Immunologie et Inflammation
Les inhibiteurs en immunologie et inflammation sont des composés qui modulent la réponse immunitaire et les processus inflammatoires. Ces inhibiteurs sont cruciaux pour étudier les mécanismes de la régulation immunitaire, l'auto-immunité et l'inflammation chronique, ainsi que pour développer des traitements pour les maladies inflammatoires, les allergies et les troubles immunitaires. En ciblant des voies clés du système immunitaire, ces inhibiteurs peuvent aider à réduire les réponses immunitaires excessives ou inappropriées. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité en immunologie et inflammation pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Sous-catégories appartenant à la catégorie "Immunologie et Inflammation"
- RCC(143 produits)
- CXCR(158 produits)
- Paroi cellulaire(5 produits)
- Récepteur IL(105 produits)
- IκB/IKK(58 produits)
- LTR(3 produits)
- MALT(25 produits)
- MRP(6 produits)
- NADPH-oxydase(2 produits)
- NF-κB(389 produits)
- NOD(25 produits)
- NOS(61 produits)
- Nrf2(82 produits)
- PGE Synthase(31 produits)
- ROS(70 produits)
- TGF-beta/Smad(59 produits)
- TLR(74 produits)
- Thioredoxine(12 produits)
- gp120/CD4(4 produits)
Affichez 11 plus de sous-catégories
3396 produits trouvés pour "Immunologie et Inflammation"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
CYP1B1-IN-10
CAS :CYP1B1-IN-10 (Compound 15C) is a highly selective inhibitor of human cytochrome P450 1B1 (hCYP1B1) with an IC50 value of 0.11 μM. It shows promise for use in research focused on hormone-dependent tumors, including breast and ovarian cancers.Formule :C23H18N2Couleur et forme :SolidMasse moléculaire :322.40STING agonist-43
CAS :STINGagonist-43 (Compound 67) is a selective STING agonist with an EC50 of 20.53 μM. It selectively enhances the cGAMP-dependent STING pathway activation by modulating STING oligomerization. STINGagonist-43 demonstrates antitumor activity in a B16.F10 mouse melanoma model and can be utilized in cancer immunotherapy research.Formule :C21H23NO4Couleur et forme :SolidMasse moléculaire :353.41(S,R,S)-AHPC-Boc derivative 1
CAS :(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).Formule :C28H40N4O6SCouleur et forme :SolidMasse moléculaire :560.705α-Gracinoic acid
CAS :α-Gracinoic acid acts as an inhibitor of mPGES-1, exhibiting anti-inflammatory properties.Formule :C29H42O4Couleur et forme :SolidMasse moléculaire :454.64IRAK4-IN-12
IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).Formule :C24H31FN8OCouleur et forme :SolidMasse moléculaire :466.55Keap1-Nrf2-IN-5
CAS :Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Formule :C23H30N4O6SCouleur et forme :SolidMasse moléculaire :490.57ARG1-IN-1
CAS :ARG1-IN-1 is a human arginase 1 inhibitor with an IC 50 of 29 nM.Formule :C11H21BN2O4Couleur et forme :SolidMasse moléculaire :256.11(R)-Ketoprofen
CAS :(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.Formule :C16H14O3Couleur et forme :SolidMasse moléculaire :254.28Z-Val-Val-Nle-diazomethylketone
CAS :Z-Val-Val-Nle-diazomethylketone is an inhibitor of cathepsin S (CATS). It significantly suppresses the upregulation of IFNg-induced MHCII molecules, specifically HLA-DR and Ii-p33/35, while increasing the protein level of Ii-p10. This compound can be utilized for research into skin disorders such as psoriasis, atopic dermatitis, and actinic keratosis.Formule :C25H37N5O5Couleur et forme :SolidMasse moléculaire :487.59AS2690168 hydrochloride
CAS :AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Formule :C17H15Cl2F3N4OCouleur et forme :SolidMasse moléculaire :419.228IKZF2-degrader 1
CAS :IKZF2-degrader 1 (Compound 31) is a molecular glue-type degrader of IKZF2 with a DC50 of 0.5 nM. It exhibits relatively low degradation activity against CK1α, with a DC50 of 210 nM. This compound is applicable in research focused on IKZF2-dependent cancers.Formule :C27H30FN7O3Couleur et forme :SolidMasse moléculaire :519.57Galectin-8-IN-1
Galectin-8-IN-1 selectively binds galectin-8N with 48 μM affinity, 15x more than galectin-3.Formule :C16H18N2O6Couleur et forme :SolidMasse moléculaire :334.32Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Formule :C20H17BrO3Couleur et forme :SolidMasse moléculaire :385.25ADU-S100 disodium salt
CAS :ADU-S100 (MIW815) disodium salt is an activator of stimulator of interferon genes (STING).Formule :C20H22N10Na2O10P2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :734.51Factor B-IN-3
CAS :Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.Formule :C24H29N3O4Couleur et forme :SolidMasse moléculaire :423.5NLRP3-IN-69
CAS :NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.Formule :C25H24O7Couleur et forme :SolidMasse moléculaire :436.454Nitric oxide production-IN-2
CAS :TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is an inhibitor of TLR4, JNK, and NF-κB. It suppresses NO production in LPS-stimulated RAW264.7 cells with an IC50 of 23.2 µM. By inhibiting TLR4 expression and reducing JNK phosphorylation, TLR4/JNK/NF-κB-IN-1 prevents NF-κB activation. This leads to a decrease in the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and the production of inflammatory mediators such as NO, PGE2, and TNF-α, thereby exhibiting anti-inflammatory activity. TLR4/JNK/NF-κB-IN-1 holds potential in the study of inflammatory diseases, including rheumatoid arthritis and various other inflammatory conditions.Formule :C23H20O3Couleur et forme :SolidMasse moléculaire :344.403Antibacterial agent 259
CAS :Antibacterialagent 259 (K3) is a bactericide with EC50 values of 1.5, 1.7, and 4.9 mg/L against Xoo, Xoc, and Xac, respectively. It induces the production of reactive oxygen species (ROS) in pathogens, leading to their death. Antibacterialagent 259 is applicable in research for controlling bacterial diseases in plants.Formule :C7H6ClN3O2SCouleur et forme :SolidMasse moléculaire :231.659a15:0-i15:0 PE
CAS :a15:0-i15:0 PE is a dia-cyl phosphatidylethanolamine with two branched chains. It functions as an atypical TLR2-TLR1 heterodimer agonist and is immunogenic. This compound activates T cell and dendritic cell (DC) signaling, exhibiting anti-inflammatory properties. Additionally, a15:0-i15:0 PE induces the production of TNFα and IL-6. It is a major component of the A. muciniphila lipid membrane, constituting approximately 50%.Formule :C35H70NO8PCouleur et forme :SolidMasse moléculaire :663.91TLR7/8 agonist 7
CAS :TLR7/8 agonist 7 activates immune cells, useful in ISAC synthesis and immunity research.Formule :C26H37N7O2Couleur et forme :SolidMasse moléculaire :479.62
