Immunologie et Inflammation
Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"
- RCC(136 produits)
- CXCR(147 produits)
- Paroi cellulaire(5 produits)
- Récepteur IL(113 produits)
- IκB/IKK(61 produits)
- LTR(3 produits)
- MALT(23 produits)
- MRP(6 produits)
- NADPH-oxydase(1 produits)
- NF-κB(445 produits)
- NOD(17 produits)
- NOS(63 produits)
- Nrf2(78 produits)
- PGE Synthase(31 produits)
- ROS(69 produits)
- TGF-beta/Smad(58 produits)
- TLR(66 produits)
- Thioredoxine(12 produits)
- gp120/CD4(4 produits)
Affichez 11 plus de sous-catégories
3035 produits trouvés pour "Immunologie et Inflammation"
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Anti-inflammatory agent 6
<p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>Formule :C22H20O12Couleur et forme :SolidMasse moléculaire :476.39STING agonist-20
CAS :<p>STING agonist-20: potent, aids in XMT-2056 synthesis, used as a cancer vaccine adjuvant.</p>Formule :C36H39N11O8Couleur et forme :SolidMasse moléculaire :753.76MALT1-IN-11
CAS :<p>MALT1-IN-11: MALT1 inhibitor, IC50 <10-100 nM, reduces IL10, for cancer/autoimmune research.</p>Formule :C20H16F4N8OCouleur et forme :SolidMasse moléculaire :460.39TMC353121
CAS :<p>TMC353121 is an effective inhibitor of respiratory syncytial virus fusion (pEC50: 9.9).</p>Formule :C32H42N6O3Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :558.71YM-I-26
CAS :<p>YM-I-26 is a selective inhibitor of the NLRP3 inflammasome. This compound enhances the phagocytic activity of β-amyloid in murine microglial BV2 cells and reduces the production of IL-1β and IL-10. YM-I-26 is useful for research into inflammation-related immunomodulatory activities.</p>Formule :C28H33ClN2O5S2Couleur et forme :SolidMasse moléculaire :577.16COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Formule :C25H23N5O4S2Couleur et forme :SolidMasse moléculaire :521.61Nrf2 activator-6
CAS :<p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>Formule :C31H37ClFN5O5Couleur et forme :SolidMasse moléculaire :614.11AIM4
CAS :<p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>Formule :C25H23Br2N5O4Couleur et forme :SolidMasse moléculaire :617.289NOD1-IN-1
CAS :<p>NOD1/2-IN-1 (Compound 2) is a potent inhibitor of RIPK2 with an IC50 value of 0.65 nM as determined by the ADP-Glo assay. It selectively inhibits the NOD1 pathway, with an IC50 of 33 nM, effectively blocking the production of pro-inflammatory cytokines and thereby reducing inflammatory responses. This compound has potential applications in the research of colitis.</p>Formule :C16H14ClN3O3Couleur et forme :SolidMasse moléculaire :331.75G108
CAS :<p>G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.</p>Formule :C16H14Cl2N4O2Degré de pureté :99.13% - 99.75%Couleur et forme :SolidMasse moléculaire :365.21NOTA-FAPI
CAS :<p>NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.</p>Formule :C36H47F2N9O8Degré de pureté :99.748%Couleur et forme :SolidMasse moléculaire :771.81SLC7A11-IN-2
CAS :<p>SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.</p>Formule :C19H24N4O3Couleur et forme :SolidMasse moléculaire :356.42α-Gracinoic acid
CAS :<p>α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.</p>Formule :C29H42O4Couleur et forme :SolidMasse moléculaire :454.64SP4206
CAS :<p>SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)</p>Formule :C30H37Cl2N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :662.56CD73-IN-18
CAS :<p>CD73-IN-18 (compound 35j) is an orally effective inhibitor of the extracellular 5'-nucleotidase (CD73) enzyme. It can be utilized in anticancer research.</p>Formule :C20H17N5O3Couleur et forme :SolidMasse moléculaire :375.38SARM1-IN-4
CAS :<p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>Formule :C13H17F2N3O2Couleur et forme :SolidMasse moléculaire :285.29COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Formule :C19H14ClN5S2Couleur et forme :SolidMasse moléculaire :411.93LHC-165
CAS :<p>LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.</p>Formule :C29H32F2N3O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.55SMW139
CAS :<p>SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.</p>Formule :C19H21ClF3NO2Couleur et forme :SolidMasse moléculaire :387.824Antioxidant agent-3
<p>Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.</p>Formule :C18H14O8Couleur et forme :SolidMasse moléculaire :358.3Anti-inflammatory agent 102
CAS :<p>Anti-inflammatory agent 102 (Compound 11a) is an orally effective anti-inflammatory compound. It exerts its effects by inhibiting the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. This agent displays significant anti-inflammatory activity by suppressing the release of NO, ROS, and inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Anti-inflammatory agent 102 is applicable in research concerning inflammatory diseases, including ulcerative colitis (UC).</p>Formule :C16H16ClN3O3Couleur et forme :SolidMasse moléculaire :333.77NLRP3-IN-7
<p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>Formule :C18H15ClN2O4S3Couleur et forme :SolidMasse moléculaire :454.97cGAS-IN-4
CAS :<p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>Formule :C19H18Cl2N4O3Couleur et forme :SolidMasse moléculaire :421.277Cyclic-di-GMP sodium
<p>c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.</p>Formule :C20H24N10NaO14P2Couleur et forme :SolidMasse moléculaire :713.08464MALT1-IN-5
CAS :<p>MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.</p>Formule :C17H17ClF2N6O3Couleur et forme :SolidMasse moléculaire :426.80A-9758
CAS :<p>A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.</p>Formule :C25H23Cl2F3N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.36ABZI
CAS :<p>(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.</p>Formule :C23H24N6O3Masse moléculaire :432.48IRAK4-IN-12
<p>IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).</p>Formule :C24H31FN8OCouleur et forme :SolidMasse moléculaire :466.55IRAK4-IN-15
CAS :<p>IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.</p>Formule :C25H29FN10Couleur et forme :SolidMasse moléculaire :488.56Nrf2-ARE/hMAO-B/QR2 modulator 1
CAS :<p>Nrf2-ARE/hMAO-B/QR2 modulator 1 a resveratrol derivative activated the NRF2-ARE inhibit hMAO-B and QR2, promote hippocampal neurogenesis Alzheimer's disease .</p>Formule :C14H12N2O3Degré de pureté :98.5%Couleur et forme :SolidMasse moléculaire :256.26COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Formule :C31H32FN5O2SCouleur et forme :SolidMasse moléculaire :557.68COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Formule :C15H10ClIN2OCouleur et forme :SolidMasse moléculaire :396.61FAPI-74
CAS :<p>FAPI-74 is a PET (positron emission tomography) tracer involved in early FAPI-PET imaging.FAPI-74 can be used to study cancer tumors and degenerative diseases.</p>Formule :C36H49N9O8Couleur et forme :SolidMasse moléculaire :735.83Creatine ethyl ester
CAS :<p>Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.</p>Formule :C6H13N3O2Couleur et forme :SolidMasse moléculaire :159.186EGR-1-IN-3
CAS :<p>EGR-1-IN-3 (Compound 36) is an inhibitor of early growth response 1 (EGR-1) binding to DNA. It effectively suppresses the binding of EGR-1 to DNA and the expression of inflammation-related genes (such as TSLP, IL-31, IL-6, and CCL2) induced by TNFα. This compound is applicable to the study of inflammatory diseases.</p>Formule :C31H31N3O6SCouleur et forme :SolidMasse moléculaire :573.659Gardiquimod hydrochloride
CAS :<p>Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.</p>Formule :C17H24ClN5OCouleur et forme :SolidMasse moléculaire :349.858MSA-2 dimer
CAS :<p>MSA-2 dimer: selective oral non-nucleotide STING agonist, Kd=145 μM, long-term antitumor effect, non-covalent, higher permeability.</p>Formule :C29H28O8S2Couleur et forme :SolidMasse moléculaire :568.66Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Formule :C18H15N5O2SCouleur et forme :SolidMasse moléculaire :365.41WK692
CAS :<p>Compound WK692 (compund WK692) is a BCL6 inhibitor that effectively suppresses the growth of diffuse large B-cell lymphoma cells without toxic side effects and acts synergistically with inhibitors of EZH2 and PRMT5.</p>Formule :C26H28Br2N8O5Couleur et forme :SolidMasse moléculaire :692.36AMC-04
CAS :<p>AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].</p>Formule :C26H28N2O3Couleur et forme :SolidMasse moléculaire :416.51CPDT
CAS :<p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>Formule :C6H6S3Couleur et forme :SolidMasse moléculaire :174.307IACS-8779 disodium
CAS :<p>IACS-8779 disodium: potent STING agonist, strong systemic anti-tumor effects, effective in melanoma model.</p>Formule :C21H23N9Na2O10P2S2Couleur et forme :SolidMasse moléculaire :733.52mPGES1-IN-5
CAS :<p>mPGES1-IN-5 (compound 18) is a multi-substituted pyrimidine compound that acts as a submicromolar inhibitor of PGE2 production. It primarily exerts its anti-inflammatory effects by inhibiting mPGES-1 and demonstrates significant inhibitory activity in vivo against acute inflammation models.</p>Formule :C27H27N3OCouleur et forme :SolidMasse moléculaire :409.52NLRP3-IN-6
<p>NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.</p>Formule :C18H15ClN2O4S3Couleur et forme :SolidMasse moléculaire :454.97RIPK1-IN-19
CAS :<p>RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.</p>Formule :C28H25FN6O2Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :496.54NLRP3-IN-8
CAS :<p>NLRP3-IN-8, orally active inflammasome blocker, IC50 of 1.23μM, stable (t1/2 = 138.63min), non-toxic (IC50 >100μM).</p>Formule :C23H20N2O6Couleur et forme :SolidMasse moléculaire :420.41IRAK1/4/pan-FLT3 Kinase-IN-2
CAS :<p>IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and < 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.</p>Formule :C20H22F3N5OCouleur et forme :SolidMasse moléculaire :405.42IRAK4-IN-31
CAS :<p>IRAK4-IN-31 is a crystalline inhibitor of IRAK4. It is applicable in research related to myelodysplastic syndromes (MDS).</p>Formule :C27H33N5O5Couleur et forme :SolidMasse moléculaire :507.58DEG-35
CAS :<p>DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).</p>Formule :C25H21N3O5Couleur et forme :SolidMasse moléculaire :443.45AM679
CAS :<p>AM679: potent, selective FLAP inhibitor; IC50s—2.2 nM (FLAP), 0.6 nM (hLA), 154 nM (hWB); blocks leukotrienes in vivo; no significant CYP3A4 interaction.</p>Formule :C40H44N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :692.87
