Immunologie et Inflammation
Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"
- RCC(140 produits)
- CXCR(153 produits)
- Paroi cellulaire(5 produits)
- Récepteur IL(109 produits)
- IκB/IKK(59 produits)
- LTR(3 produits)
- MALT(25 produits)
- MRP(6 produits)
- NADPH-oxydase(1 produits)
- NF-κB(446 produits)
- NOD(17 produits)
- NOS(62 produits)
- Nrf2(82 produits)
- PGE Synthase(31 produits)
- ROS(70 produits)
- TGF-beta/Smad(59 produits)
- TLR(76 produits)
- Thioredoxine(12 produits)
- gp120/CD4(4 produits)
Affichez 11 plus de sous-catégories
3304 produits trouvés pour "Immunologie et Inflammation"
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meso-Zeaxanthin
CAS :meso-Zeaxanthin accumulates in the central retina and, together with lutein and zeaxanthin, forms the macular pigment, which functions as a light filter. meso-Zeaxanthin can quench reactive oxygen species (ROS), thereby exhibiting antioxidant properties.Formule :C40H56O2Couleur et forme :SolidMasse moléculaire :568.871STING agonist-42
CAS :STINGagonist-42 (compound 8a) is a potent STING agonist. It activates STING in THP1 and RAW 264.7 cells, with EC50 values of 0.06 μM and 14.15 μM, respectively.Formule :C17H8F2LiN5O3Couleur et forme :SolidMasse moléculaire :375.22Antioxidant agent-3
Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.Formule :C18H14O8Couleur et forme :SolidMasse moléculaire :358.3TNFα activity modulator 3
CAS :<p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>Formule :C27H24F2N6O2Couleur et forme :SolidMasse moléculaire :502.52STING agonist-43
CAS :STINGagonist-43 (Compound 67) is a selective STING agonist with an EC50 of 20.53 μM. It selectively enhances the cGAMP-dependent STING pathway activation by modulating STING oligomerization. STINGagonist-43 demonstrates antitumor activity in a B16.F10 mouse melanoma model and can be utilized in cancer immunotherapy research.Formule :C21H23NO4Couleur et forme :SolidMasse moléculaire :353.41XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Formule :C24H20N4O2SCouleur et forme :SolidMasse moléculaire :428.51YE6144
CAS :<p>YE6144, IRF5 phosphorylation blocker. Affordable Excellence: Reliable Quality You Can Trust</p>Formule :C21H27ClFN7OCouleur et forme :SolidMasse moléculaire :447.94MG-T-19
CAS :MG-T-19, a TIM-3 inhibitor, inhibit the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs.Formule :C18H8Br2ClF3N4O2SDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :596.6COX-2/PI3K-IN-1
COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).Formule :C19H14ClN5S2Couleur et forme :SolidMasse moléculaire :411.93CD73-IN-19
CAS :<p>CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.</p>Formule :C18H17N3O3SCouleur et forme :SolidMasse moléculaire :355.411SARM1-IN-4
CAS :SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.Formule :C13H17F2N3O2Couleur et forme :SolidMasse moléculaire :285.29Cbl-b-IN-1
CAS :Cbl-b-IN-1 is a potent Cbl-b inhibitor (IC50 <100 nM) with potential anticancer activity for the study of intestinal inflammation.Formule :C29H34N6O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :498.631AS2690168 (free base)
CAS :<p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Formule :C17H13F3N4OCouleur et forme :SolidMasse moléculaire :346.306FK-565
CAS :<p>FK-565 is a ligand of nucleotide-binding oligomerization domain-1 (NOD1) that induces a mouse model of arteritis.</p>Formule :C22H38N4O9Couleur et forme :SolidMasse moléculaire :502.559mPGES1-IN-9
CAS :<p>mPGES1-IN-9 (compound 1_8) is an mPGES1 inhibitor with an IC50 of 0.5 μM and is utilized in anti-inflammatory research.</p>Formule :C25H18N4OSCouleur et forme :SolidMasse moléculaire :422.502Anti-inflammatory agent 10
Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.Formule :C17H13BrN4O3S2Couleur et forme :SolidMasse moléculaire :465.34iNOs-IN-1
iNOs-IN-1 (YPW) is a strong iNOS inhibitor with dose-dependent anti-inflammatory properties, reducing IL-6, iNOS, and NO levels.Formule :C25H30N4O5Couleur et forme :SolidMasse moléculaire :466.53Indeno[1,2,3-cd]pyrene
CAS :Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon, exhibits moderate cytotoxicity to human alveolar epithelial cells (HPAEpiC). Additionally, it enhances allergic pulmonary inflammation responses through the activation of the aryl hydrocarbon receptor.Formule :C22H12Couleur et forme :SolidMasse moléculaire :276.33SARM1-IN-5
CAS :SARM1-IN-5 (compound 1-23-a) is an inhibitor of SARM1, useful for researching diseases related to axonal degeneration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).Formule :C18H17FN6OCouleur et forme :SolidMasse moléculaire :352.37Antibacterial agent 259
CAS :Antibacterialagent 259 (K3) is a bactericide with EC50 values of 1.5, 1.7, and 4.9 mg/L against Xoo, Xoc, and Xac, respectively. It induces the production of reactive oxygen species (ROS) in pathogens, leading to their death. Antibacterialagent 259 is applicable in research for controlling bacterial diseases in plants.Formule :C7H6ClN3O2SCouleur et forme :SolidMasse moléculaire :231.659IRAK4-IN-15
CAS :IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.Formule :C25H29FN10Couleur et forme :SolidMasse moléculaire :488.56CD73-IN-18
CAS :<p>CD73-IN-18 (compound 35j) is an orally effective inhibitor of the extracellular 5'-nucleotidase (CD73) enzyme. It can be utilized in anticancer research.</p>Formule :C20H17N5O3Couleur et forme :SolidMasse moléculaire :375.38SMW139
CAS :SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.Formule :C19H21ClF3NO2Couleur et forme :SolidMasse moléculaire :387.824STING agonist-20
CAS :STING agonist-20: potent, aids in XMT-2056 synthesis, used as a cancer vaccine adjuvant.Formule :C36H39N11O8Couleur et forme :SolidMasse moléculaire :753.76NLRP3-IN-44
CAS :<p>NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.</p>Formule :C25H30N4O3Couleur et forme :SolidMasse moléculaire :434.536,2′,4′-Trimethoxyflavone
CAS :6,2′,4′-Trimethoxyflavone is an AhR antagonist that does not demonstrate effective protection against ischemia-reperfusion injury in the brain of Sprague-Dawley rats.Formule :C18H18O5Couleur et forme :SolidMasse moléculaire :314.332NLRP3-IN-6
<p>NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.</p>Formule :C18H15ClN2O4S3Couleur et forme :SolidMasse moléculaire :454.97Anti-inflammatory agent 19
Anti-inflammatory agent 19: NO inhibitor (IC50: 36μM), blocks HMGB1, for late-stage inflammation, relevant for COVID-19, sepsis.Formule :C30H50O7Couleur et forme :SolidMasse moléculaire :522.71NLRP3-IN-70
CAS :<p>NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.</p>Formule :C23H23NO5Couleur et forme :SolidMasse moléculaire :393.432AIM4
CAS :<p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>Formule :C25H23Br2N5O4Couleur et forme :SolidMasse moléculaire :617.289Nrf2 activator-6
CAS :Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).Formule :C31H37ClFN5O5Couleur et forme :SolidMasse moléculaire :614.11ABZI
CAS :<p>(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.</p>Formule :C23H24N6O3Masse moléculaire :432.48Yoda2
CAS :Yoda2 (KC289), the potassium salt of Yoda1, is an agonist of PIEZO1 with an EC50 of 150 nM. It induces Ca2+ elevation in HeLa cells and can cause concentration-dependent and NO-dependent relaxation in mouse portal vein (EC50= 1.2 μM). Additionally, Yoda2 is capable of stimulating NOS3 and promoting NO production.Formule :C16H9Cl2KN2O2S2Couleur et forme :SolidMasse moléculaire :435.39CYP1B1-IN-10
CAS :CYP1B1-IN-10 (Compound 15C) is a highly selective inhibitor of human cytochrome P450 1B1 (hCYP1B1) with an IC50 value of 0.11 μM. It shows promise for use in research focused on hormone-dependent tumors, including breast and ovarian cancers.Formule :C23H18N2Couleur et forme :SolidMasse moléculaire :322.40RIPK2-IN-6
CAS :RIPK2-IN-6 (Compound 15a) is an inhibitor of RIPK that specifically targets the phosphorylation of RIPK2, thereby suppressing the NF-κB and MAPK signaling pathways. It has demonstrated anti-inflammatory and anti-fibrotic activities in a mouse model of colitis induced by Dextran sodium sulfate.Formule :C26H21NO3Couleur et forme :SolidMasse moléculaire :395.45TLR7/8 antagonist 1
Compound 16c, an imidazoquinoline, is a TLR7/8 agonist; IC50: 3.91 μM (TLR7), 2.19 μM (TLR8); targets TLR-2050 for disease treatment.Formule :C24H27N5O2Couleur et forme :SolidMasse moléculaire :417.5TrxR-IN-5
TrxR-IN-5 (compound 4f) is an effective inhibitor of thioredoxin reductase (TrxR) with an IC₅₀ of 0.16 μM. anti-proliferative and anti-metastatic.Formule :C26H22O3Couleur et forme :SolidMasse moléculaire :382.46COX-2/15-LOX-IN-5
CAS :<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>Formule :C25H21N3O3SCouleur et forme :SolidMasse moléculaire :443.52Ambuic acid
CAS :Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.Formule :C19H26O6Couleur et forme :SolidMasse moléculaire :350.41PB01
CAS :<p>PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.</p>Formule :C18H21N5O3Couleur et forme :SolidMasse moléculaire :355.3914-Octylphenol
CAS :4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.Formule :C14H22OCouleur et forme :SolidMasse moléculaire :206.32a15:0-i15:0 PE
CAS :a15:0-i15:0 PE is a dia-cyl phosphatidylethanolamine with two branched chains. It functions as an atypical TLR2-TLR1 heterodimer agonist and is immunogenic. This compound activates T cell and dendritic cell (DC) signaling, exhibiting anti-inflammatory properties. Additionally, a15:0-i15:0 PE induces the production of TNFα and IL-6. It is a major component of the A. muciniphila lipid membrane, constituting approximately 50%.Formule :C35H70NO8PCouleur et forme :SolidMasse moléculaire :663.91AhR agonist 6
CAS :Compound 6, an AhR agonist, selectively activates the aryl hydrocarbon receptor (AhR) with an EC50 of 0.01 nM [1].Formule :C17H16F2O2Couleur et forme :SolidMasse moléculaire :290.30A-9758
CAS :A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.Formule :C25H23Cl2F3N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.36Panaxcerol B
CAS :<p>Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.</p>Formule :C27H46O9Couleur et forme :SolidMasse moléculaire :514.65PSMA ligand 1
CAS :PSMAligand 1 (Compound 1c) is a PSMA ligand with an IC50 of 26.74 nM. When labeled with [18F], PSMAligand 1 serves as a PSMAPET tracer for research related to the diagnosis of prostate cancer.Formule :C20H26FN3O9Couleur et forme :SolidMasse moléculaire :471.43Antifungal agent 134
CAS :Antifungalagent 134 (Compound B13) is an antifungal agent effective against Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata with EC50 values of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL, respectively. It disrupts the fungal cell membranes and mitochondria, leading to substantial accumulation of reactive oxygen species (ROS). Additionally, Antifungalagent 134 exhibits significant herbicidal activity on field weeds such as Amaranthus retroflexus L and Abutilon theophrasti Medicus, and is applicable in crop disease and field weed research.Formule :C18H12F4N2O4Couleur et forme :SolidMasse moléculaire :396.29AS2690168 hydrochloride
CAS :<p>AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Formule :C17H15Cl2F3N4OCouleur et forme :SolidMasse moléculaire :419.228SBI-0640726
CAS :<p>SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.</p>Formule :C23H15ClN2O2Couleur et forme :SolidMasse moléculaire :386.83PVTX-405
CAS :PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a maximum degradation (Dmax) of 91%. It enhances degradation efficiency, significantly reduces off-target degradation, and minimizes hERG inhibition with an IC50 of 48 µM. PVTX-405 effectively inhibits MC38 tumor growth in Crbn391VC57BL/6 mouse xenograft models and shows superior synergistic anticancer effects when combined with immune checkpoint therapies (ICTs) such as anti-PD1 or anti-LAG3 antibodies.Formule :C30H31N5O4Couleur et forme :SolidMasse moléculaire :525.60COX-2-IN-9
COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.Formule :C25H23N5O4S2Couleur et forme :SolidMasse moléculaire :521.61Anti-inflammatory agent 18
Anti-inflammatory agent 18: NO activity blocker (IC50: 15.94 μM), hampers HMGB1-induced inflammation, potential for COVID-19, sepsis study.Formule :C30H50O6Couleur et forme :SolidMasse moléculaire :506.71PSB-0963
CAS :PSB-0963 is a selective competitive extracellular 5'-nucleotidase (eN/CD73) inhibitor with a Ki value of 150 nM for rat extracellular 5'-nucleotidase. It exhibits greater selectivity compared to other extracellular nucleotidases (NTPDases 1-3) and P2Y receptors. PSB-0963 is applicable in cancer research.Formule :C28H17N2NaO5SCouleur et forme :SolidMasse moléculaire :516.50TLR7 agonist 28
CAS :TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.Formule :C26H25N9O7Couleur et forme :SolidMasse moléculaire :575.533DEG-35
CAS :DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).Formule :C25H21N3O5Couleur et forme :SolidMasse moléculaire :443.45AMC-04
CAS :AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].Formule :C26H28N2O3Couleur et forme :SolidMasse moléculaire :416.51C5aR-IN-3
CAS :C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.Formule :C36H40FN5O3Couleur et forme :SolidMasse moléculaire :609.73Z-Val-Val-Nle-diazomethylketone
CAS :Z-Val-Val-Nle-diazomethylketone is an inhibitor of cathepsin S (CATS). It significantly suppresses the upregulation of IFNg-induced MHCII molecules, specifically HLA-DR and Ii-p33/35, while increasing the protein level of Ii-p10. This compound can be utilized for research into skin disorders such as psoriasis, atopic dermatitis, and actinic keratosis.Formule :C25H37N5O5Couleur et forme :SolidMasse moléculaire :487.59RuDiOBn
CAS :<p>RuDiOBn exhibits low antioxidant activity by scavenging DPPH and ABTS free radicals with scavenging rates of 13.2% and 5.9% at a concentration of 100 μg/mL. It inhibits collagen glycation and reduces the formation of advanced glycation end-products (AGE) with an IC50 of 2.45 μg/mL. RuDiOBn also enhances fibroblast proliferation and migration, stimulates collagen synthesis, and aids in skin repair and regeneration while inhibiting collagenase.</p>Formule :C29H22O7Couleur et forme :SolidMasse moléculaire :482.481COX-2-IN-10
COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.Formule :C31H32FN5O2SCouleur et forme :SolidMasse moléculaire :557.68Hetrombopag olamine
CAS :<p>Hetrombopag olamine is a non-peptide thrombopoietin (TPO) receptor agonist with oral activity.</p>Formule :C29H36N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.63Ocipumaltib
CAS :Ocipumaltib (Example 2) is an inhibitor of mucosa-associated lymphoid tissue protein 1 (MALT1). It functions as an antineoplastic agent and is utilized in the study of cancer, infections, neurological disorders, and hematological diseases.Formule :C20H16ClF3N8O2Couleur et forme :SolidMasse moléculaire :492.846-Alkyne-F-araNAD
CAS :6-Alkyne-F-araNAD is an irreversible CD38 inhibitor that aids in better visualization of intracellular CD38 localization when used alongside other fluorescent probes (such as SR101−F-araNMN).Formule :C24H28FN7O13P2Couleur et forme :SolidMasse moléculaire :703.464Evixapodlin
CAS :Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.Formule :C34H36Cl2N8O4Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :691.61Antiproliferative agent-22
CAS :<p>Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.</p>Formule :C17H13N3O3Degré de pureté :99.20% - 99.27%Couleur et forme :SolidMasse moléculaire :307.3HOIPIN-8 sodium
CAS :<p>HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.</p>Formule :C23H15F2N4NaO3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :456.38Dazostinag disodium
CAS :<p>Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist.Cost-effective and quality-assured.</p>Formule :C21H20F2N8Na2O10P2S2Degré de pureté :98.84% - 99.96%Couleur et forme :SolidMasse moléculaire :754.48VVD-130037
CAS :VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Formule :C17H17ClN4O2Degré de pureté :99.01% - 99.92%Couleur et forme :SolidMasse moléculaire :344.8AM103
CAS :AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).Formule :C36H38N3NaO4SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :631.76KI696
CAS :KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Formule :C28H30N4O6SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :550.63UBS109
CAS :<p>UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.</p>Formule :C18H17N3ODegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :291.352-Selenouracil
CAS :2-Selenouracil is a specialized photosensitizer for photodynamical therapy.Formule :C4H4N2OSeCouleur et forme :SolidMasse moléculaire :175.05Veledimex
CAS :Veledimex is an oral activator ligand for a proprietary gene therapy promoter system. It is also a moderate inhibitor of and substrate for CYP3A4/5.Formule :C27H38N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.6PSB-12379
CAS :PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).Formule :C18H23N5O9P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.35NSC23925
CAS :NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).Formule :C22H26Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.3611β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione
CAS :Formule :C21H28O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.44409a-Fluoro-11b,17a,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione
CAS :Formule :C22H29FO5Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :392.461111β,17α,21-Trihydroxypregn-4-ene-3,20-dione
CAS :Formule :C21H30O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.4599(11β,16α)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
CAS :Formule :C24H31FO6Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :434.4977α-Terpineol
CAS :<p>Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.</p>Formule :C10H18ODegré de pureté :97.55%Couleur et forme :Colorless LiquidMasse moléculaire :154.25DEXAMETHASONE
CAS :Formule :C22H29FO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.4611JH-X-119-01 hydrochloride
CAS :JH-X-119-01 hydrochloride is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 1 (IRAK1) that effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.Formule :C25H21ClN6O3Couleur et forme :SolidMasse moléculaire :488.93Magnesium citrate
CAS :Magnesium citrate is a useful organic compound for research related to life sciences. The catalog number is T64455 and the CAS number is 3344-18-1.Formule :C12H10Mg3O14Couleur et forme :SolidMasse moléculaire :451.113Tacalcitol
CAS :Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium and modulates immunological and inflammatory processes.Formule :C27H44O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.64TLR7/8/9 antagonist 2
CAS :<p>TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.</p>Formule :C23H31N7Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :405.54Tripeptide-41
CAS :Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.Formule :C29H30N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.57Pam2CSK4 TFA
Pam2CSK4 TFA (PUL-042 TFA) is a potent dual agonist of TLR2 and TLR6, a peptide that mimics bacterial lipoproteins.Pam2CSK4 TFA promotes platelet aggregation, and can be used to study the effects of lipoproteins on the periodontium.Formule :C67H127F3N10O14SDegré de pureté :99.90%Couleur et forme :SoildMasse moléculaire :1385.84TLQP-21 TFA
<p>TLQP-21 TFA （TLQP-21 Trifluoroacetate） 是一种 VGF 衍生肽，可通过结合后折叠机制激活C3aR1 受体。</p>Degré de pureté :98%RIDR-PI-103
CAS :<p>RIDR-PI-103 is a reactive oxygen species (ROS)-induced drug release prodrug featuring an autocyclized portion connected to the pan-PI3K inhibitor (PI-103). In MDA-MB-361 and MDA-MB-231 cells, Doxorubicin and RIDR-PI-103 exhibited synergistic inhibition of cancer cell proliferation.</p>Formule :C27H25N7O4Couleur et forme :SolidMasse moléculaire :511.53STING agonist-22
CAS :<p>STING agonist-22 (CF501) boosts vaccines by activating STING, inducing IFN-I and cytokines, aiding in SARS-CoV-2 research.</p>Formule :C40H48N14O6Couleur et forme :SolidMasse moléculaire :820.9Aurothioglucose
CAS :Aurothioglucose is a active-site TrxR1 inhibitor.Formule :C6H11AuO5SDegré de pureté :98%Couleur et forme :Yellow Crystals SolidMasse moléculaire :392.18gp91ds-tat
<p>gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.</p>Degré de pureté :98%Couleur et forme :SolidDi-O-methyldemethoxycurcumin
CAS :Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant properties Inhibition of IL-6 production, EC50 is 16.20μg/mL.Formule :C22H22O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.41Racemic Naproxen
CAS :Racemic Naproxen is a biochemical substance.Formule :C14H14O3Degré de pureté :98%Couleur et forme :Crystals From Acetone-Hexane White SolidMasse moléculaire :230.26Icatolimab
<p>Icatolimab (JS-004) is a humanized antibody targeting BTLA/CD272 for the study of lymphomas and solid tumors.</p>Degré de pureté :98.7% (SDS-PAGE); 95.6% (SEC-HPLC) - 98.7% (SDS-PAGE); 95.6% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.5 kDaElamipretide acetate
<p>Elamipretide acetate (MTP 131), a small tetrapeptide, targets mitochondria to reduce toxic species and stabilize cardiolipin.</p>Formule :C34H53N9O7Degré de pureté :99.76%Couleur et forme :SoildMasse moléculaire :699.84TLQP-21 TFA
<p>TLQP-21 TFA is a VGF-derived peptide, C3aR1 agonist (mouse EC50: 10.3μM; human EC50: 68.8μM), that raises intracellular Ca2+ for nociception research.</p>Degré de pureté :98%Couleur et forme :LiquidXibornol
CAS :Xibornol (Nanbacine) 具有广谱的抗菌和抗病毒活性，可用于研究革兰氏阳性菌感染和人呼吸道合胞病毒与人冠状病毒229E感染。Formule :C18H26OCouleur et forme :SolidMasse moléculaire :258.42,3-Bis(3-indolylmethyl)indole
CAS :2,3-Bis(3-indolylmethyl)indole exhibits a concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.Formule :C26H21N3Couleur et forme :SolidMasse moléculaire :375.475ARGX-112
CAS :<p>Temtokibart is a humanized IgG1 λ2 antibody that specifically targets IL22RA1, and is expressed by cells that are deficient in the glutamine synthetase gene.</p>Couleur et forme :Odour LiquidALPK1-IN-1
CAS :<p>ALPK1-IN-1 (A001) strongly inhibits ALPK1, key for innate immunity & NF-κB signaling via TIFA/TRAF.</p>Formule :C25H32N6O2SCouleur et forme :SolidMasse moléculaire :480.63ALPK1-IN-2
CAS :<p>ALPK1-IN-2 is a potent inhibitor of ALPK1 (α-kinase 1) (IC50: 95 nM). ALPK1-IN-2 inhibits NF-κB (IC50: 1.31 μM).</p>Formule :C20H18F2N4O2SCouleur et forme :SolidMasse moléculaire :416.44L-NIO dihydrochloride
CAS :L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) forms, respectively.Formule :C7H16ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :209.67ALPK1-IN-3
CAS :<p>ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-induced</p>Formule :C20H16F2N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.43
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