Immunologie et Inflammation
Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"
- RCC(142 produits)
- CXCR(159 produits)
- Paroi cellulaire(5 produits)
- Récepteur IL(110 produits)
- IκB/IKK(58 produits)
- LTR(3 produits)
- MALT(25 produits)
- MRP(6 produits)
- NADPH-oxydase(1 produits)
- NF-κB(425 produits)
- NOD(21 produits)
- NOS(61 produits)
- Nrf2(82 produits)
- PGE Synthase(31 produits)
- ROS(70 produits)
- TGF-beta/Smad(63 produits)
- TLR(73 produits)
- Thioredoxine(12 produits)
- gp120/CD4(4 produits)
Affichez 11 plus de sous-catégories
3389 produits trouvés pour "Immunologie et Inflammation"
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IKZF1-degrader-2
CAS :IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].Formule :C33H30FN5O5Couleur et forme :SolidMasse moléculaire :595.62SB24011
CAS :SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].Formule :C34H38N4O7Couleur et forme :SolidMasse moléculaire :614.69ZM514
ZM514 inhibits CD73 (hCD73 IC50: 1.39 μM, mCD73 IC50: 14.65 μM) with low cytotoxicity, suitable for cancer research.Formule :C36H57NO4Couleur et forme :SolidMasse moléculaire :567.84TE-11
CAS :TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.Formule :C16H13NOCouleur et forme :SolidMasse moléculaire :235.28Indeno[1,2,3-cd]pyrene
CAS :Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon, exhibits moderate cytotoxicity to human alveolar epithelial cells (HPAEpiC). Additionally, it enhances allergic pulmonary inflammation responses through the activation of the aryl hydrocarbon receptor.Formule :C22H12Couleur et forme :SolidMasse moléculaire :276.33ALR-27
CAS :ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].Formule :C19H22O3Couleur et forme :SolidMasse moléculaire :298.38Cyclic-di-GMP sodium
c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.Formule :C20H24N10NaO14P2Couleur et forme :SolidMasse moléculaire :713.0846420-Hydroxyvitamin D3
CAS :20-Hydroxyvitamin D3 (20(OH)D3) is a hydroxy metabolite of vitamin D3. It functions as a ligand for the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor (LXR), and retinoic acid receptor-related orphan receptor (ROR). 20-Hydroxyvitamin D3 inhibits cell proliferation and induces differentiation. It is applicable in research on inflammatory and autoimmune diseases.Formule :C27H44O2Couleur et forme :SolidMasse moléculaire :400.637COX-1/2-IN-2
COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.Formule :C15H10ClIN2OCouleur et forme :SolidMasse moléculaire :396.61cGAS-IN-4
CAS :cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.Formule :C19H18Cl2N4O3Couleur et forme :SolidMasse moléculaire :421.277STAT1/3-IN-1
CAS :STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.
Formule :C28H25ClN6O5Couleur et forme :SolidMasse moléculaire :560.988NLRP3-IN-7
NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.Formule :C18H15ClN2O4S3Couleur et forme :SolidMasse moléculaire :454.97CPDT
CAS :CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Formule :C6H6S3Couleur et forme :SolidMasse moléculaire :174.307IACS-8779 disodium
CAS :IACS-8779 disodium: potent STING agonist, strong systemic anti-tumor effects, effective in melanoma model.Formule :C21H23N9Na2O10P2S2Couleur et forme :SolidMasse moléculaire :733.52COX-2-IN-29
COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).Formule :C22H23FN2O6S2Couleur et forme :SolidMasse moléculaire :494.56Antioxidant agent-3
Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.Formule :C18H14O8Couleur et forme :SolidMasse moléculaire :358.3IL-17 modulator 1 disodium
CAS :Potent, orally active IL-17 Modulator 1 (disodium) from patent WO 2020127685, used in psoriasis and arthritis research.Formule :C28H37N6NaO6PCouleur et forme :SolidMasse moléculaire :607.604TIM-3-IN-1
TIM-3-IN-1 is a useful tool to enable further studies on the biology of TIM-3 immunoregulation in cancer.Formule :C20H16ClN7O3SCouleur et forme :SolidMasse moléculaire :469.9NLRP3-IN-78
CAS :NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.Formule :C12H5Cl2N3O4S2Couleur et forme :SolidMasse moléculaire :390.222COX-2/PI3K-IN-1
COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).Formule :C19H14ClN5S2Couleur et forme :SolidMasse moléculaire :411.93SARM1-IN-4
CAS :SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.Formule :C13H17F2N3O2Couleur et forme :SolidMasse moléculaire :285.29NOD1-IN-1
CAS :NOD1/2-IN-1 (Compound 2) is a potent inhibitor of RIPK2 with an IC50 value of 0.65 nM as determined by the ADP-Glo assay. It selectively inhibits the NOD1 pathway, with an IC50 of 33 nM, effectively blocking the production of pro-inflammatory cytokines and thereby reducing inflammatory responses. This compound has potential applications in the research of colitis.Formule :C16H14ClN3O3Couleur et forme :SolidMasse moléculaire :331.75OP-5244
CAS :OP-5244 has comparable potency to bisphosphonic acid series and targets CD73.Formule :C19H29ClN5O9PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :537.896-Alkyne-F-araNAD
CAS :6-Alkyne-F-araNAD is an irreversible CD38 inhibitor that aids in better visualization of intracellular CD38 localization when used alongside other fluorescent probes (such as SR101−F-araNMN).Formule :C24H28FN7O13P2Couleur et forme :SolidMasse moléculaire :703.464α-Gracinoic acid
CAS :α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.Formule :C29H42O4Couleur et forme :SolidMasse moléculaire :454.64IRAK4-IN-18
IRAK4-IN-18: Potent IRAK4 inhibitor (IC50: 15 nM), reduces IL23 in cells, prevents rat arthritis.Formule :C24H25FN6O3Couleur et forme :SolidMasse moléculaire :464.49COX-2-IN-51
CAS :COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.Formule :C23H18F4O3SCouleur et forme :SolidMasse moléculaire :450.446AIM4
CAS :AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).Formule :C25H23Br2N5O4Couleur et forme :SolidMasse moléculaire :617.289Nrf2 activator-6
CAS :Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).Formule :C31H37ClFN5O5Couleur et forme :SolidMasse moléculaire :614.11NLRP3-IN-69
CAS :NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.Formule :C25H24O7Couleur et forme :SolidMasse moléculaire :436.454NF-κB-IN-6
NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signalingFormule :C14H20N2O3Couleur et forme :SolidMasse moléculaire :264.32IRAK4 ligand-13
CAS :IRAK4ligand-13 is an IRAK4 ligand and serves as a PROTAC target protein ligand. It is utilized in the synthesis of PROTAC compounds, such as LZ-07.Formule :C23H26N10Couleur et forme :SolidMasse moléculaire :442.52AHR antagonist 5 hemimaleate
Potent oral AHR antagonist with IC50 < 0.5 μM, hinders tumor growth with anti-PD-1.Formule :C29H28FN7O4Couleur et forme :SolidMasse moléculaire :499.55BAA473
BAA473, a bile acid analog, activates the pyrin inflammasome, triggering IL-18 secretion in myeloid and intestinal cells.Formule :C36H62O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.87Fexlamose
CAS :Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).Formule :C12H22O9S2Couleur et forme :SolidMasse moléculaire :374.428COX-2-IN-9
COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.Formule :C25H23N5O4S2Couleur et forme :SolidMasse moléculaire :521.61STING agonist-21
CAS :STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].Formule :C17H11F6N5O2Couleur et forme :SolidMasse moléculaire :431.29Anti-inflammatory agent 6
Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.Formule :C22H20O12Couleur et forme :SolidMasse moléculaire :476.39PSMA ligand 1
CAS :PSMAligand 1 (Compound 1c) is a PSMA ligand with an IC50 of 26.74 nM. When labeled with [18F], PSMAligand 1 serves as a PSMAPET tracer for research related to the diagnosis of prostate cancer.Formule :C20H26FN3O9Couleur et forme :SolidMasse moléculaire :471.43IL-17 modulator 5
CAS :IL-17 modulator 5 is a IL-17 inhibitor, with an IC 50 of 1 nM .Formule :C28H23F6N9O2Couleur et forme :SolidMasse moléculaire :631.53BIO-8169
CAS :BIO-8169, a selective interleukin receptor-associated kinase 4 (IRAK 4) inhibitor, demonstrates potent activity with an IC 50 value of 0.23 nM. Exhibiting strong pharmacokinetic properties, BIO-8169 effectively reduces pro-inflammatory cytokine production and mitigates autoimmune encephalomyelitis in the EAE mouse model. Additionally, it has notable blood-brain penetration, evidenced by a rat Kpu,u of 0.7.Formule :C24H27N5O4Couleur et forme :SolidMasse moléculaire :449.50(S,R,S)-AHPC-Boc derivative 1
CAS :(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).Formule :C28H40N4O6SCouleur et forme :SolidMasse moléculaire :560.705PVTX-405
CAS :PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a maximum degradation (Dmax) of 91%. It enhances degradation efficiency, significantly reduces off-target degradation, and minimizes hERG inhibition with an IC50 of 48 µM. PVTX-405 effectively inhibits MC38 tumor growth in Crbn391VC57BL/6 mouse xenograft models and shows superior synergistic anticancer effects when combined with immune checkpoint therapies (ICTs) such as anti-PD1 or anti-LAG3 antibodies.Formule :C30H31N5O4Couleur et forme :SolidMasse moléculaire :525.60PSB-0963
CAS :PSB-0963 is a selective competitive extracellular 5'-nucleotidase (eN/CD73) inhibitor with a Ki value of 150 nM for rat extracellular 5'-nucleotidase. It exhibits greater selectivity compared to other extracellular nucleotidases (NTPDases 1-3) and P2Y receptors. PSB-0963 is applicable in cancer research.Formule :C28H17N2NaO5SCouleur et forme :SolidMasse moléculaire :516.50NLRP3-IN-6
NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.Formule :C18H15ClN2O4S3Couleur et forme :SolidMasse moléculaire :454.97Ocipumaltib
CAS :Ocipumaltib (Example 2) is an inhibitor of mucosa-associated lymphoid tissue protein 1 (MALT1). It functions as an antineoplastic agent and is utilized in the study of cancer, infections, neurological disorders, and hematological diseases.Formule :C20H16ClF3N8O2Couleur et forme :SolidMasse moléculaire :492.84Anti-inflammatory agent 23
Anti-inflammatory agent 23 blocks LPS-induced NO (IC50: 0.449 μM) and binds p65 well.Formule :C34H49NO6Couleur et forme :SolidMasse moléculaire :567.76α-Hydroxy alprazolam
CAS :α-Hydroxy alprazolam (U 40125), the primary metabolite of α-Hydroxy alprazolam, possesses pharmacological activity accounting for 60% of that of Alprazolam.Formule :C17H13ClN4OCouleur et forme :SolidMasse moléculaire :324.76HTS05585
CAS :HTS05585 (Compound Hit-1) is a selective inhibitor of macrophage migration inhibitory factor (MIF) with a Kd value of 0.29 μM determined by microscale thermophoresis (MST) and confirmed through isothermal titration calorimetry (ITC) at 0.32 μM. It suppresses the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) in macrophages induced by LPS, making it a promising candidate for the study of inflammatory diseases such as sepsis.Formule :C18H15N3OCouleur et forme :SolidMasse moléculaire :289.33Panaxcerol B
CAS :Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.Formule :C27H46O9Couleur et forme :SolidMasse moléculaire :514.65BCL6 ligand-4
CAS :BCL6ligand-4 is a BCL6 ligand used in the synthesis of PROTACs, such as BCL6PROTAC 1.Formule :C21H25ClN6O3Couleur et forme :SolidMasse moléculaire :444.92GTCpFE
CAS :GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formule :C22H20O8Couleur et forme :SolidMasse moléculaire :412.39NLRP3-IN-44
CAS :NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.Formule :C25H30N4O3Couleur et forme :SolidMasse moléculaire :434.53TNFα activity modulator 3
CAS :TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.Formule :C27H24F2N6O2Couleur et forme :SolidMasse moléculaire :502.52Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Formule :C20H17BrO3Couleur et forme :SolidMasse moléculaire :385.25Anti-inflammatory agent 13
Pentacyclic triterpene, Anti-inflammatory 13 inhibits DAMP/PAMP inflammation models.Formule :C30H48O4Couleur et forme :SolidMasse moléculaire :472.7MIF2-IN-1
MIF2-IN-1, potent inhibitor of MIF2 (IC50: 1μM), halts non-small cell lung cancer growth via MAPK pathway.Formule :C26H19F3N2O2SCouleur et forme :SolidMasse moléculaire :480.5Nitric oxide production-IN-2
CAS :TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is an inhibitor of TLR4, JNK, and NF-κB. It suppresses NO production in LPS-stimulated RAW264.7 cells with an IC50 of 23.2 µM. By inhibiting TLR4 expression and reducing JNK phosphorylation, TLR4/JNK/NF-κB-IN-1 prevents NF-κB activation. This leads to a decrease in the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and the production of inflammatory mediators such as NO, PGE2, and TNF-α, thereby exhibiting anti-inflammatory activity. TLR4/JNK/NF-κB-IN-1 holds potential in the study of inflammatory diseases, including rheumatoid arthritis and various other inflammatory conditions.Formule :C23H20O3Couleur et forme :SolidMasse moléculaire :344.403GB1490
CAS :GB1490 is an orally administered galectin inhibitor, demonstrating Kd values of 0.4 μM for galectin-1 and 2.7 μM for galectin-3 [1].Formule :C17H15Cl2FN4O4S2Couleur et forme :SolidMasse moléculaire :493.36AhR agonist 8
CAS :Compound 9, also known as AhR agonist 8, effectively activates the Aryl Hydrocarbon Receptor (AhR) with an EC50 of 0.154 nM. This compound is utilized in researching psoriasis and atopic dermatitis.Formule :C17H15FN4OCouleur et forme :SolidMasse moléculaire :310.33TLR7/8 agonist 7
CAS :TLR7/8 agonist 7 activates immune cells, useful in ISAC synthesis and immunity research.Formule :C26H37N7O2Couleur et forme :SolidMasse moléculaire :479.62a15:0-i15:0 PE
CAS :a15:0-i15:0 PE is a dia-cyl phosphatidylethanolamine with two branched chains. It functions as an atypical TLR2-TLR1 heterodimer agonist and is immunogenic. This compound activates T cell and dendritic cell (DC) signaling, exhibiting anti-inflammatory properties. Additionally, a15:0-i15:0 PE induces the production of TNFα and IL-6. It is a major component of the A. muciniphila lipid membrane, constituting approximately 50%.Formule :C35H70NO8PCouleur et forme :SolidMasse moléculaire :663.91(R)-cGAS-IN-4
CAS :(R)-cGAS-IN-4 (Compound 77A*) is the R-enantiomer of cGAS-IN-4, which acts as an orally active inhibitor of cyclic GMP-AMP synthase-adenosine synthase (cGAS).Formule :C19H18Cl2N4O3Couleur et forme :SolidMasse moléculaire :421.28GNE-2256
CAS :GNE-2256, also known as molecule 19, is an orally active compound that inhibits Interleukin 1 receptor-associated kinase 4 (IRAK4) with a K i of 1.4 nM and hasFormule :C24H27FN6O4Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :482.51AM679
CAS :AM679 is a potent, selective FLAP inhibitor with strong leukotriene suppression in vivo, minimal CYP3A4 interaction, and excellent pharmacokinetics in rodent models.Formule :C40H44N4O5SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :692.87AS2690168 hydrochloride
CAS :AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Formule :C17H15Cl2F3N4OCouleur et forme :SolidMasse moléculaire :419.228Z-Val-Val-Nle-diazomethylketone
CAS :Z-Val-Val-Nle-diazomethylketone is an inhibitor of cathepsin S (CATS). It significantly suppresses the upregulation of IFNg-induced MHCII molecules, specifically HLA-DR and Ii-p33/35, while increasing the protein level of Ii-p10. This compound can be utilized for research into skin disorders such as psoriasis, atopic dermatitis, and actinic keratosis.Formule :C25H37N5O5Couleur et forme :SolidMasse moléculaire :487.59Cyazofamid
CAS :Cyazofamid functions as a fungicide by impairing the production of ATP. It inhibits Organic Cation Transporter 3 (OCT3) and OAT1 with IC50 values of 1.54 and 17.3 μM, respectively.Formule :C13H13ClN4O2SCouleur et forme :SolidMasse moléculaire :324.79IL-6-IN-2
CAS :IL-6-IN-2 (Compound 15) is an inhibitor of the interaction between IL-6 and IL-6R proteins. The compound's binding free energy (∆G) is −36.50 kcal/mol. In its binding with IL-6, the contributions from Lys66, Phe74, Gln175, Ser176, and Arg179 are -1.10, -8.68, -6.91, -3.69, and -1.72 kcal/mol, respectively. IL-6-IN-2 exhibits low gastrointestinal (GI) absorption rates.Formule :C26H24N4O3Couleur et forme :SolidMasse moléculaire :440.49TrxR-IN-5
TrxR-IN-5 (compound 4f) is an effective inhibitor of thioredoxin reductase (TrxR) with an IC₅₀ of 0.16 μM. anti-proliferative and anti-metastatic.Formule :C26H22O3Couleur et forme :SolidMasse moléculaire :382.46YE6144
CAS :YE6144, IRF5 phosphorylation blocker. Affordable Excellence: Reliable Quality You Can TrustFormule :C21H27ClFN7OCouleur et forme :SolidMasse moléculaire :447.94Antifungal agent 134
CAS :Antifungalagent 134 (Compound B13) is an antifungal agent effective against Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata with EC50 values of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL, respectively. It disrupts the fungal cell membranes and mitochondria, leading to substantial accumulation of reactive oxygen species (ROS). Additionally, Antifungalagent 134 exhibits significant herbicidal activity on field weeds such as Amaranthus retroflexus L and Abutilon theophrasti Medicus, and is applicable in crop disease and field weed research.Formule :C18H12F4N2O4Couleur et forme :SolidMasse moléculaire :396.29CYP1B1-IN-10
CAS :CYP1B1-IN-10 (Compound 15C) is a highly selective inhibitor of human cytochrome P450 1B1 (hCYP1B1) with an IC50 value of 0.11 μM. It shows promise for use in research focused on hormone-dependent tumors, including breast and ovarian cancers.Formule :C23H18N2Couleur et forme :SolidMasse moléculaire :322.40MAO-B-IN-7
MAO-B-IN-7 inhibits MAO-B/AChE, crossing the blood-brain barrier; IC50: 41/87 nM (h/eel AChE), 0.3 μM (MAO-B). Reduces oxidative stress and neuroinflammation.Formule :C25H31NO4Couleur et forme :SolidMasse moléculaire :409.52ODN 21158
CAS :ODN 21158 is a potent, non-cytotoxic inhibitor of G-modified TLR3 and TLR9. ODN 21158 dose-dependently inhibits IFN-α secretion.Couleur et forme :SolidSTING agonist-43
CAS :STINGagonist-43 (Compound 67) is a selective STING agonist with an EC50 of 20.53 μM. It selectively enhances the cGAMP-dependent STING pathway activation by modulating STING oligomerization. STINGagonist-43 demonstrates antitumor activity in a B16.F10 mouse melanoma model and can be utilized in cancer immunotherapy research.Formule :C21H23NO4Couleur et forme :SolidMasse moléculaire :353.41hDDAH-1-IN-2 sulfate
hDDAH-1-IN-2: selective oral hDDAH-1 inhibitor with low cell toxicity.Formule :C8H24N4O10S2Couleur et forme :SolidMasse moléculaire :400.43Refinicopan
CAS :Refinicopan is a complement factor D inhibitor with an IC50 of 10 nM, demonstrating an inhibition activity on rabbit erythrocyte hemolysis with an IC50 of 41 nM. It possesses excellent pharmacokinetic and pharmacodynamic properties.Formule :C29H32N2O3Couleur et forme :SolidMasse moléculaire :456.58Antibacterial agent 259
CAS :Antibacterialagent 259 (K3) is a bactericide with EC50 values of 1.5, 1.7, and 4.9 mg/L against Xoo, Xoc, and Xac, respectively. It induces the production of reactive oxygen species (ROS) in pathogens, leading to their death. Antibacterialagent 259 is applicable in research for controlling bacterial diseases in plants.Formule :C7H6ClN3O2SCouleur et forme :SolidMasse moléculaire :231.659IRAK4-IN-14
CAS :IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.Formule :C25H28FN9OCouleur et forme :SolidMasse moléculaire :489.55CD73-IN-13
CD73-IN-13, a potent CD73 inhibitor, may be developed for tumor-related disease treatment.Formule :C13H11F3N4O2Couleur et forme :SolidMasse moléculaire :312.25SARM1-IN-5
CAS :SARM1-IN-5 (compound 1-23-a) is an inhibitor of SARM1, useful for researching diseases related to axonal degeneration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).Formule :C18H17FN6OCouleur et forme :SolidMasse moléculaire :352.37Anti-inflammatory agent 102
CAS :Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).Formule :C16H16ClN3O3Couleur et forme :SolidMasse moléculaire :333.77MALT1-IN-5
CAS :MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.Formule :C17H17ClF2N6O3Couleur et forme :SolidMasse moléculaire :426.80Itaconic acid prodrug-1
CAS :Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid that efficiently delivers Itaconic acid to skin tissues upon oral administration. It exhibits immunomodulatory effects, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 is useful for research into alopecia areata and other inflammatory skin conditions.Formule :C15H22O10Couleur et forme :SolidMasse moléculaire :362.329KBD4466
CAS :KBD4466 is a potent oral inhibitor of TLR7 and TLR8, with IC50 values of 0.9 nM and 2.8 nM, respectively. This compound effectively suppresses the inflammatory cytokines IL-6 and IFN-α. KBD4466 has shown to improve disease progression and increase survival rates in the BXSB/MpJ mouse model of systemic lupus erythematosus (SLE). It is suitable for research into autoimmune diseases.Formule :C24H23F3N6OCouleur et forme :SolidMasse moléculaire :468.47(Rel)-Factor B-IN-5
CAS :(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.Formule :C27H32N2O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :448.55Anti-inflammatory agent 18
Anti-inflammatory agent 18: NO activity blocker (IC50: 15.94 μM), hampers HMGB1-induced inflammation, potential for COVID-19, sepsis study.Formule :C30H50O6Couleur et forme :SolidMasse moléculaire :506.71NLRP3-IN-70
CAS :NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.
Formule :C23H23NO5Couleur et forme :SolidMasse moléculaire :393.432Galectin-8-IN-1
Galectin-8-IN-1 selectively binds galectin-8N with 48 μM affinity, 15x more than galectin-3.Formule :C16H18N2O6Couleur et forme :SolidMasse moléculaire :334.32Cbl-b-IN-1
CAS :Cbl-b-IN-1 is a potent Cbl-b inhibitor (IC50 <100 nM) with potential anticancer activity for the study of intestinal inflammation.Formule :C29H34N6O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :498.631trans-3-(3-Pyridyl)acrylic acid
CAS :Trans-3-(3-Pyridyl)acrylic acid (compound 15) is a trans-3-aryl acrylic acid demonstrating antiviral activity against tobacco mosaic virus (TMV) [1].Formule :C8H7NO2Couleur et forme :SolidMasse moléculaire :149.15IRAK4-IN-30
CAS :IRAK4-IN-30 (Compound I) is an inhibitor of IRAK4, with an IC50 of 0.6 nM.
Formule :C27H33N5O5Couleur et forme :SolidMasse moléculaire :507.581COX-2-IN-12
COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.Formule :C17H19NO3Couleur et forme :SolidMasse moléculaire :285.34(S)-MALT1-IN-5
CAS :(S)-MALT1-IN-5: Potent MALT1 protease inhibitor, may help in abnormal T/B-cell signalling and MALT1-linked diseases.Formule :C17H17ClF2N6O3Couleur et forme :SolidMasse moléculaire :426.80UM-3006
CAS :UM-3006 is a potent TLR7/8 agonist that enhances immune responses by activating the TLR signaling pathway. This compound holds significant research and application potential in the fields of vaccine adjuvants and immune diseases.Formule :C20H34N6O2Couleur et forme :SolidMasse moléculaire :390.52STING-IN-11
CAS :STING-IN-11 is a potent, orally bioavailable STING inhibitor (IC₅₀ = 37.8 nM) that blocks STING protein palmitoylation and downstream signaling.Formule :C21H20ClF2N3ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :403.85LD03-DEX
CAS :LD03-DEX is a precursor compound of dexamethasone, characterized by its immunosuppressive activity.Formule :C44H65FO8Couleur et forme :SolidMasse moléculaire :740.98HG-12-6
CAS :HG-12-6 is a type II IRAK4 inhibitor, targeting its inactive form with an IC50 of 165 nM, and is used in autoimmunity and inflammation.Formule :C29H27F3N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.62Amilo-5MER
CAS :Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.Formule :C23H40N6O9SCouleur et forme :SolidMasse moléculaire :576.664TLR7 agonist 28
CAS :TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.Formule :C26H25N9O7Couleur et forme :SolidMasse moléculaire :575.533mPGES1-IN-5
CAS :mPGES1-IN-5 (compound 18) is a multi-substituted pyrimidine compound that acts as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and demonstrates significant inhibitory activity in vivo against acute inflammation models.Formule :C27H27N3OCouleur et forme :SolidMasse moléculaire :409.52TMV-IN-8
CAS :TMV-IN-8 (compound 7d) is an anti-tobacco mosaic virus (TMV) agent with an antiviral EC50 of 157.6 μg/mL. TMV-IN-8 blocks the assembly of TMV by binding with coat protein (Kd = 0.7 μM) and suppresses TMV coat protein gene expression and biosynthesis process [1].Formule :C26H22N6O4Couleur et forme :SolidMasse moléculaire :482.49WK692
CAS :Compound WK692 (compund WK692) is a BCL6 inhibitor that effectively suppresses the growth of diffuse large B-cell lymphoma cells without toxic side effects and acts synergistically with inhibitors of EZH2 and PRMT5.Formule :C26H28Br2N8O5Couleur et forme :SolidMasse moléculaire :692.36ASP-8731
CAS :ASP8731 is a selective inhibitor of BACH1 that prevents inflammation and vascular occlusion, and induces fetal hemoglobin in sickle cell disease.Formule :C20H21N5O4Couleur et forme :SolidMasse moléculaire :395.41CD73-IN-12
CD73-IN-12, a compound from CN114437038A, shows strong anti-tumor activity by effectively inhibiting CD73 enzyme.Formule :C17H14F2N4O2Couleur et forme :SolidMasse moléculaire :344.32Methoxyurea
CAS :Methoxyurea (Compound 3) is a potential modulator of nitric oxide (NO) donors, interacting with hemoglobin forms such as oxyhemoglobin (OxyHb) and methemoglobin (MetHb). It holds promise for use in research on sickle cell disease (SCD).Formule :C2H6N2O2Couleur et forme :SolidMasse moléculaire :90.081COX-2/NO-IN-1
COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.Formule :C15H15NO3Couleur et forme :SolidMasse moléculaire :257.28iNOs-IN-1
iNOs-IN-1 (YPW) is a strong iNOS inhibitor with dose-dependent anti-inflammatory properties, reducing IL-6, iNOS, and NO levels.Formule :C25H30N4O5Couleur et forme :SolidMasse moléculaire :466.53FAPI-74
CAS :FAPI-74 is a PET (positron emission tomography) tracer involved in early FAPI-PET imaging.FAPI-74 can be used to study cancer tumors and degenerative diseases.
Formule :C36H49N9O8Couleur et forme :SolidMasse moléculaire :735.83NDT-30805
NDT-30805, a triazolopyridine, blocks IL-1β in PBMC (IC50: 0.013μM) & NLRP3 inflammasome, for inflammation research.Formule :C23H22N6SCouleur et forme :SolidMasse moléculaire :414.53SLC7A11-IN-2
CAS :SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.Formule :C19H24N4O3Couleur et forme :SolidMasse moléculaire :356.42Keap1-Nrf2-IN-5
CAS :Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Formule :C23H30N4O6SCouleur et forme :SolidMasse moléculaire :490.57Hypoxystat
CAS :Hypoxystat increases the affinity of hemoglobin for oxygen, thereby reducing the release of oxygen to tissues and inducing tissue hypoxia. [Hypoxystat] can alleviate mitochondrial disorder Leigh syndrome in Ndufs4 gene knockout mouse models. Hypoxystat is orally active.Formule :C21H21NO5Couleur et forme :SolidMasse moléculaire :367.395BMY-25551
CAS :BMY-25551, a Mitomycin A analog, exhibits cytotoxicity 8 to 20 times greater than Mitomycin C against both murine and human tumor cell lines. It is applicable in research pertaining to cancer and hematological disorders.Formule :C17H21N3O7Couleur et forme :SolidMasse moléculaire :379.36PB01
CAS :PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.Formule :C18H21N5O3Couleur et forme :SolidMasse moléculaire :355.391A-9758
CAS :A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.Formule :C25H23Cl2F3N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.36(R)-Ketoprofen
CAS :(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.Formule :C16H14O3Couleur et forme :SolidMasse moléculaire :254.28VS-15
CAS :VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.Formule :C29H27N5O3Couleur et forme :SolidMasse moléculaire :493.56NLRP3-IN-53
CAS :NLRP3-IN-53 (compound 1) is an NLRP3 inhibitor with an IC50 of 3.4nM.Formule :C22H27N5O4Couleur et forme :SolidMasse moléculaire :425.48BMS-986458
CAS :BMS-986458 is a highly selective, orally active BCL6 PROTAC degrader. It specifically targets cereblon (CRBN) and the BCL6 N-terminal BTB domain to catalyze proximity-induced BCL6 degradation. BMS-986458 is applicable for research in B-cell non-Hodgkin lymphoma.Formule :C32H34ClN9O3Couleur et forme :SolidMasse moléculaire :628.124mPGES1-IN-4
CAS :mPGES1-IN-4 (compound 32) is a multi-substituted pyrimidine compound acting as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and significantly suppresses acute inflammation models in vivo.Formule :C27H25F2N3OCouleur et forme :SolidMasse moléculaire :445.50S-MTC acetate
CAS :S-MTC acetate (S-Methyl-L-thiocitrulline acetate) serves as a potent inhibitor of inducible nitric oxide synthases and is especially effective in inhibiting the constitutive (neuronal) type rather than the inducible (endothelial) type.Formule :C9H19N3O4SCouleur et forme :SolidMasse moléculaire :265.336,2′,4′-Trimethoxyflavone
CAS :6,2′,4′-Trimethoxyflavone is an AhR antagonist that does not demonstrate effective protection against ischemia-reperfusion injury in the brain of Sprague-Dawley rats.Formule :C18H18O5Couleur et forme :SolidMasse moléculaire :314.332Cryptopleurine
CAS :Cryptopleurine is an inhibitor of gene products associated with cell proliferation, survival, invasion and angiogenesis. It acts by targeting the NF-κB pathway.Formule :C24H27NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.48E 5090
CAS :E5090 is a novel orally active inhibitor of IL-1 generation. It also has anti-inflammatory properties.Formule :C19H20O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.36COX-2/15-LOX-IN-5
CAS :COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.Formule :C25H21N3O3SCouleur et forme :SolidMasse moléculaire :443.52Anti-inflammatory agent 10
Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.Formule :C17H13BrN4O3S2Couleur et forme :SolidMasse moléculaire :465.34XO/COX/LOX-IN-1
XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.Formule :C24H20N4O2SCouleur et forme :SolidMasse moléculaire :428.51Galectin-3-IN-2
Galectin-3-IN-2 inhibits galactose lectin-3 (Gal-3) with an 8.3 μM IC50, impacting cancer-related metabolism.Formule :C24H30FN3O10SCouleur et forme :SolidMasse moléculaire :571.57meso-Zeaxanthin
CAS :meso-Zeaxanthin accumulates in the central retina and, together with lutein and zeaxanthin, forms the macular pigment, which functions as a light filter. meso-Zeaxanthin can quench reactive oxygen species (ROS), thereby exhibiting antioxidant properties.Formule :C40H56O2Couleur et forme :SolidMasse moléculaire :568.871COX-2-IN-7
COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.Formule :C15H13N3O2S2Couleur et forme :SolidMasse moléculaire :331.41Numidargistat
CAS :CB-1158 is a potent and orally bioavailable inhibitor of arginase (IC50s: 86 and 296 nM for recombinant human arginase 1 and 2).Formule :C11H22BN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :287.12NOTA-FAPI
CAS :NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.Formule :C36H47F2N9O8Degré de pureté :99.748%Couleur et forme :SolidMasse moléculaire :771.81ABZI
CAS :(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.Formule :C23H24N6O3Couleur et forme :SolidMasse moléculaire :432.48AMC-04
CAS :AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].Formule :C26H28N2O3Couleur et forme :SolidMasse moléculaire :416.51NLRP3-IN-8
CAS :NLRP3-IN-8, orally active inflammasome blocker, IC50 of 1.23μM, stable (t1/2 = 138.63min), non-toxic (IC50 >100μM).Formule :C23H20N2O6Couleur et forme :SolidMasse moléculaire :420.41COX-2/PI3K-IN-2
COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).Formule :C16H17N5O2Couleur et forme :SolidMasse moléculaire :311.34Factor B-IN-4
CAS :Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.Formule :C27H32N2O4Couleur et forme :SolidMasse moléculaire :448.55IRAK1/4/pan-FLT3 Kinase-IN-2
CAS :IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and < 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.Formule :C20H22F3N5OCouleur et forme :SolidMasse moléculaire :405.42IRAK4-IN-31
CAS :IRAK4-IN-31 is a crystalline inhibitor of IRAK4. It is applicable in research related to myelodysplastic syndromes (MDS).Formule :C27H33N5O5Couleur et forme :SolidMasse moléculaire :507.58HPK1-IN-56
CAS :HPK1-IN-56 (Compound A29) is an HPK1 inhibitor with an IC50 of 2.70 nM. It inhibits downstream p-SLP76 in Jurkat T cells with an IC50 of 8.1 nM. Additionally, HPK1-IN-56 induces IL-2 production in human PBMCs. This compound exhibits anticancer properties, enhancing T cell cytotoxicity and the antitumor efficacy of anti-PD-1 antibodies.Formule :C24H26N8OCouleur et forme :SolidMasse moléculaire :442.516DEG-35
CAS :DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).Formule :C25H21N3O5Couleur et forme :SolidMasse moléculaire :443.45mPGES-1-IN-1
MPGES-1, potential anti-inflammatory drug target, has IC50 of 0.03 μM with mPGES-1-IN-1.Formule :C21H14N4O2SCouleur et forme :SolidMasse moléculaire :386.43iNOS/PGE2-IN-1
iNOS/PGE2-IN-1: iNOS/PGE2 inhibitor, reduces LPS-induced NO, low ulcer risk, anti-inflammatory.Formule :C26H22ClN3O4Couleur et forme :SolidMasse moléculaire :475.92MG-T-19
CAS :MG-T-19, a TIM-3 inhibitor, inhibit the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs.Formule :C18H8Br2ClF3N4O2SDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :596.6Ref: TM-T201721
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€Factor B-IN-3
CAS :Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.Formule :C24H29N3O4Couleur et forme :SolidMasse moléculaire :423.5HOIPIN-8 sodium
CAS :HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.Formule :C23H15F2N4NaO3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :456.38Ref: TM-T62826
1mg70,00€5mg154,00€10mg235,00€25mg378,00€50mg540,00€100mg747,00€200mg1.026,00€1mL*10mM (DMSO)155,00€VVD-130037
CAS :VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Formule :C17H17ClN4O2Degré de pureté :99.01% - 99.92%Couleur et forme :SolidMasse moléculaire :344.8Ref: TM-T88838
1mg148,00€5mg357,00€10mg522,00€25mg833,00€50mg1.103,00€100mg1.508,00€1mL*10mM (DMSO)390,00€AM103
CAS :AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).Formule :C36H38N3NaO4SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :631.76KI696
CAS :KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Formule :C28H30N4O6SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :550.63Ref: TM-T11758L
1mg144,00€5mg298,00€10mg445,00€25mg747,00€50mg1.074,00€100mg1.549,00€200mg2.072,00€1mL*10mM (DMSO)360,00€Evixapodlin
CAS :Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.Formule :C34H36Cl2N8O4Degré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :691.61Ref: TM-T36487
1mg111,00€5mg264,00€10mg424,00€25mg747,00€50mg1.008,00€100mg1.359,00€200mg1.833,00€1mL*10mM (DMSO)405,00€UBS109
CAS :UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.Formule :C18H17N3ODegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :291.35Ref: TM-T88314
2mg38,00€5mg57,00€10mg92,00€25mg166,00€50mg254,00€100mg389,00€200mg566,00€1mL*10mM (DMSO)63,00€Antiproliferative agent-22
CAS :Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.Formule :C17H13N3O3Degré de pureté :99.20% - 99.27%Couleur et forme :SolidMasse moléculaire :307.3Dazostinag disodium
CAS :Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist.Cost-effective and quality-assured.
Formule :C21H20F2N8Na2O10P2S2Degré de pureté :98.84% - 99.96%Couleur et forme :SolidMasse moléculaire :754.482-Selenouracil
CAS :2-Selenouracil is a specialized photosensitizer for photodynamical therapy.Formule :C4H4N2OSeCouleur et forme :SolidMasse moléculaire :175.05PSB-12379
CAS :PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).Formule :C18H23N5O9P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.35Veledimex
CAS :Veledimex is an oral activator ligand for a proprietary gene therapy promoter system. It is also a moderate inhibitor of and substrate for CYP3A4/5.Formule :C27H38N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.6NSC23925
CAS :NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).Formule :C22H26Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.3611β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione
CAS :Formule :C21H28O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.4440(11β,16α)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
CAS :Formule :C24H31FO6Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :434.4977DEXAMETHASONE
CAS :Formule :C22H29FO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.461111β,17α,21-Trihydroxypregn-4-ene-3,20-dione
CAS :Formule :C21H30O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.45999a-Fluoro-11b,17a,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione
CAS :Formule :C22H29FO5Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :392.4611α-Terpineol
CAS :Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.
Formule :C10H18ODegré de pureté :97.55%Couleur et forme :Colorless LiquidMasse moléculaire :154.25Tripeptide-41
CAS :Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.Formule :C29H30N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.57Pam2CSK4 TFA
Pam2CSK4 TFA (PUL-042 TFA) is a potent dual agonist of TLR2 and TLR6, a peptide that mimics bacterial lipoproteins.Pam2CSK4 TFA promotes platelet aggregation, and can be used to study the effects of lipoproteins on the periodontium.Formule :C67H127F3N10O14SDegré de pureté :99.90%Couleur et forme :SoildMasse moléculaire :1385.84Racemic Naproxen
CAS :Racemic Naproxen is a biochemical substance.Formule :C14H14O3Degré de pureté :98%Couleur et forme :Crystals From Acetone-Hexane White SolidMasse moléculaire :230.26Xibornol
CAS :Xibornol (Nanbacine) 具有广谱的抗菌和抗病毒活性，可用于研究革兰氏阳性菌感染和人呼吸道合胞病毒与人冠状病毒229E感染。Formule :C18H26OCouleur et forme :SolidMasse moléculaire :258.4Di-O-methyldemethoxycurcumin
CAS :Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant properties Inhibition of IL-6 production, EC50 is 16.20μg/mL.Formule :C22H22O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.412,3-Bis(3-indolylmethyl)indole
CAS :2,3-Bis(3-indolylmethyl)indole exhibits a concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.Formule :C26H21N3Couleur et forme :SolidMasse moléculaire :375.475RIDR-PI-103
CAS :RIDR-PI-103 is a reactive oxygen species (ROS)-induced drug release prodrug featuring an autocyclized portion connected to the pan-PI3K inhibitor (PI-103). In MDA-MB-361 and MDA-MB-231 cells, Doxorubicin and RIDR-PI-103 exhibited synergistic inhibition of cancer cell proliferation.Formule :C27H25N7O4Couleur et forme :SolidMasse moléculaire :511.53Icatolimab
Icatolimab (JS-004) is a humanized antibody targeting BTLA/CD272 for the study of lymphomas and solid tumors.
Degré de pureté :98.7% (SDS-PAGE); 95.6% (SEC-HPLC) - 98.7% (SDS-PAGE); 95.6% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.5 kDagp91ds-tat
gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.
Degré de pureté :98%Couleur et forme :SolidJH-X-119-01 hydrochloride
CAS :JH-X-119-01 hydrochloride is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 1 (IRAK1) that effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.Formule :C25H21ClN6O3Couleur et forme :SolidMasse moléculaire :488.93Elamipretide acetate
Elamipretide acetate (MTP 131), a small tetrapeptide, targets mitochondria to reduce toxic species and stabilize cardiolipin.
Formule :C34H53N9O7Degré de pureté :99.76%Couleur et forme :SoildMasse moléculaire :699.84TLQP-21 TFA
TLQP-21 TFA is a VGF-derived peptide, C3aR1 agonist (mouse EC50: 10.3μM; human EC50: 68.8μM), that raises intracellular Ca2+ for nociception research.
Degré de pureté :98%Couleur et forme :LiquidTacalcitol
CAS :Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium and modulates immunological and inflammatory processes.Formule :C27H44O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.64STING agonist-22
CAS :STING agonist-22 (CF501) boosts vaccines by activating STING, inducing IFN-I and cytokines, aiding in SARS-CoV-2 research.
Formule :C40H48N14O6Couleur et forme :SolidMasse moléculaire :820.9Aurothioglucose
CAS :Aurothioglucose is a active-site TrxR1 inhibitor.Formule :C6H11AuO5SDegré de pureté :98%Couleur et forme :Yellow Crystals SolidMasse moléculaire :392.18Magnesium citrate
CAS :Magnesium citrate is a useful organic compound for research related to life sciences. The catalog number is T64455 and the CAS number is 3344-18-1.Formule :C12H10Mg3O14Couleur et forme :SolidMasse moléculaire :451.113TLR7/8/9 antagonist 2
CAS :TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.Formule :C23H31N7Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :405.54Nogapendekin alfa inbakicept
CAS :Nogapendekin alfa inbakicept is an IL-15 superagonist that enhances anti-tumor immune responses by activating NK cells and T cells. It is being studied for use in non-muscle invasive bladder cancer (NMIBC).Couleur et forme :SolidTLQP-21 TFA
TLQP-21 TFA （TLQP-21 Trifluoroacetate） 是一种 VGF 衍生肽，可通过结合后折叠机制激活C3aR1 受体。
Degré de pureté :98%ARGX-112
CAS :Temtokibart is a humanized IgG1 λ2 antibody that specifically targets IL22RA1, and is expressed by cells that are deficient in the glutamine synthetase gene.
Couleur et forme :Odour LiquidL-NIO dihydrochloride
CAS :L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) forms, respectively.Formule :C7H16ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :209.67ALPK1-IN-1
CAS :ALPK1-IN-1 (A001) strongly inhibits ALPK1, key for innate immunity & NF-κB signaling via TIFA/TRAF.
Formule :C25H32N6O2SCouleur et forme :SolidMasse moléculaire :480.63ALPK1-IN-2
CAS :ALPK1-IN-2 is a potent inhibitor of ALPK1 (α-kinase 1) (IC50: 95 nM). ALPK1-IN-2 inhibits NF-κB (IC50: 1.31 μM).
Formule :C20H18F2N4O2SCouleur et forme :SolidMasse moléculaire :416.44ALPK1-IN-3
CAS :ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-induced
Formule :C20H16F2N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.43
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