Immunologie et Inflammation
Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"
- RCC(140 produits)
- CXCR(153 produits)
- Paroi cellulaire(5 produits)
- Récepteur IL(108 produits)
- IκB/IKK(59 produits)
- LTR(3 produits)
- MALT(24 produits)
- MRP(6 produits)
- NADPH-oxydase(1 produits)
- NF-κB(445 produits)
- NOD(17 produits)
- NOS(62 produits)
- Nrf2(82 produits)
- PGE Synthase(31 produits)
- ROS(70 produits)
- TGF-beta/Smad(59 produits)
- TLR(74 produits)
- Thioredoxine(12 produits)
- gp120/CD4(4 produits)
Affichez 11 plus de sous-catégories
3269 produits trouvés pour "Immunologie et Inflammation"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
AhR agonist 8
CAS :<p>Compound 9, also known as AhR agonist 8, effectively activates the Aryl Hydrocarbon Receptor (AhR) with an EC50 of 0.154 nM. This compound is utilized in researching psoriasis and atopic dermatitis.</p>Formule :C17H15FN4OCouleur et forme :SolidMasse moléculaire :310.33DEG-35
CAS :DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).Formule :C25H21N3O5Couleur et forme :SolidMasse moléculaire :443.45PVTX-405
CAS :PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a maximum degradation (Dmax) of 91%. It enhances degradation efficiency, significantly reduces off-target degradation, and minimizes hERG inhibition with an IC50 of 48 µM. PVTX-405 effectively inhibits MC38 tumor growth in Crbn391VC57BL/6 mouse xenograft models and shows superior synergistic anticancer effects when combined with immune checkpoint therapies (ICTs) such as anti-PD1 or anti-LAG3 antibodies.Formule :C30H31N5O4Couleur et forme :SolidMasse moléculaire :525.60PSB-0963
CAS :PSB-0963 is a selective competitive extracellular 5'-nucleotidase (eN/CD73) inhibitor with a Ki value of 150 nM for rat extracellular 5'-nucleotidase. It exhibits greater selectivity compared to other extracellular nucleotidases (NTPDases 1-3) and P2Y receptors. PSB-0963 is applicable in cancer research.Formule :C28H17N2NaO5SCouleur et forme :SolidMasse moléculaire :516.50Cyclic-di-GMP sodium
c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.Formule :C20H24N10NaO14P2Couleur et forme :SolidMasse moléculaire :713.08464Ocipumaltib
CAS :Ocipumaltib (Example 2) is an inhibitor of mucosa-associated lymphoid tissue protein 1 (MALT1). It functions as an antineoplastic agent and is utilized in the study of cancer, infections, neurological disorders, and hematological diseases.Formule :C20H16ClF3N8O2Couleur et forme :SolidMasse moléculaire :492.84Cbl-b-IN-1
CAS :Cbl-b-IN-1 is a potent Cbl-b inhibitor (IC50 <100 nM) with potential anticancer activity for the study of intestinal inflammation.Formule :C29H34N6O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :498.631Indeno[1,2,3-cd]pyrene
CAS :Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon, exhibits moderate cytotoxicity to human alveolar epithelial cells (HPAEpiC). Additionally, it enhances allergic pulmonary inflammation responses through the activation of the aryl hydrocarbon receptor.Formule :C22H12Couleur et forme :SolidMasse moléculaire :276.33Anti-inflammatory agent 23
Anti-inflammatory agent 23 blocks LPS-induced NO (IC50: 0.449 μM) and binds p65 well.Formule :C34H49NO6Couleur et forme :SolidMasse moléculaire :567.76α-Hydroxy alprazolam
CAS :α-Hydroxy alprazolam (U 40125), the primary metabolite of α-Hydroxy alprazolam, possesses pharmacological activity accounting for 60% of that of Alprazolam.Formule :C17H13ClN4OCouleur et forme :SolidMasse moléculaire :324.76HTS05585
CAS :HTS05585 (Compound Hit-1) is a selective inhibitor of macrophage migration inhibitory factor (MIF) with a Kd value of 0.29 μM determined by microscale thermophoresis (MST) and confirmed through isothermal titration calorimetry (ITC) at 0.32 μM. It suppresses the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) in macrophages induced by LPS, making it a promising candidate for the study of inflammatory diseases such as sepsis.Formule :C18H15N3OCouleur et forme :SolidMasse moléculaire :289.33TNFα activity modulator 3
CAS :<p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>Formule :C27H24F2N6O2Couleur et forme :SolidMasse moléculaire :502.52RGT-068A
CAS :RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .Formule :C17H16ClN9O2Couleur et forme :SolidMasse moléculaire :413.82NLRP3-IN-44
CAS :<p>NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.</p>Formule :C25H30N4O3Couleur et forme :SolidMasse moléculaire :434.53IRAK4-IN-14
CAS :IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.Formule :C25H28FN9OCouleur et forme :SolidMasse moléculaire :489.55cGAS-IN-4
CAS :<p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>Formule :C19H18Cl2N4O3Couleur et forme :SolidMasse moléculaire :421.277NLRP3-IN-6
<p>NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.</p>Formule :C18H15ClN2O4S3Couleur et forme :SolidMasse moléculaire :454.97NLRP3-IN-57
<p>NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.</p>Formule :C44H60O7Couleur et forme :SolidMasse moléculaire :700.94CYP1B1-IN-10
CAS :CYP1B1-IN-10 (Compound 15C) is a highly selective inhibitor of human cytochrome P450 1B1 (hCYP1B1) with an IC50 value of 0.11 μM. It shows promise for use in research focused on hormone-dependent tumors, including breast and ovarian cancers.Formule :C23H18N2Couleur et forme :SolidMasse moléculaire :322.40Itaconic acid prodrug-1
CAS :Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid that efficiently delivers Itaconic acid to skin tissues upon oral administration. It exhibits immunomodulatory effects, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 is useful for research into alopecia areata and other inflammatory skin conditions.Formule :C15H22O10Couleur et forme :SolidMasse moléculaire :362.329CD73-IN-13
CD73-IN-13, a potent CD73 inhibitor, may be developed for tumor-related disease treatment.Formule :C13H11F3N4O2Couleur et forme :SolidMasse moléculaire :312.25PB01
CAS :<p>PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.</p>Formule :C18H21N5O3Couleur et forme :SolidMasse moléculaire :355.391STING agonist-43
CAS :STINGagonist-43 (Compound 67) is a selective STING agonist with an EC50 of 20.53 μM. It selectively enhances the cGAMP-dependent STING pathway activation by modulating STING oligomerization. STINGagonist-43 demonstrates antitumor activity in a B16.F10 mouse melanoma model and can be utilized in cancer immunotherapy research.Formule :C21H23NO4Couleur et forme :SolidMasse moléculaire :353.41NLRP3-IN-70
CAS :<p>NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.</p>Formule :C23H23NO5Couleur et forme :SolidMasse moléculaire :393.432GTCpFE
CAS :GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formule :C22H20O8Couleur et forme :SolidMasse moléculaire :412.39Panaxcerol B
CAS :<p>Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.</p>Formule :C27H46O9Couleur et forme :SolidMasse moléculaire :514.65BCL6 ligand-4
CAS :BCL6ligand-4 is a BCL6 ligand used in the synthesis of PROTACs, such as BCL6PROTAC 1.Formule :C21H25ClN6O3Couleur et forme :SolidMasse moléculaire :444.92NLRP3-IN-7
<p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>Formule :C18H15ClN2O4S3Couleur et forme :SolidMasse moléculaire :454.97HOIPIN-8 sodium
CAS :<p>HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.</p>Formule :C23H15F2N4NaO3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :456.38VVD-130037
CAS :VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Formule :C17H17ClN4O2Degré de pureté :99.01% - 99.92%Couleur et forme :SolidMasse moléculaire :344.8UBS109
CAS :<p>UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.</p>Formule :C18H17N3ODegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :291.35KI696
CAS :KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Formule :C28H30N4O6SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :550.63Evixapodlin
CAS :Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.Formule :C34H36Cl2N8O4Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :691.61AM103
CAS :AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).Formule :C36H38N3NaO4SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :631.76Antiproliferative agent-22
CAS :<p>Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.</p>Formule :C17H13N3O3Degré de pureté :99.20% - 99.27%Couleur et forme :SolidMasse moléculaire :307.3Dazostinag disodium
CAS :<p>Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist.Cost-effective and quality-assured.</p>Formule :C21H20F2N8Na2O10P2S2Degré de pureté :98.84% - 99.96%Couleur et forme :SolidMasse moléculaire :754.482-Selenouracil
CAS :2-Selenouracil is a specialized photosensitizer for photodynamical therapy.Formule :C4H4N2OSeCouleur et forme :SolidMasse moléculaire :175.05NSC23925
CAS :NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).Formule :C22H26Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.36PSB-12379
CAS :PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).Formule :C18H23N5O9P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.35Veledimex
CAS :Veledimex is an oral activator ligand for a proprietary gene therapy promoter system. It is also a moderate inhibitor of and substrate for CYP3A4/5.Formule :C27H38N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.69a-Fluoro-11b,17a,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione
CAS :Formule :C22H29FO5Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :392.461111β,17α,21-Trihydroxypregn-4-ene-3,20-dione
CAS :Formule :C21H30O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.4599DEXAMETHASONE
CAS :Formule :C22H29FO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.4611α-Terpineol
CAS :<p>Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.</p>Formule :C10H18ODegré de pureté :97.55%Couleur et forme :Colorless LiquidMasse moléculaire :154.25(11β,16α)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
CAS :Formule :C24H31FO6Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :434.497711β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione
CAS :Formule :C21H28O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.4440Tacalcitol
CAS :Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium and modulates immunological and inflammatory processes.Formule :C27H44O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.64TLR7/8/9 antagonist 2
CAS :<p>TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.</p>Formule :C23H31N7Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :405.54Pam2CSK4 TFA
<p>Pam2CSK4 TFA (PUL-042 TFA) is a potent dual agonist of TLR2 and TLR6, a peptide that mimics bacterial lipoproteins.Pam2CSK4 TFA promotes platelet aggregation, and can be used to study the effects of lipoproteins on the periodontium.</p>Formule :C67H127F3N10O14SDegré de pureté :99.90%Couleur et forme :SoildMasse moléculaire :1385.84Aurothioglucose
CAS :Aurothioglucose is a active-site TrxR1 inhibitor.Formule :C6H11AuO5SDegré de pureté :98%Couleur et forme :Yellow Crystals SolidMasse moléculaire :392.18
![Indeno[1,2,3-cd]pyrene](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT201817.webp&w=3840&q=75)
![(11β,16α)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb-webp%2FDA0039HQ.webp&w=3840&q=75)
