur et forme :SolidMasse moléculaire :573.659Gardiquimod hydrochloride
CAS :<p>Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.</p>Formule :C17H24ClN5OCouleur et forme :SolidMasse moléculaire :349.858MSA-2 dimer
CAS :<p>MSA-2 dimer: selective oral non-nucleotide STING agonist, Kd=145 μM, long-term antitumor effect, non-covalent, higher permeability.</p>Formule :C29H28O8S2Couleur et forme :SolidMasse moléculaire :568.66Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Formule :C18H15N5O2SCouleur et forme :SolidMasse moléculaire :365.41WK692
CAS :<p>Compound WK692 (compund WK692) is a BCL6 inhibitor that effectively suppresses the growth of diffuse large B-cell lymphoma cells without toxic side effects and acts synergistically with inhibitors of EZH2 and PRMT5.</p>Formule :C26H28Br2N8O5Couleur et forme :SolidMasse moléculaire :692.36AMC-04
CAS :<p>AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].</p>Formule :C26H28N2O3Couleur et forme :SolidMasse moléculaire :416.51CPDT
CAS :<p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>Formule :C6H6S3Couleur et forme :SolidMasse moléculaire :174.307IACS-8779 disodium
CAS :<p>IACS-8779 disodium: potent STING agonist, strong systemic anti-tumor effects, effective in melanoma model.</p>Formule :C21H23N9Na2O10P2S2Couleur et forme :SolidMasse moléculaire :733.52mPGES1-IN-5
CAS :<p>mPGES1-IN-5 (compound 18) is a multi-substituted pyrimidine compound that acts as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and demonstrates significant inhibitory activity in vivo against acute inflammation models.</p>Formule :C27H27N3OCouleur et forme :SolidMasse moléculaire :409.52NLRP3-IN-6
<p>NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.</p>Formule :C18H15ClN2O4S3Couleur et forme :SolidMasse moléculaire :454.97RIPK1-IN-19
CAS :<p>RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.</p>Formule :C28H25FN6O2Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :496.54NLRP3-IN-8
CAS :<p>NLRP3-IN-8, orally active inflammasome blocker, IC50 of 1.23μM, stable (t1/2 = 138.63min), non-toxic (IC50 >100μM).</p>Formule :C23H20N2O6Couleur et forme :SolidMasse moléculaire :420.41IRAK1/4/pan-FLT3 Kinase-IN-2
CAS :<p>IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and < 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.</p>Formule :C20H22F3N5OCouleur et forme :SolidMasse moléculaire :405.42IRAK4-IN-31
CAS :<p>IRAK4-IN-31 is a crystalline inhibitor of IRAK4. It is applicable in research related to myelodysplastic syndromes (MDS).</p>Formule :C27H33N5O5Couleur et forme :SolidMasse moléculaire :507.58DEG-35
CAS :<p>DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).</p>Formule :C25H21N3O5Couleur et forme :SolidMasse moléculaire :443.45AM679
CAS :<p>AM679: potent, selective FLAP inhibitor; IC50s—2.2 nM (FLAP), 0.6 nM (hLA), 154 nM (hWB); blocks leukotrienes in vivo; no significant CYP3A4 interaction.</p>Formule :C40H44N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :692.87IKZF2-degrader 1
CAS :<p>IKZF2-degrader 1 (Compound 31) is a molecular glue-type degrader of IKZF2 with a DC50 of 0.5 nM. It exhibits relatively low degradation activity against CK1α, with a DC50 of 210 nM. This compound is applicable in research focused on IKZF2-dependent cancers.</p>Formule :C27H30FN7O3Couleur et forme :SolidMasse moléculaire :519.57CD73-IN-19
CAS :<p>CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.</p>Formule :C18H17N3O3SCouleur et forme :SolidMasse moléculaire :355.411AhR agonist 8
CAS :<p>Compound 9, also known as AhR agonist 8, effectively activates the Aryl Hydrocarbon Receptor (AhR) with an EC50 of 0.154 nM. This compound is utilized in researching psoriasis and atopic dermatitis.</p>Formule :C17H15FN4OCouleur et forme :SolidMasse moléculaire :310.33TNFα activity modulator 3
CAS :<p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>Formule :C27H24F2N6O2Couleur et forme :SolidMasse moléculaire :502.52NLRP3-IN-44
CAS :<p>NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.</p>Formule :C25H30N4O3Couleur et forme :SolidMasse moléculaire :434.53GTCpFE
CAS :<p>GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.</p>Formule :C22H20O8Couleur et forme :SolidMasse moléculaire :412.39TBK1/IKKε-IN-1
CAS :<p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).</p>Formule :C28H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.53COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Formule :C22H23FN2O6S2Couleur et forme :SolidMasse moléculaire :494.56Panaxcerol B
CAS :<p>Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.</p>Formule :C27H46O9Couleur et forme :SolidMasse moléculaire :514.65IL-17 modulator 1 disodium
CAS :<p>Potent, orally active IL-17 Modulator 1 (disodium) from patent WO 2020127685, used in psoriasis and arthritis research.</p>Formule :C28H37N6NaO6PCouleur et forme :SolidMasse moléculaire :607.604SBI-0640726
CAS :<p>SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.</p>Formule :C23H15ClN2O2Couleur et forme :SolidMasse moléculaire :386.83IRAK4 modulator-1
CAS :<p>IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].</p>Formule :C19H13ClN4O2Couleur et forme :SolidMasse moléculaire :364.79TIM-3-IN-1
<p>TIM-3-IN-1 is a useful tool to enable further studies on the biology of TIM-3 immunoregulation in cancer.</p>Formule :C20H16ClN7O3SCouleur et forme :SolidMasse moléculaire :469.9IKZF1-degrader-2
CAS :<p>IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].</p>Formule :C33H30FN5O5Couleur et forme :SolidMasse moléculaire :595.62SB24011
CAS :<p>SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].</p>Formule :C34H38N4O7Couleur et forme :SolidMasse moléculaire :614.696-Alkyne-F-araNAD
CAS :<p>6-Alkyne-F-araNAD is an irreversible CD38 inhibitor that aids in better visualization of intracellular CD38 localization when used alongside other fluorescent probes (such as SR101−F-araNMN).</p>Formule :C24H28FN7O13P2Couleur et forme :SolidMasse moléculaire :703.464NF-κB-IN-6
<p>NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signaling</p>Formule :C14H20N2O3Couleur et forme :SolidMasse moléculaire :264.32IRAK4 ligand-13
CAS :<p>IRAK4ligand-13 is an IRAK4 ligand and serves as a PROTAC target protein ligand. It is utilized in the synthesis of PROTAC compounds, such as LZ-07.</p>Formule :C23H26N10Couleur et forme :SolidMasse moléculaire :442.52BAA473
<p>BAA473, a bile acid analog, activates the pyrin inflammasome, triggering IL-18 secretion in myeloid and intestinal cells.</p>Formule :C36H62O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.87Fexlamose
CAS :<p>Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).</p>Formule :C12H22O9S2Couleur et forme :SolidMasse moléculaire :374.428Hypoxystat
CAS :<p>Hypoxystat increases the affinity of hemoglobin for oxygen, thereby reducing the release of oxygen to tissues and inducing tissue hypoxia. [Hypoxystat] can alleviate mitochondrial disorder Leigh syndrome in Ndufs4 gene knockout mouse models. Hypoxystat is orally active.</p>Formule :C21H21NO5Couleur et forme :SolidMasse moléculaire :367.395IACS-8779
CAS :<p>IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.</p>Formule :C21H25N9O10P2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :689.55STING agonist-42
CAS :<p>STINGagonist-42 (compound 8a) is a potent STING agonist. It activates STING in THP1 and RAW 264.7 cells, with EC50 values of 0.06 μM and 14.15 μM, respectively.</p>Formule :C17H8F2LiN5O3Couleur et forme :SolidMasse moléculaire :375.22NLRP3-IN-4
<p>NLRP3-IN-4 is an effective, oral NLRP3 inflammasome inhibitor with potent anti-inflammatory effects on colitis.</p>Formule :C22H22N2O5Couleur et forme :SolidMasse moléculaire :394.42Balsalazide disodium
CAS :<p>Balsalazide disodium is an aminosalicylate prodrug that releases mesalamine in the colon, providing diverse anti-inflammatory effects in regions affected by colitis. Additionally, it exhibits anticancer properties by modulating the IL-6/STAT3 pathway.</p>Formule :C17H13N3Na2O6Couleur et forme :SolidMasse moléculaire :401.281TE-11
CAS :<p>TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.</p>Formule :C16H13NOCouleur et forme :SolidMasse moléculaire :235.28ALR-27
CAS :<p>ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].</p>Formule :C19H22O3Couleur et forme :SolidMasse moléculaire :298.38Itaconic acid prodrug-1
CAS :<p>Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid that efficiently delivers Itaconic acid to skin tissues upon oral administration. It exhibits immunomodulatory effects, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 is useful for research into alopecia areata and other inflammatory skin conditions.</p>Formule :C15H22O10Couleur et forme :SolidMasse moléculaire :362.329K-14585
CAS :<p>K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.</p>Formule :C51H56Cl2N8O4Couleur et forme :SolidMasse moléculaire :915.95AS2690168 (free base)
CAS :<p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Formule :C17H13F3N4OCouleur et forme :SolidMasse moléculaire :346.306FK-565
CAS :<p>FK-565 is a ligand of nucleotide-binding oligomerization domain-1 (NOD1) that induces a mouse model of arteritis.</p>Formule :C22H38N4O9Couleur et forme :SolidMasse moléculaire :502.559mPGES1-IN-9
CAS :<p>mPGES1-IN-9 (compound 1_8) is an mPGES1 inhibitor with an IC50 of 0.5 μM and is utilized in anti-inflammatory research.</p>Formule :C25H18N4OSCouleur et forme :SolidMasse moléculaire :422.502Ambuic acid
CAS :<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Formule :C19H26O6Couleur et forme :SolidMasse moléculaire :350.41DPP4-In hydrochloride
CAS :<p>DPP4-In (hydrochloride) is an inhibitor of dipeptidyl peptidase 4 (DPP4) that effectively reduces the expression of DPP4.</p>Formule :C14H21ClN4O2Couleur et forme :SolidMasse moléculaire :312.8STING agonist-21
CAS :<p>STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].</p>Formule :C17H11F6N5O2Couleur et forme :SolidMasse moléculaire :431.29NIK-IN-2
CAS :<p>NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.</p>Formule :C20H22N4O3Couleur et forme :SolidMasse moléculaire :366.41NLRP3-IN-57
<p>NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.</p>Formule :C44H60O7Couleur et forme :SolidMasse moléculaire :700.94Indeno[1,2,3-cd]pyrene
CAS :<p>Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon, exhibits moderate cytotoxicity to human alveolar epithelial cells (HPAEpiC). Additionally, it enhances allergic pulmonary inflammation responses through the activation of the aryl hydrocarbon receptor.</p>Formule :C22H12Couleur et forme :SolidMasse moléculaire :276.33STING-IN-15
CAS :<p>STING-IN-15 (compound 66) is a potent STING inhibitor, effectively suppressing human and mouse STING with IC50 values of 116 nM and 96.3 nM, respectively. In the REX1 D18N mouse model, STING-IN-15 significantly reduces tissue damage and inflammation.</p>Formule :C20H14F2N4O3Couleur et forme :SolidMasse moléculaire :396.354-Octylphenol
CAS :<p>4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.</p>Formule :C14H22OCouleur et forme :SolidMasse moléculaire :206.32ROS inducer 9
CAS :<p>ROS inducer 9 (compound 4e) is an antibacterial agent with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against Escherichia coli. It eradicates bacteria by inhibiting GSH activity and increasing ROS levels. Additionally, ROS inducer 9 exhibits low toxicity toward red blood cells and RAW 264.7 cells.</p>Formule :C26H26BrF4N3O3Couleur et forme :SolidMasse moléculaire :584.401Darizmetinib
CAS :<p>Darizmetinib (HRX215) is an MKK4 inhibitor.</p>Formule :C21H17F2N5O3SDegré de pureté :98.03% - 99.57%Couleur et forme :SolidMasse moléculaire :457.45UBS109
CAS :<p>UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.</p>Formule :C18H17N3ODegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :291.35KI696
CAS :<p>KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.</p>Formule :C28H30N4O6SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :550.63AM103
CAS :<p>AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).</p>Formule :C36H38N3NaO4SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :631.76Zharp1-211
CAS :<p>Zharp1-211 is a RIPK3 inhibitor，reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.</p>Formule :C24H25N5O4Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :447.49Dazostinag disodium
CAS :<p>Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist.Cost-effective and quality-assured.</p>Formule :C21H20F2N8Na2O10P2S2Degré de pureté :98.84% - 99.96%Couleur et forme :SolidMasse moléculaire :754.48Antiproliferative agent-22
CAS :<p>Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.</p>Formule :C17H13N3O3Degré de pureté :99.20% - 99.27%Couleur et forme :SolidMasse moléculaire :307.3Evixapodlin
CAS :<p>Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.</p>Formule :C34H36Cl2N8O4Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :691.61HOIPIN-8 sodium
CAS :<p>HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.</p>Formule :C23H15F2N4NaO3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :456.38
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