Immunologie et Inflammation
Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"
- RCC(136 produits)
- CXCR(147 produits)
- Paroi cellulaire(5 produits)
- Récepteur IL(113 produits)
- IκB/IKK(61 produits)
- LTR(3 produits)
- MALT(23 produits)
- MRP(6 produits)
- NADPH-oxydase(1 produits)
- NF-κB(445 produits)
- NOD(17 produits)
- NOS(63 produits)
- Nrf2(78 produits)
- PGE Synthase(31 produits)
- ROS(69 produits)
- TGF-beta/Smad(58 produits)
- TLR(66 produits)
- Thioredoxine(12 produits)
- gp120/CD4(4 produits)
Affichez 11 plus de sous-catégories
3035 produits trouvés pour "Immunologie et Inflammation"
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2-Guanidinobezimidazole
CAS :<p>2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB).</p>Formule :C8H9N5Couleur et forme :SolidMasse moléculaire :175.191IRAK4-IN-11
<p>IRAK4-IN-11 (compound 6) is a potent inhibitor of IRAK4 with an IC 50 of 0.008 μM. IRAK4-IN-11 exhibits cell pIRAK4 potencies with an IC 50 of 0.19 μM [1].</p>Formule :C16H19N7OCouleur et forme :SolidMasse moléculaire :325.37E 5090
CAS :<p>E5090 is a novel orally active inhibitor of IL-1 generation. It also has anti-inflammatory properties.</p>Formule :C19H20O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.36COX-2/PI3K-IN-2
<p>COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>Formule :C16H17N5O2Couleur et forme :SolidMasse moléculaire :311.34VISTA-IN-3
CAS :<p>VISTA-IN-3 (Compound A4), a potent small molecule inhibitor of VISTA, exhibits a dissociation constant (K D) of 0.49 μM. This compound effectively induces the release of IFN-γ cytokines and demonstrates synergistic enhancement of anti-cancer activity when combined with PD-L1 antibody [1].</p>Formule :C14H18N4O3Couleur et forme :SolidMasse moléculaire :290.32AMS-17
<p>AMS-17, a strong NLRP3 inhibitor, quells microglia activation and cytokines like caspase-1, TNF-α, IL-1β, iNOS in studies.</p>Formule :C15H13F3N4O3SCouleur et forme :SolidMasse moléculaire :386.35IL-17 modulator 5
CAS :<p>IL-17 modulator 5 is a IL-17 inhibitor, with an IC 50 of 1 nM .</p>Formule :C28H23F6N9O2Couleur et forme :SolidMasse moléculaire :631.53NLRP3-IN-29
CAS :<p>NLRP3-IN-29 (Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) with potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. It can be used for research on Alzheimer's disease [1].</p>Formule :C21H22N2O3SCouleur et forme :SolidMasse moléculaire :382.48(S,R,S)-AHPC-Boc derivative 1
CAS :<p>(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).</p>Formule :C28H40N4O6SCouleur et forme :SolidMasse moléculaire :560.705COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Formule :C19H19N3O4S2Couleur et forme :SolidMasse moléculaire :417.5SP11
CAS :<p>SP11 is a mitochondrial reactive oxygen species (ROS) inhibitor. It activates Fis1 with an IC50 of 9.4 µM by binding to Cys41 and enhances the translocation of Drp1 to mitochondria. SP11 is utilized for research into oxidative stress damage.</p>Formule :C18H19ClN2OSCouleur et forme :SolidMasse moléculaire :346.87Galectin-8-IN-1
<p>Galectin-8-IN-1 selectively binds galectin-8N with 48 μM affinity, 15x more than galectin-3.</p>Formule :C16H18N2O6Couleur et forme :SolidMasse moléculaire :334.32Amilo-5MER
CAS :<p>Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.</p>Formule :C23H40N6O9SCouleur et forme :SolidMasse moléculaire :576.664Nrf2 activator-2
<p>Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.</p>Formule :C20H17BrO3Couleur et forme :SolidMasse moléculaire :385.25cGAS-IN-2
CAS :<p>cGAS-IN-2 (compound 109) serves as a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), exhibiting an IC50 of 0.01512 μM against h-cGAS [1].</p>Formule :C16H18Cl2N2O2Couleur et forme :SolidMasse moléculaire :341.23Cryptopleurine
CAS :<p>Cryptopleurine is an inhibitor of gene products associated with cell proliferation, survival, invasion and angiogenesis. It acts by targeting the NF-κB pathway.</p>Formule :C24H27NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.48BIO-8169
CAS :<p>BIO-8169, a selective interleukin receptor-associated kinase 4 (IRAK 4) inhibitor, demonstrates potent activity with an IC 50 value of 0.23 nM. Exhibiting strong pharmacokinetic properties, BIO-8169 effectively reduces pro-inflammatory cytokine production and mitigates autoimmune encephalomyelitis in the EAE mouse model. Additionally, it has notable blood-brain penetration, evidenced by a rat Kpu,u of 0.7.</p>Formule :C24H27N5O4Couleur et forme :SolidMasse moléculaire :449.50CD73-IN-12
<p>CD73-IN-12, a compound from CN114437038A, shows strong anti-tumor activity by effectively inhibiting CD73 enzyme.</p>Formule :C17H14F2N4O2Couleur et forme :SolidMasse moléculaire :344.32Nitric oxide production-IN-2
CAS :<p>TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is an inhibitor of TLR4, JNK, and NF-κB. It suppresses NO production in LPS-stimulated RAW264.7 cells with an IC50 of 23.2 µM. By inhibiting TLR4 expression and reducing JNK phosphorylation, TLR4/JNK/NF-κB-IN-1 prevents NF-κB activation. This leads to a decrease in the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and the production of inflammatory mediators such as NO, PGE2, and TNF-α, thereby exhibiting anti-inflammatory activity. TLR4/JNK/NF-κB-IN-1 holds potential in the study of inflammatory diseases, including rheumatoid arthritis and various other inflammatory conditions.</p>Formule :C23H20O3Couleur et forme :SolidMasse moléculaire :344.403GB1490
CAS :<p>GB1490 is an orally administered galectin inhibitor, demonstrating Kd values of 0.4 μM for galectin-1 and 2.7 μM for galectin-3 [1].</p>Formule :C17H15Cl2FN4O4S2Couleur et forme :SolidMasse moléculaire :493.36IRAK4-IN-30
CAS :<p>IRAK4-IN-30 (Compound I) is an inhibitor of IRAK4, with an IC50 of 0.6 nM.</p>Formule :C27H33N5O5Couleur et forme :SolidMasse moléculaire :507.581Methoxyurea
CAS :<p>Methoxyurea (Compound 3) is a potential modulator of nitric oxide (NO) donors, interacting with hemoglobin forms such as oxyhemoglobin (OxyHb) and methemoglobin (MetHb). It holds promise for use in research on sickle cell disease (SCD).</p>Formule :C2H6N2O2Couleur et forme :SolidMasse moléculaire :90.081S-MTC acetate
CAS :<p>S-MTC acetate (S-Methyl-L-thiocitrulline acetate) serves as a potent inhibitor of inducible nitric oxide synthases and is especially effective in inhibiting the constitutive (neuronal) type rather than the inducible (endothelial) type.</p>Formule :C9H19N3O4SCouleur et forme :SolidMasse moléculaire :265.33meso-Zeaxanthin
CAS :<p>meso-Zeaxanthin accumulates in the central retina and, together with lutein and zeaxanthin, forms the macular pigment, which functions as a light filter. meso-Zeaxanthin can quench reactive oxygen species (ROS), thereby exhibiting antioxidant properties.</p>Formule :C40H56O2Couleur et forme :SolidMasse moléculaire :568.871TLR7/8 agonist 7
CAS :<p>TLR7/8 agonist 7 activates immune cells, useful in ISAC synthesis and immunity research.</p>Formule :C26H37N7O2Couleur et forme :SolidMasse moléculaire :479.62mPGES1-IN-4
CAS :<p>mPGES1-IN-4 (compound 32) is a multi-substituted pyrimidine compound acting as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and significantly suppresses acute inflammation models in vivo.</p>Formule :C27H25F2N3OCouleur et forme :SolidMasse moléculaire :445.50NLRP3-IN-53
CAS :<p>NLRP3-IN-53 (compound 1) is an NLRP3 inhibitor with an IC50 of 3.4nM.</p>Formule :C22H27N5O4Couleur et forme :SolidMasse moléculaire :425.48VS-15
CAS :<p>VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.</p>Formule :C29H27N5O3Couleur et forme :SolidMasse moléculaire :493.56Numidargistat
CAS :<p>CB-1158 is a potent and orally bioavailable inhibitor of arginase (IC50s: 86 and 296 nM for recombinant human arginase 1 and 2).</p>Formule :C11H22BN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :287.12COX-2/NO-IN-1
<p>COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.</p>Formule :C15H15NO3Couleur et forme :SolidMasse moléculaire :257.28(R)-cGAS-IN-4
CAS :<p>(R)-cGAS-IN-4 (Compound 77A*) is the R-enantiomer of cGAS-IN-4, which acts as an orally active inhibitor of cyclic GMP-AMP synthase-adenosine synthase (cGAS).</p>Formule :C19H18Cl2N4O3Couleur et forme :SolidMasse moléculaire :421.28trans-3-(3-Pyridyl)acrylic acid
CAS :<p>Trans-3-(3-Pyridyl)acrylic acid (compound 15) is a trans-3-aryl acrylic acid demonstrating antiviral activity against tobacco mosaic virus (TMV) [1].</p>Formule :C8H7NO2Couleur et forme :SolidMasse moléculaire :149.15NLRP3-IN-70
CAS :<p>NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.</p>Formule :C23H23NO5Couleur et forme :SolidMasse moléculaire :393.432TMV-IN-8
CAS :<p>TMV-IN-8 (compound 7d) is an anti-tobacco mosaic virus (TMV) agent with an antiviral EC50 of 157.6 μg/mL. TMV-IN-8 blocks the assembly of TMV by binding with coat protein (Kd = 0.7 μM) and suppresses TMV coat protein gene expression and biosynthesis process [1].</p>Formule :C26H22N6O4Couleur et forme :SolidMasse moléculaire :482.49TLR7 agonist 28
CAS :<p>TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.</p>Formule :C26H25N9O7Couleur et forme :SolidMasse moléculaire :575.533(R)-Ketoprofen
CAS :<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Formule :C16H14O3Couleur et forme :SolidMasse moléculaire :254.28DBMB
CAS :<p>DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.</p>Formule :C24H22N4OCouleur et forme :SolidMasse moléculaire :382.4586,2′,4′-Trimethoxyflavone
CAS :<p>6,2′,4′-Trimethoxyflavone is an AhR antagonist that does not demonstrate effective protection against ischemia-reperfusion injury in the brain of Sprague-Dawley rats.</p>Formule :C18H18O5Couleur et forme :SolidMasse moléculaire :314.332iNOs-IN-1
<p>iNOs-IN-1 (YPW) is a strong iNOS inhibitor with dose-dependent anti-inflammatory properties, reducing IL-6, iNOS, and NO levels.</p>Formule :C25H30N4O5Couleur et forme :SolidMasse moléculaire :466.53AhR agonist 2
<p>AhR agonist 2 is aryl hydrocarbon receptor (AhR) agonist,oral, inducing rapid nuclear enrichment of the AhR and facilitating skin barrier repair,psoriasis.</p>Formule :C12H7Br2N3Couleur et forme :SolidMasse moléculaire :353.01Factor B-IN-3
CAS :<p>Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.</p>Formule :C24H29N3O4Couleur et forme :SolidMasse moléculaire :423.5ND-2158
CAS :<p>ND-2158 is a potent and selective inhibitor of IRAK4.</p>Formule :C22H30N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.56mPGES-1-IN-1
<p>MPGES-1, potential anti-inflammatory drug target, has IC50 of 0.03 μM with mPGES-1-IN-1.</p>Formule :C21H14N4O2SCouleur et forme :SolidMasse moléculaire :386.43nNOS-IN-5
CAS :<p>nNOS-IN-5 (Compound 9) is a potent inhibitor of human neuronal nitric oxide synthase (nNOS) with a Ki of 22 nM. It exhibits remarkable selectivity, being 900 times more selective for human nNOS over endothelial nitric oxide synthase (eNOS). nNOS-IN-5 is applicable in research related to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.</p>Formule :C23H22N4OCouleur et forme :SolidMasse moléculaire :370.447NOD1/2 antagonist-1
CAS :<p>NOD1/2 antagonist-1 inhibits NOD1 (IC50 1.13 μM) and NOD2 (IC50 0.77 μM), enhances paclitaxel antitumor efficacy and is used to study innate immune signaling.</p>Formule :C32H28ClF5N4O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :663.03HPK1-IN-56
CAS :<p>HPK1-IN-56 (Compound A29) is an HPK1 inhibitor with an IC50 of 2.70 nM. It inhibits downstream p-SLP76 in Jurkat T cells with an IC50 of 8.1 nM. Additionally, HPK1-IN-56 induces IL-2 production in human PBMCs. This compound exhibits anticancer properties, enhancing T cell cytotoxicity and the antitumor efficacy of anti-PD-1 antibodies.</p>Formule :C24H26N8OCouleur et forme :SolidMasse moléculaire :442.516iNOS/PGE2-IN-1
<p>iNOS/PGE2-IN-1: iNOS/PGE2 inhibitor, reduces LPS-induced NO, low ulcer risk, anti-inflammatory.</p>Formule :C26H22ClN3O4Couleur et forme :SolidMasse moléculaire :475.92Rafutrombopag
CAS :<p>Rafutrombopag is a thrombopoietin (TPO) agonist.</p>Formule :C25H22N4O5Couleur et forme :SolidMasse moléculaire :458.47GNE-2256
CAS :<p>GNE-2256, also known as molecule 19, is an orally active compound that inhibits Interleukin 1 receptor-associated kinase 4 (IRAK4) with a K i of 1.4 nM and has</p>Formule :C24H27FN6O4Couleur et forme :SolidMasse moléculaire :482.51CDA-IN-3
CAS :<p>CDA-IN-3 (NCDI) is a chitin deacetylase (CDA) inhibitor with antiparasitic properties. It disrupts chitin metabolism in nematodes, increasing ROS levels within these organisms and causing cellular damage. CDA-IN-3 significantly inhibits all developmental stages of Caenorhabditis elegans and can be utilized in research focused on anti-infective applications.</p>Formule :C16H27N3O3S2Couleur et forme :SolidMasse moléculaire :373.534
