Immunologie et Inflammation
Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"
- RCC(136 produits)
- CXCR(147 produits)
- Paroi cellulaire(5 produits)
- Récepteur IL(113 produits)
- IκB/IKK(61 produits)
- LTR(3 produits)
- MALT(23 produits)
- MRP(6 produits)
- NADPH-oxydase(1 produits)
- NF-κB(445 produits)
- NOD(17 produits)
- NOS(63 produits)
- Nrf2(78 produits)
- PGE Synthase(31 produits)
- ROS(69 produits)
- TGF-beta/Smad(58 produits)
- TLR(66 produits)
- Thioredoxine(12 produits)
- gp120/CD4(4 produits)
Affichez 11 plus de sous-catégories
3035 produits trouvés pour "Immunologie et Inflammation"
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IKZF2-degrader 1
CAS :<p>IKZF2-degrader 1 (Compound 31) is a molecular glue-type degrader of IKZF2 with a DC50 of 0.5 nM. It exhibits relatively low degradation activity against CK1α, with a DC50 of 210 nM. This compound is applicable in research focused on IKZF2-dependent cancers.</p>Formule :C27H30FN7O3Couleur et forme :SolidMasse moléculaire :519.57CD73-IN-19
CAS :<p>CD73-IN-19 (Compound 4ab) is an inhibitor of CD73, demonstrating a 44% inhibition rate of CD73 enzyme activity at 100 μM. It entirely counters T cell proliferation blockade triggered by TCR activation (induced by CD73 activity) at 10 μM and 100 μM and inhibits hA2A receptor activity in HEK-293 cells with a Ki of 3.31 μM. CD73-IN-19 holds potential for research in the field of immune diseases.</p>Formule :C18H17N3O3SCouleur et forme :SolidMasse moléculaire :355.411AhR agonist 8
CAS :<p>Compound 9, also known as AhR agonist 8, effectively activates the Aryl Hydrocarbon Receptor (AhR) with an EC50 of 0.154 nM. This compound is utilized in researching psoriasis and atopic dermatitis.</p>Formule :C17H15FN4OCouleur et forme :SolidMasse moléculaire :310.33TNFα activity modulator 3
CAS :<p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>Formule :C27H24F2N6O2Couleur et forme :SolidMasse moléculaire :502.52NLRP3-IN-44
CAS :<p>NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.</p>Formule :C25H30N4O3Couleur et forme :SolidMasse moléculaire :434.53GTCpFE
CAS :<p>GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.</p>Formule :C22H20O8Couleur et forme :SolidMasse moléculaire :412.39TBK1/IKKε-IN-1
CAS :<p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).</p>Formule :C28H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.53COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Formule :C22H23FN2O6S2Couleur et forme :SolidMasse moléculaire :494.56Panaxcerol B
CAS :<p>Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.</p>Formule :C27H46O9Couleur et forme :SolidMasse moléculaire :514.65IL-17 modulator 1 disodium
CAS :<p>Potent, orally active IL-17 Modulator 1 (disodium) from patent WO 2020127685, used in psoriasis and arthritis research.</p>Formule :C28H37N6NaO6PCouleur et forme :SolidMasse moléculaire :607.604SBI-0640726
CAS :<p>SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.</p>Formule :C23H15ClN2O2Couleur et forme :SolidMasse moléculaire :386.83IRAK4 modulator-1
CAS :<p>IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].</p>Formule :C19H13ClN4O2Couleur et forme :SolidMasse moléculaire :364.79TIM-3-IN-1
<p>TIM-3-IN-1 is a useful tool to enable further studies on the biology of TIM-3 immunoregulation in cancer.</p>Formule :C20H16ClN7O3SCouleur et forme :SolidMasse moléculaire :469.9IKZF1-degrader-2
CAS :<p>IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].</p>Formule :C33H30FN5O5Couleur et forme :SolidMasse moléculaire :595.62SB24011
CAS :<p>SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].</p>Formule :C34H38N4O7Couleur et forme :SolidMasse moléculaire :614.696-Alkyne-F-araNAD
CAS :<p>6-Alkyne-F-araNAD is an irreversible CD38 inhibitor that aids in better visualization of intracellular CD38 localization when used alongside other fluorescent probes (such as SR101−F-araNMN).</p>Formule :C24H28FN7O13P2Couleur et forme :SolidMasse moléculaire :703.464NF-κB-IN-6
<p>NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signaling</p>Formule :C14H20N2O3Couleur et forme :SolidMasse moléculaire :264.32IRAK4 ligand-13
CAS :<p>IRAK4ligand-13 is an IRAK4 ligand and serves as a PROTAC target protein ligand. It is utilized in the synthesis of PROTAC compounds, such as LZ-07.</p>Formule :C23H26N10Couleur et forme :SolidMasse moléculaire :442.52BAA473
<p>BAA473, a bile acid analog, activates the pyrin inflammasome, triggering IL-18 secretion in myeloid and intestinal cells.</p>Formule :C36H62O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.87Fexlamose
CAS :<p>Fexlamose is an interventional nebulization solution with mucolytic properties, intended for research in chronic obstructive pulmonary disease (COPD).</p>Formule :C12H22O9S2Couleur et forme :SolidMasse moléculaire :374.428Hypoxystat
CAS :<p>Hypoxystat increases the affinity of hemoglobin for oxygen, thereby reducing the release of oxygen to tissues and inducing tissue hypoxia. [Hypoxystat] can alleviate mitochondrial disorder Leigh syndrome in Ndufs4 gene knockout mouse models. Hypoxystat is orally active.</p>Formule :C21H21NO5Couleur et forme :SolidMasse moléculaire :367.395IACS-8779
CAS :<p>IACS-8779 is a potent STING agonist that efficiently stimulates interferon gene activity and exhibits strong systemic antitumor effects.</p>Formule :C21H25N9O10P2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :689.55STING agonist-42
CAS :<p>STINGagonist-42 (compound 8a) is a potent STING agonist. It activates STING in THP1 and RAW 264.7 cells, with EC50 values of 0.06 μM and 14.15 μM, respectively.</p>Formule :C17H8F2LiN5O3Couleur et forme :SolidMasse moléculaire :375.22NLRP3-IN-4
<p>NLRP3-IN-4 is an effective, oral NLRP3 inflammasome inhibitor with potent anti-inflammatory effects on colitis.</p>Formule :C22H22N2O5Couleur et forme :SolidMasse moléculaire :394.42Balsalazide disodium
CAS :<p>Balsalazide disodium is an aminosalicylate prodrug that releases mesalamine in the colon, providing diverse anti-inflammatory effects in regions affected by colitis. Additionally, it exhibits anticancer properties by modulating the IL-6/STAT3 pathway.</p>Formule :C17H13N3Na2O6Couleur et forme :SolidMasse moléculaire :401.281TE-11
CAS :<p>TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.</p>Formule :C16H13NOCouleur et forme :SolidMasse moléculaire :235.28ALR-27
CAS :<p>ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].</p>Formule :C19H22O3Couleur et forme :SolidMasse moléculaire :298.38Itaconic acid prodrug-1
CAS :<p>Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid that efficiently delivers Itaconic acid to skin tissues upon oral administration. It exhibits immunomodulatory effects, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 is useful for research into alopecia areata and other inflammatory skin conditions.</p>Formule :C15H22O10Couleur et forme :SolidMasse moléculaire :362.329K-14585
CAS :<p>K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.</p>Formule :C51H56Cl2N8O4Couleur et forme :SolidMasse moléculaire :915.95AS2690168 (free base)
CAS :<p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Formule :C17H13F3N4OCouleur et forme :SolidMasse moléculaire :346.306FK-565
CAS :<p>FK-565 is a ligand of nucleotide-binding oligomerization domain-1 (NOD1) that induces a mouse model of arteritis.</p>Formule :C22H38N4O9Couleur et forme :SolidMasse moléculaire :502.559mPGES1-IN-9
CAS :<p>mPGES1-IN-9 (compound 1_8) is an mPGES1 inhibitor with an IC50 of 0.5 μM and is utilized in anti-inflammatory research.</p>Formule :C25H18N4OSCouleur et forme :SolidMasse moléculaire :422.502Ambuic acid
CAS :<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Formule :C19H26O6Couleur et forme :SolidMasse moléculaire :350.41DPP4-In hydrochloride
CAS :<p>DPP4-In (hydrochloride) is an inhibitor of dipeptidyl peptidase 4 (DPP4) that effectively reduces the expression of DPP4.</p>Formule :C14H21ClN4O2Couleur et forme :SolidMasse moléculaire :312.8STING agonist-21
CAS :<p>STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].</p>Formule :C17H11F6N5O2Couleur et forme :SolidMasse moléculaire :431.29NIK-IN-2
CAS :<p>NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.</p>Formule :C20H22N4O3Couleur et forme :SolidMasse moléculaire :366.41NLRP3-IN-57
<p>NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.</p>Formule :C44H60O7Couleur et forme :SolidMasse moléculaire :700.94Indeno[1,2,3-cd]pyrene
CAS :<p>Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon, exhibits moderate cytotoxicity to human alveolar epithelial cells (HPAEpiC). Additionally, it enhances allergic pulmonary inflammation responses through the activation of the aryl hydrocarbon receptor.</p>Formule :C22H12Couleur et forme :SolidMasse moléculaire :276.33STING-IN-15
CAS :<p>STING-IN-15 (compound 66) is a potent STING inhibitor, effectively suppressing human and mouse STING with IC50 values of 116 nM and 96.3 nM, respectively. In the REX1 D18N mouse model, STING-IN-15 significantly reduces tissue damage and inflammation.</p>Formule :C20H14F2N4O3Couleur et forme :SolidMasse moléculaire :396.354-Octylphenol
CAS :<p>4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.</p>Formule :C14H22OCouleur et forme :SolidMasse moléculaire :206.32ROS inducer 9
CAS :<p>ROS inducer 9 (compound 4e) is an antibacterial agent with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against Escherichia coli. It eradicates bacteria by inhibiting GSH activity and increasing ROS levels. Additionally, ROS inducer 9 exhibits low toxicity toward red blood cells and RAW 264.7 cells.</p>Formule :C26H26BrF4N3O3Couleur et forme :SolidMasse moléculaire :584.401Darizmetinib
CAS :<p>Darizmetinib (HRX215) is an MKK4 inhibitor.</p>Formule :C21H17F2N5O3SDegré de pureté :98.03% - 99.57%Couleur et forme :SolidMasse moléculaire :457.45UBS109
CAS :<p>UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.</p>Formule :C18H17N3ODegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :291.35KI696
CAS :<p>KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.</p>Formule :C28H30N4O6SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :550.63AM103
CAS :<p>AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).</p>Formule :C36H38N3NaO4SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :631.76Zharp1-211
CAS :<p>Zharp1-211 is a RIPK3 inhibitor，reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.</p>Formule :C24H25N5O4Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :447.49Dazostinag disodium
CAS :<p>Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist.Cost-effective and quality-assured.</p>Formule :C21H20F2N8Na2O10P2S2Degré de pureté :98.84% - 99.96%Couleur et forme :SolidMasse moléculaire :754.48Antiproliferative agent-22
CAS :<p>Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.</p>Formule :C17H13N3O3Degré de pureté :99.20% - 99.27%Couleur et forme :SolidMasse moléculaire :307.3Evixapodlin
CAS :<p>Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.</p>Formule :C34H36Cl2N8O4Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :691.61HOIPIN-8 sodium
CAS :<p>HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.</p>Formule :C23H15F2N4NaO3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :456.38
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